Nature Reviews Molecular Cell Biology contents August 2016 Volume 17 Number 9 pp 533-604

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TABLE OF CONTENTS
September 2016 Volume 17 Number 9		Advertisement
Impact Factor 38.602 *	In this issue Research Highlights Reviews Analysis Perspectives Also this month Article series: Cell death and autophagy Article series: DNA damage Article series: Post-translational modifications Article series: Technologies and techniques  Featured article: Applying CRISPR–Cas9 tools to identify and characterize transcriptional enhancers Rui Lopes, Gozde Korkmaz & Reuven Agami	nature.com webcasts Nature Publishing Group presents a custom webcast on: Holistic workflow solutions to target, purify and characterize glycoprotein profiles Date: Thursday August 25, 2016 Time: 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST  Register for the webcast and live Q&A session:  Sponsored by:  Thermo Fisher
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RESEARCH HIGHLIGHTS Top Mechanotransduction: May the force be with you p533 | doi:10.1038/nrm.2016.105 Mechanical strain, transmitted by the remodelling of the actomyosin cytoskeleton and concomitant depletion of the nuclear actin pool, is shown to induce silencing of differentiation genes in epidermal stem cells, linking mechanical cues to the genetic regulation of cell fate. PDF Cell signalling: The motif behind PP2A-B56 specificity p534 | doi:10.1038/nrm.2016.107 A study now shows that PP2A-B56 achieves specificity by binding to a LxxIxE motif. PDF Nuclear organization: Keeping X chromosomes quiet p534 | doi:10.1038/nrm.2016.112 A Xist-lamin B receptor interaction recruits the X chromosome to the nuclear lamina to enable Xist-mediated gene silencing. PDF Translation: Profiling ribosome dynamics p535 | doi:10.1038/nrm.2016.109 A new method, translation complex profile sequencing (TCP-seq), enables the study of translation regulation and dynamics in live cells. PDF Cell signalling: Signalling to cell cycle arrest p536 | doi:10.1038/nrm.2016.108 Three independent studies provide molecular insights into the mechanism governing cell cycle arrest in response to centrosome loss. PDF JOURNAL CLUB Actin assembly: never forget rate constants p536 | doi:10.1038/nrm.2016.98 Laurent Blanchoin reminds us of a seminal paper by Tom Pollard reporting the meticulous measurement of rate constants of actin assembly, and highlights its contribution to quantitative understanding of actin filament dynamics as well as its impact on his own research interests. PDF IN BRIEF RNA decay: The exosome TRAMPs on viral RNA | Protein metabolism: Ceramide switches membrane protein topology | Nuclear organization: The plant nucleolus arranges chromosomes PDF Molecular Cell Biology JOBS of the week Tenure-Track Faculty Position (Open Rank) in Cell and Molecular Biology Dartmouth College Group Leader Positions in Stem Cell & Developmental Biology and Molecular Medicine IMBA - Institute of Molecular Biotechnology Assistant Professor - Cryo-Electron Microscopy - Department of Molecular and Cell Biology University of California, Berkeley More Science jobs from
REVIEWS		Top
Article series: Cell death and autophagy Mechanistic insights into selective autophagy pathways: lessons from yeast Jean-Claude Farré & Suresh Subramani p537 | doi:10.1038/nrm.2016.74 Selective autophagy pathways engage selective autophagy receptors (SARs) that identify and bind to cellular cargoes (proteins or organelles) destined for degradation. Recent yeast studies have provided insights into the regulation and mechanisms underlying SAR function. As these mechanisms are conserved from yeast to mammals, it is now possible to formulate general principles of how selectivity during autophagy is achieved. Abstract | Full Text | PDF | Supplementary information
Article series: DNA damage Transcription-replication conflicts: how they occur and how they are resolved Tatiana García-Muse & Andrés Aguilera p553 | doi:10.1038/nrm.2016.88 Encounters and conflicts between the transcription and replication machineries are common and represent a major intrinsic source of genome instability. Recent data shed new light on the biological relevance of transcription-replication conflicts and the factors and mechanisms involved in either preventing or resolving them. Abstract | Full Text | PDF
Tight junctions: from simple barriers to multifunctional molecular gates Ceniz Zihni, Clare Mills, Karl Matter & Maria S. Balda p564 | doi:10.1038/nrm.2016.80 Tight junctions are barriers between epithelial and endothelial cells that regulate the diffusion of molecules across tissues; they also contribute to cell polarity and serve as signalling platforms. Recent findings have broadened our understanding of tight junction organization, assembly and function. Abstract | Full Text | PDF
ANALYSIS		Top
Article series: Post-translational modifications A comprehensive compilation of SUMO proteomics Ivo A. Hendriks & Alfred C. O. Vertegaal p581 | doi:10.1038/nrm.2016.81 Analysis of the available human small ubiquitin-like modifier (SUMO) proteomics data provided evidence for the sumoylation of thousands of proteins and residues, and clustered the sumoylated proteins into functional networks. Sumoylation is a frequent modification, occurring mostly on nuclear proteins, with functions including transcription, mRNA processing and the DNA-damage response. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
INNOVATION Article series: Technologies and techniques Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers Rui Lopes, Gozde Korkmaz & Reuven Agami p597 | doi:10.1038/nrm.2016.79 CRISPR-Cas9-based genome editing tools have been developed recently to study non-coding transcriptional regulatory elements, enabling the characterization of enhancers in their endogenous context. The applications, current limitations and future development of such CRISPR-Cas9 tools are discussed, with emphasis on identifying and characterizing enhancer elements in a high-throughput manner. Abstract | Full Text | PDF
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