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Advertisement | | | | | | | | | | | Nature Communications - all content now freely available including back files
As of January 2016, the journal only publishes open access content, and legacy subscription content published in Nature Communications prior to 2016 has been made freely accessible. For more information visit our website.
Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | | | | | Latest Articles | View all Articles | | | | | A time transect of exomes from a Native American population before and after European contact OPEN | | | John Lindo, Emilia Huerta-Sánchez, Shigeki Nakagome, Morten Rasmussen, Barbara Petzelt, Joycelynn Mitchell, Jerome S. Cybulski, Eske Willerslev, Michael DeGiorgio and Ripan S. Malhi | | | A First Nation population declined after European contact, likely as a result of infectious disease. Here, researchers partner with indigenous communities to analyse ancient and modern Native American exomes, and find a shift in selection pressure on immune genes, correlated to European-borne epidemics. | | | 15 November 2016 | doi: 10.1038/ncomms13175 | | |
| Long-term coding of personal and universal associations underlying the memory web in the human brain OPEN | | | Emanuela De Falco, Matias J. Ison, Itzhak Fried and Rodrigo Quian Quiroga | | | Neurons in the medial temporal lobe change their firing patterns as people learn to pair items together, yet it is unclear if this pairing lasts. Here, authors find that single medial temporal lobe neurons in humans tend to respond similarly to items that are closely conceptually related. | | | 15 November 2016 | doi: 10.1038/ncomms13408 | | |
| Contribution of Arctic seabird-colony ammonia to atmospheric particles and cloud-albedo radiative effect OPEN | | | B. Croft, G. R. Wentworth, R. V. Martin, W. R. Leaitch, J. G. Murphy, B. N. Murphy, J. K. Kodros, J. P. D. Abbatt and J. R. Pierce | | | The climatic impact of ammonia emissions from Arctic seabird-colony guano is poorly understood. Here, using observations and a chemical transport model, Croft et al. illustrate that guano-associated particles promote cloud-droplet formation, resulting in a pan-Arctic cooling tendency of approximately −0.5 W m−2. | | | 15 November 2016 | doi: 10.1038/ncomms13444 | | |
| Multidimensional heritability analysis of neuroanatomical shape OPEN | | | Tian Ge, Martin Reuter, Anderson M. Winkler, Avram J. Holmes, Phil H. Lee, Lee S. Tirrell, Joshua L. Roffman, Randy L. Buckner, Jordan W. Smoller and Mert R. Sabuncu | | | Neuroanatomical shape measurements are multidimensional geometric descriptions of brain structure. This study develops multivariate heritability analysis methods and examines structural brain MRI scans and genetic data to estimate the heritability of neuroanatomical shape. | | | 15 November 2016 | doi: 10.1038/ncomms13291 | | |
| Smectic phase in suspensions of gapped DNA duplexes OPEN | | | Miroslaw Salamonczyk, Jing Zhang, Giuseppe Portale, Chenhui Zhu, Emmanuel Kentzinger, James T. Gleeson, Antal Jakli, Cristiano De Michele, Jan K. G. Dhont, Samuel Sprunt and Emmanuel Stiakakis | | | DNA can be used as a tunable building block to create a variety of self-assembly-driven liquid crystals. Here, the authors report the stabilization of a smectic-A liquid crystal phase, where constituent molecules—two rigid dsDNA segments linked by a flexible ssDNA spacer—attain a folded configuration. | | | 15 November 2016 | doi: 10.1038/ncomms13358 | | |
| Two-dimensional antimonene single crystals grown by van der Waals epitaxy OPEN | | | Jianping Ji, Xiufeng Song, Jizi Liu, Zhong Yan, Chengxue Huo, Shengli Zhang, Meng Su, Lei Liao, Wenhui Wang, Zhenhua Ni, Yufeng Hao and Haibo Zeng | | | Several two-dimensional materials have been synthesized to date, yet elemental materials, consisting of individual atomic species, are still scarce. Here, the authors synthesize few-layer, monocrystalline polygons of antimonene via van der Waals epitaxy growth. | | | 15 November 2016 | doi: 10.1038/ncomms13352 | | |
| BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity OPEN | | | Rikke D. Rasmussen, Madhavsai K. Gajjar, Lucie Tuckova, Kamilla E. Jensen, Apolinar Maya-Mendoza, Camilla B. Holst, Kjeld Møllgaard, Jane S. Rasmussen, Jannick Brennum, Jiri Bartek, Martin Syrucek, Eva Sedlakova, Klaus K. Andersen, Marie H. Frederiksen, Jiri Bartek and Petra Hamerlik | | | BRCA1 loss can result in collapse of replication forks into DNA double strand breaks that can contribute to malignant transformation. Here, the authors find that BRCA1 promotes the expression of RRM2 protecting glioblastoma cells from replication stress, DNA damage and apoptosis. | | | 15 November 2016 | doi: 10.1038/ncomms13398 | | |
| Bivalence Mn5O8 with hydroxylated interphase for high-voltage aqueous sodium-ion storage OPEN | | | Xiaoqiang Shan, Daniel S. Charles, Yinkai Lei, Ruimin Qiao, Guofeng Wang, Wanli Yang, Mikhail Feygenson, Dong Su and Xiaowei Teng | | | Rechargeable aqueous electrochemical energy storage is a promising technology but suffers from a narrow potential window. Here the authors report a surface hydroxylated Mn5O8 pseudocapacitor electrode with bivalence structure that expands the potential window to deliver high energy and power performance. | | | 15 November 2016 | doi: 10.1038/ncomms13370 | | |
| Structure of the NS2B-NS3 protease from Zika virus after self-cleavage OPEN | | | Wint Wint Phoo, Yan Li, Zhenzhen Zhang, Michelle Yueqi Lee, Ying Ru Loh, Yaw Bia Tan, Elizabeth Yihui Ng, Julien Lescar, CongBao Kang and Dahai Luo | | | The proteases of flaviviruses are promising targets for development of specific antiviral drugs. Here, the authors report a high resolution crystal structure of the NS2B-NS3 protease of Zika virus that provides insight into substrate and inhibitor binding. | | | 15 November 2016 | doi: 10.1038/ncomms13410 | | |
| Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response OPEN | | | Jan Rossaint, Katharina Kühne, Jennifer Skupski, Hugo Van Aken, Mark R. Looney, Andres Hidalgo and Alexander Zarbock | | | Interaction between platelets and neutrophils promotes neutrophil activation. Here the authors show that neutrophils initiate the cross-talk with platelets by shuttling arachidonic acid via extracellular vesicles, which platelets convert to thromboxane A2 that then elicits neutrophil activation. | | | 15 November 2016 | doi: 10.1038/ncomms13464 | | |
| Microbe-mediated host defence drives the evolution of reduced pathogen virulence OPEN | | | Suzanne A. Ford, Damian Kao, David Williams and Kayla C. King | | | Some microbes protect their hosts from pathogens and likely drive pathogens’ evolution. Here, Ford et al. show that a host-protective microbe selects for reduced virulence of a pathogen in the model organism Caenorhabditis elegans. | | | 15 November 2016 | doi: 10.1038/ncomms13430 | | |
| Boosting functionality of synthetic DNA circuits with tailored deactivation OPEN | | | Kevin Montagne, Guillaume Gines, Teruo Fujii and Yannick Rondelez | | | Nonlinearity in synthetic molecular circuits is usually achieved by manipulation of network topology or of production kinetics. Here, the authors achieve bistability and other nonlinear behaviours by manipulating the individual degradation rate laws of circuit components using saturable pathways. | | | 15 November 2016 | doi: 10.1038/ncomms13474 | | |
| Surface to bulk Fermi arcs via Weyl nodes as topological defects OPEN | | | Kun Woo Kim, Woo-Ram Lee, Yong Baek Kim and Kwon Park | | | Understanding how surface Fermi arcs connect different Weyl nodes in presence of multiple Weyl-node pairs is intriguing yet unclear. Here, Kim et al. show that the winding of the Zak phase around each projected Weyl node manifests itself as a topological defect, leading to non-trivial surface as well as bulk Fermi arcs. | | | 15 November 2016 | doi: 10.1038/ncomms13489 | | |
| High spatial dynamics-photoluminescence imaging reveals the metallurgy of the earliest lost-wax cast object OPEN | | | M. Thoury, B. Mille, T. Séverin-Fabiani, L. Robbiola, M. Réfrégiers, J-F Jarrige and L. Bertrand | | | Photoluminescence is a powerful probe of chemical composition and structure, but it is challenging to image heterogeneous materials over large scale. Thoury et al. develop a full-field imaging approach to map two cuprous oxide phases in the earliest known lost-wax cast artefact manufactured 6,000 years ago. | | | 15 November 2016 | doi: 10.1038/ncomms13356 | | |
| Reader domain specificity and lysine demethylase-4 family function OPEN | | | Zhangli Su, Fengbin Wang, Jin-Hee Lee, Kimberly E. Stephens, Romeo Papazyan, Ekaterina Voronina, Kimberly A. Krautkramer, Ana Raman, Jeremy J. Thorpe, Melissa D. Boersma, Vyacheslav I. Kuznetsov, Mitchell D. Miller, Sean D. Taverna, George N. Phillips and John M. Denu | | | KDM4 histone demethylases target specific chromatin regions by a mechanism that is not fully characterised. Here, the authors identify trimethyl-lysine histone-binding preferences for closely related KDM4 double tudor domains and use structural and biochemical information to examine the molecular details of this interaction. | | | 14 November 2016 | doi: 10.1038/ncomms13387 | | |
| Competition among networks highlights the power of the weak OPEN | | | Jaime Iranzo, Javier M. Buldú and Jacobo Aguirre | | | Network science and game theory have been traditionally combined to analyse interactions between nodes of a network. Here, the authors model competition for importance among networks themselves, and reveal dominance of the underdogs in the fate of networks-of-networks. | | | 14 November 2016 | doi: 10.1038/ncomms13273 | | |
| Anomalous time delays and quantum weak measurements in optical micro-resonators OPEN | | | M. Asano, K. Y. Bliokh, Y. P. Bliokh, A. G. Kofman, R. Ikuta, T. Yamamoto, Y. S. Kivshar, L. Yang, N. Imoto, Ş.K. Özdemir and F. Nori | | | Interference of linear plane waves produces non-trivial phenomena in both classical and quantum wave systems. Here, the authors describe and observe anomalously large time delays and frequency shifts in the resonant inelastic scattering of a 1D wave packet near a zero of the scattering coefficient. | | | 14 November 2016 | doi: 10.1038/ncomms13488 | | |
| Absolute abundance of southern bluefin tuna estimated by close-kin mark-recapture OPEN | | | Mark V. Bravington, Peter M. Grewe and Campbell R. Davies | | | Accurate determination of population size for highly-mobile marine animals is often prohibitively difficult. Here, Bravington et al. estimate the abundance of southern bluefin tuna using a method based on the number of parent-offspring pairs detected genetically in samples from the catch. | | | 14 November 2016 | doi: 10.1038/ncomms13162 | | |
| CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells OPEN | | | Jae-Ho Cho, Hee-Ok Kim, Young-Jun Ju, Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Cheol-Heui Yun, Nunzio Bottini, Kylie Webster, Christopher C. Goodnow, Charles D. Surh, Cecile King and Jonathan Sprent | | | Naïve T cells establish self-tolerance via negative selection of cells with strong reactivity for self-peptide/MHC complexes, but undergo T-cell receptor (TCR) desensitisation when leaving the thymus. Here, Cho et al. show that TCR desensitisation correlates with cell-surface density of the phosphatase CD45. | | | 14 November 2016 | doi: 10.1038/ncomms13373 | | |
| Ultrafast all-optical coherent control of single silicon vacancy colour centres in diamond OPEN | | | Jonas Nils Becker, Johannes Görlitz, Carsten Arend, Matthew Markham and Christoph Becher | | | All-optical coherent control schemes offer well-localized and ultrafast control of individual qubits in many-qubit systems. Here the authors report on all-optical resonant and Raman-based control of single silicon vacancies using picosecond pulses, much faster than the ground state coherence time. | | | 14 November 2016 | doi: 10.1038/ncomms13512 | | |
| Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila OPEN | | | Nikolay P. Kandul, Ting Zhang, Bruce A. Hay and Ming Guo | | | Heteroplasmy, in which mutant and wild-type mitochondrial DNA (mtDNA) coexist in a cell, can result in diseases. Here the authors generate transgenic flies with heteroplasmic mtDNA in flight muscles, and show that stimulation of autophagy, or a decrease in mitofusin, promotes clearance of mutant mtDNA. | | | 14 November 2016 | doi: 10.1038/ncomms13100 | | |
| Modulated phases of graphene quantum Hall polariton fluids OPEN | | | Francesco M. D. Pellegrino, Vittorio Giovannetti, Allan H. MacDonald and Marco Polini | | | High-mobility graphene can play host to exciton polaritons—hybrid matter–light particles, which can form into a state known as a quantum Hall polariton fluid. Here, the authors show that electron–electron interactions can act to destabilize this state and lead to the formation of a modulated phase. | | | 14 November 2016 | doi: 10.1038/ncomms13355 | | |
| Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability OPEN | | | Jodi R. Paul, Daniel DeWoskin, Laura J. McMeekin, Rita M. Cowell, Daniel B. Forger and Karen L. Gamble | | | It is not clear how circadian biochemical cascades are encoded into neural electrical signals. Here, using a combination of electrophysiology and modelling approaches in mice, the authors show activation of glycogen synthase kinase 3 modulates neural activity in the suprachiasmatic nuclei via regulation of the persistent sodium current, INaP. | | | 14 November 2016 | doi: 10.1038/ncomms13470 | | |
| Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion OPEN | | | Francesca Sacco, Sean J. Humphrey, Jürgen Cox, Marcel Mischnik, Anke Schulte, Thomas Klabunde, Matthias Schäfer and Matthias Mann | | | Dysfunction in insulin secretion is a main driver of type 2 diabetes development. Here the authors monitor phosphoproteome modulation in cells stimulated with glucose and treated with drugs affecting glucose-mediated insulin secretion to reveal phosphorylation sites implicated in insulin secretion control and gene expression regulation. | | | 14 November 2016 | doi: 10.1038/ncomms13250 | | |
| Quantum criticality in an organic spin-liquid insulator κ-(BEDT-TTF)2Cu2(CN)3 OPEN | | | Takayuki Isono, Taichi Terashima, Kazuya Miyagawa, Kazushi Kanoda and Shinya Uji | | | Quantum spin liquids emerge when quantum fluctuations suppress a magnetically ordered state. Here the authors measure magnetic torque in κ-(BEDT-TTF)2Cu2(CN)3, showing universal critical scaling in the magnetic susceptibilities, with critical exponents incompatible with known models for quantum spin liquids. | | | 14 November 2016 | doi: 10.1038/ncomms13494 | | |
| Optical analogues of the Newton–Schrödinger equation and boson star evolution OPEN | | | Thomas Roger, Calum Maitland, Kali Wilson, Niclas Westerberg, David Vocke, Ewan M. Wright and Daniele Faccio | | | In the weak field limit, boson star evolution is governed by the Newton-Schrödinger equation. Here the authors report an optical setup that provides a formal analogue of such dynamics via the interaction between vortex beams and a medium with positive thermo-optical nonlinearity. | | | 14 November 2016 | doi: 10.1038/ncomms13492 | | |
| Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance OPEN | | | Oscar Molina, Giulia Vargiu, Maria Alba Abad, Alisa Zhiteneva, A. Arockia Jeyaprakash, Hiroshi Masumoto, Natalay Kouprina, Vladimir Larionov and William C. Earnshaw | | | Centromeres are centrochromatin domains with CENP-A and H3 nucleosomes carrying transcription-associated modifications. Here the authors target synthetic modules to the centromeres to show that transcription plus histone modifications are required for CENP-A assembly and centrochromatin maintenance. | | | 14 November 2016 | doi: 10.1038/ncomms13334 | | |
| The reversibility and first-order nature of liquid–liquid transition in a molecular liquid OPEN | | | Mika Kobayashi and Hajime Tanaka | | | The nature of the phenomenon of so-called ‘liquid-liquid transitions’ in molecular liquids is a long-standing debate. Here, the authors demonstrate the reversibility and first-order nature of the liquid-liquid transition in triphenyl phosphite via flash differential scanning calorimetry. | | | 14 November 2016 | doi: 10.1038/ncomms13438 | | |
| Deoxyfluorination of alcohols with 3,3-difluoro-1,2-diarylcyclopropenes OPEN | | | Lingchun Li, Chuanfa Ni, Fei Wang and Jinbo Hu | | | Fluorination of organic molecules can dramatically change the properties and is commonly used for the synthesis of bioactive molecules. Here, the authors report the deoxyfluorination of alcohols and the selective monofluorination of diols using bench stable, tunable difluorocyclopropene reagents. | | | 14 November 2016 | doi: 10.1038/ncomms13320 | | |
| Experimental realization of entanglement in multiple degrees of freedom between two quantum memories OPEN | | | Wei Zhang, Dong-Sheng Ding, Ming-Xin Dong, Shuai Shi, Kai Wang, Shi-Long Liu, Yan Li, Zhi-Yuan Zhou, Bao-Sen Shi and Guang-Can Guo | | | Establishing multi-degree-of-freedom entangled memories is important for high-capacity quantum communications and computing. Here, authors experimentally demonstrate hyper- and hybrid entanglement between two atomic ensembles in multiple degrees of freedom including path and orbital angular momentum. | | | 14 November 2016 | doi: 10.1038/ncomms13514 | | |
| Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism OPEN | | | Renee L. Greer, Xiaoxi Dong, Ana Carolina F. Moraes, Ryszard A. Zielke, Gabriel R. Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, Alexi A. Schoenborn, Everton P. Gomes, Alexandre C. Pereira, Sandra R. G. Ferreira, Michael Yao, Ivan J. Fuss, Warren Strober, Aleksandra E. Sikora, Gregory A. Taylor, Ajay S. Gulati, Andrey Morgun and Natalia Shulzhenko | | | Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbe Akkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism. | | | 14 November 2016 | doi: 10.1038/ncomms13329 | | |
| Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies OPEN | | | Yukinori Hirano, Kunio Ihara, Tomoko Masuda, Takuya Yamamoto, Ikuko Iwata, Aya Takahashi, Hiroko Awata, Naosuke Nakamura, Mai Takakura, Yusuke Suzuki, Junjiro Horiuchi, Hiroyuki Okuno and Minoru Saitoe | | | Transcriptional regulation is necessary for maintaining long-term memories (LTM) but the mechanistic details are not completely defined. Here the authors identify transcriptional machinery and histone modifiers required for LTM maintenance in Drosophila and show that transcriptional regulation for LTM maintenance is distinct from that for LTM formation. | | | 14 November 2016 | doi: 10.1038/ncomms13471 | | |
| Product lambda-doublet ratios as an imprint of chemical reaction mechanism OPEN | | | P. G. Jambrina, A. Zanchet, J. Aldegunde, M. Brouard and F. J. Aoiz | | | Propensity for a given Λ-doublet level is a common feature in many chemical reactions, but has so far remained unexplained. Here, the authors show how to predict computationally those propensities and relate them to the reaction mechanism on concurrent potential energy surfaces. | | | 11 November 2016 | doi: 10.1038/ncomms13439 | | |
| Wearable energy-smart ribbons for synchronous energy harvest and storage OPEN | | | Chao Li, Md. Monirul Islam, Julian Moore, Joseph Sleppy, Caleb Morrison, Konstantin Konstantinov, Shi Xue Dou, Chait Renduchintala and Jayan Thomas | | | Flexible materials for harvesting and storing energy are desirable for wearable electronics, but efficiency is still an issue. Here, the authors demonstrate a flexible and weavable ribbon which integrates a solar cell and supercapacitor via a shared electrode for efficient energy harvesting and storage. | | | 11 November 2016 | doi: 10.1038/ncomms13319 | | |
| tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence OPEN | | | Yok Hian Chionh, Megan McBee, I. Ramesh Babu, Fabian Hia, Wenwei Lin, Wei Zhao, Jianshu Cao, Agnieszka Dziergowska, Andrzej Malkiewicz, Thomas J. Begley, Sylvie Alonso and Peter C. Dedon | | | Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovis BCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes. | | | 11 November 2016 | doi: 10.1038/ncomms13302 | | |
| Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6 OPEN | | | Kevin P. Mouillesseaux, David S. Wiley, Lauren M. Saunders, Lyndsay A. Wylie, Erich J. Kushner, Diana C. Chong, Kathryn M. Citrin, Andrew T. Barber, Youngsook Park, Jun-Dae Kim, Leigh Ann Samsa, Jongmin Kim, Jiandong Liu, Suk-Won Jin and Victoria L. Bautch | | | The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade. | | | 11 November 2016 | doi: 10.1038/ncomms13247 | | |
| Continuous injection synthesis of indium arsenide quantum dots emissive in the short-wavelength infrared OPEN | | | Daniel Franke, Daniel K. Harris, Ou Chen, Oliver T. Bruns, Jessica A. Carr, Mark W. B. Wilson and Moungi G. Bawendi | | | Indium arsenide quantum dots are promising materials for short-wavelength infrared emissive applications. Here, the authors investigate the kinetics of indium arsenide nanocrystal growth and design large quantum dots with narrow emission wavelengths which can be used for through-skull fluorescence imaging. | | | 11 November 2016 | doi: 10.1038/ncomms12749 | | |
| Experimental demonstration of anomalous Floquet topological insulator for sound OPEN | | | Yu-Gui Peng, Cheng-Zhi Qin, De-Gang Zhao, Ya-Xi Shen, Xiang-Yuan Xu, Ming Bao, Han Jia and Xue-Feng Zhu | | | Topological protected acoustic wave propagation has been predicted, but yet awaits for experimental demonstration. Here, Peng et al. report one-way propagation of pseudo-spin-dependent edge states for sound, analogous to Floquet topological insulator in solid state. | | | 11 November 2016 | doi: 10.1038/ncomms13368 | | |
| High-performance shape-engineerable thermoelectric painting OPEN | | | Sung Hoon Park, Seungki Jo, Beomjin Kwon, Fredrick Kim, Hyeong Woo Ban, Ji Eun Lee, Da Hwi Gu, Se Hwa Lee, Younghun Hwang, Jin-Sang Kim, Dow-Bin Hyun, Sukbin Lee, Kyoung Jin Choi, Wook Jo and Jae Sung Son | | | Thermoelectric devices are often rigid and do not adapt conformally to surfaces. Here, Park et al. prepare a Bi2Te3-based thermoelectric paint, containing a Sb2Te3 chalcogenidometalate additive, that can be paint-brushed onto curved surfaces and form thermoelectric modules with good efficiencies. | | | 11 November 2016 | doi: 10.1038/ncomms13403 | | |
| Biocatalytic trifluoromethylation of unprotected phenols OPEN | | | Robert C. Simon, Eduardo Busto, Nina Richter, Verena Resch, Kendall N. Houk and Wolfgang Kroutil | | | The introduction of fluorine into organic molecules often requires prefunctionalised molecules or protection of reactive functional groups. Here, the authors report a biocatalytic method for the trifluoromethylation of unprotected phenols under mild conditions. | | | 11 November 2016 | doi: 10.1038/ncomms13323 | | |
| More frequent intense and long-lived storms dominate the springtime trend in central US rainfall OPEN | | | Zhe Feng, L. Ruby Leung, Samson Hagos, Robert A. Houze, Casey D. Burleyson and Karthik Balaguru | | | The central United States has exhibited increased extreme precipitation. Here, using satellite, radar, and rain-gauge data, Feng et al. show that springtime total and extreme rainfall trends are linked to increased intensity and frequency of long-lived Mesoscale Convective Systems. | | | 11 November 2016 | doi: 10.1038/ncomms13429 | | |
