Nature Reviews Neuroscience contents February 2018 Volume 19 Number 2 pp 59-118

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TABLE OF CONTENTS
February 2018 Volume 19 Number 2
2016 2-year Impact Factor 28.880 Journal Metrics 2-year Median 23	In this issue Research Highlights Reviews Perspectives   Also this month Article series: Food intake, metabolism and the brain  Featured article: Mitochondria at the neuronal presynapse in health and disease Michael J. Devine & Josef T. Kittler
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RESEARCH HIGHLIGHTS   Top Learning and memory: You only learn once p59 | doi:10.1038/nrn.2018.4 When mice explore a new context, neurons in the locus coeruleus that project to hippocampal regions CA3 enable the learning of the new environment. PDF Neural coding: Investigating social spaces p60 | doi:10.1038/nrn.2017.169 In mice, projections from the prelimbic cortex to the nucleus accumbens encode a combination of social and spatial information and may promote 'social investigation' behaviour by enabling social–spatial learning. PDF Neuroimmunology: Brain police p60 | doi:10.1038/nrn.2018.5 Microglial surveillance of the brain is dependent on maintenance of microglia membrane potential by the K+ channel THIK1, which is potentiated by ATP released at sites of tissue injury acting on P2Y12 receptors. PDF Neurodegenerative disease: A proteostatic boost p61 | doi:10.1038/nrn.2018.3 Amyloid-β (Aβ)-induced proteotoxicity is linked to a mitochondrial stress response that may be conserved across species, and promoting mitochondrial proteostasis counteracts Aβ aggregation in worms and an Alzheimer disease mouse model. PDF
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REVIEWS		Top
Article series: Food intake, metabolism and the brain Intermittent metabolic switching, neuroplasticity and brain health Mark P. Mattson et al. p63 | doi:10.1038/nrn.2017.156 Eating patterns in modern societies often preclude the metabolic switch from utilization of glucose to ketones as a cellular energy source. In this Review, Mattson and colleagues discuss how intermittent metabolic switching impacts brain function and vulnerability to injury and disease. Abstract | Full Text | PDF
Mitochondria at the neuronal presynapse in health and disease Michael J. Devine & Josef T. Kittler p63 | doi:10.1038/nrn.2017.170 Mitochondria may be actively recruited to presynapses to supply energy, buffer calcium and, potentially, fulfil other functions. In this Review, Devine and Kittler examine the importance of this presynaptic population of mitochondria in the maintenance of neuronal homeostasis and how dysfunctional presynaptic mitochondria might contribute to neurodegenerative diseases. Abstract | Full Text | PDF
Article series: Food intake, metabolism and the brain Leptin and the maintenance of elevated body weight Warren W. Pan & Martin G. Myers, Jr p95 | doi:10.1038/nrn.2017.168 Although leptin administration decreases food intake and body weight in lean mice, it has no effect in obese mice. In this Review, Pan and Myers discuss how leptin action becomes dysfunctional in obesity and suggest that elevated leptin levels promote processes that limit leptin action. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity Vincenzo Crunelli et al. p107 | doi:10.1038/nrn.2017.151 During low-vigilance states, thalamic neurons exhibit diverse rhythmic activities that contribute to specific parts of the electroencephalogram rhythm. In this perspective, Crunelli and colleagues propose that thalamic oscillations of these low-vigilance states also have a plasticity function that modifies the strength of excitatory and inhibitory synapses in local neuronal assemblies. Abstract | Full Text | PDF
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