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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Recent pause in the growth rate of atmospheric CO2 due to enhanced terrestrial carbon uptake OPEN | | | Trevor F Keenan, I. Colin Prentice, Josep G Canadell, Christopher A Williams, Han Wang, Michael Raupach and G. James Collatz | | | Year-to-year variability in atmospheric CO2 is strongly influenced by the terrestrial biosphere. Despite increasing anthropogenic emissions, Keenan et al. report a recent pause in the growth rate of atmospheric CO2 using observations and vegetation models, attributed to an enhanced terrestrial carbon sink. | | | 08 November 2016 | doi: 10.1038/ncomms13428 | | |
| Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes OPEN | | | Marek Cyrklaff, Sirikamol Srismith, Britta Nyboer, Kvetoslava Burda, Angelika Hoffmann, Felix Lasitschka, Sophie Adjalley, Cyrille Bisseye, Jacques Simpore, Ann-Kristin Mueller, Cecilia P. Sanchez, Friedrich Frischknecht and Michael Lanzer | | | Carriers of haemoglobinopathies are protected from severe malaria, likely due to reduced surface expression of virulence factors. Here, Cyrklaff et al. show that, similar to haemoglobinopathies, a transient oxidative insult affects actin reorganization and mitigates the development of cerebral malaria in mice. | | | 08 November 2016 | doi: 10.1038/ncomms13401 | | |
| DNA evidence of bowhead whale exploitation by Greenlandic Paleo-Inuit 4,000 years ago OPEN | | | Frederik Valeur Seersholm, Mikkel Winther Pedersen, Martin Jensen Søe, Hussein Shokry, Sarah Siu Tze Mak, Anthony Ruter, Maanasa Raghavan, William Fitzhugh, Kurt H. Kjær, Eske Willerslev, Morten Meldgaard, Christian M.O. Kapel and Anders Johannes Hansen | | | Our current understanding of the demographic history of Greenland relies on preserved fossils. Here, the authors sequence ancient DNA from four midden deposits and find a prominent role for caribou, walrus and whale species in Paleo-Inuit cultures not evident from the fossil record. | | | 08 November 2016 | doi: 10.1038/ncomms13389 | | |
| Post-eruptive flooding of Santorini caldera and implications for tsunami generation OPEN | | | P. Nomikou, T. H. Druitt, C. Hübscher, T. A. Mather, M. Paulatto, L. M. Kalnins, K. Kelfoun, D. Papanikolaou, K. Bejelou, D. Lampridou, D. M. Pyle, S. Carey, A. B. Watts, B. Weiß and M. M. Parks | | | The Bronze Age eruption of Santorini is known to have generated tsunamis with caldera collapse as the likely mechanism. However, new bathymetric and seismic data presented by Nomikou et al. show that the entry of pyroclastic flows into the sea is the most likely tsunami-generating mechanism at Santorini. | | | 08 November 2016 | doi: 10.1038/ncomms13332 | | |
| De novo genic mutations among a Chinese autism spectrum disorder cohort OPEN | | | Tianyun Wang, Hui Guo, Bo Xiong, Holly A.F. Stessman, Huidan Wu, Bradley P. Coe, Tychele N. Turner, Yanling Liu, Wenjing Zhao, Kendra Hoekzema, Laura Vives, Lu Xia, Meina Tang, Jianjun Ou, Biyuan Chen, Yidong Shen, Guanglei Xun, Min Long, Janice Lin, Zev N. Kronenberg et al. | | | Recurrent sporadic mutations are important risk factors for autism spectrum disorders (ASDs) but have been primarily investigated in European cohorts. Here, Eichler, Xia and colleagues analyse risk genes in a large Chinese ASD cohort and find novel recurrences of potential pathogenic significance. | | | 08 November 2016 | doi: 10.1038/ncomms13316 | | |
| Genome-wide association study of 12 agronomic traits in peach OPEN | | | Ke Cao, Zhengkui Zhou, Qi Wang, Jian Guo, Pei Zhao, Gengrui Zhu, Weichao Fang, Changwen Chen, Xinwei Wang, Xiaoli Wang, Zhixi Tian and Lirong Wang | | | Peach is both an economically important crop species and a model for Rosaceae fruit development research. Here, the authors perform genome-wide association analysis in peach and find candidate genes associated with variation in agronomically important fruit phenotypes. | | | 08 November 2016 | doi: 10.1038/ncomms13246 | | |
| The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis OPEN | | | Shuo Geng, Keqiang Chen, Ruoxi Yuan, Liang Peng, Urmila Maitra, Na Diao, Chun Chen, Yao Zhang, Yuan Hu, Chen-Feng Qi, Susan Pierce, Wenhua Ling, Huabao Xiong and Liwu Li | | | Chronic low-grade inflammation has been suspected to promote atherosclerosis. Here, Geng et al. show that sustained low-grade inflammation promotes atherosclerosis in mice via monocyte programing that involves a coupled disruption of IRAK-M regulation and induction of miR-24. | | | 08 November 2016 | doi: 10.1038/ncomms13436 | | |
| Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity OPEN | | | Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens and Albert J. R. Heck | | | Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and properdin to discover new PTMs on properdin and derive a biosimilarity score for various sources of EPO. | | | 08 November 2016 | doi: 10.1038/ncomms13397 | | |
| Origin and structure of polar domains in doped molecular crystals OPEN | | | E. Meirzadeh, I. Azuri, Y. Qi, D. Ehre, A. M. Rappe, M. Lahav, L. Kronik and I. Lubomirsky | | | Doping can introduce structural distortions in a molecular crystal in the form of polar domains. Here, the authors combine pyroelectric measurements and computation to reveal the molecular structure of such domains in centrosymmetric α-glycine crystals doped with L-amino acids. | | | 08 November 2016 | doi: 10.1038/ncomms13351 | | |
| AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors OPEN | | | Jing Hu, Alireza Khodadadi-Jamayran, Miaowei Mao, Kushani Shah, Zhenhua Yang, Md Talat Nasim, Zefeng Wang and Hao Jiang | | | The chromatin-associated protein AKAP95 is known for its chromatin-related functions including enhancing transcription. Here the authors show that AKAP95 interacts with the splicing regulatory factors as well as RNAs to regulate the inclusion of exons and pre-mRNA splicing. | | | 08 November 2016 | doi: 10.1038/ncomms13347 | | |
| Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia OPEN | | | Zhaohui Gu, Michelle Churchman, Kathryn Roberts, Yongjin Li, Yu Liu, Richard C. Harvey, Kelly McCastlain, Shalini C. Reshmi, Debbie Payne-Turner, Ilaria Iacobucci, Ying Shao, I-Ming Chen, Marcus Valentine, Deqing Pei, Karen L. Mungall, Andrew J. Mungall, Yussanne Ma, Richard Moore, Marco Marra, Eileen Stonerock et al. | | | Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro. | | | 08 November 2016 | doi: 10.1038/ncomms13331 | | |
| Record of massive upwellings from the Pacific large low shear velocity province OPEN | | | Pilar Madrigal, Esteban Gazel, Kennet E. Flores, Michael Bizimis and Brian Jicha | | | Large igneous provinces may record pulses mantle plume upwellings and their relationship with deep-rooted mantle sources. Madrigal et al. present a new petrological model of the Pacific Ocean Large Igneous Province finding that mantle plume pulses were separated by 10–20 Ma. | | | 08 November 2016 | doi: 10.1038/ncomms13309 | | |
| Genome sequence and analysis of the Japanese morning glory Ipomoea nil OPEN | | | Atsushi Hoshino, Vasanthan Jayakumar, Eiji Nitasaka, Atsushi Toyoda, Hideki Noguchi, Takehiko Itoh, Tadasu Shin-I, Yohei Minakuchi, Yuki Koda, Atsushi J. Nagano, Masaki Yasugi, Mie N. Honjo, Hiroshi Kudoh, Motoaki Seki, Asako Kamiya, Toshiyuki Shiraki, Piero Carninci, Erika Asamizu, Hiroyo Nishide, Sachiko Tanaka et al. | | | Japanese morning glory (Ipomoea nil) has diverse flowering traits. Here, the authors describe the reference genome sequence of I. nil, annotations of genes and transposons, and compare evolution of the I. nil genome to other Convolvulaceae and Solanales genomes. | | | 08 November 2016 | doi: 10.1038/ncomms13295 | | |
| Magnetic slippery extreme icephobic surfaces OPEN | | | Peyman Irajizad, Munib Hasnain, Nazanin Farokhnia, Seyed Mohammad Sajadi and Hadi Ghasemi | | | Anti-icing surfaces are useful in our daily life, but creation of these surfaces at low temperatures remains challenging due to the onset of heterogeneous nucleation. Irajizad et al. show a surface design using magnetic fluid that lowers the freezing temperature to −34 °C and ice adhesion strength to 2 Pa. | | | 08 November 2016 | doi: 10.1038/ncomms13395 | | |
| Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex OPEN | | | Jacob Reimer, Matthew J McGinley, Yang Liu, Charles Rodenkirch, Qi Wang, David A McCormick and Andreas S Tolias | | | In addition to light intensity, changes in pupil diameter are correlated with mental effort, attention and levels of arousal. Reimer et al. report that across behavioural states, fluctuations in pupil diameter are highly correlated with activity of noradrenergic and cholinergic projection neurons. | | | 08 November 2016 | doi: 10.1038/ncomms13289 | | |
