The EMBO Journal Table of Contents for 15 August 2016; Vol. 35, No. 16

15 August 2016 | Volume 35, Number 16 Submit Table of Contents News & Views Commentary Articles Volume 35, Number 16 News & Views Messages from forgotten friends: classic cell adhesion molecules inhibit regeneration too Trans‐cellular signaling between neurons and scar‐forming cells mediated by the adhesion molecule NB‐3 constitutes one of the brakes that inhibits axon regeneration following spinal cord injury. Matt C Danzi and Vance P Lemmon Published online 12.07.2016 Cloud storage for endosomes ER‐associated E3 ubiquitin ligase RNF26 restrains fast transport of diverse vesicles, thereby controlling endosomal maturation, trafficking of cargoes, and the architecture of the immobile perinuclear vesicle cloud; this activity is opposed by deubiquinating enzyme USP15 to allow vesicle release into the cell's periphery. Teegan Dellibovi‐Ragheb and Nihal Altan‐Bonnet Published online 04.07.2016 Commentary Focus: Study Design & Statistical Analysis: Statistical relevance—relevant statistics, part II: presenting experimental data A best‐practice summary and hands‐on guide on how to most usefully display your data in graphs. Bernd Klaus Published online 19.07.2016 Articles Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation In vivo fate mapping combined with transcriptomics shows the existence of distinct mouse macrophage subsets and an important role for the transcription factor Irf8 in regulating their development. Nora Hagemeyer, Katrin Kierdorf, Kathrin Frenzel, Jia Xue, Marc Ringelhan, Zeinab Abdullah, Isabelle Godin, Peter Wieghofer, Marta Joana Costa Jordão, Thomas Ulas, Gülden Yorgancioglu, Frank Rosenbauer, Percy A Knolle, Mathias Heikenwalder, Joachim L Schultze, and Marco Prinz Published online 13.07.2016 NB‐3 signaling mediates the cross‐talk between post‐traumatic spinal axons and scar‐forming cells The neural recognition molecule NB‐3 negatively regulates axon regeneration by promoting trans‐homophilic interactions between injured axons and scar‐forming cells to suppress axon growth. Zhenhui Huang, Yarong Gao, Yuhui Sun, Chao Zhang, Yue Yin, Yasushi Shimoda, Kazutada Watanabe, and Yaobo Liu Published online 18.05.2016 GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death A caspase‐1‐processed fragment of gasdermin D inserts into plasma membranes to form large permeable pores, demonstrating the direct role of gasdermin D in pyroptotic cell death. Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill, Joka Pipercevic, Rosalie Heilig, Henning Stahlberg, Christopher J Farady, Daniel J Müller, Petr Broz, and Sebastian Hiller Published online 14.07.2016 Recruitment of TBK1 to cytosol‐invading Salmonella induces WIPI2‐dependent antibacterial autophagy The recruitment of catalytically active TANK‐binding kinase 1 to cytosol‐invading Salmonella induces anti‐bacterial autophagy via the upstream autophagy regulator WIPI2. Teresa LM Thurston, Keith B Boyle, Mark Allen, Benjamin J Ravenhill, Maryia Karpiyevich, Stuart Bloor, Annie Kaul, Jessica Noad, Agnes Foeglein, Sophie A Matthews, David Komander, Mark Bycroft, and Felix Randow Published online 01.07.2016 Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor‐dependent apoptosis Activation‐induced cell death (AICD) in T lymphocytes is essential for immune tolerance regulation. AICD relies on autophagy inhibition, mitochondrial fragmentation and cristae remodelling, which result in the accumulation of dysfunctional mitochondria and consequent release of pro‐apoptotic factors. Mauro Corrado, Francesca R Mariotti, Laura Trapani, Lucia Taraborrelli, Francesca Nazio, Valentina Cianfanelli, Maria Eugenia Soriano, Emilie Schrepfer, Francesco Cecconi, Luca Scorrano, and Silvia Campello Published online 07.07.2016 Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion The SNARE complex required for membrane fusion consists of four alpha‐helices. PKCB‐dependent phosphorylation of highly conserved residues forming the interaction surface facing the inside of the helical bundle suppresses secretion by inhibiting vesicle fusion without impeding docking. Seth Malmersjö, Serena Di Palma, Jiajie Diao, Ying Lai, Richard A Pfuetzner, Austin L Wang, Moira A McMahon, Arnold Hayer, Matthew Porteus, Bernd Bodenmiller, Axel T Brunger, and Tobias Meyer Published online 11.07.2016 Hormone‐induced repression of genes requires BRG1‐mediated H1.2 deposition at target promoters While ligand binding to progesterone receptor (PR) is known to induce transcription of target genes, the ligand‐activated PR also exerts a repressive function by recruiting BRG1 and the HP1γ‐LSD1 repressor complex. Ana Silvina Nacht, Andy Pohl, Roser Zaurin, Daniel Soronellas, Javier Quilez, Priyanka Sharma, Roni H Wright, Miguel Beato, and Guillermo P Vicent Published online 07.07.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.