| The pangenome of an agronomically important crop plant Brassica oleracea OPEN | | | Agnieszka A. Golicz, Philipp E. Bayer, Guy C. Barker, Patrick P. Edger, HyeRan Kim, Paula A. Martinez, Chon Kit Kenneth Chan, Anita Severn-Ellis, W. Richard McCombie, Isobel A. P. Parkin, Andrew H. Paterson, J. Chris Pires, Andrew G. Sharpe, Haibao Tang, Graham R. Teakle, Christopher D. Town, Jacqueline Batley and David Edwards | | | Brassica oleracea is a single species that includes diverse crops such as cabbage, broccoli and Brussels sprouts. Here, the authors identify genes not captured in existing B. oleracea reference genomes by the assembly of a pangenome and show variations in gene content that may be related to important agronomic traits | | | 11 November 2016 | doi: 10.1038/ncomms13390 | | |
| Amazonian chemical weathering rate derived from stony meteorite finds at Meridiani Planum on Mars OPEN | | | Christian Schröder, Phil A. Bland, Matthew P. Golombek, James W. Ashley, Nicholas H. Warner and John A. Grant | | | Little is known about the impacts of Mars’ contemporary dryness on weathering processes. Here, using iron oxidation estimates from the Mars Rover Opportunity, the authors quantify chemical weathering rates for Mars, finding appreciably slower rates compared with the lowest values on Earth. | | | 11 November 2016 | doi: 10.1038/ncomms13459 | | |
| In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075 OPEN | | | Xia Wu, Juan D. Chavez, Devin K. Schweppe, Chunxiang Zheng, Chad R. Weisbrod, Jimmy K. Eng, Ananya Murali, Samuel A. Lee, Elizabeth Ramage, Larry A. Gallagher, Hemantha D. Kulasekara, Mauna E. Edrozo, Cassandra N. Kamischke, Mitchell J. Brittnacher, Samuel I. Miller, Pradeep K. Singh, Colin Manoil and James E. Bruce | | | The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumannii isolate, indicative of porin-localised antibiotic inactivation. | | | 11 November 2016 | doi: 10.1038/ncomms13414 | | |
| A two-dimensional spin field-effect switch OPEN | | | Wenjing Yan, Oihana Txoperena, Roger Llopis, Hanan Dery, Luis E. Hueso and Fèlix Casanova | | | By forming heterostructures of different layered two-dimensional materials, functional spintronic devices may be built by exploiting the materials’ different spin-orbit coupling and spin transport properties. Here, the authors demonstrate a spin switch in a gated structure of graphene and MoS2. | | | 11 November 2016 | doi: 10.1038/ncomms13372 | | |
| Spin injection and inverse Edelstein effect in the surface states of topological Kondo insulator SmB6 OPEN | | | Qi Song, Jian Mi, Dan Zhao, Tang Su, Wei Yuan, Wenyu Xing, Yangyang Chen, Tianyu Wang, Tao Wu, Xian Hui Chen, X. C. Xie, Chi Zhang, Jing Shi and Wei Han | | | Spin injection in pure topological surface states of topological insulators is challenging due to the coexistence of highly conducting bulk states. Here, Song et al. report spin injection and inverse Edelstein effect in the spin–momentum locked surface states of topological Kondo insulator SmB6. | | | 11 November 2016 | doi: 10.1038/ncomms13485 | | |
| Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma OPEN | | | Fang Sun, Hsiang-Chieh Hung, Andrew Sinclair, Peng Zhang, Tao Bai, Daniel David Galvan, Priyesh Jain, Bowen Li, Shaoyi Jiang and Qiuming Yu | | | Despite the high sensitivity of SERS analysis, non-specific binding of proteins can impact the effectiveness in biologically important media such as blood. Here the authors report a SERS substrate modified to prevent protein fouling and demonstrate drug detection in undiluted plasma. | | | 11 November 2016 | doi: 10.1038/ncomms13437 | | |
| Arabidopsis seed germination speed is controlled by SNL histone deacetylase-binding factor-mediated regulation of AUX1 OPEN | | | Zhi Wang, Fengying Chen, Xiaoying Li, Hong Cao, Meng Ding, Cun Zhang, Jinghong Zuo, Chaonan Xu, Jimei Xu, Xin Deng, Yong Xiang, Wim J. J. Soppe and Yongxiu Liu | | | Histone acetylation influences the speed of seed germination. Here, Wang et al. show that loss of the SNL1/SNL2 histone deacetylase binding factors accelerates seed germination and provide evidence that they act by regulating the expression of AUX1 which in turn influences cell division. | | | 11 November 2016 | doi: 10.1038/ncomms13412 | | |
| Ultrasensitive plasmonic sensing in air using optical fibre spectral combs OPEN | | | Christophe Caucheteur, Tuan Guo, Fu Liu, Bai-Ou Guan and Jacques Albert | | | Fibre sensors are key to many minimally-invasive detection techniques but, owing to an index mismatch, they are often limited to aqueous environments. Here, Caucheteur et al. develop a high-resolution fibre gas sensor with a tilted in-fibre grating that allows coupling to higher-order plasmon modes. | | | 11 November 2016 | doi: 10.1038/ncomms13371 | | |
| Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS OPEN | | | Line S. Reinert, Katarína Lopušná, Henriette Winther, Chenglong Sun, Martin K. Thomsen, Ramya Nandakumar, Trine H. Mogensen, Morten Meyer, Christian Vægter, Jens R. Nyengaard, Katherine A. Fitzgerald and Søren R. Paludan | | | The cGAS–STING pathway is an important immune defence pathway against viral infection, including HSV-1. Here the authors use an HSV-1 encephalitis model and show microglia are the main producers of type 1 interferons that induce antiviral activity in neurons and prime the TLR3-interferon pathway in astrocytes. | | | 10 November 2016 | doi: 10.1038/ncomms13348 | | |
| Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes OPEN | | | Yelin Wu, Yanchun Quan, Yuanqi Liu, Keiwei Liu, Hongquan Li, Ziwei Jiang, Tian Zhang, Hu Lei, Katherine A. Radek, Dongqing Li, Zhenhua Wang, Jilong Lu, Wang Wang, Shizhao Ji, Zhaofan Xia and Yuping Lai | | | Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds. | | | 10 November 2016 | doi: 10.1038/ncomms13393 | | |
| Direct observation of confined acoustic phonon polarization branches in free-standing semiconductor nanowires OPEN | | | Fariborz Kargar, Bishwajit Debnath, Joona-Pekko Kakko, Antti Säynätjoki, Harri Lipsanen, Denis L. Nika, Roger K. Lake and Alexander A. Balandin | | | In nanostructures, phonon confinement could lead to better control of phonon-electron coupling and thermal properties. Here, the authors use light scattering spectroscopy to measure acoustic phonons confinement in individual free-standing nanowires, their energy dispersion and energy scaling. | | | 10 November 2016 | doi: 10.1038/ncomms13400 | | |