| Random synaptic feedback weights support error backpropagation for deep learning OPEN | | | Timothy P. Lillicrap, Daniel Cownden, Douglas B. Tweed and Colin J. Akerman | | | Multi-layered neural architectures that implement learning require elaborate mechanisms for symmetric backpropagation of errors that are biologically implausible. Here the authors propose a simple resolution to this problem of blame assignment that works even with feedback using random synaptic weights. | | | 08 November 2016 | doi: 10.1038/ncomms13276 | | |
| An enduring rapidly moving storm as a guide to Saturn’s Equatorial jet’s complex structure OPEN | | | A. Sánchez-Lavega, E. García-Melendo, S. Pérez-Hoyos, R. Hueso, M. H. Wong, A. Simon, J. F. Sanz-Requena, A. Antuñano, N. Barrado-Izagirre, I. Garate-Lopez, J. F. Rojas, T. del Río-Gaztelurrutia, J. M. Gómez-Forrellad, I. de Pater, L. Li and T. Barry | | | The origin, variability, and structure of Saturn’s intense and broad eastward equatorial jet at upper cloud level are complex and unexplained. Here, based on observations of a large, bright equatorial disturbance in 2015, the authors characterise the vertical structure of the jet and its long-term variability. | | | 08 November 2016 | doi: 10.1038/ncomms13262 | | |
| Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry OPEN | | | Kristin Kiosze-Becker, Alessandro Ori, Milan Gerovac, André Heuer, Elina Nürenberg-Goloub, Umar Jan Rashid, Thomas Becker, Roland Beckmann, Martin Beck and Robert Tampé | | | Ribosome recycling orchestrated by ABCE1 connects translation termination and mRNA surveillance mechanisms with re-initiation. Using a cross-linking and mass spectrometry approach, Kiosze-Becker et al. provide new information on the large conformational rearrangements that occur during ribosome recycling. | | | 08 November 2016 | doi: 10.1038/ncomms13248 | | |
| Promotion of behavior and neuronal function by reactive oxygen species in C. elegans OPEN | | | Guang Li, Jianke Gong, Haoyun Lei, Jianfeng Liu and X. Z. Shawn Xu | | | The deleterious role of reactive oxygen species has been widely reported in the nervous system. Here the authors report that surprisingly, low doses of H2O2 in fact enhances sensory neuron function and promotes sensory behaviors in C. elegans. | | | 08 November 2016 | doi: 10.1038/ncomms13234 | | |
| Ancient and methane-derived carbon subsidizes contemporary food webs OPEN | | | Amanda G. DelVecchia, Jack A. Stanford and Xiaomei Xu | | | Alluvial aquifers of river floodplains support abundant large-bodied consumers despite an absence of light and scarcity of organic carbon. DelVecchia et al. reveal that much of the biomass carbon in these freshwater consumers is ancient and derived from methane. | | | 08 November 2016 | doi: 10.1038/ncomms13163 | | |
| New porous water ice metastable at atmospheric pressure obtained by emptying a hydrogen-filled ice OPEN | | | Leonardo del Rosso, Milva Celli and Lorenzo Ulivi | | | By trapping guest molecules, solid water shows peculiar structures in addition to the known fifteen forms of ice at different conditions. Here, the authors report a new porous ice phase, termed ice XVII, which is metastable at ambient pressure and is able to adsorb and release hydrogen reversibly. | | | 07 November 2016 | doi: 10.1038/ncomms13394 | | |
| Growing three-dimensional biomorphic graphene powders using naturally abundant diatomite templates towards high solution processability OPEN | | | Ke Chen, Cong Li, Liurong Shi, Teng Gao, Xiuju Song, Alicja Bachmatiuk, Zhiyu Zou, Bing Deng, Qingqing Ji, Donglin Ma, Hailin Peng, Zuliang Du, Mark Hermann Rümmeli, Yanfeng Zhang and Zhongfan Liu | | | High-volume, low-cost production of graphene is pivotal for the industrial advance of this 2D material. Here, the authors make use of naturally occurring diatomite as a 3D substrate for graphene growth, obtaining non-planar porous graphene structures after removal of the silica templates. | | | 07 November 2016 | doi: 10.1038/ncomms13440 | | |
