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KACST Impact is a new online publication highlighting the latest cutting edge scientific research conducted at King Abdulaziz City for Science and Technology (KACST) that features various stories ranging from exciting new scientific finds to the commercialization of innovative discoveries.
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All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | Latest Comment | | | | | | | | Latest Articles | View all Articles | | | Cloaking nanoparticles with protein corona shield for targeted drug delivery OPEN | | Jun Yong Oh, Han Sol Kim, L. Palanikumar, Eun Min Go, Batakrishna Jana, Soo Ah Park, Ho Young Kim, Kibeom Kim, Jeong Kon Seo, Sang Kyu Kwak, Chaekyu Kim, Sebyung Kang & Ja-Hyoung Ryu | | | The efficacy of nanoparticles can be significantly inhibited by serum proteins binding to them. Here, the author developed a supramolecularly constructed protein corona on nanoparticles, which minimises interactions with serum proteins to prevent the clearance of these particles by macrophages. | | 31 October 2018 | doi: 10.1038/s41467-018-06979-4 | | Drug delivery Nanoparticles | Management of transition dipoles in organic hole-transporting materials under solar irradiation for perovskite solar cells OPEN | | Song Ah Ok, Bonghyun Jo, Sivaraman Somasundaram, Hwi Je Woo, Dae Woon Lee, Zijia Li, Bong-Gi Kim, Jong H. Kim, Young Jae Song, Tae Kyu Ahn, Sanghyuk Park & Hui Joon Park | | | In perovskite solar cells, the excited state property of hole-transport layer is not usually considered for the devices. Here the authors design organic hole-transport materials with high transition dipoles having extended lifetime at the excited states to improve the charge extraction of the devices. | | 31 October 2018 | doi: 10.1038/s41467-018-06998-1 | | Solar cells | Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex OPEN | | Javier Oroz, Bliss J. Chang, Piotr Wysoczanski, Chung-Tien Lee, Ángel Pérez-Lara, Pijush Chakraborty, Romina V. Hofele, Jeremy D. Baker, Laura J. Blair, Jacek Biernat, Henning Urlaub, Eckhard Mandelkow, Chad A. Dickey & Markus Zweckstetter | | | The chaperone Hsp90 plays a key role in maintaining cellular homeostasis. Here the authors provide structural insights into substrate recognition and the pro-folding mechanism of Hsp90/co-chaperone complexes by studying the complex of Hsp90 with its co-chaperone FKBP51 and the substrate Tau bound Hsp90/FKBP51 ternary complex using a NMR based integrative approach. | | 31 October 2018 | doi: 10.1038/s41467-018-06880-0 | | Chaperones Solution-state NMR | Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin OPEN | | Cuijun Zhang, Xuan Du, Kai Tang, Zhenlin Yang, Li Pan, Peipei Zhu, Jinyan Luo, Yuwei Jiang, Hui Zhang, Huafang Wan, Xingang Wang, Fengkai Wu, W. Andy Tao, Xin-Jian He, Heng Zhang, Ray A. Bressan, Jiamu Du & Jian-Kang Zhu | | | DNA methylation and H3K9 dimethylation are two linked epigenetic marks of silenced chromatin in plants that depend on the activity of CMT3/2 and SUVH4/5/6. Here the authors identify AGDP1 as an H3K9me2-binding protein required for heterochromatic non-CG DNA methylation, H3K9 dimethylation, and transcriptional silencing. | | 31 October 2018 | doi: 10.1038/s41467-018-06965-w | | DNA methylation Histone post-translational modifications Plant signalling X-ray crystallography | PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma OPEN | | Feng Dong, Qian Li, Chao Yang, Dawei Huo, Xing Wang, Chunbo Ai, Yu Kong, Xiaoyu Sun, Wen Wang, Yan Zhou, Xing Liu, Wei Li, Weiwei Gao, Wen Liu, Chunsheng Kang & Xudong Wu | | | The role of protein arginine methyltransferases (PRMTs) in epigenetic regulation in cancer is still poorly understood. Here, the authors show that PRMT2 is highly expressed in Glioblastoma multiforme (GBM) and provide evidence that PRMT2 acts as a transcriptional co-activator for oncogenic gene expression programs, at least partly dependent on its H3R8me2a activity, in GBM pathogenesis. | | 31 October 2018 | doi: 10.1038/s41467-018-06968-7 | | Histone post-translational modifications Oncogenes | Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif OPEN | | Sandip A. Shelke, Yaming Shao, Artur Laski, Deepak Koirala, Benjamin P. Weissman, James R. Fuller, Xiaohong Tan, Tudor P. Constantin, Alan S. Waggoner, Marcel P. Bruchez, Bruce A. Armitage & Joseph A. Piccirilli | | | The DIR2s RNA aptamer activates the fluorescence of cyanine dyes allowing detection of two well-resolved emission colors. Here authors solve the crystal structures of the apo and OTB-SO3 