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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Tectonic collision and uplift of Wallacea triggered the global songbird radiation OPEN | | | Robert G. Moyle, Carl H. Oliveros, Michael J. Andersen, Peter A. Hosner, Brett W. Benz, Joseph D. Manthey, Scott L. Travers, Rafe M. Brown and Brant C. Faircloth | | | Songbirds originated in Australia and have now diversified into approximately 5,000 species found across the world. Here, Moyle et al. combine phylogenomic and biogeographic analyses to show that songbird diversification was associated with the formation of islands providing a route out of Australia. | | | 30 August 2016 | doi: 10.1038/ncomms12709 | | |
| Sesquinary catenae on the Martian satellite Phobos from reaccretion of escaping ejecta OPEN | | | M. Nayak and E. Asphaug | | | The origin of the numerous linear grooves and craters that litter the Martian moon Phobos' surface remains enigmatic. Here, by modelling low-velocity escaping ejecta from impacts to Phobos, the authors show that several of these chains can be explained by reimpacting sesquinary ejecta shortly after ejection. | | | 30 August 2016 | doi: 10.1038/ncomms12591 | | |
| Rapid evolutionary response to a transmissible cancer in Tasmanian devils OPEN | | | Brendan Epstein, Menna Jones, Rodrigo Hamede, Sarah Hendricks, Hamish McCallum, Elizabeth P. Murchison, Barbara Schönfeld, Cody Wiench, Paul Hohenlohe and Andrew Storfer | | | A recently emerged infectious cancer has caused the near extinction of the Tasmanian devil, but some populations persist. Here, Epstein et al. provide evidence for possible resistance via rapid evolution in two genomic regions that contain cancer-related immune response genes. | | | 30 August 2016 | doi: 10.1038/ncomms12684 | | |
| Photon upconversion with directed emission OPEN | | | K. Börjesson, P. Rudquist, V. Gray and K. Moth-Poulsen | | | Photon upconversion can be used to harvest low energy photons, which are otherwise lost in solar cells. Here, Börjesson et al. use a well-oriented liquid crystal matrix to host the upconversion system in order to emit upconverted photons in a preferential direction, where the solar cells would be located. | | | 30 August 2016 | doi: 10.1038/ncomms12689 | | |
| Optical patterning of trapped charge in nitrogen-doped diamond OPEN | | | Harishankar Jayakumar, Jacob Henshaw, Siddharth Dhomkar, Daniela Pagliero, Abdelghani Laraoui, Neil B. Manson, Remus Albu, Marcus W. Doherty and Carlos A. Meriles | | | Manipulating nitrogen vacancies in nitrogen-doped diamond is important for quantum information processing. Here the authors use a two-colour excitation to redistribute the localized trapping charges in type-1b diamonds. | | | 30 August 2016 | doi: 10.1038/ncomms12660 | | |
| Spin-current probe for phase transition in an insulator OPEN | | | Zhiyong Qiu, Jia Li, Dazhi Hou, Elke Arenholz, Alpha T. N’Diaye, Ali Tan, Ken-ichi Uchida, Koji Sato, Satoshi Okamoto, Yaroslav Tserkovnyak, Z. Q. Qiu and Eiji Saitoh | | | Whilst neutron scattering is a powerful tool for studying spin fluctuations in materials, its availability is limited to large-scale user facilities. Here, the authors demonstrate how the pumping of pure spin currents can be used as a desktop probe to detect an antiferromagnetic transition. | | | 30 August 2016 | doi: 10.1038/ncomms12670 | | |
| Broadband giant-refractive-index material based on mesoscopic space-filling curves OPEN | | | Taeyong Chang, Jong Uk Kim, Seung Kyu Kang, Hyowook Kim, Do Kyung Kim, Yong-Hee Lee and Jonghwa Shin | | | The refractive index of natural materials only covers a limited range. Here, Chang et al. use the principle of space-filling curves to construct a mesoscopic crystal with a refractive index greater than 1000 at GHz frequencies. The concept is inherently broadband and scalable. | | | 30 August 2016 | doi: 10.1038/ncomms12661 | | |
| Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia OPEN | | | Francis P. Pankowicz, Mercedes Barzi, Xavier Legras, Leroy Hubert, Tian Mi, Julie A. Tomolonis, Milan Ravishankar, Qin Sun, Diane Yang, Malgorzata Borowiak, Pavel Sumazin, Sarah H. Elsea, Beatrice Bissig-Choisat and Karl-Dimiter Bissig | | | Hereditary tyrosinaemia type I is caused by a gene defect that leads to a lethal accumulation of toxic metabolites in the liver. Here the authors use CRISPR/Cas9 to 'cure' the disease in mice by inactivating another gene, rather than targeting the disease-causing gene itself, to reroute hepatic tyrosine catabolism. | | | 30 August 2016 | doi: 10.1038/ncomms12642 | | |
| Source identification and distribution reveals the potential of the geochemical Antarctic sea ice proxy IPSO25 OPEN | | | S. T. Belt, L. Smik, T. A. Brown, J.-H. Kim, S. J. Rowland, C. S. Allen, J.-K. Gal, K.-H. Shin, J. I. Lee and K. W. R. Taylor | | | The sedimentary presence of the diatom lipid diene II (hereafter IPSO25) has been proposed as a proxy for palaeo Antarctic sea ice. Here, the authors identify a source of IPSO25 and hypothesize that its sedimentary distribution may provide proxy evidence of landfast ice influenced by freshwater discharge. | | | 30 August 2016 | doi: 10.1038/ncomms12655 | | |
| Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice OPEN | | | Ja Young Kim-Muller, Jason Fan, Young Jung R. Kim, Seung-Ah Lee, Emi Ishida, William S. Blaner and Domenico Accili | | | Diabetes is associated with the de-differentiation of β-cells into a more progenitor-like cell type. Here, the authors identify Aldh3 as a marker of de-differentiating β-cell in animal models of diabetes, and show Aldh3+ cells have impaired insulin secretion and mitochondrial dysfunction. | | | 30 August 2016 | doi: 10.1038/ncomms12631 | | |
| Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma OPEN | | | Jeffrey J. Wallin, Johanna C. Bendell, Roel Funke, Mario Sznol, Konstanty Korski, Suzanne Jones, Genevive Hernandez, James Mier, Xian He, F. Stephen Hodi, Mitchell Denker, Vincent Leveque, Marta Cañamero, Galina Babitski, Hartmut Koeppen, James Ziai, Neeraj Sharma, Fabien Gaire, Daniel S. Chen, Daniel Waterkamp et al. | | | Cancer immunotherapy can be used in combination with other therapies for a better response. Here, the authors conduct a phase Ib clinical study and report the clinical activity and the immune response of the anti-PDL1 agent, atezolizumab, in combination with bevacizumab in ten patients with metastatic renal cell carcinoma. | | | 30 August 2016 | doi: 10.1038/ncomms12624 | | |
| Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity OPEN | | | Chia-Wei Li, Seung-Oe Lim, Weiya Xia, Heng-Huan Lee, Li-Chuan Chan, Chu-Wei Kuo, Kay-Hooi Khoo, Shih-Shin Chang, Jong-Ho Cha, Taewan Kim, Jennifer L. Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Qingqing Ding, Yan Wang, Jun Yao, Cheng-Chung Lee, Hsing-Ju Wu, Aysegul A. Sahin et al. | | | Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation. | | | 30 August 2016 | doi: 10.1038/ncomms12632 | | |
| Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining OPEN | | | Hannes Uchtenhagen, Cliff Rims, Gabriele Blahnik, I-Ting Chow, William W. Kwok, Jane H. Buckner and Eddie A. James | | | Detection of antigen specificity in a blood sample is limited by low frequencies of individual clones. Here the authors develop an MHC class II combinatorial technique and apply it to immunophenotype human CD4+ T cells of multiple specificities in response to influenza vaccine in single blood samples. | | | 30 August 2016 | doi: 10.1038/ncomms12614 | | |
| Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates OPEN | | | Vida Chitsazzadeh, Cristian Coarfa, Jennifer A. Drummond, Tri Nguyen, Aaron Joseph, Suneel Chilukuri, Elizabeth Charpiot, Charles H. Adelmann, Grace Ching, Tran N. Nguyen, Courtney Nicholas, Valencia D. Thomas, Michael Migden, Deborah MacFarlane, Erika Thompson, Jianjun Shen, Yoko Takata, Kayla McNiece, Maxim A. Polansky, Hussein A. Abbas et al. | | | Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development. | | | 30 August 2016 | doi: 10.1038/ncomms12601 | | |
| Synthesis and characterization of attosecond light vortices in the extreme ultraviolet OPEN | | | R. Géneaux, A. Camper, T. Auguste, O. Gobert, J. Caillat, R. Taïeb and T. Ruchon | | | Twisted light beams have found several applications in the infrared and visible regime, but reaching the extreme ultraviolet has been difficult due to lack of sources. Here the authors report generation of helically shaped extreme ultraviolet trains of attosecond pulses via high harmonic generation. | | | 30 August 2016 | doi: 10.1038/ncomms12583 | | |
| Purification of a single-photon nonlinearity OPEN | | | H. Snijders, J. A. Frey, J. Norman, M. P. Bakker, E. C. Langman, A. Gossard, J. E. Bowers, M. P. van Exter, D. Bouwmeester and W. Löffler | | | Single-photon optical nonlinearity is possible using an optical cavity to create strong coupling between a cavity mode and a two-level quantum system. Here, the authors demonstrate it is also possible in the weak-coupling regime by using quantum interference in a polarization-degenerate cavity. | | | 30 August 2016 | doi: 10.1038/ncomms12578 | | |
| Chemoselective single-site Earth-abundant metal catalysts at metal–organic framework nodes OPEN | | | Kuntal Manna, Pengfei Ji, Zekai Lin, Francis X. Greene, Ania Urban, Nathan C. Thacker and Wenbin Lin | | | Catalysis with non-precious metals presents many advantages including ease of availability, security of supply and low cost. Here, the authors report a metal–organic framework with cobalt or iron sites for use as single-site solid catalysts in a number of chemoselective reactions. | | | 30 August 2016 | doi: 10.1038/ncomms12610 | | |
| Temperature-driven massless Kane fermions in HgCdTe crystals OPEN | | | F. Teppe, M. Marcinkiewicz, S. S. Krishtopenko, S. Ruffenach, C. Consejo, A. M. Kadykov, W. Desrat, D. But, W. Knap, J. Ludwig, S. Moon, D. Smirnov, M. Orlita, Z. Jiang, S. V. Morozov, V.I. Gavrilenko, N. N. Mikhailov and S. A. Dvoretskii | | | Kane fermions are predicted to be tunable with external parameters such as temperature. Here, Teppe et al. show a band structure evolution of bulk HgCdTe as temperature is tuned across topological phase transition, demonstrating that Kane fermions change sign in rest-mass and remain constant in velocity. | | | 30 August 2016 | doi: 10.1038/ncomms12576 | | |
| Rewiring of jasmonate and phytochrome B signalling uncouples plant growth-defense tradeoffs OPEN | | | Marcelo L. Campos, Yuki Yoshida, Ian T. Major, Dalton de Oliveira Ferreira, Sarathi M. Weraduwage, John E. Froehlich, Brendan F. Johnson, David M. Kramer, Georg Jander, Thomas D. Sharkey and Gregg A. Howe | | | Plant immune responses are often associated with reduced growth. Here, the authors show that combining mutations in transcriptional repressors of the defense and light perception pathways can confer both robust growth and strong herbivore defense, demonstrating that growth-defense tradeoffs can be uncoupled. | | | 30 August 2016 | doi: 10.1038/ncomms12570 | | |