| Phosphorene/rhenium disulfide heterojunction-based negative differential resistance device for multi-valued logic OPEN | | | Jaewoo Shim, Seyong Oh, Dong-Ho Kang, Seo-Hyeon Jo, Muhammad Hasnain Ali, Woo-Young Choi, Keun Heo, Jaeho Jeon, Sungjoo Lee, Minwoo Kim, Young Jae Song and Jin-Hong Park | | | Electronic devices based on negative differential resistance hold promise for multi-valued logic applications. Here, the authors implement such functionalities using an atomically thin phosphorene/rhenium disulfide van der Waals heterostructure, and further demonstrate the implementation of a ternary inverter. | | | 07 November 2016 | doi: 10.1038/ncomms13413 | | |
| Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation OPEN | | | Martijn H. den Brok, Christian Büll, Melissa Wassink, Annemarie M. de Graaf, Jori A. Wagenaars, Marthe Minderman, Mayank Thakur, Sebastian Amigorena, Eric O. Rijke, Carla C. Schrier and Gosse J. Adema | | | Saponin-based adjuvants are being explored as vaccine components as they induce high levels of antigen cross-presentation, but it is unknown how. Here the authors show that these adjuvants enhance cross-presentation by driving production of lipid bodies inside CD11b dendritic cells. | | | 07 November 2016 | doi: 10.1038/ncomms13324 | | |
| Excitonic linewidth and coherence lifetime in monolayer transition metal dichalcogenides OPEN | | | Malte Selig, Gunnar Berghäuser, Archana Raja, Philipp Nagler, Christian Schüller, Tony F. Heinz, Tobias Korn, Alexey Chernikov, Ermin Malic and Andreas Knorr | | | The interplay between dark and bright excitons has a significant impact on the optical properties of semiconducting transition metal dichalcogenides. Here, the authors perform computational and experimental studies which unveil the microscopic origin of the excitonic coherence lifetime in WS2 and MoSe2. | | | 07 November 2016 | doi: 10.1038/ncomms13279 | | |
| Large-scale self-organization of reconfigurable topological defect networks in nematic liquid crystals OPEN | | | Yuji Sasaki, V.S.R. Jampani, Chiharu Tanaka, Nobutaka Sakurai, Shin Sakane, Khoa V. Le, Fumito Araoka and Hiroshi Orihara | | | Patterning liquid crystals is essential for their applications in photonics, which is commonly achieved by top-down lithographic approaches. Here, Sasaki et al. show a template-free approach that enables fabricating a large number of ordered square microarrays with tunable lattice on millimetre scale. | | | 07 November 2016 | doi: 10.1038/ncomms13238 | | |
| Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF OPEN | | | Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo C.P. van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J. Read, Alexandre M.J.J. Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche and Savvas N. Savvides | | | Viruses often subvert the host immune system using molecular decoys to prevent an effective immune response. Here, the authors examine the structural details of the viral decoy receptor GIF and its antagnosim of GM-CSF and IL-2. | | | 07 November 2016 | doi: 10.1038/ncomms13228 | | |
| Highly durable organic electrode for sodium-ion batteries via a stabilized α-C radical intermediate OPEN | | | Shaofei Wu, Wenxi Wang, Minchan Li, Lujie Cao, Fucong Lyu, Mingyang Yang, Zhenyu Wang, Yang Shi, Bo Nan, Sicen Yu, Zhifang Sun, Yao Liu and Zhouguang Lu | | | Reactive radical intermediates can be a problem leading to fast degradation of organic electrodes in sodium-ion batteries. Here, the authors show a stabilized α-C radical displaying reversible transformations between C=C, α-C radical and α-C anionic states to facilitate long cycling and improved capacity. | | | 07 November 2016 | doi: 10.1038/ncomms13318 | | |
| Observation of the spin-polarized surface state in a noncentrosymmetric superconductor BiPd OPEN | | | Madhab Neupane, Nasser Alidoust, M. Mofazzel Hosen, Jian-Xin Zhu, Klauss Dimitri, Su-Yang Xu, Nagendra Dhakal, Raman Sankar, Ilya Belopolski, Daniel S. Sanchez, Tay-Rong Chang, Horng-Tay Jeng, Koji Miyamoto, Taichi Okuda, Hsin Lin, Arun Bansil, Dariusz Kaczorowski, Fangcheng Chou, M. Zahid Hasan and Tomasz Durakiewicz et al. | | | A superconducting material containing a topologically non-trivial electronic band structure presents the possibility of realizing Majorana states as well as exotic excitations with potential in quantum computing. Here, the authors evidence the required ingredients in the noncentrosymmetric superconductor BiPd. | | | 07 November 2016 | doi: 10.1038/ncomms13315 | | |
