Nature Immunology Contents: December 2016 Volume 17 pp 1335 - 1479

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Advertisement Nature Reviews Cancer Focus on Tumour Metabolism This Focus explores the dynamic and varied metabolism in tumour cells, discussing the importance of these pathways for many tumorigenic processes, such as tumour progression, survival, growth, epigenetic changes and how these can be translated to the clinic.  Access the Focus free online.  Produced with support from Agios Pharmaceuticals, Inc.   TABLE OF CONTENTS December 2016 Volume 17, Issue 12 News and Views Research Highlights Articles Resource Corrigenda Erratum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Immunogenomics of Disease: Accelerating to Patient Benefit (6-8 February 2017) A conference bringing together scientists working in molecular immunology, and functional genomics and immune-mediated disease genetics to share new insights into disease and novel therapeutics. Deadlines: Bursary: 22 Nov / Abstracts: 6 Dec / Registration: 10 Jan   Advertisement Nature Focus and Animation: Innate lymphoid cells Nature Immunology presents this Focus on the evolution, development, functional diversity and immunotherapeutic potential of innate lymphoid cells (ILCs). Access the Focus free online   Watch the accompanying animation showing the complexity of ILC biology in the gut here   Produced with support from MedImmune     Advertisement ENVIRONMENTAL MICROBIAL BIOFILMS AND HUMAN MICROBIOMES: DRIVERS OF FUTURE SUSTAINABILITY  February 12-15, 2017 | Nanyang Executive Centre, Singapore Presented by: Nanyang Technological University (NTU) | Singapore Centre for Environmental Life Sciences Engineering (SCELSE) | npj Biofilms and Microbiomes REGISTER NOW!   News and Views Top Phagocyte mayHEME caused by severe hemolysis   pp1335 - 1337 Sioh-Yang Tan and Wolfgang Weninger doi:10.1038/ni.3616 Free heme released by hemolysis directly inhibits bacterial phagocytosis by macrophages via alterations of actin cytoskeletal dynamics. See also: Article by Martins et al. Resident memory T cells are a Notch above the rest   pp1337 - 1338 Sathi Wijeyesinghe and David Masopust doi:10.1038/ni.3617 Notch signaling promotes the maintenance of lung-resident CD8+ memory T cells that are transcriptionally poised for rapid effector responses but have heightened expression of inhibitory receptors, suggestive of tight regulation. See also: Resource by Hombrink et al. Lost GRP on cytotoxicity?   pp1339 - 1340 Jeroen P Roose doi:10.1038/ni.3620 Deficiency in the RASGRP1 guanine-nucleotide-exchange factor leads to a novel primary immunodeficiency with impaired activation and proliferation of T cells and B cells and defective killing by cytotoxic T cells and natural killer cells. See also: Article by Salzer et al. Immunology JOBS of the week Roche Postdoctoral Fellow in Immunology of chronic HBV infection F. Hoffmann-La Roche PhD Student / Postdoc Position in Neuroinflammation and Mucosal Immunology Max Planck Institute of Biochemistry Postdoc In Vascular Biology Uppsala University MRC WIMM Prize PhD Studentships the Weatherall Institute of Molecular Medicine (WIMM), University of Oxford Animal health – Immunology Research assistant / Team leadership Institute of Virology and Immunology, University of Bern More Science jobs from Immunology EVENT Systems Biology of Adaptive Immunity 14.05.17 Ascona, Switzerland More science events from Research Highlights Top Deworming gives a boost | Human regulatory cells miss their target | Exit from the liver | TLR4 in lung regeneration | Spliced-peptide presentation | IFN-α/β-mediated suppression of B cells Advertisement Nature Insight: Intestinal Microbiota in Health and Disease:   This Insight explores human development biology and how intestinal microbiota is associated closely with health and disease. Click here to access the free Nature Insight available for 6 months Produced with support from Yakult Honsha Co., Ltd.     Articles Top E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1   pp1342 - 1351 Guanhua Song, Bingyu Liu, Zhihui Li, Haifeng Wu, Peng Wang et al. doi:10.1038/ni.3588 Gao and colleagues show that the T cell anergy-related E3 ubiquitin ligase RNF128 is a positive regulator of TBK1 activation and interferon-β production. RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics   pp1352 - 1360 Elisabeth Salzer, Deniz Cagdas, Miroslav Hons, Emily M Mace, Wojciech Garncarz et al. doi:10.1038/ni.3575 Boztug and colleagues identify an immunodeficient patient with a deficiency in the guanine-nucleotide-exchange factor RASGRP1. They find that human RASGRP1 is important for the function of T cells, B cells and NK cells and that it has a role in the regulation of the cytoskeleton. See also: News and Views by Roose Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions   pp1361 - 1372 Rui Martins, Julia Maier, Anna-Dorothea Gorki, Kilian V M Huber, Omar Sharif et al. doi:10.1038/ni.3590 Knapp and colleagues show that elevated heme levels following hemolysis impair the control of bacterial proliferation by inhibiting phagocytosis and migration of human and mouse phagocytes independently of heme-iron acquisition by bacteria as a source of nutrients. See also: News and Views by Tan & Weninger Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract   pp1373 - 1380 Junji Xing, Leiyun Weng, Bin Yuan, Zhuo Wang, Li Jia et al. doi:10.1038/ni.3580 Alveolar macrophages help maintain lung-tissue homeostasis despite constant microbial exposure. Zhang and colleagues show that the E3 ligase TRIM29 suppresses excessive proinflammatory responses by targeting the adaptor NEMO in alveolar macrophages. A tissue checkpoint regulates type 2 immunity   pp1381 - 1387 Steven J Van Dyken, Jesse C Nussbaum, Jinwoo Lee, Ari B Molofsky, Hong-Erh Liang et al. doi:10.1038/ni.3582 Type 2 responses can be elicited by ILC2s and TH2 cells. Locksley and colleagues show that the epithelium-derived cytokines IL-25, IL-33 and TSLP are required for full effector activation of poised ILC2 and primed TH2 cell populations. Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs   pp1388 - 1396 Cristina Gil-Cruz, Christian Perez-Shibayama, Lucas Onder, Qian Chai, Jovana Cupovic et al. doi:10.1038/ni.3566 Fibroblastic reticular cells influence the function of lymphocytes in secondary lymphoid organs. Ludewig and colleagues demonstrate that they also specifically restrain the activation of group 1 innate lymphoid cells in the presence of microbial stimulation to prevent immunopathology. Sall1 is a transcriptional regulator defining microglia identity and function   pp1397 - 1406 Anne Buttgereit, Iva Lelios, Xueyang Yu, Melissa Vrohlings, Natalie R Krakoski et al. doi:10.1038/ni.3585 Microglia are CNS-resident macrophages, but studying their functions in health and disease has been challenging due to a lack of specific markers. Greter and colleagues identify the transcription factor Sall1 as being uniquely associated with microglia in the CNS, where it is important for defining their fate and homeostatic function. Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses   pp1407 - 1414 Thomas Hagglof, Saikiran K Sedimbi, Jennifer L Yates, Roham Parsa, Briana Hauff Salas et al. doi:10.1038/ni.3583 The cytokine IL-18 can drive autoantibody production. Karlsson and colleagues show that such responses are limited by a three-way cellular interaction whereby splenic neutrophils activate both B cells and invariant natural killer T cells but the activated B cells are killed by FasL+ invariant natural killer T cells. Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors   pp1415 - 1423 Motoko Y Kimura, Julien Thomas, Xuguang Tai, Terry I Guinter, Miho Shinzawa et al. doi:10.1038/ni.3560 The CD4-versus-CD8 lineage 'choice' is a critical stage of thymocyte development. Singer and colleagues reveal that CD8 positive selection occurs in a defined time window and involves a compensatory mechanism that dynamically adjusts to TCR and cytokine signals. Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors   pp1424 - 1435 Tiago C Luis, Sidinh Luc, Takuo Mizukami, Hanane Boukarabila, Supat Thongjuea et al. doi:10.1038/ni.3576 The identity and lineage potential of the embryonic thymus-seeding progenitors that first seed the embryonic thymic rudiment is unclear. Jacobsen and colleagues find that these cells do not include multipotent stem cells or T cell-restricted progenitors but instead are lympho-myeloid progenitors. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function   pp1436 - 1446 Peter T Sage, Noga Ron-Harel, Vikram R Juneja, Debattama R Sen, Seth Maleri et al. doi:10.1038/ni.3578 Follicular regulatory T cells (TFR cells) inhibit follicular helper T cell (TFH cell)-mediated antibody production. Sharpe and colleagues show that TFR cells induce a distinct suppressive state in TFH cells and B cells that can be reversed by the cytokine IL-21. Protective neutralizing influenza antibody response in the absence of T follicular helper cells   pp1447 - 1458 Kosuke Miyauchi, Akiko Sugimoto-Ishige, Yasuyo Harada, Yu Adachi, Yoshiko Usami et al. doi:10.1038/ni.3563 T follicular helper (TFH) cells are important for the formation of germinal centers and antibody responses. Kubo and colleagues show that TH1 cells can induce a protective antibody response in the complete absence of TFH cells and germinal centers. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression   pp1459 - 1466 Valerie A Gerriets, Rigel J Kishton, Marc O Johnson, Sivan Cohen, Peter J Siska et al. doi:10.1038/ni.3577 T cells undergo metabolic reprogramming after they are activated. Rathmell and colleagues show that inflammatory Toll-like receptor signals induce glycolysis and impair the suppression of regulatory T cells, but Foxp3 can promote a switch to oxidative phosphorylation and suppression. Advertisement nature.com webcasts Join us for our upcoming webcast with live Q&A presented by BioPharma Dealmakers  ADVANCES IN PRECISION MEDICINE AND GENOMIC SEQUENCING Sponsored by: Aperiomics Inc. | Bluebee | iNanoBio | Becton Dickinson (BD)   Resource Top Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells   pp1467 - 1478 Pleun Hombrink, Christina Helbig, Ronald A Backer, Berber Piet, Anna E Oja et al. doi:10.1038/ni.3589 A goal of vaccination is to elicit and maintain tissue-resident memory T cells. Amsen and colleagues show human lung-resident memory CD8+ T cells express distinct transcriptional programs, including a role for Notch in cellular metabolism and maintenance. See also: News and Views by Wijeyesinghe & Masopust Corrigenda Top Corrigendum: Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract   p1479 Junji Xing, Leiyun Weng, Bin Yuan, Zhuo Wang, Li Jia et al. doi:10.1038/ni1216-1479a Corrigendum: Evidence of innate lymphoid cell redundancy in humans   p1479 Frederic Vely, Vincent Barlogis, Blandine Vallentin, Benedicte Neven, Christelle Piperoglou et al. doi:10.1038/ni1216-1479b Erratum Top Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation   p1479 Sabrina Torre, Maria J Polyak, David Langlais, Nassima Fodil, James M Kennedy et al. doi:10.1038/ni1216-1479c Top Advertisement Emerging Microbes & Infections is an open access, peer-review journal that provides an integrated forum to allow for the timely dissemination of large amount of information gathered about microbes and infections, especially ones associated with increasing biological and clinical significance and pathogenic frequency. 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