fluorophore-bound DIR2s and show how the fluorophore ligand is bound. | | 31 October 2018 | doi: 10.1038/s41467-018-06942-3 | | Chemical biology RNA Structural biology | MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma OPEN | | Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton & Manjeet K. Rao | | | The radiation and chemotherapy used for treating medulloblastoma patients cause debilitating side effects. Here, the authors show that miR-584 acts as a therapeutic adjuvant as it sensitizes medulloblastoma to radiation and chemotherapy by targeting HDAC1 or eIF4E3 to enhance spindle defects and DNA damage. | | 31 October 2018 | doi: 10.1038/s41467-018-06808-8 | | Cell biology CNS cancer Paediatric cancer | In situ strain tuning of the metal-insulator-transition of Ca2RuO4 in angle-resolved photoemission experiments OPEN | | S. Riccò, M. Kim, A. Tamai, S. McKeown Walker, F. Y. Bruno, I. Cucchi, E. Cappelli, C. Besnard, T. K. Kim, P. Dudin, M. Hoesch, M. J. Gutmann, A. Georges, R. S. Perry & F. Baumberger | | | The role of the lattice in the correlated metal-insulator transition of Ca2RuO4 has led to significant interest but experiments that are at the same time sensitive to crystal and electronic structure are difficult. Riccò et al. successfully combine ARPES measurements with in situ strain tuning across the Mott transition. | | 31 October 2018 | doi: 10.1038/s41467-018-06945-0 | | Electronic properties and materials Phase transitions and critical phenomena | Induced-fit expansion and contraction of a self-assembled nanocube finely responding to neutral and anionic guests OPEN | | Yi-Yang Zhan, Tatsuo Kojima, Takashi Nakamura, Toshihiro Takahashi, Satoshi Takahashi, Yohei Haketa, Yoshiaki Shoji, Hiromitsu Maeda, Takanori Fukushima & Shuichi Hiraoka | | | Induced-fit binding, common in biological systems, is still relatively rare in artificial hosts. Here, the authors assemble a molecular cube from six gear-shaped faces, whose interdigitated design allows the cube to expand and contract in response to the size, shape, and charge of a guest molecule. | | 31 October 2018 | doi: 10.1038/s41467-018-06874-y | | Molecular capsules Self-assembly | Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo OPEN | | Sabil Huda, Bettina Weigelin, Katarina Wolf, Konstantin V. Tretiakov, Konstantin Polev, Gary Wilk, Masatomo Iwasa, Fateme S. Emami, Jakub W. Narojczyk, Michal Banaszak, Siowling Soh, Didzis Pilans, Amir Vahid, Monika Makurath, Peter Friedl, Gary G. Borisy, Kristiana Kandere-Grzybowska & Bartosz A. Grzybowski | | | 31 October 2018 | doi: 10.1038/s41467-018-06563-w | | Cellular motility Metastasis | Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics OPEN | | Prashant Dogra, Natalie L. Adolphi, Zhihui Wang, Yu-Shen Lin, Kimberly S. Butler, Paul N. Durfee, Jonas G. Croissant, Achraf Noureddine, Eric N. Coker, Elaine L. Bearer, Vittorio Cristini & C. Jeffrey Brinker | | | Nanoparticle applications are limited by insufficient understanding of physiochemical properties on in vivo disposition. Here, the authors explore the influence of size, surface chemistry and administration on the biodisposition of mesoporous silica nanoparticles using image-based pharmacokinetics. | | 31 October 2018 | doi: 10.1038/s41467-018-06730-z | | Drug delivery Imaging techniques and agents Nanoparticles Nanotechnology in cancer Scientific data | Interactions between callose and cellulose revealed through the analysis of biopolymer mixtures OPEN | | Radwa H. Abou-Saleh, Mercedes C. Hernandez-Gomez, Sam Amsbury, Candelas Paniagua, Matthieu Bourdon, Shunsuke Miyashima, Ykä Helariutta, Martin Fuller, Tatiana Budtova, Simon D. Connell, Michael E. Ries & Yoselin Benitez-Alfonso | | | Despite their importance in plant development and defence the properties of (1,3)-β-glucan remain largely unknown. Here, the authors find that addition of (1,3)-β-glucans increases the flexibility of cellulose and its resilience to high strain, an effect originating in molecular level interactions. | | 31 October 2018 | doi: 10.1038/s41467-018-06820-y | | Biological physics Biopolymers in vivo Cell wall Soft materials | Identification and characterization of a large family of superbinding bacterial SH2 domains OPEN | | Tomonori Kaneko, Peter J. Stogios, Xiang Ruan, Courtney Voss, Elena Evdokimova, Tatiana Skarina, Amy Chung, Xiaoling Liu, Lei Li, Alexei Savchenko, Alexander W. Ensminger & Shawn S.