| An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy OPEN | | | Yichao Chen, Rui Xia, Yixian Huang, Wenchen Zhao, Jiang Li, Xiaolan Zhang, Pengcheng Wang, Raman Venkataramanan, Jie Fan, Wen Xie, Xiaochao Ma, Binfeng Lu and Song Li | | | The use of immunostimulatory agents to enhance the efficacy of chemotherapy is a promising strategy in cancer therapy. Here, the authors report on a micellar nanoparticle that can effectively co-deliver chemo- and immunotherapeutics, resulting in an improved in vivo antitumour response. | | | 07 November 2016 | doi: 10.1038/ncomms13443 | | |
| Cryo-EM study of start codon selection during archaeal translation initiation OPEN | | | Pierre-Damien Coureux, Christine Lazennec-Schurdevin, Auriane Monestier, Eric Larquet, Lionel Cladière, Bruno P. Klaholz, Emmanuelle Schmitt and Yves Mechulam | | | Initiation factor eIF2, common to eukaryotes and archaea, is a central actor in translation initiation. Here the authors describe two cryo-EM structures of archaeal 30S initiation complexes that provide a novel view of the central role that e/aIF2 plays in start codon selection. | | | 07 November 2016 | doi: 10.1038/ncomms13366 | | |
| REST regulation of gene networks in adult neural stem cells OPEN | | | Shradha Mukherjee, Rebecca Brulet, Ling Zhang and Jenny Hsieh | | | The transcription factor REST plays a crucial role in maintaining the adult neural stem cell pool. To better understand how REST maintains quiescence in neural progenitors, the authors use ChIP-seq and RNA-seq and find that REST regulates represses ribosome biogenesis, cell cycle and neuronal genes. | | | 07 November 2016 | doi: 10.1038/ncomms13360 | | |
| Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission OPEN | | | Himanish Ghosh, Luca Auguadri, Sereina Battaglia, Zahra Simone Thirouin, Khaled Zemoura, Simon Messner, Mario A. Acuña, Hendrik Wildner, Gonzalo E. Yévenes, Andrea Dieter, Hiroshi Kawasaki, Michael O. Hottiger, Hanns Ulrich Zeilhofer, Jean-Marc Fritschy and Shiva K. Tyagarajan | | | Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transmission that involve acetylation, SUMOylation and phosphorylation. | | | 07 November 2016 | doi: 10.1038/ncomms13365 | | |
| Bacterial viruses enable their host to acquire antibiotic resistance genes from neighbouring cells OPEN | | | Jakob Haaber, Jørgen J. Leisner, Marianne T. Cohn, Arancha Catalan-Moreno, Jesper B. Nielsen, Henrik Westh, José R. Penadés and Hanne Ingmer | | | Prophages are quiescent bacterial viruses that, when activated, produce viral particles and kill their host cells. Here, Haaber et al. show that these viral particles can mediate the transfer of antibiotic resistance genes from neighbouring cells back to the remaining prophage-containing cells. | | | 07 November 2016 | doi: 10.1038/ncomms13333 | | |
| Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology OPEN | | | Taylor W. Schmitz, R. Nathan Spreng, The Alzheimer's Disease Neuroimaging Initiative, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marc Raichle, Steven Paul et al. | | | Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical diagnosis to show that tissue volume changes appear earlier in the basal forebrain than in the entorhinal cortex. | | | 04 November 2016 | doi: 10.1038/ncomms13249 | | |
| Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA OPEN | | | Emmanuelle Despras, Méghane Sittewelle, Caroline Pouvelle, Noémie Delrieu, Agnès M Cordonnier and Patricia L Kannouche | | | Translesion synthesis polymerase eta has a well characterized role in replicating past UV-induced DNA lesions and has recently been shown to act at difficult to replicate sequences. Here the authors show that its SUMOylation is required to recruit pol eta at the replication fork and to prevent under-replicated DNA. | | | 04 November 2016 | doi: 10.1038/ncomms13326 | | |
| Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres OPEN | | | Wei-Hao Shang, Tetsuya Hori, Frederick G. Westhorpe, Kristina M. Godek, Atsushi Toyoda, Sadahiko Misu, Norikazu Monma, Kazuho Ikeo, Christopher W. Carroll, Yasunari Takami, Asao Fujiyama, Hiroshi Kimura, Aaron F. Straight and Tatsuo Fukagawa | | | The deposition of histone H3 variant CENP-A bound with histone H4 is a key feature designating the centromere region of a chromosome. Here the authors show acetylation on residues K5 and K12 in histone H4, mediated by the RbAp46/48-Hat1 complex, is required for deposition of CENP-A-H4 into centromeres. | | | 04 November 2016 | doi: 10.1038/ncomms13465 | | |
| Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling OPEN | | | Chen Xu, Yan Zhang, Qiaoling Wang, Zhenyu Xu, Junfeng Jiang, Yuping Gao, Minzhi Gao, Jiuhong Kang, Minjuan Wu, Jun Xiong, Kaihong Ji, Wen Yuan, Yue Wang and Houqi Liu | | | Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs. | | | 04 November 2016 | doi: 10.1038/ncomms13287 | | |
| Photoemission-based microelectronic devices OPEN | | | Ebrahim Forati, Tyler J. Dill, Andrea R. Tao and Dan Sievenpiper | | | Most microelectronic devices today exploit the electronic properties of semiconductors. Here, the authors demonstrate a microelectronic device for free-space electrons by using the enhanced fields in a microstructured metal surface to induce effective photoemission. | | | 04 November 2016 | doi: 10.1038/ncomms13399 | | |
| Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition OPEN | | | Julianty Frost, Carles Galdeano, Pedro Soares, Morgan S. Gadd, Katarzyna M. Grzes, Lucy Ellis, Ola Epemolu, Satoko Shimamura, Marcus Bantscheff, Paola Grandi, Kevin D. Read, Doreen A. Cantrell, Sonia Rocha and Alessio Ciulli | | | Small molecule probes used to trigger hypoxic response by activating hypoxia inducible factors (HIFs) often lack specificity. Here the authors report a potent small molecule inhibitor that induces hypoxic response by blocking VHL:HIF interactions, providing a selective route to probe hypoxic signalling. | | | 04 November 2016 | doi: 10.1038/ncomms13312 | | |
| Selenium single-wavelength anomalous diffraction de novo phasing using an X-ray-free electron laser OPEN | | | Mark S. Hunter, Chun Hong Yoon, Hasan DeMirci, Raymond G. Sierra, E. Han Dao, Radman Ahmadi, Fulya Aksit, Andrew L. Aquila, Halilibrahim Ciftci, Serge Guillet, Matt J. Hayes, Thomas J. Lane, Meng Liang, Ulf Lundström, Jason E. Koglin, Paul Mgbam, Yashas Rao, Lindsey Zhang, Soichi Wakatsuki, James M. Holton et al. | | | X-ray free electron lasers are increasingly available for use in macromolecular structure determination. Here, the authors describe the successful use of selenium single-wavelength anomalous diffraction data to calculate experimentally derived phases. | | | 04 November 2016 | doi: 10.1038/ncomms13388 | | |
| A strict experimental test of macroscopic realism in a superconducting flux qubit OPEN | | | George C. Knee, Kosuke Kakuyanagi, Mao-Chuang Yeh, Yuichiro Matsuzaki, Hiraku Toida, Hiroshi Yamaguchi, Shiro Saito, Anthony J. Leggett and William J. Munro | | | Objective collapse theories are formulations of quantum physics that attempt to solve the measurement problem through modified dynamical laws. Here, the authors constrain such theories by testing a generalization of the Leggett-Garg inequality in a superconducting flux qubit experiment. | | | 04 November 2016 | doi: 10.1038/ncomms13253 | | |
| The flux qubit revisited to enhance coherence and reproducibility OPEN | | | Fei Yan, Simon Gustavsson, Archana Kamal, Jeffrey Birenbaum, Adam P Sears, David Hover, Ted J. Gudmundsen, Danna Rosenberg, Gabriel Samach, S Weber, Jonilyn L. Yoder, Terry P. Orlando, John Clarke, Andrew J. Kerman and William D. Oliver | | | Scalable quantum information processing requires controllable high-coherence qubits. Here, the authors present superconducting flux qubits with broad frequency tunability, strong anharmonicity and high reproducibility, identifying photon shot noise as the main source of dephasing for further improvements. | | | 03 November 2016 | doi: 10.1038/ncomms12964 | | |
| Hydrogenated vacancies lock dislocations in aluminium OPEN | | | Degang Xie, Suzhi Li, Meng Li, Zhangjie Wang, Peter Gumbsch, Jun Sun, Evan Ma, Ju Li and Zhiwei Shan | | | Due to its high diffusivity, hydrogen is considered a weak inhibitor or even a promoter of dislocation movements in metals and alloys. Here the authors quantitatively demonstrate that after exposing aluminium to hydrogen, mobile dislocations can lose mobility, due to segregation of hydrogenated vacancies to dislocations. | | | 03 November 2016 | doi: 10.1038/ncomms13341 | | |
