The EMBO Journal Table of Contents for 15 November 2016; Vol. 35, No. 22

15 November 2016 | Volume 35, Number 22 Submit Table of Contents News & Views Articles Volume 35, Number 22 News & Views T‐lymphoid progenitors – we know what they are, but know not what they may be Recent work published in The EMBO Journal yielded new insights into the biology underlying leukemogenesis, presenting evidence that a subgroup of human acute myeloid leukemia (AML) might arise from T‐cell progenitors, showing multilineage plasticity potential and transdifferentiation under oncogenic conditions. Lars Bullinger Published online 26.09.2016 Articles MicroRNA‐34/449 controls mitotic spindle orientation during mammalian cortex development A high‐throughput imaging screen identifies a set of miRNAs that control mitotic spindle orientation in neuronal progenitors and radial glial cells and whose expression is required for normal cortical development in mouse. Juan Pablo Fededa, Christopher Esk, Beata Mierzwa, Rugile Stanyte, Shuiqiao Yuan, Huili Zheng, Klaus Ebnet, Wei Yan, Juergen A Knoblich, and Daniel W Gerlich Published online 05.10.2016 Myeloid leukemia with transdifferentiation plasticity developing from T‐cell progenitors Oncogenic transformation of mouse early lymphoid progenitors with non‐committed lineage identity gives rise to myeloid leukemic cells in vivo, retaining epigenetic T‐cell memory. AML conversion is promoted by Jak/Stat signaling. Pia Riemke, Melinda Czeh, Josephine Fischer, Carolin Walter, Saeed Ghani, Matthias Zepper, Konstantin Agelopoulos, Stephanie Lettermann, Marie L Gebhardt, Nancy Mah, Andre Weilemann, Michael Grau, Verena Gröning, Torsten Haferlach, Dido Lenze, Ruud Delwel, Marco Prinz, Miguel A Andrade‐Navarro, Georg Lenz, Martin Dugas, Carsten Müller‐Tidow, and Frank Rosenbauer Published online 29.08.2016 Molecular basis for cytoplasmic RNA surveillance by uridylation‐triggered decay in Drosophila The identification of an enzyme complex degrading aberrant RNA in flies deepens our understanding of cytoplasmic RNA surveillance and sheds light on the emerging role for RNA modifications. Madalena M Reimão‐Pinto, Raphael A Manzenreither, Thomas R Burkard, Pawel Sledz, Martin Jinek, Karl Mechtler, and Stefan L Ameres Published online 11.10.2016 Mediator binding to UASs is broadly uncoupled from transcription and cooperative with TFIID recruitment to promoters A high‐resolution map of Mediator distribution in the yeast genome shows preferential binding to upstream activating sequences, poor correlation with transcription levels, and a cooperative role for TFIID and Mediator on target genes. Sebastian Grünberg, Steven Henikoff, Steven Hahn, and Gabriel E Zentner Published online 20.10.2016 Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing ESCRT protein Chm7 acts with integral inner nuclear membrane proteins Heh1 and Heh2 at sites of nuclear pore complex (NPC) assembly to seal off defective NPCs, thereby protecting nuclear compartmentalization and cell viability. Brant M Webster, David J Thaller, Jens Jäger, Sarah E Ochmann, Sapan Borah, and C Patrick Lusk Published online 12.10.2016 The Arabidopsis CERK1‐associated kinase PBL27 connects chitin perception to MAPK activation Chitin receptor CERK1 transmits immune signals to the intracellular MAPK cascade in plants. This occurs via phosphorylation of MAPKKK5 by the CERK1‐associated kinase PBL27, providing a missing link between pathogen perception and signaling output. Kenta Yamada, Koji Yamaguchi, Tomomi Shirakawa, Hirofumi Nakagami, Akira Mine, Kazuya Ishikawa, Masayuki Fujiwara, Mari Narusaka, Yoshihiro Narusaka, Kazuya Ichimura, Yuka Kobayashi, Hidenori Matsui, Yuko Nomura, Mika Nomoto, Yasuomi Tada, Yoichiro Fukao, Tamo Fukamizo, Kenichi Tsuda, Ken Shirasu, Naoto Shibuya, and Tsutomu Kawasaki Published online 27.09.2016 A pH‐ and ionic strength‐dependent conformational change in the neck region regulates DNGR‐1 function in dendritic cells The dendritic cell receptor for dead cell‐associated antigens senses its relocalization from the cell surface through acidic endosomes to facilitate efficient cross‐presentation. Pavel Hanč, Oliver Schulz, Hanna Fischbach, Stephen R Martin, Svend Kjær, and Caetano Reis e Sousa Published online 17.10.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.