-C. Li | | | SH2 domains bind to tyrosine-phosphorylated proteins and play crucial roles in signal transduction in mammalian cells. Here, Kaneko et al. identify a large family of SH2 domains in the bacterial pathogen Legionella that bind to mammalian phosphorylated proteins, in some cases with very high affinity. | | 31 October 2018 | doi: 10.1038/s41467-018-06943-2 | | Bacterial structural biology Cell signalling Pathogens X-ray crystallography | Direct cysteine sulfenylation drives activation of the Src kinase OPEN | | David E. Heppner, Christopher M. Dustin, Chenyi Liao, Milena Hristova, Carmen Veith, Andrew C. Little, Bethany A. Ahlers, Sheryl L. White, Bin Deng, Ying-Wai Lam, Jianing Li & Albert van der Vliet | | | The activity of several protein kinases is increased upon cellular production of reactive oxygen species, which can cause cysteine oxidation. Here the authors show that sulfenylation of specific cysteine residues within Src induce local structural changes that directly impact its activation. | | 30 October 2018 | doi: 10.1038/s41467-018-06790-1 | | Enzyme mechanisms Kinases Molecular modelling Post-translational modifications | Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture OPEN | | Monica Suryana Tjin, Alvin Wen Choong Chua, Aida Moreno-Moral, Li Yen Chong, Po Yin Tang, Nathan Peter Harmston, Zuhua Cai, Enrico Petretto, Bien Keem Tan & Karl Tryggvason | | | In vitro expansion of human epidermal keratinocytes to resurface severe wound defects still relies on a human/mouse xenograft culture system. Here the authors develop a fully human, xeno-free culture system using skin-associated laminins, normally present in vivo, to replace mouse feeder cells. | | 30 October 2018 | doi: 10.1038/s41467-018-06934-3 | | Skin stem cells Stem-cell research Translational research | Adrenal hormones mediate disease tolerance in malaria OPEN | | Leen Vandermosten, Thao-Thy Pham, Sofie Knoops, Charlotte De Geest, Natacha Lays, Kristof Van der Molen, Christopher J. Kenyon, Manu Verma, Karen E. Chapman, Frans Schuit, Karolien De Bosscher, Ghislain Opdenakker & Philippe E. Van den Steen | | | Disease tolerance mechanisms counter the negative effects of infection without decreasing the pathogen load. Here, the authors show that in mouse models of malaria, such disease tolerance can be conferred by adrenal hormones, by preventing excessive inflammation and hypoglycemia. | | 30 October 2018 | doi: 10.1038/s41467-018-06986-5 | | Infection Malaria Parasite host response Pathogens | Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition OPEN | | Jonathan R. LaRochelle, Michelle Fodor, Vidyasiri Vemulapalli, Morvarid Mohseni, Ping Wang, Travis Stams, Matthew J. LaMarche, Rajiv Chopra, Michael G. Acker & Stephen C. Blacklow | | | Activating mutations of the non-receptor protein tyrosine phosphatase SHP2 can cause cancer. Here the authors present the crystal structure of SHP2E76K, the most frequent cancer-associated SHP2 mutation, which adopts an open-state structure and show that the allosteric inhibitor SHP099 can revert SHP2E76K to its closed, autoinhibited conformation. | | 30 October 2018 | doi: 10.1038/s41467-018-06823-9 | | Chemical biology X-ray crystallography | Integrated silicon qubit platform with single-spin addressability, exchange control and single-shot singlet-triplet readout OPEN | | M. A. Fogarty, K. W. Chan, B. Hensen, W. Huang, T. Tanttu, C. H. Yang, A. Laucht, M. Veldhorst, F. E. Hudson, K. M. Itoh, D. Culcer, T. D. Ladd, A. Morello & A. S. Dzurak | | | Significant progress has been made developing the different methods needed for a spin-based quantum computer but the challenge of integrating them remains. Fogarty et al. present a system with single-spin addressability, spin-spin interactions and high-fidelity readout that provides a scalable foundation for error-corrected devices. | | 30 October 2018 | doi: 10.1038/s41467-018-06039-x | | Electronic devices Quantum dots Quantum information Qubits | An electrochemical thermal transistor OPEN | | Aditya Sood, Feng Xiong, Shunda Chen, Haotian Wang, Daniele Selli, Jinsong Zhang, Connor J. McClellan, Jie Sun, Davide Donadio, Yi Cui, Eric Pop & Kenneth E. Goodson | | | Thermal transistors can enable game changing applications in energy harvesting and heat routing. Here, the authors demonstrate reversible thermal modulation of nearly 10 times by ion intercalation in MoS2 nanofilms. A new thermal microscopy technique allows operando imaging of Li ion segregation. | | 30 October 2018 | doi: 10.1038/s41467-018-06760-7 | | Condensed-matter physics Electrochemistry Imaging techniques Nanoscale devices Two-dimensional materials | Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection OPEN | | Marion Rolot, Annette M. Dougall, Alisha Chetty, Justine Javaux, Ting Chen, Xue