Nature Reviews Neuroscience contents November 2018 Volume 19 Number 11

Advertisement Focal Point on Kobe  A seismic shift - How Kobe rebuilt itself after a devastating earthquake and turned into a biotechnology hub TABLE OF CONTENTS November 2018 Volume 19, Issue 11 Research Highlights Reviews Perspectives Advertisement   Imagine what you can do with a 360° view of locomotion A key endpoint to evaluate efficacy of Parkinson's disease therapies is changes in movement and balance. Typically, these endpoints are measured using established methods like rotarod tests that detect overt changes. At Charles River, we have developed a quantitative fine motor kinematics method to measure small changes in locomotor activity in rodent models of Parkinson's disease to develop a movement "signature".     Advertisement Astrocyte Development & Function Poster This new poster was developed in collaboration with Benjamin Deneen, PhD., Debosmita Sardar, PhD., and Yi-Ting Cheng, MS. at the Baylor College of Medicine. Explore the most current findings on astrocytes' development, subtype diversity, CNS function and role in disease.  Download poster   Advertisement =================================== Register for the latest nature.com webcast Role for NaV1.3 in the developing cerebral cortex - Wednesday, 31 October 2018  Register for FREE today  Sponsored by Advanced Cell Diagnostics ==================================   Research Highlights Rewarding gut feeling Sian Lewis p639 | doi:10.1038/s41583-018-0075-3 Vagal afferents projecting from the gut to the brainstem and then relayed on to the midbrain carry reward signals that trigger dopamine release in the dorsal striatum. PDF In or out of synch Natasha Bray pp640 - 641 | doi:10.1038/s41583-018-0074-4 In a genetic mouse model related to schizophrenia, restoring the excitability of parvalbumin-expressing interneurons in hippocampal CA1 ameliorates network dysfunction and behavioural deficits. PDF It's about time Katherine Whalley pp640 - 641 | doi:10.1038/s41583-018-0066-4 Study shows that population activity in the rat lateral entorhinal cortex can encode the passage of time, which may contribute to temporal aspects of episodic memory. PDF Incidental associations Sian Lewis p641 | doi:10.1038/s41583-018-0069-1 Hippocampal cannabinoid 1 receptors are shown to be involved in the formation of incidental associations between pairs of low-salience sensory stimuli, which can then become indirectly associated with certain cues and thus influence behaviour. PDF A position on vision Darran Yates p642 | doi:10.1038/s41583-018-0076-2 PDF Number crunching Katherine Whalley p642 | doi:10.1038/s41583-018-0073-5 Number neurons encoding symbolic and nonsymbolical representations of numerical value are identified in the human medial temporal lobe PDF Nature Reviews Neuroscience EVENT Neurodegenerative Diseases: Biology & Therapeutics 28.11.18 Cold Spring Harbor, USA More science events from Reviews The neural mechanisms and circuitry of the pair bond    Hasse Walum & Larry J. Young pp643 - 654 | doi:10.1038/s41583-018-0072-6 Recent research advances have yielded fresh insights into the fundamental neural processes underlying pair bonding. In this Review, Walum and Young discuss how neural representations of a partner become inherently rewarding, providing intriguing insights into the neural origins of love. Full Text | PDF CNS infection and immune privilege    John V. Forrester, Paul G. McMenamin & Samantha J. Dando pp655 - 671 | doi:10.1038/s41583-018-0070-8 Traditionally, the CNS is described to have immune privilege, largely because of its immunological barriers. Here, Forrester, McMenamin and Dando describe how this immune privilege may sometimes not be beneficial, as it enables invading pathogens to exist as latent CNS infections. Full Text | PDF Imaging-based parcellations of the human brain    Simon B. Eickhoff, B. T. Thomas Yeo & Sarah Genon pp672 - 686 | doi:10.1038/s41583-018-0071-7 The brain can be parcellated into areas or networks with different structural or functional properties. Eickhoff, Yeo and Genon describe various imaging-based strategies to parcellate the human brain, including those based on local properties, such as cytoarchitecture, and global properties, such as connectivity. Full Text | PDF Imaging the evolution and pathophysiology of Alzheimer disease    William Jagust pp687 - 700 | doi:10.1038/s41583-018-0067-3 Various techniques can be used to image aspects of the pathophysiology of Alzheimer disease in humans, notably protein deposition and neurodegeneration. In this Review, William Jagust discusses how human neuroimaging studies have shaped our understanding of this disease. Full Text | PDF Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today >>   Perspectives Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing    Roberto Cabeza, Marilyn Albert, Sylvie Belleville, Fergus I. M. Craik, Audrey Duarte et al. pp701 - 710 | doi:10.1038/s41583-018-0068-2 Age-related changes in cognitive ability are the focus of a growing field of research. Cabeza, Rajah and colleagues aim to promote clarity in the field by agreeing upon consensual definitions for three widely discussed concepts: maintenance, compensation and reserve. Full Text | PDF Advertisement Alzheimer's Disease Therapeutics: Alternatives to Amyloid December 11, 2018, NYC Featuring Rudolph Tanzi, PhD, of Harvard Medical School, this symposium will highlight non-amyloid mechanisms driving Alzheimer's disease including mitochondrial factors, the vasculature, and autophagy, and discuss strategies to identify new therapeutic targets. Abstracts Nov 2. Register   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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