Nature Reviews Immunology Contents September 2016 Volume 16 Number 9 pp 533-592

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TABLE OF CONTENTS
September 2016 Volume 16 Number 9		Advertisement
Impact Factor 30.416 *	In this issue Research Highlights Reviews Also this month  Featured article: A guide to immunometabolism for immunologists Luke A. J. O'Neill, Rigel J. Kishton & Jeff Rathmell	Free Naturejobs Career Expo London Registration is now open for the free Naturejobs Career Expo London on September 16, 2016. Be sure to attend this special 10 year anniversary of the London science career fair for your chance to meet employers face-to-face, attend all conferences and workshops, take part in our photo booth fun, win amazing prizes and so much more! Register Free today!
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RESEARCH HIGHLIGHTS Top HIV: A recipe for inducing broadly neutralizing antibodies p533 | doi:10.1038/nri.2016.92 An immune profile associated with the production of broadly neutralizing antibodies is identified in HIV-1-infected individuals. PDF Autoimmunity: Infection stimulates self-antigen presentation p534 | doi:10.1038/nri.2016.91 Apoptosis of infected cells induces both pathogen-specific and self-reactive T helper 17 cells. PDF T Cell responses: Defective mitochondria disrupt CD8+ T cells p534 | doi:10.1038/nri.2016.98 Defective mitochondrial metabolism results in dysfunction CD8+ T cells in chronic viral infections and tumours. PDF Asthma and allergy: Old McDonald had a farm (but no asthma)! p535 | doi:10.1038/nri.2016.97 Traditional farming practices in Amish communities help shape the innate immune response and protect against asthma. PDF Autoimmunity: Autoantibodies with a silver lining? p536 | doi:10.1038/nri.2016.96 Autoantibodies specific for type I IFNs can protect against type 1 diabetes. PDF Immunology JOBS of the week PhD in Mucosal Immunology KU Leuven, Center of Intestinal Neuroimmune interaction, Translational Research Center for Gastro-Intestinal Disorders (TARGID) Assistant or Associate Professor in Immunology (Tenure Track) Department of Microbiology & Immunobiology, Harvard Medical School Tumor immunology and head and neck cancer University of Lausanne (UNIL) Post-doctoral Research Scholar, Biochemistry, Immunology, Cellular Biology University of California San Diego Postdoc in Immunology Institute of Virology and Immunology (IVI) More Science jobs from Immunology EVENT Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology 19.03.17 Whistler, Canada More science events from
REVIEWS		Top
Regulation of pattern recognition receptor signalling in plants Daniel Couto & Cyril Zipfel p537 | doi:10.1038/nri.2016.77 Plants depend on cell-autonomous innate immune mechanisms for protection against infection and these pathways are activated in response to pattern recognition receptor (PRR) engagement. However, as is the case in mammals, PRR signalling in plants must be tightly controlled to avoid pathological outcomes; this Review focuses on the mechanisms that regulate plant PRR signalling. Abstract | Full Text | PDF
A guide to immunometabolism for immunologists Luke A. J. O'Neill, Rigel J. Kishton & Jeff Rathmell p553 | doi:10.1038/nri.2016.70 Immunometabolism is emerging an important area of immunological research, but for many immunologists the complexity of the field can be daunting. Here, the authors provide an overview of six key metabolic pathways that occur in immune cells and explain what is known (and what is still to be uncovered) concerning their effects on immune cell function. Abstract | Full Text | PDF
Discriminating self from non-self in nucleic acid sensing Martin Schlee & Gunther Hartmann p566 | doi:10.1038/nri.2016.78 The detection of viruses by the immune system is mediated predominantly by the sensing of nucleic acids. Here, the authors review our current understanding of how this complex immune sensory system discriminates self from non-self nucleic acids to reliably detect pathogenic viruses, and discuss the future perspectives and implications for human disease. Abstract | Full Text | PDF
Cutaneous leishmaniasis: immune responses in protection and pathogenesis Phillip Scott & Fernanda O. Novais p581 | doi:10.1038/nri.2016.72 In this Review, the authors summarize the role of adaptive and innate immune responses to Leishmania infection and how immune responses drive pathogenesis. Advances in our understanding of immunity to cutaneous leishmaniasis could help to improve vaccine development and immunotherapy. Abstract | Full Text | PDF | Supplementary information
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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