Nature Reviews Cancer contents September 2017 Volume 17 Number 9 pp 509-569

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TABLE OF CONTENTS
September 2017 Volume 17 Number 9		Advertisement
2016 2-year Impact Factor 37.147 Journal Metrics 2-year Median 28	In this issue Research Highlights Reviews Perspectives   Also this month  Featured article: Therapy-related myeloid neoplasms: when genetics and environment collide Megan E. McNerney, Lucy A. Godley & Michelle M. Le Beau	Free Naturejobs Career Expo London - registration is now open The 11th annual Naturejobs Career Expo will be held in London on October 4, 2017. Join us for your chance to network with leading global employers, receive one-to-one CV checking, attend free talks and workshops, learn how to enhance your employability and lots more.  Register FREE today!
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A community map of cancer immunity Immunotherapy is influenced by a complex set of tumour, host and environmental factors. Such factors combine to characterise the immunological status — or cancer-immune set point — of an individual. Collaborate with peers to update, evolve and improve the cancer-immune set point framework
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RESEARCH HIGHLIGHTS   Top Tumour evolution: Metastasis takes a different route p509 | doi:10.1038/nrc.2017.70 A new study has looked at the evolutionary origins of lymphatic and distant metastases in human colorectal cancer and found that, in most cases, cancer spread to lymph nodes is not a precursor for seeding of cancer cells to other organs. PDF Therapeutic resistance: Ironing it out p510 | doi:10.1038/nrc.2017.71 Since mesenchymal-like properties in cancer cells are often associated with therapy resistance, Viswanathan et al. explored vulnerabilities of these cells. They identified an enzyme of the lipid peroxidase pathway, inhibition of which caused ferroptosis in a range of cancer types. PDF Metastasis: Throwing oil into the flames p510 | doi:10.1038/nrc.2017.76 Both obesity and systemic inflammation promote cancer progression, although how obesity-associated inflammation affects cancer metastasis is poorly understood. Quail et al. now show that obesity induces cytokines that stimulate lung neutrophilia in mice, thereby promoting breast cancer metastasis. PDF Immunotherapy: Searching in the immune checkpoint black box p511 | doi:10.1038/nrc.2017.75 Reporting in Nature, the team led by Haining has identified that deletion of Ptpn2, among other genes, in tumour cells makes them more susceptible to PD1 inhibitors. PDF   Cancer JOBS of the week Faculty Position in Cancer Immunology Penn State College of Medicine / Penn State Milton S. Hershey Medical Center Postdoctoral Fellowships in Biomedical Science (Cancer Research) Columbia University Medical Center Cancer and / or Glioma Stem Cell Biologist Cornell University Postdoctoral / Scientist Position in Cancer Immunology / Immunotherapy Universitatsspital Basel Associate Director, Joint Center For Cancer Precision Medicine (CCPM) Dana-Farber Cancer Institute (DFCI) More Science jobs from Cancer EVENT Quantitative Imaging Workshop XIV: Lung Cancer, COPD and Cardiovascular Disease 02.10.17 McLean, USA More science events from
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REVIEWS		Top
Therapy-related myeloid neoplasms: when genetics and environment collide Megan E. McNerney, Lucy A. Godley & Michelle M. Le Beau p513 | doi:10.1038/nrc.2017.60 Therapy-related myeloid neoplasms occur as a late complication following chemotherapy and/or radiotherapy administered for a primary condition. In this Review, McNerney et al. discuss recent studies that have improved our understanding of the aetiology of this disease. Abstract | Full Text | PDF
Targeting autophagy in cancer Jean M. Mulcahy Levy, Christina G. Towers & Andrew Thorburn p528 | doi:10.1038/nrc.2017.53 Autophagy is a process that delivers cytoplasmic components to lysosomes for degradation. This Review discusses clinical interventions to target autophagy in cancer and explains how understanding the context-dependent role of autophagy in cancer should dictate future clinical trial design. Abstract | Full Text | PDF
Evolutionary biology of high-risk multiple myeloma Charlotte Pawlyn & Gareth J. Morgan p543 | doi:10.1038/nrc.2017.63 Understanding how high-risk multiple myeloma evolves from more therapeutically tractable stages is crucial for improving outcomes for patients. This Review discusses the evolution of high-risk disease, how it may be diagnosed and how this might improve treatment. Abstract | Full Text | PDF
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nature.com webcasts Nature Research Custom presents: Visualizing divisions and development in 3D Date: Wednesday, August 30 2017 Time: 8AM PDT | 11AM EDT | 4PM BST | 5PM CEST  The webcast will last for 60 minutes and there will be an opportunity to ask your questions during the live broadcast! Register for FREE  Sponsored by: Bitplane
PERSPECTIVES		Top
OPINION Unravelling biology and shifting paradigms in cancer with single-cell sequencing Timour Baslan & James Hicks p557 | doi:10.1038/nrc.2017.58 In this Opinion article, Baslan and Hicks discuss how single-cell sequencing could be used to advance our understanding of tumour biology and genetics, in addition to translational applications in the clinic. Abstract | Full Text | PDF
Corrigendum: Targeting neoantigens to augment antitumour immunity Mark Yarchoan, Burles A. Johnson, III, Eric R. Lutz, Daniel A. Laheru & Elizabeth M. Jaffee p569 | doi:10.1038/nrc.2017.74 Full Text | PDF
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Open for Submissions npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota. Explore the benefits of submitting your manuscript >>
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