Xiao, Bénédicte Machiels, Murray E. Selkirk, Rick M. Maizels, Cornelis Hokke, Olivier Denis, Frank Brombacher, Alain Vanderplasschen, Laurent Gillet, William G. C. Horsnell & Benjamin G. Dewals | | | Parasitic helminth infection is known to impact upon the host response to other bystander inflammatory processes. Here the authors show that IL4 production induced by helminth infection results in expansion of bystander CD8+ memory T cells and enhanced control to viral infection. | | 30 October 2018 | doi: 10.1038/s41467-018-06978-5 | | CD8-positive T cells Infection Parasitic infection Viral infection | Network integration of multi-tumour omics data suggests novel targeting strategies OPEN | | Ítalo Faria do Valle, Giulia Menichetti, Giorgia Simonetti, Samantha Bruno, Isabella Zironi, Danielle Fernandes Durso, José C. M. Mombach, Giovanni Martinelli, Gastone Castellani & Daniel Remondini | | | Tumours of different tissues can show similarities in genomic alterations. Here, the authors combine tumour transcriptome and protein interaction data in a network-based analysis of 11 tumours types, and identify clusters of tumours with specific signatures for multi-tumour drug targeting and survival prognosis. | | 30 October 2018 | doi: 10.1038/s41467-018-06992-7 | | Cancer genomics Data integration Network topology Systems analysis | Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms OPEN | | Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C. De Smedt, Tom Coenye & Kevin Braeckmans | | | Eradication of bacterial infections can be hindered by poor penetration of antibiotics through biofilms. Here, Teirlinck et al. show that laser-induced vapour nanobubbles formed around plasmonic nanoparticles can be used to locally disturb biofilm integrity and improve antibiotic diffusion. | | 30 October 2018 | doi: 10.1038/s41467-018-06884-w | | Antibiotics Biofilms Nanoparticles Optics and photonics | A high-energy sulfur cathode in carbonate electrolyte by eliminating polysulfides via solid-phase lithium-sulfur transformation OPEN | | Xia Li, Mohammad Banis, Andrew Lushington, Xiaofei Yang, Qian Sun, Yang Zhao, Changqi Liu, Qizheng Li, Biqiong Wang, Wei Xiao, Changhong Wang, Minsi Li, Jianwen Liang, Ruying Li, Yongfeng Hu, Lyudmila Goncharova, Huamin Zhang, Tsun-Kong Sham & Xueliang Sun | | | Carbonate-based electrolytes can impart advantages in lithium sulfur batteries, but performance is often limited by incompatibility with sulfur-based cathodes. Here the authors elucidate a mechanism for conversion of sulfur to lithium sulfide and demonstrate improved performance in a Li-S cell. | | 30 October 2018 | doi: 10.1038/s41467-018-06877-9 | | Batteries Characterization and analytical techniques | Seeded X-ray free-electron laser generating radiation with laser statistical properties OPEN | | Oleg Yu. Gorobtsov, Giuseppe Mercurio, Flavio Capotondi, Petr Skopintsev, Sergey Lazarev, Ivan A. Zaluzhnyy, Miltcho B. Danailov, Martina Dell'Angela, Michele Manfredda, Emanuele Pedersoli, Luca Giannessi, Maya Kiskinova, Kevin C. Prince, Wilfried Wurth & Ivan A. Vartanyants | | | Free electron lasers are emerging as important tools for nonlinear spectroscopy in the X-ray regime. Here the authors demonstrate the second order coherence of a seeded FEL source that may be useful for measurements in quantum optics. | | 29 October 2018 | doi: 10.1038/s41467-018-06743-8 | | Free-electron lasers Optical spectroscopy | Molecular definition of group 1 innate lymphoid cells in the mouse uterus OPEN | | Iva Filipovic, Laura Chiossone, Paola Vacca, Russell S. Hamilton, Tiziano Ingegnere, Jean-Marc Doisne, Delia A. Hawkes, Maria Cristina Mingari, Andrew M. Sharkey, Lorenzo Moretta & Francesco Colucci | | | Studying the uterine lymphocyte pool is difficult due to its dynamic nature induced by various pregnancy-related factors. Here the authors provide, using transcriptome data from sorted mouse group 1 innate lymphoid cells (ILC), a molecular atlas of these cells, which implicates tissue-resident natural killer cells as a hub for uterine immune crosstalk. | | 29 October 2018 | doi: 10.1038/s41467-018-06918-3 | | Applied immunology Gene regulation in immune cells Innate lymphoid cells Transforming growth factor beta | Candida albicans gains azole resistance by altering sphingolipid composition OPEN | | Jiaxin Gao, Haitao Wang, Zeyao Li, Ada Hang-Heng Wong, Yi-Zheng Wang, Yahui Guo, Xin Lin, Guisheng Zeng, Yue Wang & Jianbin Wang | | | The fungal pathogen Candida albicans is diploid, which hinders genome-wide studies. Here, Gao et al. present a piggyBac transposon-mediated mutagenesis