Nature Reviews Neuroscience contents December 2016 Volume 17 Number 12 pp 733 - 792

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TABLE OF CONTENTS
December 2016 Volume 17 Number 12		Advertisement
2015 2-year Impact Factor 29.298 Journal Metrics 2-year Median 22	In this issue Comment Research Highlights Reviews Also this month Article series: Scaling up neuroscience  Featured article: Keeping it in check: chronic viral infection and antiviral immunity in the brain Katelyn D. Miller, Matthias J. Schnell & Glenn F. Rall	LDI Multiline Laser Illuminator for spinning disk confocal, photactivation, optogenetics, TIRF, PALM/STORM. High power/Low cost. Up to 1W of power per channel, feedback controlled stability, up to 7 wavelengths, ultimate price to performance ratio. www.89north.com/LDI
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Springer Nature presents a custom webcast on: Nutrition and brain health Date: Thursday December 1, 2016 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CET Register for the webcast and live Q&A session Sponsored by: Nestlé
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Nature Outlook: Parkinson's disease  It is 200 years since Parkinson's disease was first described. This Outlook charts the progress of research in an engaging timeline and shows how our understanding of Parkinson's motor and non-motor symptoms has evolved. It also reveals the exciting new applications of smartphones in monitoring the disease. Access the Outlook free online
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Article series: Scaling up neuroscience Comment: How can brain mapping initiatives cooperate to achieve the same goal? Hideyuki Okano & Tetsuo Yamamori p733 | doi:10.1038/nrn.2016.126 Okano and Yamamori consider how the different international brain research initiatives might collaborate to achieve their common aims. Abstract | Full Text | PDF
Article series: Scaling up neuroscience Comment: How do we know what we know? Discovering neuroscience data sets through minimal metadata Sean L. Hill p735 | doi:10.1038/nrn.2016.134 Sean Hill explains why the growing importance of data-intensive neuroscience makes it crucial for the community to establish minimal metadata standards Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Neural circuits: Cortical replacements p737 | doi:10.1038/nrn.2016.160 Transplanted embryonic neurons can functionally replace ablated neurons in the primary visual cortex in adult mice. PDF Behavioural neuroscience: Descending into dishonesty p738 | doi:10.1038/nrn.2016.157 Reductions in the response of the amygdala to dishonesty predict the escalation of self-serving dishonesty. PDF Neurodegenerative disease: Straining the brain p738 | doi:10.1038/nrn.2016.161 Following injection into the brain, different strains of tau aggregates induce different presentations of tau neuropathology in a mouse model of tauopathy. PDF Synaptic plasticity: Spinal signals p740 | doi:10.1038/nrn.2016.148 This study suggests that brain-derived neurotrophic factor (BDNF) is released from dendritic spines in response to activity and acts in an autocrine manner to mediate structural plasticity of the spine from which it was released. PDF Neural circuits: Halting hunger p740 | doi:10.1038/nrn.2016.156 Cholinergic neurons in the basal forebrain of mice influence the intake of food and body weight by regulating appetite suppression. PDF Addiction: Under a stressful influence p741 | doi:10.1038/nrn.2016.149 In rats, stress promotes alcohol use by altering chloride gradients across the membranes of GABAergic neurons in the ventral tegmental area. PDF IN BRIEF Neurodegenerative disease: Actin up | Neural development: The river runs through it | Neurodegenerative disease: Resisting the chop | Sleep and memory: Rippling memories PDF Nature Reviews Neuroscience JOBS of the week Postdoc Positions in Cell Biology and Molecular Neuroscience Laboratory Lee Kong Chian School of Medicine, Joint medical school between, Imperial College London and Nanyang Technological University in Singapore Sussex Neuroscience 4-Year PhD Programme University of Sussex PhD Student (F / M) in Neurobiology and Neuroproteomics German Center for Neurodegenerative Diseases (DZNE) Tenure Track Position in Developmental Biology & Molecular Genetics University of Calgary Cheeloo College of Medicine(CCOM), Shandong University Recruit Outstanding Talents Cheeloo College of Medicine(CCOM), Shandong University More Science jobs from Nature Reviews Neuroscience EVENT ICAFM 2017 The 2nd International Conference on Advanced Functional Materials 04.08.17 Los Angeles, USA More science events from
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Poster on Molecular mechanisms of amyotrophic lateral sclerosis This poster from Nature Reviews Neuroscience provides an overview of the molecular and cellular mechanisms that have been proposed to contribute to the pathogenesis of amyotrophic lateral sclerosis, which is the most common form of motor neuron disease.  Download free online  Funded by a grant from MT Pharma America, Inc
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Integrins in synapse regulation Yun Kyung Park & Yukiko Goda p745 | doi:10.1038/nrn.2016.138 The properties and location of synaptic integrins put them in an ideal position to transduce signals from the extracellular matrix to intracellular signalling pathways. Park and Goda, here, describe the mechanisms underlying integrin-mediated synapse regulation and its contributions to development, plasticity and disease. Abstract | Full Text | PDF
The mirror mechanism: a basic principle of brain function Giacomo Rizzolatti & Corrado Sinigaglia p757 | doi:10.1038/nrn.2016.135 Mirror neurons transform sensory representations of others' behaviour into the observers' motor or visceromotor representations of that behaviour. In this Review, Giacomo Rizzolatti and Corrado Sinigaglia describe how the mirror mechanism is also likely to be involved in both action and emotion processing. Abstract | Full Text | PDF
Keeping it in check: chronic viral infection and antiviral immunity in the brain Katelyn D. Miller, Matthias J. Schnell & Glenn F. Rall p766 | doi:10.1038/nrn.2016.140 Viral entry into the CNS and infection of neural cells pose a specific challenge for the immune system: how to eradicate the invading pathogen without disrupting neuronal circuits. Rall and colleagues outline the host immune response to CNS viral infection and consider the possible consequences of non-lytic viral clearance in the brain. Abstract | Full Text | PDF
Network abnormalities and interneuron dysfunction in Alzheimer disease Jorge J. Palop & Lennart Mucke p777 | doi:10.1038/nrn.2016.141 The cognitive abnormalities observed in Alzheimer disease (AD) may be linked to alterations in oscillatory rhythmic activity and neuronal network hypersynchrony. Palop and Mucke review these links and explore how countering these network abnormalities and interneuron dysfunction may hold therapeutic potential for AD. Abstract | Full Text | PDF | Supplementary information
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Nature Outlook: Lysosomal Storage Disorders Lysosomal storage disorders are individually rare but collectively common. The study of these diseases is not only leading to better treatments, but also revealing many of the secrets of this underappreciated organelle.  Access the Outlook >  Produced with support from:  Alexion Pharmaceuticals, Inc. Ultragenyx Pharmaceutical Inc. Produced with support of a grant from: Shire plc BioMarin Pharmaceutical Inc
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