Nature Genetics Contents: November 2018 Volume 50 Number 11

Advertisement Does Your Taq Need to Go? Upgrade from standard Taq to GoTaq® G2 Hot Start and enjoy the convenience of room-temperature setup and higher yield, sensitivity and specificity. Compare your current Taq to GoTaq® G2 Hot Start and submit your data. You'll be entered to win monthly prizes and an Eppendorf thermal cycler.  Request free sample TABLE OF CONTENTS November 2018 Volume 50, Issue 11 Editorial Correspondence News & Views Letters Articles Analysis Technical Reports Amendments & Corrections Advertisement   SPOTLIGHT ON KANAZAWA An alternative Japan experience - Meet the sides of Japanese cities that most international researchers never see Advertisement The 10th Annual RNA Therapeutics Conference will bring together industry experts from leading RNA companies to discuss the challenges of clinical translation of RNA-based therapeutics, with an emphasis on recent advances made in delivery technologies. The event will also present an in-depth overview of the applications of RNA-based drugs for modulation of gene and protein expression, and genome editing.  More info   Advertisement Nature Outlook: Science and technology education A strong background in science and technology is crucial not only for students who go on to become scientists. The jobs of the future will increasingly require skills in STEM subjects. Science education is being updated to help prepare young people for modern life. Access free online  Produced with support from Amgen Foundation   Advertisement Editor's choice: plant genome editing This collection showcases advances in plant genome editing research, recently published in Scientific Reports, touching on applications of CRISPR-based editing systems and crop breeding.  Explore the collection     Editorial African genetics for human society    p1495 doi:10.1038/s41588-018-0277-7 Correspondence Organization of the genome sequence of the polyploid crop species Brassica juncea    pp1496 - 1497 Zhesi He & Ian Bancroft doi:10.1038/s41588-018-0239-0 Reply to: ‘Organization of the genome sequence of the polyploid crop species Brassica juncea’    pp1497 - 1498 Jinghua Yang, Changmian Ji, Dongyuan Liu, Xiaowu Wang & Mingfang Zhang doi:10.1038/s41588-018-0240-7 Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   News & Views Public resources aid diabetes gene discovery    pp1499 - 1500 Diana L. Cousminer & Struan F. A. Grant doi:10.1038/s41588-018-0242-5 Nature Genetics EVENT BSGCT Autumn Conference: Genome editing for gene and cell therapy - technologies, models and translation 23.11.18 London, UK More science events from Advertisement Focal Point on Kobe  A seismic shift - How Kobe rebuilt itself after a devastating earthquake and turned into a biotechnology hub   Letters Genetic dissection of interspecific differences in yeast thermotolerance    pp1501 - 1504 Carly V. Weiss, Jeremy I. Roop, Rylee K. Hackley, Julie N. Chuong, Igor V. Grigoriev et al. doi:10.1038/s41588-018-0243-4 A mapping approach that screens mutants in a sterile interspecific hybrid identifies the genetic determinants of differences in high-temperature growth between divergent Saccharomyces cerevisiae and Saccharomyces paradoxus yeast species. Articles Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps    pp1505 - 1513 Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres et al. doi:10.1038/s41588-018-0241-6 Combining 32 genome-wide association studies with high-density imputation provides a comprehensive view of the genetic contribution to type 2 diabetes in individuals of European ancestry with respect to locus discovery, causal-variant resolution, and mechanistic insight. Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program    pp1514 - 1523 Derek Klarin, Scott M. Damrauer, Kelly Cho, Yan V. Sun, Tanya M. Teslovich et al. doi:10.1038/s41588-018-0222-9 Analysis of genetic data and blood lipid measurements from over 300,000 participants in the Million Veteran Program identifies new associations for blood lipid traits. Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome    pp1524 - 1532 Daria V. Zhernakova, Trang H. Le, Alexander Kurilshikov, Biljana Atanasovska, Marc Jan Bonder et al. doi:10.1038/s41588-018-0224-7 Genome-wide and metagenome-wide association study of 92 cardiovascular-diseases-related proteins identifies genetic and microbial factors that explain 76.6% of inter-individual variation, highlighting the role of gut microbiome in cardiovascular disease. Single-molecule nascent RNA sequencing identifies regulatory domain architecture at promoters and enhancers    pp1533 - 1541 Jacob M. Tome, Nathaniel D. Tippens & John T. Lis doi:10.1038/s41588-018-0234-5 Sequencing nascent RNAs at single-molecule resolution with CoPRO unravels the interplay between Pol II initiation, capping and pausing. Transcription start site clusters provide a framework for understanding genome regulatory architecture. Insights