| Rapid and reversible photoinduced switching of a rotaxane crystal OPEN | | | Kai-Jen Chen, Ya-Ching Tsai, Yuji Suzaki, Kohtaro Osakada, Atsushi Miura and Masaki Horie | | | Crystalline phase transition can be used to detect changes in the solid state properties of materials. Here, the authors describe the mechanical response of a crystal composed of ferrocene-containing rotaxane to laser irradiation. | | | 03 November 2016 | doi: 10.1038/ncomms13321 | | |
| Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria OPEN | | | Isabella C. Hirako, Marco A. Ataide, Lucas Faustino, Patricia A. Assis, Elizabeth W. Sorensen, Hisashi Ueta, Natalia M. Araújo, Gustavo B. Menezes, Andrew D. Luster and Ricardo T. Gazzinelli | | | Cerebral malaria is an often fatal complication of Plasmodium infection involving accumulation of inflammatory leukocytes in the central nervous system. Here the authors map the development and trafficking of CCR5+ monocyte-derived dendritic cells from the spleen to the brains of Plasmodium berghei ANKA infected mice. | | | 03 November 2016 | doi: 10.1038/ncomms13277 | | |
| Integration and segregation of large-scale brain networks during short-term task automatization OPEN | | | Holger Mohr, Uta Wolfensteller, Richard F. Betzel, Bratislav Mišić, Olaf Sporns, Jonas Richiardi and Hannes Ruge | | | Humans can quickly learn to efficiently execute tasks yet how the brain activity is dynamically reconfigured during this process remains unknown. Here the authors demonstrate that large-scale functional brain networks are reorganized flexibly to support rapid task automation. | | | 03 November 2016 | doi: 10.1038/ncomms13217 | | |
| DNA looping mediates nucleosome transfer OPEN | | | Lucy D. Brennan, Robert A. Forties, Smita S. Patel and Michelle D. Wang | | | Replicating the genome presents a major challenge to the maintenance of the epigenetic landscape. Here the authors use a minimal experimental system to show how nucleosomes are transferred to double-stranded DNA, with the transfer mediated by a quantitative loop formation model. | | | 03 November 2016 | doi: 10.1038/ncomms13337 | | |
| Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death OPEN | | | Teresa L. M. Thurston, Sophie A. Matthews, Elliott Jennings, Eric Alix, Feng Shao, Avinash R. Shenoy, Mark A. Birrell and David W. Holden | | | Inflammatory caspases restrict microbial growth by inducing cytokine production and pyroptosis, but other caspase-induced mechanisms are thought to contribute. Here the authors use time-lapse microscopy of single cells to show that caspase1/11 has anti-Salmonella functions that occur in advance of cell death induction. | | | 03 November 2016 | doi: 10.1038/ncomms13292 | | |
| Following lithiation fronts in paramagnetic electrodes with in situ magnetic resonance spectroscopic imaging OPEN | | | Mingxue Tang, Vincent Sarou-Kanian, Philippe Melin, Jean-Bernard Leriche, Michel Ménétrier, Jean-Marie Tarascon, Michaël Deschamps and Elodie Salager | | | Magnetic resonance imaging is a promising non-invasive approach to visualize paramagnetic materials in devices, but the short lifetime of signals currently limits its use. Here, the authors develop an approach which overcomes this hurdle to spectroscopically image lithiation fronts during battery operation. | | | 03 November 2016 | doi: 10.1038/ncomms13284 | | |
| Powerful decomposition of complex traits in a diploid model OPEN | | | Johan Hallin, Kaspar Märtens, Alexander I. Young, Martin Zackrisson, Francisco Salinas, Leopold Parts, Jonas Warringer and Gianni Liti | | | Dissecting the architecture of complex trait is challenging. Here, Hallin, Märtens et al. devises Phased Outbred Lines (POLs) in order to accurately decompose growth trait variation in diploid yeast across different environments. | | | 02 November 2016 | doi: 10.1038/ncomms13311 | | |
| Towards first-principles molecular design of liquid crystal-based chemoresponsive systems OPEN | | | Luke T. Roling, Jessica Scaranto, Jeffrey A. Herron, Huaizhe Yu, Sangwook Choi, Nicholas L. Abbott and Manos Mavrikakis | | | Nematic liquid crystals have potential as sensors for various molecules. Here, the authors present a computational chemistry model for describing the detection of a warfare agent by liquid crystals, opening the door for the atomic-scale design of sensitive and selective chemoresponsive systems. | | | 02 November 2016 | doi: 10.1038/ncomms13338 | | |
