Nature Reviews Molecular Cell Biology contents December 2016 Volume 17 Number 12 pp 737-810

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TABLE OF CONTENTS
December 2016 Volume 17 Number 12		Advertisement
2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30	In this issue Research Highlights Comment Focus on: The 3D genome Reviews Perspectives Also this month  Collection on: The 3D genome  Featured article: Regulation of disease-associated gene expression in the 3D genome Peter Hugo Lodewijk Krijger & Wouter de Laat Article series: Technologies and techniques	For essential cell health data you need on a routine basis, there isn't always time for the relaxed pace of the Western. Apoptosis. Oxidative stress. Cell cycle effects. Viability. Get quantitative, single-cell results in a fraction of the time needed for traditional immunoassays. Simple, rapid assessment of critical cell events on your benchtop with the Muse® cell analyzer. See how it works - Watch video
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RESEARCH HIGHLIGHTS Top Genome organization: Add a TAD of duplication p737 | doi:10.1038/nrm.2016.144 Genomic duplications that modify the structure and function of topologically associated domains can deregulate gene expression and cause disease without altering gene copy numbers. PDF Organelle dynamics: RecovERy after stress p738 | doi:10.1038/nrm.2016.145 Selective autophagy that is dependent on the ER translocon component SEC62 mediates ER recovery following protein stress. PDF JOURNAL CLUB Turning the tide on 3D nuclear organization p738 | doi:10.1038/nrm.2016.146 Physically bridging an enhancer to a [beta]-globin gene increased transcription and explained how enhancers could function over long distances. PDF Nuclear organization: NUP-tial binding to super-enhancers p738 | doi:10.1038/nrm.2016.158 Super-enhancers interact with human nucleoporins at the nuclear pore complex to regulate cell type-specific genes. PDF JOURNAL CLUB 3D solutions to complex gene regulation p739 | doi:10.1038/nrm.2016.154 Edith Heard describes how the discovery of lamina-associated domains changed her thinking about the mechanisms of X-chromosome inactivation and gene regulation. PDF Plant cell biology: Blue light gives CRY the blues p740 | doi:10.1038/nrm.2016.150 The activity of the plant photoreceptor cryptochrome 2 is regulated by a newly characterized interacting protein that prevents cryptochrome 2 homodimerization. PDF IN BRIEF DNA Repair: RNA-DNA hybrids: a double-edged sword in genomic stability | Stem cells: Coordinated expansion of cells in the skin | Cell Senescence: Controlling the senescence-associated secretory phenotype PDF Molecular Cell Biology JOBS of the week FACULTY POSITION Physics - Atomic, Molecular and Optical physics ; NYU Shanghai NYU SHANGHAI Research Group Leader (M / F) with Focus on Molecular Biology / Gastrointestinal Oncology / Hepatology University Hospital Regensburg Postdoctoral Fellow / Molecular Biology The University of Tennessee Health Science Center POSTDOC in Cardiopulmonary Molecular Biology Hannover Medical School (MHH) Postdoc Positions in Cell Biology and Molecular Neuroscience Laboratory Lee Kong Chian School of Medicine, Joint medical school between, Imperial College London and Nanyang Technological University in Singapore More Science jobs from
Comment: Mapping the 3D genome: Aiming for consilience Job Dekker p741 | doi:10.1038/nrm.2016.151 Job Dekker asserts that cases in which data from microscopy- and 3C-based methods appear discordant about genome organization will provide opportunities to improve our models of chromatin folding. Abstract | Full Text | PDF
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Nature Reviews Cancer Focus on Tumour Metabolism This Focus explores the dynamic and varied metabolism in tumour cells, discussing the importance of these pathways for many tumorigenic processes, such as tumour progression, survival, growth, epigenetic changes and how these can be translated to the clinic.  Access the Focus free online.  Produced with support from Agios Pharmaceuticals, Inc.
Focus on: The 3D genome REVIEWS Top Article series: Technologies and techniques Genome-wide mapping and analysis of chromosome architecture Anthony D. Schmitt, Ming Hu & Bing Ren p743 | doi:10.1038/nrm.2016.104 The three-dimensional (3D) organization of eukaryote chromosomes regulates genome function and nuclear processes such as DNA replication, transcription and DNA-damage repair. Experimental and computational methodologies for 3D genome analysis have been rapidly expanding, with a focus on high-throughput chromatin conformation capture techniques and on data analysis. Abstract | Full Text | PDF Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression Jesse M. Engreitz, Noah Ollikainen & Mitchell Guttman p756 | doi:10.1038/nrm.2016.126 Mechanistic insights are emerging into how long non-coding RNAs (lncRNAs) regulate gene expression by coordinating regulatory proteins, localizing to genomic loci and shaping nuclear organization. Interestingly, lncRNAs can perform functions that cannot be carried out by DNA elements or proteins alone, such as amplifying regulatory signals in the nucleus. Abstract | Full Text | PDF | Supplementary information Regulation of disease-associated gene expression in the 3D genome Peter Hugo Lodewijk Krijger & Wouter de Laat p771 | doi:10.1038/nrm.2016.138 Mutations in non-coding parts of the genome can cause disease. Technological advances are providing unprecedented detail on genome organization and folding, and have revealed that enhancer-target gene coupling is spatially restricted, as it occurs within topologically associated domains (TADs), and that disrupting such organization can lead to disease-associated gene dysregulation. Abstract | Full Text | PDF
REVIEWS		Top
Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors Ellis R. Levin & Stephen R. Hammes p783 | doi:10.1038/nrm.2016.122 Steroid hormone receptors are well known to regulate various aspects of animal physiology by acting as transcriptional regulators in the nucleus. However, it is now evident that these receptors can also be targeted to extranuclear locations (such as the plasma membrane), where they instigate rapid signals that contribute to steroid-mediated cellular responses. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Internetwork competition for monomers governs actin cytoskeleton organization Cristian Suarez & David R. Kovar p799 | doi:10.1038/nrm.2016.106 The establishment of various coexisting actin networks supports a plethora of cellular processes and functions. How actin incorporation into these different networks is regulated to balance their growth and maintain homeostasis has remained elusive. Here, the authors propose that the internetwork competition for a limited pool of actin monomers underlies the homeostatic control of actin cytoskeleton organization. Abstract | Full Text | PDF
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*2015 Journal Citation Reports (Thomson Reuters, 2016)

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