| A substrate-driven allosteric switch that enhances PDI catalytic activity OPEN | | | Roelof H. Bekendam, Pavan K. Bendapudi, Lin Lin, Partha P. Nag, Jun Pu, Daniel R. Kennedy, Alexandra Feldenzer, Joyce Chiu, Kristina M. Cook, Bruce Furie, Mingdong Huang, Philip J. Hogg and Robert Flaumenhaft | | | Protein Disulfide Isomerase (PDI) is a prothrombotic, multidomain enzyme with separate substrate binding and catalytic domains. Here, the authors identify a new class of compounds that target the PDI substrate binding site, inducing a conformational change in the catalytic domains and inhibiting thrombosis. | | | 30 August 2016 | doi: 10.1038/ncomms12579 | | |
| Photonic water dynamically responsive to external stimuli OPEN | | | Koki Sano, Youn Soo Kim, Yasuhiro Ishida, Yasuo Ebina, Takayoshi Sasaki, Takaaki Hikima and Takuzo Aida | | | Some types of fish can change color by modifying their intracellular guanine crystal in response to external stimuli. Here, Sano et al. mimic this effect in a dilute aqueous dispersion containing titanate nanosheets, whose interlayer distance is tunable to match the entire visible light spectrum. | | | 30 August 2016 | doi: 10.1038/ncomms12559 | | |
| Enhancing droplet deposition through in-situ precipitation OPEN | | | Maher Damak, Seyed Reza Mahmoudi, Md Nasim Hyder and Kripa K. Varanasi | | | The extensive use of pesticides in agriculture calls for efficient spraying techniques to reduce pollution of soils and groundwater by toxic chemicals. Damak et al. simultaneously spray liquids containing oppositely charged polyelectrolytes that form defects, pinning droplets on targeted surfaces. | | | 30 August 2016 | doi: 10.1038/ncomms12560 | | |
| Geomagnetic reversal rates following Palaeozoic superchrons have a fast restart mechanism OPEN | | | Mark W. Hounslow | | | The mechanism behind the initiation and termination of superchrons remains unclear. Here, the author provides insight into Palaeozoic superchrons, showing that the 10 million year interal adjacent to each superchron is characterized by asymmetry in reversal rates and unusually long duration chrons. | | | 30 August 2016 | doi: 10.1038/ncomms12507 | | |
| A stochastic model of randomly accelerated walkers for human mobility OPEN | | | Riccardo Gallotti, Armando Bazzani, Sandro Rambaldi and Marc Barthelemy | | | Many human mobility studies have shown empirically long-tailed distance distributions, which are usually associated to Lévy flights. Here, the authors show that the behavior of private vehicles could be misinterpreted as Lévy flights but is fully captured by a class of accelerated random walks. | | | 30 August 2016 | doi: 10.1038/ncomms12600 | | |
| The WEIZMASS spectral library for high-confidence metabolite identification OPEN | | | Nir Shahaf, Ilana Rogachev, Uwe Heinig, Sagit Meir, Sergey Malitsky, Maor Battat, Hilary Wyner, Shuning Zheng, Ron Wehrens and Asaph Aharoni | | | Unambiguous metabolite annotation is a critical, yet problematic step, in mass spectrometry based metabolomics. Here, Shahaf et al. present WEIZMASS, a platform consisting of a diverse spectral library of more than 3500 plant metabolites and software to aid their identification in biological samples. | | | 30 August 2016 | doi: 10.1038/ncomms12423 | | |
| Environmental DNA reveals that rivers are conveyer belts of biodiversity information OPEN | | | Kristy Deiner, Emanuel A. Fronhofer, Elvira Mächler, Jean-Claude Walser and Florian Altermatt | | | DNA of a given organism can be detected from its surroundings. Here, Deiner and colleagues use so-called environmental DNA to estimate biodiversity of both aquatic and terrestrial organisms in and near river. | | | 30 August 2016 | doi: 10.1038/ncomms12544 | | |
