Nature Reviews Genetics Contents September 2017 Volume 18 Number 9 pp 513-575

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TABLE OF CONTENTS
September 2017 Volume 18 Number 9
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews Also this month Article series: Epigenetics  Featured article: Exploiting induced and natural epigenetic variation for crop improvement Nathan M. Springer & Robert J. Schmitz
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RESEARCH HIGHLIGHTS Top Epigenetics: Getting instructions from mum p513 | doi:10.1038/nrg.2017.64 PDF Genome organization: Tracking chromosomal conformation through the cell cycle p514 | doi:10.1038/nrg.2017.62 PDF Complex disease: From non-coding risk variant to biological mechanism in CAD p514 | doi:10.1038/nrg.2017.66 PDF Alternative splicing: A thermometer controlling gene expression p515 | doi:10.1038/nrg.2017.61 PDF Nature Reviews Genetics JOBS of the week Postdoctoral Position- Developmental Genetics, Cardiovascular Biology and Stroke: University of Calgary University of Calgary Faculty Position in Cellular Genetics Wellcome Trust Sanger Institute Director - Clinical Genomic Care Sidra Medical and Research Centre Postdoctoral Fellowships in Biomedical Science (Cancer Research) Columbia University Medical Center Assistant Professor of Oncology McArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health More Science jobs from Nature Reviews Genetics EVENT EMBO | EMBL Symposium: Systems Genetics: From Genotypes to Molecular Phenotypes to Complex Traits 24.10.18 UK More science events from
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REVIEWS		Top
Article series: Epigenetics TET-mediated active DNA demethylation: mechanism, function and beyond Xiaoji Wu & Yi Zhang p517 | doi:10.1038/nrg.2017.33 A key mode of regulating DNA methylation is through active demethylation driven by TET-mediated oxidation of 5-methylcytosine (5mC). This Review discusses our latest understanding of the mechanisms and regulation of active DNA demethylation, and the roles of active demethylation (and the oxidized 5mC intermediates) in gene regulation, genome stability, development and disease. Abstract | Full Text | PDF
The impact of replication stress on replication dynamics and DNA damage in vertebrate cells Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas & Michelle Debatisse p535 | doi:10.1038/nrg.2017.46 Recent studies have provided insights into the sources of endogenous replication stress, which can result in DNA damage, checkpoint activation and genome-wide replication fork slowing. The authors review established mechanisms involved in the replication stress response, and propose a new model that reconciles data gained from different cellular models. Abstract | Full Text | PDF
Network propagation: a universal amplifier of genetic associations Lenore Cowen, Trey Ideker, Benjamin J. Raphael & Roded Sharan p551 | doi:10.1038/nrg.2017.38 Network propagation is based on the principle that genes underlying similar phenotypes are more likely to interact with each other. It is proving to be a powerful approach for extracting biological information from molecular networks that is relevant to human disease. Abstract | Full Text | PDF
Article series: Epigenetics Exploiting induced and natural epigenetic variation for crop improvement Nathan M. Springer & Robert J. Schmitz p563 | doi:10.1038/nrg.2017.45 To unlock the potential of epigenetic variation for crop improvement, it will be crucial to understand how epigenetic variation is established and how it is stably inherited across generations. Springer and Schmitz review these challenges, the different sources of epigenetic variation in plants, and how epigenome profiling and engineering could help to improve crops. Abstract | Full Text | PDF
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