| | The effects of Δ9-tetrahydrocannabinol on the dopamine system
A review into the complex effects of Δ9-tetrahydrocannabinol on the dopamine system, examining data from animal and human studies and discussing the necessary future direction of research.
Michael A. P. Bloomfield, Abhishekh H. Ashok, Nora D. Volkow et al. | | CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
These preclinical studies outline a CRISPR-based methodology for correcting β-globin gene mutations in haematopoietic stem cells to advance the development of next-generation therapies for β-haemoglobinopathies.
Daniel P. Dever, Rasmus O. Bak, Andreas Reinisch et al. | Forward-genetics analysis of sleep in randomly mutagenized mice
Two mutations affecting the sleep–wakefulness balance in mice are detected, showing that the SIK3 protein kinase is essential for determining daily wake time, and the NALCN cation channel regulates the duration of rapid eye movement sleep.
Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama et al. | LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Human tumours with mutations in LKB1 and Kras have a specific hypermetabolic state associated with increased DNA methylation, pointing to potential metabolic and epigenetic vulnerabilities of specific tumours.
Filippos Kottakis, Brandon N. Nicolay, Ahlima Roumane et al. | Thermophilic archaea activate butane via alkyl-coenzyme M formation
Anaerobic archaea enriched in thermophilic microbial consortia completely degrade butane by modifying mechanisms which were hitherto thought to be specific to methane metabolism.
Rafael Laso-Pérez, Gunter Wegener, Katrin Knittel et al. | | Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
Targeting tumour-infiltrating suppressive myeloid cells with a selective PI3Kγ inhibitor overcomes resistance to checkpoint blockade therapy in various mouse myeloid-rich tumour models.
Olivier De Henau, Matthew Rausch, David Winkler et al. | Tidal evolution of the Moon from a high-obliquity, high-angular-momentum Earth
A model of the Moon’s tidal evolution, starting from the fast-spinning, high-obliquity Earth that would be expected after a giant impact, reveals that solar perturbations on the Moon’s orbit naturally produce the current lunar inclination and Earth’s low obliquity.
Matija Ćuk, Douglas P. Hamilton, Simon J. Lock et al. | Nanoscale thermal imaging of dissipation in quantum systems
A cryogenic thermal imaging technique that uses a superconducting quantum interference device fabricated on the tip of a sharp pipette can be used to image the thermal signature of extremely low power nanometre-scale dissipation processes.
D. Halbertal, J. Cuppens, M. Ben Shalom et al. | Implications for metal and volatile cycles from the pH of subduction zone fluids
A thermodynamic model of fluid pH and its variability in Earth’s mantle and subducting crust highlights chemical feedbacks that connect deep Earth to surface processes.
Matthieu E. Galvez, James A. D. Connolly, Craig E. Manning | Variability in plant nutrients reduces insect herbivore performance
Variation in plant nutrient levels suppresses insect herbivore populations and the homogenous nutrient content of modern agricultural crops could be contributing to insect pest outbreaks.
William C. Wetzel, Heather M. Kharouba, Moria Robinson et al. | Alternative modes of client binding enable functional plasticity of Hsp70
Hsp70 binds unfolded protein segments in its groove, but can also bind and stabilize folded protein structures, owing to its moveable lid, with ATP hydrolysis and co-chaperones allowing control of these contrasting effects.
Alireza Mashaghi, Sergey Bezrukavnikov, David P. Minde et al. | Local regulation of gene expression by lncRNA promoters, transcription and splicing
Various cis-regulatory functions of genomic loci that produce long non-coding RNAs are revealed, including instances where their promoters have enhancer-like activity and the lncRNA transcripts themselves are not required for activity.
Jesse M. Engreitz, Jenna E. Haines, Elizabeth M. Perez et al. | Amazon boundary layer aerosol concentration sustained by vertical transport during rainfall
Rapid vertical transport of small aerosol particles from the free troposphere to the atmospheric boundary layer occurs during precipitation and maintains the population of aerosol particles over Amazonia.
Jian Wang, Radovan Krejci, Scott Giangrande et al. | Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour
Calcium signalling in astrocytes, driven through the octopamine/tyramine receptor and the TRP channel Water witch, is essential for neuromodulation and sensory responses in Drosophila larvae.
Zhiguo Ma, Tobias Stork, Dwight E. Bergles et al. | Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development
Transcription of a long non-coding RNA, known as upperhand (Uph) located upstream of the HAND2 transcription factor is required to maintain transcription of the Hand2 gene by RNA polymerase, and blockade of Uph expression leads to heart defects and embryonic lethality in mice.
Kelly M. Anderson, Douglas M. Anderson, John R. McAnally et al. | Intrinsically stretchable and healable semiconducting polymer for organic transistors
Introducing non-covalent crosslinking moieties to polymer semiconductors produces a stretchable and healable material suitable for wearable electronics.
Jin Young Oh, Simon Rondeau-Gagné, Yu-Cheng Chiu et al. | PI3Kγ is a molecular switch that controls immune suppression
Modulation of PI3Kγ activity regulates macrophage polarization during inflammation and cancer, whilst combining PI3Kγ inhibition with immune checkpoint inhibitors leads to synergistic tumour-inhibitory effects.
Megan M. Kaneda, Karen S. Messer, Natacha Ralainirina et al. | | | | |
No comments:
Post a Comment