Nature Reviews Cancer contents November 2018 Volume 18 Number 11

Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! TABLE OF CONTENTS November 2018 Volume 18, Issue 11 Research Highlights Reviews Perspectives Amendments & Corrections Advertisement =================================== Register for the latest nature.com webcast Assembling High-quality Genomes to Solve Nature's Mysteries - Thursday, November 1, 2018  Register for FREE today Sponsored by Pac Bio ==================================   Research Highlights BETting on YAP–TAZ Ulrike Harjes p663 | doi:10.1038/s41568-018-0065-9 Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth. PDF mRNA alterations mimic genetic mutations Sarah Seton-Rogers pp664 - 665 | doi:10.1038/s41568-018-0059-7 Lee, Singh et al. find that cancer-specific intronic polyadenylation events occur frequently in tumour suppressor genes in chronic lymphocytic leukaemia (CLL) and generate truncated proteins that could act as CLL drivers. PDF STAT3's true colours Maria Giuseppina Baratta pp664 - 665 | doi:10.1038/s41568-018-0062-z D'Amico et al. show that, in the presence of oncogenic RAS mutations, STAT3 acts as a tumour modifier by regulating the epithelial differentiation of pancreatic and lung cancer cells via p63. PDF Neighbourly deaths dictate fate Anna Dart p665 | doi:10.1038/s41568-018-0064-x Seehawer, Heinzmann et al. show that lineage commitment in liver cancer is independent of oncogenic driver expression and is instead dictated by the type of cell death occurring in the nearby liver microenvironment. PDF A multiplexed view of immune infiltration Sarah Seton-Rogers pp666 - 667 | doi:10.1038/s41568-018-0063-y Keren et al. have used multiplexed imaging in intact samples from breast cancer patients to gain insights into the architecture of the tumour immune microenvironment. PDF Back to the beginning to understand metastasis Sarah Seton-Rogers pp666 - 667 | doi:10.1038/s41568-018-0069-5 Yang et al. have used genetically engineered mouse models of small cell lung cancer to show that the same genomic alterations in different cells of origin lead to the formation of tumours that follow distinct evolutionary paths to metastasis. PDF SPOP mutations disrupt phase separation Sarah Seton-Rogers p667 | doi:10.1038/s41568-018-0066-8 PDF New targets for cancer immunotherapy Anna Dart p667 | doi:10.1038/s41568-018-0067-7 PDF Oncogenic mRNA modification explained Ulrike Harjes p667 | doi:10.1038/s41568-018-0068-6 PDF Nature Reviews Cancer EVENT 17th International Congress on Hormonal Steroids and Hormones & Cancer 26.11.18 Stellenbosch, South Africa More science events from Reviews Stem cell fate in cancer growth, progression and therapy resistance    Nikki K. Lytle, Alison G. Barber & Tannishtha Reya pp669 - 680 | doi:10.1038/s41568-018-0056-x This Review discusses how cells with stem cell characteristics often serve as the tumour cell of origin, as they are preferentially primed for transformation. Furthermore, the activation of stem cell programmes can be crucial for promoting cancer progression and therapy resistance. Full Text | PDF Polyamine metabolism and cancer: treatments, challenges and opportunities    Robert A. Casero Jr, Tracy Murray Stewart & Anthony E. Pegg pp681 - 695 | doi:10.1038/s41568-018-0050-3 This Review discusses new insights into molecular mechanisms that link the dysregulation of polyamine metabolism with carcinogenesis and strategies for targeting this pathway for cancer therapy. Full Text | PDF The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers    Zbyslaw Sondka, Sally Bamford, Charlotte G. Cole, Sari A. Ward, Ian Dunham et al. pp696 - 705 | doi:10.1038/s41568-018-0060-1 This Review discusses the 2018 Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census (CGC), an expert-curated description of human cancer genes, which has recently been expanded to include functional descriptions of how each gene contributes to cancer. Full Text | PDF Advertisement SPOTLIGHT ON KANAZAWA An alternative Japan experience - Meet the sides of Japanese cities that most international researchers never see    Perspectives Fasting and cancer: molecular mechanisms and clinical application    Alessio Nencioni, Irene Caffa, Salvatore Cortellino & Valter D. Longo pp707 - 719 | doi:10.1038/s41568-018-0061-0 This Opinion discusses the potential of fasting and fasting-mimicking diets to help overcome toxicities induced by anticancer therapy. The differential response of normal and cancer cells undergoing starvation is argued to make normal cells less sensitive to therapy-induced toxicity, while cancer cells become more sensitive to therapy-induced cell death. Full Text | PDF Collection: Cancer at Nature Research Advertisement Nature Outlook: Brain cancer The uncontrolled growth of a tumour inside the brain creates an extraordinarily potent threat to our being. A diagnosis of brain cancer still carries the high likelihood of death within five years. But efforts to prolong survival are advancing on several fronts. Access free online Produced with support from Novocure   Amendments & Corrections Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities    Michael J. Mitchell, Rakesh K. Jain & Robert Langer p720 | doi:10.1038/s41568-018-0072-x Full Text | PDF Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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