| | A randomized synbiotic trial to prevent sepsis among infants in rural India
A synbiotic preparation of Lactobacillus plantarum and fructooligosaccharide was found to significantly reduce sepsis and infections of the lower respiratory tract in a trial involving newborns from rural India.
Pinaki Panigrahi, Sailajanandan Parida, Nimai C. Nanda et al. | Correction of a pathogenic gene mutation in human embryos
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
Hong Ma, Nuria Marti-Gutierrez, Sang-Wook Park et al. | The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis
An atomic model of the primed pre-fusion SNARE–complexin–synaptotagmin-1 complex in neuronal exocytosis accounting for vesicle priming and cooperation in synchronizing and activating evoked release on the sub-millisecond timescale.
Qiangjun Zhou, Peng Zhou, Austin L. Wang et al. | | Large turbulent reservoirs of cold molecular gas around high-redshift starburst galaxies
Large haloes of diffuse molecular gas discovered around high-redshift starburst galaxies show that galactic feedback, coupled to turbulence and gravity, extends the starburst phase instead of quenching it.
E. Falgarone, M. A. Zwaan, B. Godard et al. | Epitaxy of advanced nanowire quantum devices
A finely tuned growth strategy to generate nanowire networks that fulfil all the prerequisites for braiding may lead to a demonstration of Majorana braiding.
Sasa Gazibegovic, Diana Car, Hao Zhang et al. | Molecular magnetic hysteresis at 60 kelvin in dysprosocenium
Magnetic hysteresis is observed in a dysprosocenium complex at temperatures of up to 60 kelvin, the origin of which is the localized metal–ligand vibrational modes unique to dysprosocenium.
Conrad A. P. Goodwin, Fabrizio Ortu, Daniel Reta et al. | Minimal geological methane emissions during the Younger Dryas–Preboreal abrupt warming event
Measurements from Antarctic ice suggest that geological methane emissions are much lower than previously thought, and that methane emissions from hydrates and permafrost in response to climate warming are minimal.
Vasilii V. Petrenko, Andrew M. Smith, Hinrich Schaefer et al. | Mutation predicts 40 million years of fly wing evolution
A detailed analysis of fly wing phenotypes reveals a strong positive relationship between variation produced by mutation, standing genetic variation, and evolutionary rate over the past 40 million years.
David Houle, Geir H. Bolstad, Kim van der Linde et al. | Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis
Myofibroblast-derived R-spondin 3 orchestrates regeneration of antral stomach epithelium via Wnt signalling in Axin2+ stem cells.
Michael Sigal, Catriona Y. Logan, Marta Kapalczynska et al. | Polylox barcoding reveals haematopoietic stem cell fates realized in vivo
An artificial recombination locus, Polylox, that can generate hundreds of thousands of individual barcodes is used to trace the fates of haematopoietic stem cells in mice.
Weike Pei, Thorsten B. Feyerabend, Jens Rössler et al. | cGAS surveillance of micronuclei links genome instability to innate immunity
The cytoplasmic DNA sensor cGAS detects DNA in ruptured micronuclei and activates an innate immune response.
Karen J. Mackenzie, Paula Carroll, Carol-Anne Martin et al. | Mitotic progression following DNA damage enables pattern recognition within micronuclei
The authors report a link between mitosis, the formation of micronuclei and DNA-damage-induced cGAS-dependent inflammation.
Shane M. Harding, Joseph L. Benci, Jerome Irianto et al. | CDK4/6 inhibition triggers anti-tumour immunity
Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.
Shom Goel, Molly J. DeCristo, April C. Watt et al. | Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity
A vaccine-driven approach shows that the prominent stimulant features of the psychoactive profile of fenethylline can be attributed to amphetamine, with synergistic support from theophylline, and no direct contributions from the parent drug molecule.
Cody J. Wenthur, Bin Zhou, Kim D. Janda | Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
The authors report the crystal structure of the β2 adrenergic receptor in complex with compound 15, an allosteric modulator that binds to an alternative binding pocket.
Xiangyu Liu, Seungkirl Ahn, Alem W. Kahsai et al. | | | | |
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