| Pure crystal orientation and anisotropic charge transport in large-area hybrid perovskite films OPEN | | | Namchul Cho, Feng Li, Bekir Turedi, Lutfan Sinatra, Smritakshi P. Sarmah, Manas R. Parida, Makhsud I. Saidaminov, Banavoth Murali, Victor M. Burlakov, Alain Goriely, Omar F. Mohammed, Tom Wu and Osman M. Bakr | | | Lead halide perovskites are developed for a number of optoelectronic applications. Here, Cho et al. use a thermal gradient to achieve directional crystallization of methyl ammonium lead iodide films. The periodic microarrays exhibit anisotropic charge transport properties. | | | 10 November 2016 | doi: 10.1038/ncomms13407 | | |
| Glacial isostatic uplift of the European Alps OPEN | | | Jürgen Mey, Dirk Scherler, Andrew D. Wickert, David L. Egholm, Magdala Tesauro, Taylor F. Schildgen and Manfred R. Strecker | | | For half a century, the cause for recent uplift of the European Alps has been debated. Here, the authors show that ∼90% of the geodetically measured rock uplift in the Alps can be explained by the Earth’s viscoelastic response to ice melting after the Last Glacial Maximum. | | | 10 November 2016 | doi: 10.1038/ncomms13382 | | |
| Cascaded emission of single photons from the biexciton in monolayered WSe2 OPEN | | | Yu-Ming He, Oliver Iff, Nils Lundt, Vasilij Baumann, Marcelo Davanco, Kartik Srinivasan, Sven Höfling and Christian Schneider | | | Atomically thin transition metal dichalcogenides constitute an ideal platform to investigate solid state excitonic effects. Here, the authors provide experimental evidence of a localized biexciton in a monolayer of WSe2, which induces an emission cascade of single photons. | | | 10 November 2016 | doi: 10.1038/ncomms13409 | | |
| Trapped charge-driven degradation of perovskite solar cells OPEN | | | Namyoung Ahn, Kwisung Kwak, Min Seok Jang, Heetae Yoon, Byung Yang Lee, Jong-Kwon Lee, Peter V. Pikhitsa, Junseop Byun and Mansoo Choi | | | Improving the stability of perovskite solar cells remains crucial. Here, Ahn et al. show that trapped charges at grain boundaries induce the dissociation of the perovskite compound in the presence of moisture, and explain why degradation is irreversible under illumination and reversible in the dark. | | | 10 November 2016 | doi: 10.1038/ncomms13422 | | |
| Mechanism for rapid growth of organic–inorganic halide perovskite crystals OPEN | | | Pabitra K. Nayak, David T. Moore, Bernard Wenger, Simantini Nayak, Amir A. Haghighirad, Adam Fineberg, Nakita K. Noel, Obadiah G. Reid, Garry Rumbles, Philipp Kukura, Kylie A. Vincent and Henry J. Snaith | | | Single crystals of lead halide perovskites exhibit good optoelectronic properties. Here, the authors study and deduce the mechanism for crystallisation and show how controlling dissolution of colloids through varying the acidity and temperature can improve the quality of the single crystals. | | | 10 November 2016 | doi: 10.1038/ncomms13303 | | |
| Photomotility of polymers OPEN | | | Jeong Jae Wie, M. Ravi Shankar and Timothy J. White | | | The demand for soft robots urges the development of new light-responsive materials for remotely powered actuation. Here, Wie et al. show directional motion over centimeter scales using azobenzene-functionalized liquid crystalline polymer films upon continuous radiation from ultraviolet to visible light. | | | 10 November 2016 | doi: 10.1038/ncomms13260 | | |
| DciA is an ancestral replicative helicase operator essential for bacterial replication initiation OPEN | | | Pierre Brézellec, Isabelle Vallet-Gely, Christophe Possoz, Sophie Quevillon-Cheruel and Jean-Luc Ferat | | | DNA replication requires the loading of the replicative helicase onto the DNA molecule; in bacteria this was believed to be solely accomplished by DnaC and DnaI. Here the authors identify DciA as an ancestral and still widely distributed replicative helicase loader. | | | 10 November 2016 | doi: 10.1038/ncomms13271 | | |
| Crystal structure of bacterial haem importer complex in the inward-facing conformation OPEN | | | Youichi Naoe, Nozomi Nakamura, Akihiro Doi, Mia Sawabe, Hiro Nakamura, Yoshitsugu Shiro and Hiroshi Sugimoto | | | Pathogenic bacteria acquire iron from heme cofactors imported by ABC heme transporters. Here the authors present crystal structures of Burkholderia cenocepacia heme importer BhuUV with and without the heme-binding protein BhuT, gathering mechanistic insight into the catalytic cycle of heme import. | | | 10 November 2016 | doi: 10.1038/ncomms13411 | | |
| IgD attenuates the IgM-induced anergy response in transitional and mature B cells OPEN | | | Zahra Sabouri, Samuel Perotti, Emily Spierings, Peter Humburg, Mehmet Yabas, Hannes Bergmann, Keisuke Horikawa, Carla Roots, Samantha Lambe, Clara Young, T. Dan Andrews, Matthew Field, Anselm Enders, Joanne H. Reed and Christopher C. Goodnow | | | Self-reactive B cells that are anergic express mainly IgD, yet the function of IgD is not clear. Here the authors analyse primary B cells from mice to show that IgD signalling attenuates self-antigen induced gene expression and promotes survival of anergic B cells that might go on to reactivate to foreign antigens and mutate away from self-reactivity. | | | 10 November 2016 | doi: 10.1038/ncomms13381 | | |
| Hydrogenated monolayer graphene with reversible and tunable wide band gap and its field-effect transistor OPEN | | | Jangyup Son, Soogil Lee, Sang Jin Kim, Byung Cheol Park, Han-Koo Lee, Sanghoon Kim, Jae Hoon Kim, Byung Hee Hong and Jongill Hong | | | The absence of a band gap in graphene hinders its use in electronics. Here, the authors open a band gap as large as 3.9 electronvolts in graphene grown by chemical vapour deposition by treating it in hydrogen plasma, and then use this material to create a room temperature field- effect transistor. | | | 10 November 2016 | doi: 10.1038/ncomms13261 | | |
