Nature Reviews Microbiology contents December 2016 Volume 14 Number 12 pp 725-784

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TABLE OF CONTENTS
December 2016 Volume 14 Number 12		Advertisement
2015 2-year Impact Factor 24.727 Journal Metrics 2-year Median 19.5	In this issue Research Highlights News and Analysis Reviews Perspectives Also this month  Featured article: Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen Justin D. Radolf, Ranjit K. Deka, Arvind Anand, David Šmajs, Michael V. Norgard & X. Frank Yang	LDI Multiline Laser Illuminator for spinning disk confocal, photactivation, optogenetics, TIRF, PALM/STORM. High power/Low cost. Up to 1W of power per channel, feedback controlled stability, up to 7 wavelengths, ultimate price to performance ratio. www.89north.com/LDI
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RESEARCH HIGHLIGHTS Top Antimicrobials: Putting antibiotic action into context 725 | doi:10.1038/nrmicro.2016.165 This study reveals that ribosomal antibiotics function in a context-specific manner, dependent on the penultimate amino acid in the nascent chain and the amino acid in the P-site of the peptidyl transferase center. PDF Bacterial toxins: A true competitor p726 | doi:10.1038/nrmicro.2016.163 This study reports that the T7SS has antibacterial activity and is involved in intraspecies competition. PDF Archaeal biology: Masters of methane p726 | doi:10.1038/nrmicro.2016.170 Three new studies investigate the metabolic pathways that anaerobic archaea use to produce hydrocarbons such as methane and butane. PDF Cellular microbiology: Tagging proteins for the Clp protease p728 | doi:10.1038/nrmicro.2016.159 This study reveals that arginine phosphorylation tags proteins for degradation by the ClpCP protease. PDF Bacterial pathogenesis: Rickettsia releases the tension p728 | doi:10.1038/nrmicro.2016.166 This study shows that the bacterial effector Sca4 promotes intercellular spread of the obligate intracellular pathogen Rickettsia parkeri by disrupting the transmission of intercellular tension at cell-cell adherence junctions. PDF IN BRIEF Viral infection: Rabies virus causes stress | Microbiome: Complexity at the sub-genus level | Fungal biology: A key regulator of secondary metabolites | Antimicrobials: The central role of lipids in daptomycin action | Techniques and applications: Shining a light on persisters | Environmental microbiology: A small soil bacterium dominates PDF
NEWS AND ANALYSIS		Top
GENOME WATCH Species Mash-up Silvia Argimón & David M. Aanensen p730 | doi:10.1038/nrmicro.2016.175 This month's Genome Watch describes how Mash can be used to tackle comparisons between large amounts of genomic and metagenomic sequence data for taxonomic applications. PDF
REVIEWS		Top
How multi-partner endosymbioses function Angela E. Douglas p731 | doi:10.1038/nrmicro.2016.151 Why have multi-partner endosymbioses evolved on several independent occasions in plant sap-feeding insects? In this Review, Douglas discusses the composition and functions of these endosymbioses, and considers the processes and adaptive forces that drive their evolution. Abstract | Full Text | PDF | Supplementary information
Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen Justin D. Radolf, Ranjit K. Deka, Arvind Anand, David Šmajs, Michael V. Norgard & X. Frank Yang p744 | doi:10.1038/nrmicro.2016.141 Treponema pallidum, the causative agent of syphilis, is extremely well adapted to its host. In this Review, Radolf and colleagues discuss how this pathogen has streamlined its cell envelope, metabolism and genome to thrive and cause disease in humans. Abstract | Full Text | PDF
Unearthing the roots of ectomycorrhizal symbioses Francis Martin, Annegret Kohler, Claude Murat, Claire Veneault-Fourrey & David S. Hibbett p760 | doi:10.1038/nrmicro.2016.149 Fungal genomics studies have shown that ectomycorrhizal fungi have arisen in approximately 60 independent saprotrophic lineages. In this Review, Martin and colleagues describe the functional gains and losses that have occurred during the evolution of ectomycorrhizal symbioses. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Competing endogenous RNAs: a target-centric view of small RNA regulation in bacteria Lionello Bossi & Nara Figueroa-Bossi p775 | doi:10.1038/nrmicro.2016.129 Similarly to competing endogenous RNAs (ceRNAs) in mammalian cells, competition for regulatory RNAs and proteins can lead to crosstalk between bacterial mRNAs. In this Opinion article, Bossi and Figueroa-Bossi argue that such competition for regulatory targets may have a substantial influence on bacterial gene networks. Abstract | Full Text | PDF
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