system using stable haploid C. albicans strains, and use it to identify genes and mechanisms underlying azole resistance. | | 29 October 2018 | doi: 10.1038/s41467-018-06944-1 | | Fungi Microbiology | Pressure-induced emission of cesium lead halide perovskite nanocrystals OPEN | | Zhiwei Ma, Zhun Liu, Siyu Lu, Lingrui Wang, Xiaolei Feng, Dongwen Yang, Kai Wang, Guanjun Xiao, Lijun Zhang, Simon A. T. Redfern & Bo Zou | | | The potential optoelectronic applications of metal halide perovskites make exploration and tuning of their optical properties of great interest. Here the authors show that non-emitting zero-dimensional cesium lead halide perovskites become strongly fluorescent under high pressure, due to distortion-induced effects. | | 29 October 2018 | doi: 10.1038/s41467-018-06840-8 | | Materials science Physical chemistry | IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates OPEN | | Lyssia Belarif, Caroline Mary, Lola Jacquemont, Hoa Le Mai, Richard Danger, Jeremy Hervouet, David Minault, Virginie Thepenier, Veronique Nerrière-Daguin, Elisabeth Nguyen, Sabrina Pengam, Eric Largy, Arnaud Delobel, Bernard Martinet, Stéphanie Le Bas-Bernardet, Sophie Brouard, Jean-Paul Soulillou, Nicolas Degauque, Gilles Blancho, Bernard Vanhove et al. | | | Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can reduce the frequency of antigen-specific T cell to help repress chronic skin inflammation. | | 26 October 2018 | doi: 10.1038/s41467-018-06804-y | | Immunological memory Immunotherapy Interleukins T cells | Determinants of promoter and enhancer transcription directionality in metazoans OPEN | | Mahmoud M. Ibrahim, Aslihan Karabacak, Alexander Glahs, Ena Kolundzic, Antje Hirsekorn, Alexa Carda, Baris Tursun, Robert P. Zinzen, Scott A. Lacadie & Uwe Ohler | | | Divergent transcription from promoters and enhancers occurs in many species, but it is unclear if it is a general feature of all eukaryotic cis regulatory elements. Here the authors define cis regulatory elements in worms, flies, and human; and identify several differences in regulatory architecture among metazoans. | | 26 October 2018 | doi: 10.1038/s41467-018-06962-z | | Epigenomics Gene regulation Genome informatics Transcription | Breaking the scaling relationship via thermally stable Pt/Cu single atom alloys for catalytic dehydrogenation OPEN | | Guodong Sun, Zhi-Jian Zhao, Rentao Mu, Shenjun Zha, Lulu Li, Sai Chen, Ketao Zang, Jun Luo, Zhenglong Li, Stephen C. Purdy, A. Jeremy Kropf, Jeffrey T. Miller, Liang Zeng & Jinlong Gong | | | Enhancing the catalytic activity of noble-metal alloys is frequently accompanied by side reactions. Here, the authors describe an approach to break the scaling relationship for propane dehydrogenation, by assembling single atom alloys, to achieve simultaneous enhancement of propylene selectivity and propane conversion. | | 26 October 2018 | doi: 10.1038/s41467-018-06967-8 | | Atomistic models Chemical engineering Heterogeneous catalysis | Sexual rejection via a vomeronasal receptor-triggered limbic circuit OPEN | | Takuya Osakada, Kentaro K. Ishii, Hiromi Mori, Ryo Eguchi, David M. Ferrero, Yoshihiro Yoshihara, Stephen D. Liberles, Kazunari Miyamichi & Kazushige Touhara | | | Sex pheromones that increase mating have been reported across a number of different species, yet there is little known about pheromones that suppress female mating drive. This study reports that juvenile female mice release a pheromone, ESP22, which suppresses sexual receptivity of adult female mice by evoking a robust rejection behavior upon male mounting. | | 26 October 2018 | doi: 10.1038/s41467-018-07003-5 | | Neural circuits Pheromone | Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion OPEN | | Noumeira Hamoud, Viviane Tran, Takahiro Aimi, Wataru Kakegawa, Sylvie Lahaie, Marie-Pier Thibault, Ariane Pelletier, G. William Wong, In-San Kim, Artur Kania, Michisuke Yuzaki, Michel Bouvier & Jean-François Côté | | | Myoblast fusion is an essential step in muscle growth and regeneration, and is regulated by the G-protein coupled receptor (GPCR) BAI3. Here Hamoud et al. show that the GPCR activity of BAI3 is spatiotemporally regulated during myoblast fusion, and identify C1qL4 and Stabilin-2 as, respectively, negative and positive regulators of its activity. | | 26 October 2018 | doi: 10.1038/s41467-018-06897-5 | | Developmental biology Extracellular signalling molecules Muscle stem cells | Extremely rapid isotropic irradiation of nanoparticles with ions generated in situ by a nuclear reaction OPEN | | Jan Havlik, Vladimira Petrakova, Jan Kucka, Helena Raabova, Dalibor