| Theranostic barcoded nanoparticles for personalized cancer medicine OPEN | | | Zvi Yaari, Dana da Silva, Assaf Zinger, Evgeniya Goldman, Ashima Kajal, Rafi Tshuva, Efrat Barak, Nitsan Dahan, Dov Hershkovitz, Mor Goldfeder, Janna Shainsky Roitman and Avi Schroeder | | | Determining the most effective treatment for each cancer patient is a key challenge in cancer therapy. In this article, the authors show, in a mouse model of breast cancer, that DNA barcoded nanoparticles can be used for pre-screening the efficacy of anticancer drugs. | | | 10 November 2016 | doi: 10.1038/ncomms13325 | | |
| Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes OPEN | | | Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, Shozo Itoh, Makoto Hirata, Yoko Hosaka, Yuki Taniguchi, Keita Okada, Yoshifumi Mori, Fumiko Yano, Ung-il Chung, Haruhiko Akiyama, Hiroshi Kawaguchi, Sakae Tanaka and Taku Saito | | | Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression. | | | 10 November 2016 | doi: 10.1038/ncomms13336 | | |
| Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk OPEN | | | Albert Guskov, Sonja Jensen, Ignacio Faustino, Siewert J. Marrink and Dirk Jan Slotboom | | | In neurons and glia, glutamate transporters catalyse the reuptake of this neurotransmitter by coupling it with cation transport. Here the authors combine X-ray crystallography and molecular dynamics simulations of the archeal glutamate transporter GltTk to get insight into the coupled transport mechanism. | | | 10 November 2016 | doi: 10.1038/ncomms13420 | | |
| Structure-conserving spontaneous transformations between nanoparticles OPEN | | | K. R. Krishnadas, Ananya Baksi, Atanu Ghosh, Ganapati Natarajan and Thalappil Pradeep | | | Ambient chemical transformations between nanoparticles are poorly explored in materials science. Here, the authors find that two atomically precise, isomorphic clusters of gold and silver can convert between each other in solution through a series of alloy clusters, preserving structure, topology, and metal-ligand stoichiometry. | | | 10 November 2016 | doi: 10.1038/ncomms13447 | | |
| Unusually efficient photocurrent extraction in monolayer van der Waals heterostructure by tunnelling through discretized barriers OPEN | | | Woo Jong Yu, Quoc An Vu, Hyemin Oh, Hong Gi Nam, Hailong Zhou, Soonyoung Cha, Joo-Youn Kim, Alexandra Carvalho, Munseok Jeong, Hyunyong Choi, A. H. Castro Neto, Young Hee Lee and Xiangfeng Duan | | | Vertical integration of two-dimensional materials can open unprecedented possibilities towards design of efficient optoelectronic devices. Here, the authors investigate the photoresponse properties of a graphene/MoS2/graphene heterostructure, revealing promising quantum efficiency performances. | | | 09 November 2016 | doi: 10.1038/ncomms13278 | | |
| Chaperone addiction of toxin–antitoxin systems OPEN | | | Patricia Bordes, Ambre Julie Sala, Sara Ayala, Pauline Texier, Nawel Slama, Anne-Marie Cirinesi, Valérie Guillet, Lionel Mourey and Pierre Genevaux | | | Some bacterial toxin-antitoxin systems consist of a labile antitoxin that inhibits a toxin, and a chaperone that stabilizes the antitoxin. Here, Bordes et al. identify a sequence within the antitoxin to which the chaperone binds and which can be transferred to other proteins to make them chaperone-dependent. | | | 09 November 2016 | doi: 10.1038/ncomms13339 | | |
| Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 OPEN | | | Bilgen Ekim Üstünel, Kilian Friedrich, Adriano Maida, Xiaoyue Wang, Anja Krones-Herzig, Oksana Seibert, Anke Sommerfeld, Allan Jones, Tjeerd P. Sijmonsma, Carsten Sticht, Norbert Gretz, Thomas Fleming, Peter P. Nawroth, Wolfgang Stremmel, Adam J. Rose, Mauricio Berriel-Diaz, Matthias Blüher and Stephan Herzig | | | TSC22D4 regulates hepatic lipoprotein production, but has so far mainly been studied in the context of cancer cachexia. Here, the authors show TSC22D4 inhibition improves insulin sensitivity in several mouse models of diabetes, which they attribute at least in part to the induction of secreted LCN13. | | | 09 November 2016 | doi: 10.1038/ncomms13267 | | |
| BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization OPEN | | | Felicia Gray, Hyo Je Cho, Shirish Shukla, Shihan He, Ashley Harris, Bohdan Boytsov, Łukasz Jaremko, Mariusz Jaremko, Borries Demeler, Elizabeth R. Lawlor, Jolanta Grembecka and Tomasz Cierpicki | | | BMI1, a core element of the polycomb repressive complex 1, is suggested to have oncogenic activity in a variety of cancers. Here, the authors report the structure of BMI1 bound to the protein PHC2, identify BMI1 homo-oligomerization interfaces, and analyse the role of BMI1 protein-protein interactions in PRC1 function. | | | 09 November 2016 | doi: 10.1038/ncomms13343 | | |
| Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation OPEN | | | Pascal Gellert, Corrinne V. Segal, Qiong Gao, Elena López-Knowles, Lesley-Ann Martin, Andrew Dodson, Tiandao Li, Christopher A. Miller, Charles Lu, Elaine R. Mardis, Alexa Gillman, James Morden, Manuela Graf, Kally Sidhu, Abigail Evans, Michael Shere, Christopher Holcombe, Stuart A. McIntosh, Nigel Bundred, Anthony Skene et al. | | | Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor responders have more mutations than good responders and also more frequently harbour p53 mutations. | | | 09 November 2016 | doi: 10.1038/ncomms13294 | | |
| MHC class II complexes sample intermediate states along the peptide exchange pathway OPEN | | | Marek Wieczorek, Jana Sticht, Sebastian Stolzenberg, Sebastian Günther, Christoph Wehmeyer, Zeina El Habre, Miguel Álvaro-Benito, Frank Noé and Christian Freund | | | MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response. Here, the authors combine NMR-detected H/D exchange with Markov modelling analysis to shed light on the dynamics of MHCII peptide exchange. | | | 09 November 2016 | doi: 10.1038/ncomms13224 | | |
