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| | A large oxygen-dominated core from the seismic cartography of a pulsating white dwarf
Asteroseismic 'sounding' reveals the internal chemical stratification of the white dwarf KIC08626021, which has a central homogeneous core—composed of 86 per cent oxygen—that has a mass of 0.45 solar masses. | Systems of mechanized and reactive droplets powered by multi-responsive surfactants
Droplets covered with surfactants that respond to multiple stimuli can assemble into hierarchical assemblies or non-spherical, patchy structures, mimic systems of mechanical gears, and even harbour sequences of chemical reactions. | Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
REV-ERBs, nuclear hormone receptors that regulate transcription as part of the circadian clock cell machinery, inhibit autophagy and lipogenesis in premalignant and malignant cells and impair tumour growth in vivo. | A global map of travel time to cities to assess inequalities in accessibility in 2015
Travel time to cities in 2015 is quantified in a high-resolution global map that will be useful for socio-economic policy design and conservation research. | An extracellular network of Arabidopsis leucine-rich repeat receptor kinases
A high-throughput assay is used to analyse 40,000 potential extracellular domain interactions of a large family of plant cell surface receptors (LRR-RKs) and provide a cell surface interaction network for these receptors. | High response rate to PD-1 blockade in desmoplastic melanomas
Immune checkpoint blockade with anti-PD-1 or anti-PD-L1 agents produces a high response rate in patients with desmoplastic melanoma. | Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus
In hybrid inviability between Xenopus laevis and Xenopus tropicalis, genomic regions on two X. laevis chromosomes are incompatible with the X. tropicalis cytoplasm and are mis-segregated during mitosis, leading to unbalanced gene expression at the maternal to zygotic transition, followed by cell-autonomous catastrophic embryo death. | Architecture of a channel-forming O-antigen polysaccharide ABC transporter
The crystal structure of a channel-forming O-antigen polysaccharide ABC transporter suggests a novel biopolymer translocation mechanism. | Warfare and wildlife declines in Africa's protected areas
Assessment of the impact of armed conflict on large herbivores in Africa between 1946 and 2010 reveals that high conflict frequency is an important predictor of wildlife population declines. | | Erratum: Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours | | Opening of the human epithelial calcium channel TRPV6
The cryo-electron microscopy structure of the calcium channel TRPV6 in its open and closed states demonstrates a novel gating mechanism involving an alanine hinge.
Luke L. McGoldrick, Appu K. Singh, Kei Saotome et al. | An extreme magneto-ionic environment associated with the fast radio burst source FRB 121102
Polarimetric observations of the repeating fast radio burst source FRB 121102 suggest that the bursts may originate from a neutron star in the extreme magneto-ionic environment of an accreting massive black hole or supernova remnant.
D. Michilli, A. Seymour, J. W. T. Hessels et al. | Bright triplet excitons in caesium lead halide perovskites
The lowest-energy exciton state in caesium lead halide perovskite nanocrystals is shown to be a bright triplet state, contrary to expectations that lowest-energy excitons should always be dark.
Michael A. Becker, Roman Vaxenburg, Georgian Nedelcu et al. | Fire frequency drives decadal changes in soil carbon and nitrogen and ecosystem productivity
A meta-analysis and field data show that frequent fires in savannas and broadleaf forests decrease soil carbon and nitrogen over many decades; modelling shows that nitrogen loss drives carbon loss by reducing net primary productivity.
Adam F. A. Pellegrini, Anders Ahlström, Sarah E. Hobbie et al. | Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
CRISPR–Cas9 genome editing is used to correct a dominant-negative mutation in a mouse model of inherited deafness, resulting in improvements in cochlear function and hearing.
Xue Gao, Yong Tao, Veronica Lamas et al. | Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators
The retrotransposition of L1 is controlled by functionally diverse genes at the transcriptional or post-transcriptional levels, and its silencing can lead to the downregulation of host gene expression.
Nian Liu, Cameron H. Lee, Tomek Swigut et al. | Rotation in [C ɪɪ]-emitting gas in two galaxies at a redshift of 6.8
The emission of singly ionized carbon is used to identify two galaxies with redshifts of nearly 7—corresponding to the Universe's first billion years—and with velocity structures suggestive of rotation.
Renske Smit, Rychard J. Bouwens, Stefano Carniani et al. | Clonal analysis of lineage fate in native haematopoiesis
Transposon tagging to clonally trace progenitors and stem cells provides evidence for a substantially revised roadmap for unperturbed haematopoiesis, and highlights unique properties of multipotent progenitors and haematopoietic stem cells in situ.
Alejo E. Rodriguez-Fraticelli, Samuel L. Wolock, Caleb S. Weinreb et al. | Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans
An Ancient Beringian population from Late Pleistocene Alaska and the ancestors of other Native American groups descended from a single founding population that diversified around twenty thousand years ago.
J. Víctor Moreno-Mayar, Ben A. Potter, Lasse Vinner et al. | Precision editing of the gut microbiota ameliorates colitis
Tungstate inhibits molybdenum-cofactor-dependent microbial respiratory pathways and shows potential as a selective treatment for microbial imbalances that occur during inflammation of the gastrointestinal tract.
Wenhan Zhu, Maria G. Winter, Mariana X. Byndloss et al. | Successful conservation of global waterbird populations depends on effective governance
Statistical modelling of global survey datasets of waterbirds as an indicator taxon for biodiversity changes in wetland ecosystems demonstrates that effective governance is the strongest predictor of species abundance increases and conservation benefits.
Tatsuya Amano, Tamás Székely, Brody Sandel et al. | A rapid decrease in the rotation rate of comet 41P/Tuttle–Giacobini–Kresák
The rotation rate of comet 41P/Tuttle–Giacobini–Kresák decreased rapidly between March and May 2017, owing to gas emission from the comet aligning to produce an anomalously strong torque.
Dennis Bodewits, Tony L. Farnham, Michael S. P. Kelley et al. | A metabolic function of FGFR3-TACC3 gene fusions in cancer
Oncogenic FGFR3-TACC3 gene fusions signal through phosphorylated PIN4 to trigger biogenesis of peroxisomes and synthesis of new proteins, enabling mitochondrial respiration and tumour growth.
Véronique Frattini, Stefano M. Pagnotta, Tala et al. | | | | |
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