into imprinting from parent-of-origin phased methylomes and transcriptomes    pp1542 - 1552 Florian Zink, Droplaug N. Magnusdottir, Olafur T. Magnusson, Nicolas J. Walker, Tiffany J. Morris et al. doi:10.1038/s41588-018-0232-7 Two hundred and eighty-five methylomes and 11,617 transcriptomes from peripheral blood samples with parent-of-origin-phased haplotypes produce a new map of imprinted methylation and gene expression patterns across the human genome. Chromatin run-on and sequencing maps the transcriptional regulatory landscape of glioblastoma multiforme    pp1553 - 1564 Tinyi Chu, Edward J. Rice, Gregory T. Booth, H. Hans Salamanca, Zhong Wang et al. doi:10.1038/s41588-018-0244-3 Chromatin run-on and sequencing (ChRO-seq) is a new method that maps the location of RNA polymerase using virtually any input sample. Here, ChRO-seq is used to study nascent transcription in human glioblastoma, and to identify regulators of tumor subtype. Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L.    pp1565 - 1573 Jisen Zhang, Xingtan Zhang, Haibao Tang, Qing Zhang, Xiuting Hua et al. doi:10.1038/s41588-018-0237-2 Sequencing of haploid sugarcane, Saccharum spontaneum, allows assembly of a prototypical version of the sugarcane chromosome set. This new reference genome will serve as a resource to accelerate sugarcane improvement. Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci    pp1574 - 1583 Jingtao Lilue, Anthony G. Doran, Ian T. Fiddes, Monica Abrudan, Joel Armstrong et al. doi:10.1038/s41588-018-0223-8 Sequence assemblies for the genomes of 16 widely used inbred laboratory mouse strains highlight considerable strain-specific haplotype variation and allow for the identification of regions with the greatest sequence diversity between strains. Analysis Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility    pp1584 - 1592 Towfique Raj, Yang I. Li, Garrett Wong, Jack Humphrey, Minghui Wang et al. doi:10.1038/s41588-018-0238-1 Analysis of mRNA splicing in the dorsolateral prefrontal cortex from two cohorts established to study aging identifies variations in pre-mRNA splicing events that are associated with Alzheimer’s disease. An atlas of genetic associations in UK Biobank    pp1593 - 1599 Oriol Canela-Xandri, Konrad Rawlik & Albert Tenesa doi:10.1038/s41588-018-0248-z GeneATLAS is a web resource that presents genetic association results for 118 non-binary and 660 binary traits using UK Biobank data. This atlas allows researchers to query these results without incurring high computational costs. Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations    pp1600 - 1607 Steven Gazal, Po-Ru Loh, Hilary K. Finucane, Andrea Ganna, Armin Schoech et al. doi:10.1038/s41588-018-0231-8 The authors extend stratified linkage disequilibrium score regression to partition the heritability of both low-frequency and common variants in 40 heritable traits from the UK Biobank, providing insights into low-frequency and rare variant functional architectures. Technical Reports Identifying loci affecting trait variability and detecting interactions in genome-wide association studies    pp1608 - 1614 Alexander I. Young, Fabian L. Wauthier & Peter Donnelly doi:10.1038/s41588-018-0225-6 The heteroskedastic linear mixed model is a new framework for testing both mean and variance effects on quantitative traits. Applying the heteroskedastic linear mixed model to body mass index in the UK Biobank shows that the approach increases the power to detect associated loci. Amendments & Corrections Author Correction: Parent-of-origin-specific signatures of de novo mutations    p1615 Jakob M Goldmann, Wendy S W Wong, Michele Pinelli, Terry Farrah, Dale Bodian et al. doi:10.1038/s41588-018-0226-5 Author Correction: The genome sequence of allopolyploid Brassica juncea and analysis of differential homoeolog gene expression influencing selection    p1616 Jinghua Yang, Dongyuan Liu, Xiaowu Wang, Changmian Ji, Feng Cheng et al. doi:10.1038/s41588-018-0227-4 Author Correction: The rate of meiotic gene conversion varies by sex and age    p1616 Bjarni V Halldorsson, Marteinn T Hardarson, Birte Kehr, Unnur Styrkarsdottir, Arnaldur Gylfason et al. doi:10.1038/s41588-018-0228-3 Publisher Correction: Ancient hybridization and strong adaptation to viruses across African vervet monkey populations    p1617 Hannes Svardal, Anna J Jasinska, Cristian Apetrei, Giovanni Coppola, Yu Huang et al. doi:10.1038/s41588-018-0124-x Publisher Correction: The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution    p1617 Jeramiah J. Smith, Nataliya Timoshevskaya, Chengxi Ye, Carson Holt, Melissa C. Keinath et al. doi:10.1038/s41588-018-0199-4 Publisher Correction: Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza    p1618 Joshua C. Stein, Yeisoo Yu, Dario Copetti, Derrick J. Zwickl, Li Zhang et al. doi:10.1038/s41588-018-0261-2 Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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