Nature Reviews Molecular Cell Biology contents September 2017 Volume 18 Number 9 pp 529-589

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TABLE OF CONTENTS
September 2017 Volume 18 Number 9
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews Analysis   Also this month Article series: DNA damage  Featured article: Genes and molecular pathways underpinning ciliopathies Jeremy F. Reiter & Michel R. Leroux
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RESEARCH HIGHLIGHTS   Top Splicing: Phasing alternative exons p529 | doi:10.1038/nrm.2017.78 Two papers report a new mechanism of controlling alternative splicing through phase separation-mediated formation of higher-order assemblies of splicing factors. PDF Adult stem cells: Fat cells promote blood regeneration p530 | doi:10.1038/nrm.2017.79 Following irradiation, adipocytes derived from a specified subset of leptin receptor-positive cells in the bone marrow become a major source of stem cell factor for haematopoietic regeneration. PDF Stress responses: SIRT1 puts an embargo on mRNA export p530 | doi:10.1038/nrm.2017.82 Sirtuin 1 deacetylates polyadenylate-binding protein 1 (PABP1), thereby suppressing nuclear export of polyadenylated mRNAs and translation to preserve energy under stress. PDF Epigenetics: Getting instructions from mum p531 | doi:10.1038/nrm.2017.81 Patterns of histone H3 Lys27 trimethylation are maternally inherited in both fly and mammalian embryos, and control gene expression during early development. PDF Cancer biology: A Neat target of p53 p532 | doi:10.1038/nrm.2017.80 The lincRNA Neat1 is a p53 target gene that can suppress the initiation of pancreatic cancer. PDF Genome organization: A vision of 3D chromatin organization p532 | doi:10.1038/nrm.2017.88 A new imaging technique (ChromEMT) enables the visualization of the local polymer structure and global 3D organization of chromatin in the nucleus of intact interphase and mitotic human cells. PDF   Nature Reviews Molecular Cell Biology JOBS of the week Research Scientist I Gilead Sciences Senior Research Scientist MiNA Therapeutics Postdoctoral researcher in Biochemistry / Molecular Biology International Clinical Research Center Director - Clinical Genomic Care Sidra Medical and Research Centre Postdoctoral Fellowships in Biomedical Science (Cancer Research) Columbia University Medical Center More Science jobs from Nature Reviews Molecular Cell Biology EVENT International Congress of Cell Biology 2018 27.01.18 Hyderabad, India More science events from
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REVIEWS		Top
Genes and molecular pathways underpinning ciliopathies Jeremy F. Reiter & Michel R. Leroux p533 | doi:10.1038/nrm.2017.60 Motile and non-motile primary cilia are nearly ubiquitous cellular organelles. Dysfunction of cilia is being found to cause increasing numbers of diseases that are known as ciliopathies. The characterization of ciliopathy-associated proteins and phenotypes is increasing our understanding of how cilia are formed and compartmentalized and how they function to maintain human health. Abstract | Full Text | PDF | Supplementary information
Understanding nucleosome dynamics and their links to gene expression and DNA replication William K. M. Lai & B. Franklin Pugh p548 | doi:10.1038/nrm.2017.47 The presence of nucleosomes and their substructures affects local chromatin structure and function. Thus, nucleosome occupancy, their exact positioning and composition need to be dynamically regulated. Advances in genomic technologies have improved our understanding of nucleosome dynamics in various cellular processes, most notably DNA replication and transcription. Abstract | Full Text | PDF
Article series: DNA damage Mechanisms of DNA-protein crosslink repair Julian Stingele, Roberto Bellelli & Simon J. Boulton p563 | doi:10.1038/nrm.2017.56 Covalent DNA-protein crosslinks (DPCs) are induced by various compounds, which include widely used anticancer drugs, and are highly cytotoxic. Recent studies have revealed the mechanisms and the regulation of DPC repair pathways and suggest that components of these pathways can serve as targets for anticancer therapies. Abstract | Full Text | PDF
ANALYSIS		Top
Classification and function of small open reading frames Juan-Pablo Couso & Pedro Patraquim p575 | doi:10.1038/nrm.2017.58 A comprehensive analysis of small open reading frames (smORFs) in flies, mice and humans supports their classification into different functional groups, from inert DNA sequences to transcribed and translated smORFs that have various activities. The different smORF classes could represent steps in gene, peptide and protein evolution. Abstract | Full Text | PDF
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