Nature Cell Biology contents: November 2018 Volume 20 Number 11

Advertisement How will your cell culture needs evolve in the future? Upgradeability | Remote Monitoring | Easy Documentation | User Management | Connected Lab Whatever challenges you will face, the new Eppendorf CellXpert CO2 incubator family will support you to get ready for the Culture of Tomorrow.  Explore more in 360° TABLE OF CONTENTS November 2018 Volume 20, Issue 11 Editorial News & Views Review Articles Letters Articles Technical Reports Amendments & Corrections Advertisement New Poster on: Epitranscriptome regulation Download a new poster from Nature Structural & Molecular Biology on epitranscriptome regulation, a key mechanism affecting gene expression as well as cellular functions, development and disease.  Available free online  Produced with support from Accent Therapeutics, Inc.   Advertisement =================================== Register for the latest nature.com webcast Role for NaV1.3 in the developing cerebral cortex - Wednesday, 31 October 2018 Register for FREE today  Sponsored by Advanced Cell Diagnostics ==================================   Editorial The challenge of the post-truth era    p1231 doi:10.1038/s41556-018-0231-z News & Views CRAD as a cytoskeletal tumour suppressor    pp1232 - 1233 George Eng, Jonathan Braverman & Ömer H. Yilmaz doi:10.1038/s41556-018-0225-x Atypical matrix adhesions guide cell division    pp1233 - 1235 Ronen Zaidel-Bar doi:10.1038/s41556-018-0226-9 CRISPR mutagenesis screening of mice    pp1235 - 1237 Yevgeniy V. Serebrenik & Ophir Shalem doi:10.1038/s41556-018-0224-y Differentiation keeps skin cancer at bay    pp1237 - 1239 Paola Kuri & Panteleimon Rompolas doi:10.1038/s41556-018-0222-0 Nature Cell Biology EVENT Metabolism in Cancer and Stromal Cells (2nd edition) 26.11.18 Leuven, Belgium More science events from Review Articles Dormant tumour cells, their niches and the influence of immunity    pp1240 - 1249 Erica T. Goddard, Ivana Bozic, Stanley R. Riddell & Cyrus M. Ghajar doi:10.1038/s41556-018-0214-0 Goddard et al review recent advances in our understanding of dormant tumour cells, highlight their cross-talk with immune responses, and elaborate therapeutic implications to treat metastatic malignancies. Letters The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia    pp1250 - 1255 Mareike A. Jordan, Dennis R. Diener, Ludek Stepanek & Gaia Pigino doi:10.1038/s41556-018-0213-1 Opposing kinesin-2 and dynein-1b motors drive IFT bidirectionally along microtubules. Using cryo-electron tomography, Jordan et al. uncover mechanisms of dynein-1 inhibition to promote unidirectional IFT to the ciliary tip. Articles Oncogenic activation of PI3K induces progenitor cell differentiation to suppress epidermal growth    pp1256 - 1266 Zhe Ying, Madeline Sandoval & Slobodan Beronja doi:10.1038/s41556-018-0218-9 Ying et al. show that oncogenic PI3K–AKT activation, through the suppression of SH3RF1, induces epidermal differentiation, inhibits progenitor self-renewal and prevents tumour initiation. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells    pp1267 - 1277 Valentina Cigliola, Luiza Ghila, Fabrizio Thorel, Léon van Gurp, Delphine Baronnier et al. doi:10.1038/s41556-018-0216-y Cigliola et al. show that β-cell loss activates insulin production in a small number of α-cells and that insulin and Hedgehog signalling actively maintain and enforce the α-cell fate. Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation    pp1278 - 1289 Neophytos Christodoulou, Christos Kyprianou, Antonia Weberling, Ran Wang, Guizhong Cui et al. doi:10.1038/s41556-018-0211-3 Using time-lapse microscopy and transcriptome analysis of the post-implantation mouse embryo, Christodoulou et al. show that cavity fusion occurs through the formation and polarized resolution of multiple, multicellular three-dimensional rosettes. Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis    pp1290 - 1302 John G. Lock, Matthew C. Jones, Janet A. Askari, Xiaowei Gong, Anna Oddone et al. doi:10.1038/s41556-018-0220-2 Lock et al. identify reticular adhesion complexes that maintain cell–extracellular-matrix attachments during cell division. Reticular adhesions transmit spatial memory between cell generations, mediated by αvβ5 integrin and PtdIns(4,5)P2. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin    pp1303 - 1314 Youn-Sang Jung, Wenqi Wang, Sohee Jun, Jie Zhang, Mrinal Srivastava et al. doi:10.1038/s41556-018-0215-z Jung et al. demonstrate that loss of CRAD impairs F-actin polymerization and disrupts the cadherin–catenin–actin complex, thereby hyperactivating Wnt signalling and promoting mucinous intestinal tumorigenesis. Technical Reports CRISPR–Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development    pp1315 - 1325 Qing Li, Yanjing Li, Suming Yang, Shuo Huang, Meng Yan et al. doi:10.1038/s41556-018-0202-4 Li and colleagues develop a CRISPR–Cas9-based screen strategy that combines base editing and haploid embryonic stem cell technologies to identify amino acids critical for protein function in mice. Amendments & Corrections Author Correction: Topoisomerase IIα controls the decatenation checkpoint    pp1326 - 1327 Kuntian Luo, Jian Yuan, Junjie Chen & Zhenkun Lou doi:10.1038/s41556-018-0182-4 Author Correction: AMP kinase promotes glioblastoma bioenergetics and tumour growth    p1328 Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang et al. doi:10.1038/s41556-018-0203-3 Retraction Note: Formin' a perinuclear actin cage in confined migration    p1328 Alexia-Ileana Zaromytidou doi:10.1038/s41556-018-0197-x Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. 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