| Structural and mechanistic insights into regulation of the retromer coat by TBC1d5 OPEN | | | Da Jia, Jin-San Zhang, Fang Li, Jing Wang, Zhihui Deng, Mark A. White, Douglas G. Osborne, Christine Phillips-Krawczak, Timothy S. Gomez, Haiying Li, Amika Singla, Ezra Burstein, Daniel D. Billadeau and Michael K. Rosen | | | Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss the implications for receptor trafficking. | | | 09 November 2016 | doi: 10.1038/ncomms13305 | | |
| CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2 OPEN | | | Haina Shin, Yosuke Kumamoto, Smita Gopinath and Akiko Iwasaki | | | Tissue-resident memory T cells are needed for optimal antiviral immunity at mucosal surfaces. Here the authors provide a mechanism for this protection, showing that vaginal CD301b+ DC-dependent IFN-γ production by CD8+ tissue-resident memory T cells, not circulating T cells, is central to HSV-2 resistance. | | | 09 November 2016 | doi: 10.1038/ncomms13346 | | |
| Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function OPEN | | | Martin H. Berryer, Bidisha Chattopadhyaya, Paul Xing, Ilse Riebe, Ciprian Bosoi, Nathalie Sanon, Judith Antoine-Bertrand, Maxime Lévesque, Massimo Avoli, Fadi F. Hamdan, Lionel Carmant, Nathalie Lamarche-Vane, Jean-Claude Lacaille, Jacques L. Michaud and Graziella Di Cristo | | | Glutamatergic signalling regulation by Syngap1 has been linked to intellectual disabilities. Here, the authors find Syngap1 also regulates cortical GABAergic synaptic signalling development and that this reduced inhibitory signalling contributes to cognitive deficits in a mouse model. | | | 09 November 2016 | doi: 10.1038/ncomms13340 | | |
| Vasculogenic mimicry in small cell lung cancer OPEN | | | Stuart C. Williamson, Robert L. Metcalf, Francesca Trapani, Sumitra Mohan, Jenny Antonello, Benjamin Abbott, Hui Sun Leong, Christopher P. E. Chester, Nicole Simms, Radoslaw Polanski, Daisuke Nonaka, Lynsey Priest, Alberto Fusi, Fredrika Carlsson, Anders Carlsson, Mary J. C. Hendrix, Richard E. B. Seftor, Elisabeth A. Seftor, Dominic G. Rothwell, Andrew Hughes et al. | | | Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters tumour growth, chemotherapy delivery and efficacy. | | | 09 November 2016 | doi: 10.1038/ncomms13322 | | |
| Neural correlates of working memory development in adolescent primates OPEN | | | Xin Zhou, Dantong Zhu, Xue-Lian Qi, Sihai Li, Samson G. King, Emilio Salinas, Terrence R. Stanford and Christos Constantinidis | | | Working memory is known to improve through adolescence into adulthood, yet the associated changes in neuronal activity are not well understood. Zhou and colleagues report increased delay period activity correlated with changes in performance on working memory tasks in monkeys as they transition into adulthood. | | | 09 November 2016 | doi: 10.1038/ncomms13423 | | |
| Functional competence of a partially engaged GPCR–β-arrestin complex OPEN | | | Punita Kumari, Ashish Srivastava, Ramanuj Banerjee, Eshan Ghosh, Pragya Gupta, Ravi Ranjan, Xin Chen, Bhagyashri Gupta, Charu Gupta, Deepika Jaiman and Arun K. Shukla | | | β-arrestins initially contact with the phosphorylated carboxyl-terminus of GPCRs before engaging with the GPCR core. Here, the authors use a chimeric GPCR partially and fully engaged with β-arrestin1 and show that the core interaction is dispensable for receptor endocytosis and signalling. | | | 09 November 2016 | doi: 10.1038/ncomms13416 | | |
| Experimental verification of multipartite entanglement in quantum networks OPEN | | | W. McCutcheon, A. Pappa, B. A. Bell, A. McMillan, A. Chailloux, T. Lawson, M. Mafu, D. Markham, E. Diamanti, I. Kerenidis, J. G. Rarity and M. S. Tame | | | Multipartite entangled states are a fundamental resource for quantum information processing tasks; it is thus important to verify their presence. Here the authors present and demonstrate a protocol that allows any party in a network to verify if an untrusted source is distributing multipartite entangled states. | | | 09 November 2016 | doi: 10.1038/ncomms13251 | | |
| Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase OPEN | | | Cinzia Cinesi, Lorène Aeschbach, Bin Yang and Vincent Dion | | | The expansion of trinucleotide repeats has been linked to several neurodegenerative disorders. Here, the authors show that the CRISPR-Cas9 nuclease induces both expansions and contractions of the repeat region, whereas the nickase leads predominantly to contractions. | | | 09 November 2016 | doi: 10.1038/ncomms13272 | | |
| Increasing the density of passive photonic-integrated circuits via nanophotonic cloaking OPEN | | | Bing Shen, Randy Polson and Rajesh Menon | | | Photonic-integrated devices need to be spaced apart to prevent signal crosstalk, which limits their packing density. Here, Shen et al. report the use of nanophotonic cloaking to render neighbouring devices invisible to one another, which allows them to be placed closer together than is otherwise achievable. | | | 09 November 2016 | doi: 10.1038/ncomms13126 | | | | | | | | | | | | | Latest Corrigenda | | | | | | Corrigendum: Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients OPEN | | | Jacob J. Chabon, Andrew D. Simmons, Alexander F. Lovejoy, Mohammad S. Esfahani, Aaron M. Newman, Henry J. Haringsma, David M. Kurtz, Henning Stehr, Florian Scherer, Chris A. Karlovich, Thomas C. Harding, Kathleen A. Durkin, Gregory A. Otterson, W. Thomas Purcell, D. Ross Camidge, Jonathan W. Goldman, Lecia V. Sequist, Zofia Piotrowska, Heather A. Wakelee, Joel W. Neal et al. | | | 14 November 2016 | doi: 10.1038/ncomms13513 | | |
| | | | | Corrigendum: IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses OPEN | | | Chang-Min Lee, Chuan Hua He, Adel M. Nour, Yang Zhou, Bing Ma, Jin Wook Park, Kyung Hee Kim, Charles Dela Cruz, Lokesh Sharma, Mahmoud L. Nasr, Yorgo Modis, Chun Geun Lee and Jack A. Elias | | | 14 November 2016 | doi: 10.1038/ncomms13541 | | | | | | | |
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