Nature Immunology Contents: September 2016 Volume 17 pp 1007 - 1127

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The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.  Explore the benefits of submitting your manuscript >>   News and Views Top Differentiate or die!   pp1007 - 1008 Toshiaki Kawakami doi:10.1038/ni.3531 Membrane immunoglobulin E (IgE) on germinal-center-like B cells, without engagement of IgE, uses the CD19-PI3K-Akt-IRF4 axis and the BLNK-Jnk-p38 axis, with the former used for plasma-cell differentiation and the latter used for apoptotic death. See also: Article by Haniuda et al. Mitochondria provide a 'complex' solution to a bacterial problem   pp1009 - 1010 Marissa A Holmbeck and Gerald S Shadel doi:10.1038/ni.3534 Adaptations in the mitochondrial electron-transport chain mediate antibacterial responses in macrophages. See also: Article by Garaude et al. Immunogenic cross-talk between dengue and Zika viruses   pp1010 - 1012 Stephen C Harrison doi:10.1038/ni.3539 At least five recent papers have shown an unexpected antigenic relationship between Zika and dengue viruses, with potential implications for vaccines and therapeutics. See also: Article by Dejnirattisai et al. HLA-Fatal attraction   pp1012 - 1014 Frederic Vely, Rachel Golub and Eric Vivier doi:10.1038/ni.3541 Open conformers of the non-classical and monomorphic major histocompatibility complex (MHC) class I molecule HLA-F are ligands for the activating receptor KIR3DS1 and trigger the activation of natural killer (NK) cells. See also: Article by Garcia-Beltran et al. Immunology JOBS of the week PhD in Mucosal Immunology KU Leuven, Center of Intestinal Neuroimmune interaction, Translational Research Center for Gastro-Intestinal Disorders (TARGID) Assistant or Associate Professor in Immunology (Tenure Track) Department of Microbiology & Immunobiology, Harvard Medical School Tumor immunology and head and neck cancer University of Lausanne (UNIL) Post-doctoral Research Scholar, Biochemistry, Immunology, Cellular Biology University of California San Diego Postdoc in Immunology Institute of Virology and Immunology (IVI) More Science jobs from Immunology EVENT Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology 19th - 23rd March 2017 Whistler, Canada More science events from Research Highlights Top Brain defenders | Meta-inflammation and IRF3 | Of mitochondria: part I | Of mitochondria: part II | Kinase Cdk5 in tumors | Protecting lymph nodes Reviews Top Emerging concepts of epigenetic dysregulation in hematological malignancies   pp1016 - 1024 Panagiotis Ntziachristos, Omar Abdel-Wahab and Iannis Aifantis doi:10.1038/ni.3517 In this Review, Aifantis and colleagues describe recent insights into the epigenetic dysregulation of malignant blood stem cell differentiation. Targeting natural killer cells in cancer immunotherapy   pp1025 - 1036 Camille Guillerey, Nicholas D Huntington and Mark J Smyth doi:10.1038/ni.3518 There is now a major effort to fully exploit the anti-tumor properties of NK cells in the clinic. In this Review, Smyth and colleagues detail recent advances in NK cell-based immunotherapies and discuss the advantages and limitations of these strategies. Advertisement Emerging Microbes & Infections is an open access, peer-reviewed journal, providing an integrated forum to allow for the timely dissemination of large amount of information gathered about microbes and infections, especially ones associated with increasing biological and clinical significance and pathogenic frequency. Submit your manuscript.   