Panek, Vaclav Stepan, Zuzana Zlamalova Cilova, Philipp Reineck, Jan Stursa, Jan Kucera, Martin Hruby & Petr Cigler | | | Mass production of nanoparticles containing well-controlled structural defects is a challenge. Here the authors demonstrate the feasibility of homogeneous ion irradiation generated in a nuclear reactor, for the preparation of fluorescent nanodiamonds and silicon carbide nanoparticles. | | 26 October 2018 | doi: 10.1038/s41467-018-06789-8 | | Design, synthesis and processing Experimental nuclear physics Synthesis and processing | A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma OPEN | | Maolei Zhang, Kun Zhao, Xiaoping Xu, Yibing Yang, Sheng Yan, Ping Wei, Hui Liu, Jianbo Xu, Feizhe Xiao, Huangkai Zhou, Xuesong Yang, Nunu Huang, Jinglei Liu, Kejun He, Keping Xie, Gong Zhang, Suyun Huang & Nu Zhang | | | Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes. | | 26 October 2018 | doi: 10.1038/s41467-018-06862-2 | | CNS cancer Non-coding RNAs | Flexible and stable high-energy lithium-sulfur full batteries with only 100% oversized lithium OPEN | | Jian Chang, Jian Shang, Yongming Sun, Luis K. Ono, Dongrui Wang, Zhijun Ma, Qiyao Huang, Dongdong Chen, Guoqiang Liu, Yi Cui, Yabing Qi & Zijian Zheng | | | Lightweight and flexible energy storage devices are needed to persistently power wearable devices. Here the authors employ metallized carbon fabrics as hosts for sulfur and lithium to achieve flexibility, electrochemical stability and high energy density in a lithium-sulfur battery. | | 26 October 2018 | doi: 10.1038/s41467-018-06879-7 | | Energy science and technology Materials science | Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation OPEN | | Alexander Teumer, Layal Chaker, Stefan Groeneweg, Yong Li, Celia Di Munno, Caterina Barbieri, Ulla T. Schultheiss, Michela Traglia, Tarunveer S. Ahluwalia, Masato Akiyama, Emil Vincent R. Appel, Dan E. Arking, Alice Arnold, Arne Astrup, Marian Beekman, John P. Beilby, Sofie Bekaert, Eric Boerwinkle, Suzanne J. Brown, Marc De Buyzere et al. | | | Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme. | | 26 October 2018 | doi: 10.1038/s41467-018-06356-1 | | Endocrine system and metabolic diseases Genome-wide association studies Thyroid diseases Thyroid gland | A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs OPEN | | Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M. Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura & Hiroyasu Nakano | | | Necroptotic cells activate MLKL and release inflammatory DAMPs, although the underlying regulatory mechanisms of this process are poorly understood. Here, Murai et al. develop a necroptosis-specific FRET sensor (SMART) that monitors MLKL membrane translocation to identify two modes of DAMP release. | | 26 October 2018 | doi: 10.1038/s41467-018-06985-6 | | Cell death and immune response Necroptosis Protein–protein interaction networks | The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD OPEN | | Taylor K. Soderborg, Sarah E. Clark, Christopher E. Mulligan, Rachel C. Janssen, Lyndsey Babcock, Diana Ir, Dominick J. Lemas, Linda K. Johnson, Tiffany Weir, Laurel L. Lenz, Daniel N. Frank, Teri L. Hernandez, Kristine A. Kuhn, Angelo D'Alessandro, Linda A. Barbour, Karim C. El Kasmi & Jacob E. Friedman | | | Infants born to obese mothers have altered microbiome and increased risk of obesity and NAFLD. Here the authors establish causality by showing that maternal obesity-shaped infant gut microbiome induces macrophage dysfunction, inflammation, and diet-induced metabolic disease in germ-free mice. | | 26 October 2018 | doi: 10.1038/s41467-018-06929-0 | | Microbiome Non-alcoholic fatty liver disease Obesity Risk factors | Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 OPEN | | Prasun Kundu, Anthony Semesi, Matthijs M. Jore, Merribeth J. Morin, Virginia L. Price, Alice Liang, Jingxing Li, Kazutoyo Miura, Robert W. Sauerwein, C. Richter King & Jean-Philippe Julien | | | Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity. | | 26 October 2018 | doi: 10.1038/s41467-018-06742-9 | | Malaria X-ray crystallography | Identifying long-term stable refugia for relict plant species in East Asia OPEN | | Cindy Q. Tang, Tetsuya Matsui, Haruka Ohashi, Yi-Fei Dong, Arata Momohara, Sonia Herrando-Moraira, Shenhua Qian, Yongchuan Yang, Masahiko Ohsawa, Hong Truong Luu, Paul J. Grote, Pavel V. Krestov, Ben LePage, Marinus Werger, Kevin Robertson, Carsten Hobohm, Chong-Yun Wang, Ming-Chun Peng, Xi Chen, Huan-Chong Wang et al. | | | East Asia contains "relict" plant species that persist under narrow climatic conditions after once having