The EMBO Journal Table of Contents for 2 November 2016; Vol. 35, No. 21

2 November 2016 | Volume 35, Number 21 Submit Table of Contents News & Views Review Articles Volume 35, Number 21 News & Views Too much to differentiate: aneuploidy promotes proliferation and teratoma formation in embryonic stem cells Uneven number of chromosomes has mostly detrimental consequences in eukaryotic somatic cells, including impaired proliferation and DNA replication. In contrast, work published in this issue of The EMBO Journal shows that aneuploid murine ES cells maintain proliferative capacity and induce tumorigenesis in vivo, but are hindered in their differentiation. Zuzana Storchová Published online 28.09.2016 Polycomb‐dependent control of cell fate in adult tissue While the contribution from Polycomb complexes in early development has been extensively studied, two papers now show that PRC2 is required for the proper control of cell fate decisions in the adult intestinal epithelium. Pedro Vizán, Malte Beringer, and Luciano Di Croce Published online 04.10.2016 Review Membrane fission by dynamin: what we know and what we need to know This consensus review summarizes our current understanding of the function of the fission GTPase dynamin and highlights open questions in the field. Bruno Antonny, Christopher Burd, Pietro De Camilli, Elizabeth Chen, Oliver Daumke, Katja Faelber, Marijn Ford, Vadim A Frolov, Adam Frost, Jenny E Hinshaw, Tom Kirchhausen, Michael M Kozlov, Martin Lenz, Harry H Low, Harvey McMahon, Christien Merrifield, Thomas D Pollard, Phillip J Robinson, Aurélien Roux, and Sandra Schmid Published online 26.09.2016 Articles Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential Aneuploid mouse ES cell lines display impaired differentiation, but increased self‐renewal and tumorigenic potential, which can be rescued by extracellular BMP4. Meili Zhang, Li Cheng, Yuyan Jia, Guang Liu, Cuiping Li, Shuhui Song, Allan Bradley, and Yue Huang Published online 24.08.2016 PRC2 preserves intestinal progenitors and restricts secretory lineage commitment PRC2 exerts a dual role in intestinal homeostasis by controlling progenitor cell proliferation via repression of Cdkn2a and restricting secretory commitment by targeting key regulators of cell differentiation. Fulvio Chiacchiera, Alessandra Rossi, SriGanesh Jammula, Marika Zanotti, and Diego Pasini Published online 01.09.2016 Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence A new VEGF‐independent pathway triggers Notch‐mediated conversion of dorsal aorta endothelial cells into definitive hematopoietic stem cells during embryonic endothelial‐to‐hematopoietic transition. Martina Konantz, Elisa Alghisi, Joëlle S Müller, Anna Lenard, Virginie Esain, Kelli J Carroll, Lothar Kanz, Trista E North, and Claudia Lengerke Published online 16.09.2016 A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP Proteolytic activation of the fission yeast sterol‐responsive transcriptional regulator requires its sequential ubiquitination and Cdc48‐dependent presentation to an intramembrane protease. Jiwon Hwang, Diedre Ribbens, Sumana Raychaudhuri, Leah Cairns, He Gu, Adam Frost, Siniša Urban, and Peter J Espenshade Published online 21.09.2016 TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons The loss of TDP‐43 function, as often seen in neurodegenerative diseases, blocks trafficking of recycling endosomes and impairs the proper localization of cell surface receptors. Benjamin M Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin H Schludi, Daniel Hornburg, Felix Meissner, Denise Orozco, Alessio Colombo, Sabina Tahirovic, Meike Michaelsen, Franziska Schreiber, Simone Haupt, Michael Peitz, Oliver Brüstle, Clemens Küpper, Thomas Klopstock, Markus Otto, Albert C Ludolph, Thomas Arzberger, Peer‐Hendrik Kuhn, and Dieter Edbauer Published online 12.09.2016 Molecular requirements of the B‐cell antigen receptor for sensing monovalent antigens Proximity ligation assays reveal that monovalent antigen‐binding site ligands are sufficient to induce B‐cell receptor conformational changes, promoting downstream intracellular signalling. Christoph Volkmann, Naema Brings, Martin Becker, Elias Hobeika, Jianying Yang, and Michael Reth Published online 15.09.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.