Nature Reviews Immunology Contents September 2017 Volume 17 Number 9 pp 529-592

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TABLE OF CONTENTS
September 2017 Volume 17 Number 9		Advertisement
2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29	In this issue Research Highlights Reviews Correspondence   Also this month  Featured article: The dichotomous nature of T helper 17 cells Brigitta Stockinger & Sara Omenetti	Think Antibodies. Think Bio-Rad.   Empowering your every step from antibody selection to successful results. Bio-Rad provides all the vital ingredients whether you need antibodies, reagents, instrumentation or expert advice, all from a trusted brand.  Achieve more with Bio-Rad
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RESEARCH HIGHLIGHTS   Top Tumour immunology: Cell cycle inhibitors boost tumour immunogenicity p529 | doi:10.1038/nri.2017.104 Cyclin-dependent kinase inhibitors promote tumour regression by increasing antigen presentation and decreasing immune regulation. PDF Antibodies: Herd immunity p530 | doi:10.1038/nri.2017.94 Broadly neutralizing antibodies against HIV can be rapidly generated by immunizing cows. PDF Immunometabolism: NK cell subset expands with your waistline p530 | doi:10.1038/nri.2017.96 A distinct subset of natural killer cells with a myeloid signature is associated with metainflammation. PDF Mucosal immunology: Eye spy a protective commensal p531 | doi:10.1038/nri.2017.92 A candidate ocular commensal organism isolated from mice drives ocular immune responses and protects against infection with pathogens. PDF JOURNAL CLUB T cell-B cell collaboration p532 | doi:10.1038/nri.2017.62 Jonathan Sprent describes a 1968 study by Graham Mitchell and Jacques Miller that showed the requirement for T cell-B cell collaboration for antibody production. PDF Innate immunity: A new way out for lysozyme p532 | doi:10.1038/nri.2017.98 Endoplasmic reticulum stress in Paneth cells induces secretory autophagy of lysozyme. PDF Innate immunity: Nuclear waste ignites cGAS p533 | doi:10.1038/nri.2017.102 Cytosolic chromatin activates cGAS and inflammatory gene expression following DNA damage. PDF   Nature Reviews Immunology JOBS of the week Physician-Scientist, Translational Immunology / Vaccinology, Assistant or Associate Professor Brown University Faculty Position in Cancer Immunology Penn State College of Medicine / Penn State Milton S. Hershey Medical Center 30 PhD positions in infection biology and immunology ZIBI Graduate School Post-Doctoral Fellow Tumor Immunology Position - Gabrilovich Lab The Wistar Institute Postdoctoral / Scientist Position in Cancer Immunology / Immunotherapy Universitatsspital Basel More Science jobs from Nature Reviews Immunology EVENT The 3rd Int'l Conference on Tuberculosis and Respiratory Medicine (TRM 2018) 29.05.18 Chengdu, China More science events from
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REVIEWS		Top
The dichotomous nature of T helper 17 cells Brigitta Stockinger & Sara Omenetti p535 | doi:10.1038/nri.2017.50 T helper 17 (TH17) cells have a well-known role in immune pathology, but they also have protective and homeostatic roles. A detailed understanding of their plasticity and how their opposing functions are regulated is crucial for enabling the therapeutic targeting of TH17 cells in disease settings. Abstract | Full Text | PDF
The non-canonical NF-κB pathway in immunity and inflammation Shao-Cong Sun p545 | doi:10.1038/nri.2017.52 Defects in the non-canonical pathway of NF-κB activation are associated with severe immune deficiencies, and aberrant activation of this pathway can cause autoimmune and inflammatory diseases. Here, the author investigates the activation, signalling mechanisms and the biological function of the non-canonical NF-κB pathway. Abstract | Full Text | PDF
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy Nisha Nagarsheth, Max S. Wicha & Weiping Zou p559 | doi:10.1038/nri.2017.49 This Review details how chemokines shape immune responses in the tumour microenvironment through their effects on immune cells, stromal cells and the tumour cells themselves. The authors discuss the potential of targeting chemokine networks for cancer therapy. Abstract | Full Text | PDF
Adult haematopoietic stem cell niches Genevieve M. Crane, Elise Jeffery & Sean J. Morrison p573 | doi:10.1038/nri.2017.53 Recent advances in imaging techniques and genetic tools have rapidly increased our understanding of the niches that maintain adult haematopoietic stem cells, including the constituent cell types and the factors that directly or indirectly regulate these niches. Abstract | Full Text | PDF
CORRESPONDENCE		Top
The pros and cons of dying tumour cells in adaptive immune responses Xiaochen Wang, Xiao-Jie Lu & Beicheng Sun p591 | doi:10.1038/nri.2017.87 Full Text | PDF
The dichotomy of T helper 17 cells in cancer Lekh N. Dahal p592 | doi:10.1038/nri.2017.93 Full Text | PDF
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