wider distributions. Here, using distribution records coupled with ecological niche models, the authors identify long-term stable refugia possessing past, current and future climatic suitability favoring ancient plant lineages. | | 26 October 2018 | doi: 10.1038/s41467-018-06837-3 | | Biogeography Climate-change ecology Plant ecology | Deconvolution of octahedral Pt3Ni nanoparticle growth pathway from in situ characterizations OPEN | | Xiaochen Shen, Changlin Zhang, Shuyi Zhang, Sheng Dai, Guanghui Zhang, Mingyuan Ge, Yanbo Pan, Stephen M. Sharkey, George W. Graham, Adrian Hunt, Iradwikanari Waluyo, Jeffrey T. Miller, Xiaoqing Pan & Zhenmeng Peng | | | Understanding the growth pathway of faceted alloy nanoparticles at the atomic level is crucial to morphology control and property tuning, but remains a challenge. Here, the authors reveal the particle growth and facet formation mechanisms of octahedral Pt3Ni nanoparticles using multiple cutting-edge in situ techniques. | | 26 October 2018 | doi: 10.1038/s41467-018-06900-z | | Nanoparticle synthesis Natural gas | Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling OPEN | | Jessie Qiaoyi Liang, Narcissus Teoh, Lixia Xu, Sharon Pok, Xiangchun Li, Eagle S. H. Chu, Jonathan Chiu, Ling Dong, Evi Arfianti, W. Geoffrey Haigh, Matthew M. Yeh, George N. Ioannou, Joseph J. Y. Sung, Geoffrey Farrell & Jun Yu | | | Nonalcoholic steatohepatitis (NASH) and dietary cholesterol are risk factors for hepatocellular carcinoma (HCC). Here, the authors utilise mouse models to show that dietary cholesterol induces NASH by deregulating genes involved in metabolism, inflammation and calcium signaling to induce NASH-HCC. | | 26 October 2018 | doi: 10.1038/s41467-018-06931-6 | | Cancer genomics Genomics | Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation OPEN | | Lucrezia Colonna, Christopher W. Peterson, John B. Schell, Judith M. Carlson, Victor Tkachev, Melanie Brown, Alison Yu, Sowmya Reddy, Willi M. Obenza, Veronica Nelson, Patricia S. Polacino, Heather Mack, Shiu-Lok Hu, Katie Zeleski, Michelle Hoffman, Joe Olvera, Scott N. Furlan, Hengqi Zheng, Agne Taraseviciute, Daniel J. Hunt et al. | | | Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV reservoir persists in multiple tissues early after transplantation. | | 25 October 2018 | doi: 10.1038/s41467-018-06736-7 | | Allotransplantation Animal disease models Bone marrow transplantation HIV infections | Contribution of epigenetic variation to adaptation in Arabidopsis OPEN | | Marc W. Schmid, Christian Heichinger, Diana Coman Schmid, Daniela Guthörl, Valeria Gagliardini, Rémy Bruggmann, Sirisha Aluri, Catharine Aquino, Bernhard Schmid, Lindsay A. Turnbull & Ueli Grossniklaus | | | Whether plant epigenetic variation is subject to selection and contributes to adaptation is under debate. Here, the authors compare DNA methylation and phenotypes of Arabidopsis lines subject to simulated selection and their nearly isogenic ancestors and provide evidence that epigenetic variation contributes to adaptive responses. | | 25 October 2018 | doi: 10.1038/s41467-018-06932-5 | | Epigenomics Plant genetics | Medial temporal lobe functional connectivity predicts stimulation-induced theta power OPEN | | E. A. Solomon, J. E. Kragel, R. Gross, B. Lega, M. R. Sperling, G. Worrell, S. A. Sheth, K. A. Zaghloul, B. C. Jobst, J. M. Stein, S. Das, R. Gorniak, C. S. Inman, S. Seger, D. S. Rizzuto & M. J. Kahana | | | Direct electrical brain stimulation can induce widespread changes in neural activity, offering a means to modulate network-wide activity and treat disease. Here, the authors show that the low-frequency functional connectivity profile of a stimulation target predicts where induced theta activity occurs. | | 25 October 2018 | doi: 10.1038/s41467-018-06876-w | | Electroencephalography – EEG Neural circuits Neurophysiology Neuroscience | RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer OPEN | | Hanna Yang, Dongwan Hong, Soo Young Cho, Young Soo Park, Woo Ri Ko, Ju Hee Kim, Hoon Hur, Jongkeun Lee, Su-Jin Kim, Sun Young Kwon, Jae-Hyuk Lee, Do Youn Park, Kyu Sang Song, Heekyung Chang, Min-Hee Ryu, Kye Soo Cho, Jeong Won Kang, Myeong-Cherl Kook, Nina Thiessen, An He et al. | | | Diffuse Gastric Cancer (DGC) is increasingly being considered separate to intestinal type gastric cancer; several fusions events have been reported as drivers of the disease but few of those have been subsequently validated. Here the authors perform RNA-seq on early-onset DGC patients who had not been treated with chemotherapy or radiation and identify a previously unknown fusion. | | 