Nature Reviews Genetics Contents September 2016 Volume 17 Number 9 pp501-578

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TABLE OF CONTENTS
September 2016 Volume 17 Number 9		Advertisement
Impact Factor 35.898 *	In this issue Research Highlights Reviews Analysis Perspectives Also this month Article series: Applications of next-generation sequencing Epigenetics  Featured article: Towards precision medicine Euan A. Ashley	23andMe offers Genotyping Services for Research. It's more than a new way to conduct genetic studies. Expand your recruitment with the only end-to-end solution that allows you to return genetic reports to participants, providing them with their own 23andMe experience. Imagine being able to focus on the science - and give something back to each research participant - while we take care of every detail of your genotyping study. Welcome to a new era of genetic studies. Learn more
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RESEARCH HIGHLIGHTS Top Evolutionary genetics: Knowing when to stop p501 | doi:10.1038/nrg.2016.100 PDF Microbiomes: Symbionts — in it for the long run p502 | doi:10.1038/nrg.2016.102 PDF Genetic variation: Nuclear and mitochondrial genome interplay p502 | doi:10.1038/nrg.2016.96 PDF Plant genomics: 1001 genomes and epigenomes p503 | doi:10.1038/nrg.2016.99 PDF Chromatin: Chromatin variation underLINEd p504 | doi:10.1038/nrg.2016.101 PDF Genetic screen: A network to guide precision cancer therapy p504 | doi:10.1038/nrg.2016.105 PDF Gene regulation: May the force be with you p505 | doi:10.1038/nrg.2016.103 PDF IN BRIEF DNA sequencing: Real-time prioritization of sequencing output | Genetic interactions: Leveraging context-dependent essentiality | Technology: Enabling accurate single-cell genome amplification PDF Genetics JOBS of the week Postdoctoral fellowship in genetics and genomics of neuropsychiatric disorders University of Chicago Senior Officer Regulatory Affairs Nicotine-Containing Products (NCP) – RoW outside EU Philip Morris International (PMI) Postdoctoral Fellow in Human Developmental Genetics Harvard University Head Scientist in Mosquito Ecology and Genetics Polo d'Innovazione Genomica Genetica e Biologia SCaRL Postdoctoral Fellow Georgia Cancer Center at Augusta University More Science jobs from Genetics EVENT World Congress of Psychiatric Genetics 30.10.13 Jerusalem, Israel More science events from
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REVIEWS		Top
Article series: Applications of next-generation sequencing Towards precision medicine Euan A. Ashley p507 | doi:10.1038/nrg.2016.86 Precision medicine is a strategy for tailoring clinical decision making to the underlying genetic causes of disease. This Review describes how, despite the straightforward overall principles of precision medicine, adopting it responsibly into clinical practice will require many technical and conceptual hurdles to be overcome. Such challenges include optimized sequencing strategies, clinically focused bioinformatics pipelines and reliable metrics for the disease causality of genetic variants. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing The life aquatic: advances in marine vertebrate genomics Joanna L. Kelley, Anthony P. Brown, Nina Overgaard Therkildsen & Andrew D. Foote p523 | doi:10.1038/nrg.2016.66 Marine vertebrates are key contributors to global biodiversity and human food supply. In this Review, the authors discuss how comparative genomics studies in marine vertebrates have provided insight into major evolutionary transitions between the land and sea, as well as intra-species adaptation to diverse types of aquatic environments. They also highlight applications in species management and conservation. Abstract | Full Text | PDF
Type 2 diabetes: genetic data sharing to advance complex disease research Jason Flannick & Jose C. Florez p535 | doi:10.1038/nrg.2016.56 The authors review the history of, and recent progress towards, mapping genes for type 2 diabetes mellitus (T2D), discuss the consequent implications for disease genetic architecture and propose open and interactive sharing of data by an integrated T2D web portal as a new research paradigm to hasten clinical translation of genetic discoveries. Abstract | Full Text | PDF
ANALYSIS		Top
Article series: Epigenetics Transcription factors as readers and effectors of DNA methylation Heng Zhu, Guohua Wang & Jiang Qian p551 | doi:10.1038/nrg.2016.83Evidence is emerging that transcription factors (TFs) lacking methyl-CpG binding domains can interact with methylated DNA. This Analysis article reviews the in vitro and in vivo evidence for methylation-mediated interactions between TFs and DNA, and their functional consequences. Abstract | Full Text | PDF | Supplementary information
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PERSPECTIVES		Top
OPINION Open questions in the study of de novo genes: what, how and why Aoife McLysaght & Laurence D. Hurst p567 | doi:10.1038/nrg.2016.78 In this Opinion article, the authors discuss important questions relating to the study of de novo genes. They discuss the challenges of identifying de novo genes, understanding how they originate and why they spread, and propose that antagonistic evolution may have a key role in their evolution. Abstract | Full Text | PDF
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*2015 Journal Citation Report (Thomson Reuters, 2016)

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