| Tetrapod limb and sarcopterygian fin regeneration share a core genetic programme OPEN | | | Acacio F. Nogueira, Carinne M. Costa, Jamily Lorena, Rodrigo N. Moreira, Gabriela N. Frota-Lima, Carolina Furtado, Mark Robinson, Chris T. Amemiya, Sylvain Darnet and Igor Schneider | | | Salamanders are unique among extant tetrapods for their ability to completely regenerate their limbs. Here, Nogueira and colleagues show that lungfishes, the sister clade of tetrapods, regenerate their fins using analogous gene regulatory changes and morphological steps. | | | 02 November 2016 | doi: 10.1038/ncomms13364 | | |
| Striped nanoscale phase separation at the metal–insulator transition of heteroepitaxial nickelates OPEN | | | G. Mattoni, P. Zubko, F. Maccherozzi, A.J.H. van der Torren, D. B. Boltje, M. Hadjimichael, N. Manca, S. Catalano, M. Gibert, Y. Liu, J. Aarts, J.-M. Triscone, S. S. Dhesi and A. D. Caviglia | | | Probing the evolution of mixed-phase states in materials offers unique insights into the microscopic mechanism of phase transitions. Here, Mattoni et al. report imaging of nanoscale formation and growth of insulating domains across the metal-insulator transition in NdNiO3 thin films, uncovering a rich interplay between structural and electronic degrees of freedom. | | | 02 November 2016 | doi: 10.1038/ncomms13141 | | |
| Engineering and optimising deaminase fusions for genome editing OPEN | | | Luhan Yang, Adrian W. Briggs, Wei Leong Chew, Prashant Mali, Marc Guell, John Aach, Daniel Bryan Goodman, David Cox, Yinan Kan, Emal Lesha, Venkataramanan Soundararajan, Feng Zhang and George Church | | | Precision genome engineering using homology donors and the endogenous DNA break repair machinery and recently CRISPR-Cas9 targeted APOBECs have been demonstrated. Here the authors design zinc-finger and TALE chimeric deaminases and investigate editing efficiency and off-target effects. | | | 02 November 2016 | doi: 10.1038/ncomms13330 | | |
| Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease OPEN | | | Youngbin Lim, So Young Bak, Keewon Sung, Euihwan Jeong, Seung Hwan Lee, Jin-Soo Kim, Sangsu Bae and Seong Keun Kim | | | In bacteria, CRISPR-Cas9 identifies and cleaves the target DNA with the assistance of a tracrRNA and a crRNA. Here the authors use single-molecule spectroscopy to investigate conformational changes and show that the tracrRNA keeps Cas9 in a functionally active form. | | | 02 November 2016 | doi: 10.1038/ncomms13350 | | | | | | | | | | | | | Latest Corrigenda | | | | | | Corrigendum: Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5 OPEN | | | Yang Duan, Dawei Huo, Jie Gao, Heng Wu, Zheng Ye, Zhe Liu, Kai Zhang, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Xiang Ding, Lei Shi, Yan Wang, Yongfeng Shang and Chenghao Xuan | | | 04 November 2016 | doi: 10.1038/ncomms13462 | | |
| | | | | Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect OPEN | | | Paula Lopez-Serra, Miguel Marcilla, Alberto Villanueva, Antonio Ramos-Fernandez, Anna Palau, Lucía Leal, Jessica E. Wahi, Fernando Setien-Baranda, Karolina Szczesna, Catia Moutinho, Anna Martinez-Cardus, Holger Heyn, Juan Sandoval, Sara Puertas, August Vidal, Xavier Sanjuan, Eva Martinez-Balibrea, Francesc Viñals, Jose C. Perales, Jesper B. Bramsem et al. | | | 02 November 2016 | doi: 10.1038/ncomms13467 | | | | | | | | | | Latest Errata | | | | | | Erratum: Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma OPEN | | | Ling-Hao Zhao, Xiao Liu, He-Xin Yan, Wei-Yang Li, Xi Zeng, Yuan Yang, Jie Zhao, Shi-Ping Liu, Xue-Han Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Ze-Ya Pan, Gang Huang, Hui Liu, Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv et al. | | | 08 November 2016 | doi: 10.1038/ncomms13591 | | |
| | | | | Erratum: Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host OPEN | | | Shuai Wang, Sen Wang, Yingfeng Luo, Lihua Xiao, Xuenong Luo, Shenghan Gao, Yongxi Dou, Huangkai Zhang, Aijiang Guo, Qingshu Meng, Junling Hou, Bing Zhang, Shaohua Zhang, Meng Yang, Xuelian Meng, Hailiang Mei, Hui Li, Zilong He, Xueliang Zhu, Xinyu Tan et al. | | | 03 November 2016 | doi: 10.1038/ncomms13469 | | | | | | | |
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