Nature Reviews Immunology Contents November 2018 Volume 18 Number 11

Advertisement Detect, Modulate, and Analyze T Cell Activation in Real Time Agilent Seahorse XF Analyzers detect real-time T cell activation response within minutes upon stimulation with CD3/CD28 immunogenic beads by measuring discrete changes in cellular glycolysis. Accelerate your analysis with XF technology and learn how XF analysis can be used to optimize CAR T durability.  Watch the webinar TABLE OF CONTENTS November 2018 Volume 18, Issue 11 Comment Research Highlights Reviews Perspectives Amendments & Corrections Advertisement   Focal Point on Kobe A seismic shift - How Kobe rebuilt itself after a devastating earthquake and turned into a biotechnology hub  Comment Are tolerance and training required to end TB?    Maziar Divangahi pp661 - 663 | doi:10.1038/s41577-018-0070-y In this comment, Maziar Divangahi discusses the roles of disease tolerance and trained immunity in tuberculosis infection. Full Text | PDF Research Highlights NETs awaken sleeping cancer cells Yvonne Bordon p665 | doi:10.1038/s41577-018-0081-8 Neutrophil extracellular traps awaken dormant cancer cells by remodelling the extracellular matrix. PDF There's NO limit Yvonne Bordon pp666 - 667 | doi:10.1038/s41577-018-0075-6 A quorum-sensing mechanism downregulates tissue inflammation by regulating metabolism in monocyte-derived cells. PDF lncRNA NKILA: a killer regulator Lucy Bird pp666 - 667 | doi:10.1038/s41577-018-0078-3 The long non-coding RNA NKILA sensitizes antitumour T cells to activation-induced cell death. Targeting this pathway can improve adoptive T cell therapy for cancer. PDF Making new memories Laura K. Mackay p667 | doi:10.1038/s41577-018-0064-9 Laura Mackay describes two landmark papers by Gebhardt et al. and Masopust et al., published in 2009 and 2010, that signified the advent of tissue-resident memory T cells as a distinct T cell subset. PDF Autoreactive T cells in narcolepsy Kirsty Minton pp668 - 669 | doi:10.1038/s41577-018-0073-8 This study supports the suspected autoimmune nature of narcolepsy by showing that patients have memory T cells targeting self-antigens expressed by hypocretin neurons. PDF Uncovering the mystery of secreted IgD Alexandra Flemming pp668 - 669 | doi:10.1038/s41577-018-0080-9 This study demonstrates that secreted IgD promotes protective humoral responses to soluble antigens such as food allergens. PDF Statins as adjuvants Lucy Bird p669 | doi:10.1038/s41577-018-0076-5 Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy. PDF Nature Reviews Immunology EVENT Global Biotechnology Summit (Bio-18) 01.12.18 Wasshington DC, USA More science events from Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Reviews Natural killer cells and other innate lymphoid cells in cancer    Laura Chiossone, Pierre-Yves Dumas, Margaux Vienne & Eric Vivier pp671 - 688 | doi:10.1038/s41577-018-0061-z Eric Vivier and colleagues discuss the emerging roles for natural killer (NK) cells and other innate lymphoid cell populations in cancer immunity. The authors highlight the current immunotherapy trials that are targeting NK cells to treat patients with cancer. Full Text | PDF Perivascular macrophages in health and disease    Antonio Lapenna, Michele De Palma & Claire E. Lewis pp689 - 702 | doi:10.1038/s41577-018-0056-9 This Review examines the functions of a specialized population of macrophages that make direct contact with or are found within one cell thickness of the abluminal surface of blood vessels in various tissues during both steady-state conditions and pathological processes. Full Text | PDF Forkhead box transcription factors as context-dependent regulators of lymphocyte homeostasis    Dietmar M. W. Zaiss & Paul J. Coffer pp703 - 715 | doi:10.1038/s41577-018-0048-9 This Review highlights the key roles of forkhead box transcription factors (FTFs) in regulating lymphocyte responses. The authors discuss how FTFs function as context-dependent rheostats, allowing lymphocytes to fine-tune their responses to diverse environmental challenges. Full Text | PDF Perspectives Studying tissue macrophages in vitro: are iPSC-derived cells the answer?    Christopher Z. W. Lee, Tatsuya Kozaki & Florent Ginhoux pp716 - 725 | doi:10.1038/s41577-018-0054-y Can macrophages derived from induced pluripotent stem cells (iPSCs) be used to effectively model in vivo tissue macrophages? Here, the authors consider the pros and cons of the different protocols for generating macrophages from iPSCs and suggest that a two-step model, based on ontogeny and tissue-specific microenvironment, enables the generation of biologically relevant macrophages. Full Text | PDF Amendments & Corrections Author Correction: Natural killer cells and other innate lymphoid cells in cancer    Laura Chiossone, Pierre-Yves Dumas, Margaux Vienne & Eric Vivier p726 | doi:10.1038/s41577-018-0077-4 Full Text | PDF Publisher Correction: Studying tissue macrophages in vitro: are iPSC-derived cells the answer?    Christopher Z. W. Lee, Tatsuya Kozaki & Florent Ginhoux p726 | doi:10.1038/s41577-018-0060-0 Full Text | PDF Publisher Correction: T cells under starter's orders    Kirsty Minton p726 | doi:10.1038/s41577-018-0074-7 Full Text | PDF Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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