Articles Top Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense   pp1037 - 1045 Johan Garaude, Rebeca Acin-Perez, Sarai Martinez-Cano, Michel Enamorado, Matteo Ugolini et al. doi:10.1038/ni.3509 Garaude and colleagues show that innate immunological sensing of live bacteria by macrophages elicits transient adaptations to the electron-transport chain of mitochondria. See also: News and Views by Holmbeck & Shadel C13orf31 (FAMIN) is a central regulator of immunometabolic function   pp1046 - 1056 M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi, Sarah L Kempster et al. doi:10.1038/ni.3532 Variants of the human gene C13orf31 (LACC1) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called /`FAMIN/') in regulating macrophage fatty-acid oxidation and lipogenesis. iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING   pp1057 - 1066 Wei-Wei Luo, Shu Li, Chen Li, Huan Lian, Qing Yang et al. doi:10.1038/ni.3510 DNA viruses activate antiviral immune responses dependent on the adaptor STING. Shu and colleagues identify iRhom2 as a positive regulator that stabilizes STING and facilitates its vesicular trafficking from the endoplasmic reticulum to perinuclear microsomes after activation. Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1   pp1067 - 1074 Wilfredo F Garcia-Beltran, Angelique Holzemer, Gloria Martrus, Amy W Chung, Yovana Pacheco et al. doi:10.1038/ni.3513 The activating NK cell receptor KIR3DS1 has been linked to the outcome of various human diseases, yet a ligand that would account for its biological effects has remained unknown. Altfeld and colleagues establish HLA-F as a ligand of KIR3DS1, which helps to explain the widespread influence of this receptor in disease. See also: News and Views by Vely et al. WNK1 kinase balances T cell adhesion versus migration in vivo   pp1075 - 1083 Robert Kochl, Flavian Thelen, Lesley Vanes, Tiago F Brazao, Kathryn Fountain et al. doi:10.1038/ni.3495 The kinase WNK1 is part of a pathway that controls the uptake of ions into kidney cells. Tybulewicz and colleagues show that a related pathway involving WNK1 also operates in T cells, in which it negatively regulates adhesion and positively regulates migration. Apoptosis in response to microbial infection induces autoreactive TH17 cells   pp1084 - 1092 Laura Campisi, Gaetan Barbet, Yi Ding, Enric Esplugues, Richard A Flavell et al. doi:10.1038/ni.3512 Autoimmunity can often be associated with prior infection. Blander and colleagues demonstrate a mechanism by which self-tolerance can be broken after the presentation of antigens derived from bacteria-infected apoptotic cells. Affinity for self antigen selects Treg cells with distinct functional properties   pp1093 - 1101 Lena Wyss, Brian D Stadinski, Carolyn G King, Sonja Schallenberg, Nicholas I McCarthy et al. doi:10.1038/ni.3522 Regulatory T cells (Treg cells) have essential roles in maintaining immunohomeostasis. Palmer and colleagues identify two distinct subsets of Treg cells with differing degrees of self-reactivity and regulatory function. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus   pp1102 - 1108 Wanwisa Dejnirattisai, Piyada Supasa, Wiyada Wongwiwat, Alexander Rouvinski, Giovanna Barba-Spaeth et al. doi:10.1038/ni.3515 Infection with Zika virus has occurred in areas previously exposed to dengue virus, a closely related flavivirus. Screaton and colleagues find that monoclonal antibodies to dengue virus cross-react with Zika virus and enhance infection. See also: News and Views by Harrison Autonomous membrane IgE signaling prevents IgE-memory formation   pp1109 - 1117 Kei Haniuda, Saori Fukao, Tadahiro Kodama, Hitoshi Hasegawa and Daisuke Kitamura doi:10.1038/ni.3508 Under normal conditions, IgE+ memory B cells and IgE serum antibody are extremely scarce. Kitamura and colleagues demonstrate that the IgE B cell receptor has unique signaling properties that autonomously control IgE+ B cell numbers. See also: News and Views by Kawakami Resource Top Tumor-induced stromal reprogramming drives lymph node transformation   pp1118 - 1127 Angela Riedel, David Shorthouse, Lisa Haas, Benjamin A Hall and Jacqueline Shields doi:10.1038/ni.3492 The contribution of stromal cells to the microenvironment of tumor-draining lymph nodes is poorly characterized. By comparative transcriptional analysis, Shields and colleagues find that tumors induce the stromal reprogramming of key pathways that affect the structure and function of such lymph nodes. Top Advertisement Experimental & Molecular Medicine is an open access journal to communicate experimental and translational research performed using molecular tools. Submit your manuscript.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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