25 October 2018 | doi: 10.1038/s41467-018-06747-4 | | Cancer genomics Gastric cancer | A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects OPEN | | A. Petersen, A. Princ, G. Korus, A. Ellinghaus, H. Leemhuis, A. Herrera, A. Klaumünzer, S. Schreivogel, A. Woloszyk, K. Schmidt-Bleek, S. Geissler, I. Heschel & G. N. Duda | | | A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment. | | 25 October 2018 | doi: 10.1038/s41467-018-06504-7 | | Biomedical materials Regeneration Tissue engineering | Nanocardboard as a nanoscale analog of hollow sandwich plates OPEN | | Chen Lin, Samuel M. Nicaise, Drew E. Lilley, Joan Cortes, Pengcheng Jiao, Jaspreet Singh, Mohsen Azadi, Gerald G. Lopez, Meredith Metzler, Prashant K. Purohit & Igor Bargatin | | | Sandwich structures such as corrugated cardboard offer low weight and high bending stiffness, but they are difficult to produce at the nanoscale. Here, the authors combine webbing and perforation to produce alumina 'nanocardboard' with ultralow areal density that recovers without damage from extreme deformation. | | 25 October 2018 | doi: 10.1038/s41467-018-06818-6 | | Ceramics Mechanical engineering Metamaterials | A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease OPEN | | Gudny A. Arnadottir, Gudmundur L. Norddahl, Steinunn Gudmundsdottir, Arna B. Agustsdottir, Snaevar Sigurdsson, Brynjar O. Jensson, Kristbjorg Bjarnadottir, Fannar Theodors, Stefania Benonisdottir, Erna V. Ivarsdottir, Asmundur Oddsson, Ragnar P. Kristjansson, Gerald Sulem, Kristjan F. Alexandersson, Thorhildur Juliusdottir, Kjartan R. Gudmundsson, Jona Saemundsdottir, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson et al. | | | Mutations in genes encoding NAPDH oxidase subunits are known to be causative for the primary immunodeficiency chronic granulomatous disease (CGD). Here, the authors identify CYBC1 mutations in patients with CGD and show that CYBC1 is important for formation of the NADPH complex and respiratory burst. | | 25 October 2018 | doi: 10.1038/s41467-018-06964-x | | Antimicrobial responses Disease genetics Immunological deficiency syndromes Rare variants | Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting OPEN | | Arthur Charles-Orszag, Feng-Ching Tsai, Daria Bonazzi, Valeria Manriquez, Martin Sachse, Adeline Mallet, Audrey Salles, Keira Melican, Ralitza Staneva, Aurélie Bertin, Corinne Millien, Sylvie Goussard, Pierre Lafaye, Spencer Shorte, Matthieu Piel, Jacomine Krijnse-Locker, Françoise Brochard-Wyart, Patricia Bassereau & Guillaume Duménil | | | Meningococci remodel the plasma membrane of host cells during infection. Here, Charles-Orszag et al. show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that they term 'one-dimensional' membrane wetting. | | 25 October 2018 | doi: 10.1038/s41467-018-06948-x | | Cell biology Cellular microbiology Membrane biophysics Pathogens | | | | | | | | Latest Author Corrections | | | | Author Correction: Jungle Express is a versatile repressor system for tight transcriptional control OPEN | | Thomas L. Ruegg, Jose H. Pereira, Joseph C. Chen, Andy DeGiovanni, Pavel Novichkov, Vivek K. Mutalik, Giovani P. Tomaleri, Steven W. Singer, Nathan J. Hillson, Blake A. Simmons, Paul D. Adams & Michael P. Thelen | | 30 October 2018 | doi: 10.1038/s41467-018-07111-2 | | Applied microbiology Synthetic biology Transcriptional regulatory elements | | | | | Latest Publisher Corrections | | | | Publisher Correction: Carrier density and disorder tuned superconductor-metal transition in a two-dimensional electron system OPEN | | Zhuoyu Chen, Adrian G. Swartz, Hyeok Yoon, Hisashi Inoue, Tyler A. Merz, Di Lu, Yanwu Xie, Hongtao Yuan, Yasuyuki Hikita, Srinivas Raghu & Harold Y. Hwang | | 29 October 2018 | doi: 10.1038/s41467-018-06960-1 | | Superconducting devices Superconducting properties and materials Surfaces, interfaces and thin films | Publisher Correction: Engineered bidirectional promoters enable rapid multi-gene co-expression optimization OPEN | | Thomas Vogl, Thomas Kickenweiz, Julia Pitzer, Lukas Sturmberger, Astrid Weninger, Bradley W. Biggs, Eva-Maria Köhler, Armin Baumschlager, Jasmin Elgin Fischer, Patrick Hyden, Marlies Wagner, Martina Baumann, Nicole Borth, Martina Geier, Parayil Kumaran Ajikumar & Anton Glieder | | 29 October 2018 | doi: 10.1038/s41467-018-07112-1 | | Expression systems Genetic vectors High-throughput screening Non-model organisms Synthetic biology | | | | | Advertisement | | Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up. | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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