| Intertidal resource use over millennia enhances forest productivity OPEN | | | Andrew J. Trant, Wiebe Nijland, Kira M. Hoffman, Darcy L. Mathews, Duncan McLaren, Trisalyn A. Nelson and Brian M. Starzomski | | | Human settlements are often associated with degraded landscapes. Trant and colleagues now show that near-shore settlements in British Columbia have locally enhanced forest productivity over millennia by enriching soils with calcium and phosphorous derived from shellfish remnants. | | | 30 August 2016 | doi: 10.1038/ncomms12491 | | |
| Lithium-ion battery electrolyte mobility at nano-confined graphene interfaces OPEN | | | Boaz Moeremans, Hsiu-Wei Cheng, Qingyun Hu, Hector F. Garces, Nitin P. Padture, Frank Uwe Renner and Markus Valtiner | | | Electrochemical processes strongly depend on the wetting and mobility phenomena at the involved nano-confined interfaces. Here, the authors use a surface forces apparatus to understand the wetting behavior of graphene, gold, and mica surfaces by Li-ion battery electrolytes. | | | 26 August 2016 | doi: 10.1038/ncomms12693 | | |
| Asymmetric synthesis using chiral-encoded metal OPEN | | | Thittaya Yutthalekha, Chularat Wattanakit, Veronique Lapeyre, Somkiat Nokbin, Chompunuch Warakulwit, Jumras Limtrakul and Alexander Kuhn | | | Chiral compounds are extremely important as they can be used in medicine, agriculture and biotechnology. Here, Kuhn and co-workers use a mesoporous metal structure encoded with chiral information in order to induce asymmetry in electrochemical synthesis of mandelic acid. | | | 26 August 2016 | doi: 10.1038/ncomms12678 | | |
| Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases OPEN | | | Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya-Min Tian, Martine I. Abboud, Wei Ge, Carmen Domene, François-Xavier Cantrelle, Isabelle Landrieu, Adam P. Hardy, Christopher W. Pugh, Peter J. Ratcliffe, Timothy D. W. Claridge and Christopher J. Schofield | | | The response to hypoxia involves multiple genes regulated by the hypoxia inducible transcription factors (HIFs), whose stability is regulated by prolyl hydroxylation. Here the authors provide a molecular basis for the substrate selectivity of the HIF prolyl hydroxylases that can be altered in erythrocytosis and cancer. | | | 26 August 2016 | doi: 10.1038/ncomms12673 | | |
| VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease OPEN | | | Xing Guo, XiaoYan Sun, Di Hu, Ya-Juan Wang, Hisashi Fujioka, Rajan Vyas, Sudha Chakrapani, Amit Umesh Joshi, Yu Luo, Daria Mochly-Rosen and Xin Qi | | | Mitochondria defects caused by mutant huntingtin (mtHtt) have been implicated in Huntington's disease. Here authors show that VCP binds to mtHtt on the mitochondria, and that treatment with a peptide that disrupts this interaction reduces the cellular and behavioural deficits in mouse models of HD. | | | 26 August 2016 | doi: 10.1038/ncomms12646 | | |
| Room-temperature tetragonal non-collinear Heusler antiferromagnet Pt2MnGa OPEN | | | Sanjay Singh, S. W. D’Souza, J. Nayak, E. Suard, L. Chapon, A. Senyshyn, V. Petricek, Y. Skourski, M. Nicklas, C. Felser and S. Chadov | | | The control of different types of magnetic order is central to the study and development of spintronic devices. Here, the authors evidence an exchange-stabilized helix state with a low energy barrier for reversal in a room-temperature antiferromagnetic Heusler material. | | | 26 August 2016 | doi: 10.1038/ncomms12671 | | |
| Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status OPEN | | | F. Coscia, K. M. Watters, M. Curtis, M. A. Eckert, C. Y. Chiang, S. Tyanova, A. Montag, R. R. Lastra, E. Lengyel and M. Mann | | | High-grade serous ovarian cancer is the most common and aggressive ovarian cancer, with uncertain cell of origin. Here, the authors undertake a mass spectrometric analysis of 26 cancer cell lines and identify a protein signature that classifies ovarian cancer tissues into epithelial and mesenchymal groups. | | | 26 August 2016 | doi: 10.1038/ncomms12645 | | |
| Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection OPEN | | | Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav I. Enchev, Matthias Peter, Raimundo Freire, Antonio Porro and Alessandro A. Sartori | | | CtIP has a key role in DNA double-strand break repair as its role in resecting DNA at the break commits a cell to homologous recombination. Here the authors show that KLHL15 interacts with CtIP and regulates repair by controlling protein turnover. | | | 26 August 2016 | doi: 10.1038/ncomms12628 | | |
| Ecological constraints increase the climatic debt in forests OPEN | | | Romain Bertrand, Gabriela Riofrío-Dillon, Jonathan Lenoir, Jacques Drapier, Patrice de Ruffray, Jean-Claude Gégout and Michel Loreau | | | Many species show a time-lagged response to climate change, a phenomenon called climatic debt. Here, Bertrand and colleagues show that climate severity and plant tolerance to climate warming mainly influence the climatic debt of forest herbaceous plant communities. | | | 26 August 2016 | doi: 10.1038/ncomms12643 | | |
| Hypersensitivity to DNA damage in antephase as a safeguard for genome stability OPEN | | | Femke M. Feringa, Lenno Krenning, André Koch, Jeroen van den Berg, Bram van den Broek, Kees Jalink and René H. Medema | | | The DNA damage response induces a reversible arrest at different cell cycle stages. Here the authors find that loss of the APC/C inhibitor Emi1 in antephase (late G2) results in hypersensitivity to DNA damage and cell cycle exit at DNA damage levels that induce a reversible arrest in early G2. | | | 26 August 2016 | doi: 10.1038/ncomms12618 | | |
| Molecular logic of the Zur-regulated zinc deprivation response in Bacillus subtilis OPEN | | | Jung-Ho Shin and John D. Helmann | | | The transcription factor Zur controls the zinc deprivation response in Bacillus subtilis. Here, Shin and Helmann show that Zur-regulated genes are derepressed in three waves in response to zinc deprivation, and this is linked to the biochemistry of zinc sensing by Zur. | | | 26 August 2016 | doi: 10.1038/ncomms12612 | | |
| Single-molecule imaging of UvrA and UvrB recruitment to DNA lesions in living Escherichia coli OPEN | | | Mathew Stracy, Marcin Jaciuk, Stephan Uphoff, Achillefs N. Kapanidis, Marcin Nowotny, David J. Sherratt and Pawel Zawadzki | | | Nucleotide excision repair is able to identify and remove a wide range of DNA helix distorting lesions from the genome. Here the authors use single molecule imaging of UvrA and UvrB molecules and suggest a two-step ‘scan and recruit’ model for UvrA function. | | | 26 August 2016 | doi: 10.1038/ncomms12568 | | |
| TNIK inhibition abrogates colorectal cancer stemness OPEN | | | Mari Masuda, Yuko Uno, Naomi Ohbayashi, Hirokazu Ohata, Ayako Mimata, Mutsuko Kukimoto-Niino, Hideki Moriyama, Shigeki Kashimoto, Tomoko Inoue, Naoko Goto, Koji Okamoto, Mikako Shirouzu, Masaaki Sawa and Tesshi Yamada | | | TRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice. | | | 26 August 2016 | doi: 10.1038/ncomms12586 | | |
| Coherence and multimode correlations from vacuum fluctuations in a microwave superconducting cavity OPEN | | | Pasi Lähteenmäki, Gheorghe Sorin Paraoanu, Juha Hassel and Pertti J. Hakonen | | | Vacuum fluctuations can produce observable phenomena which can potentially be harnessed, for example using the dynamical Casimir effect. Here, the authors show that, on the basis of the same effect, it is possible to establish distinct two-mode coherence correlations in a pumped microwave cavity owing to absence of which-way information. | | | 26 August 2016 | doi: 10.1038/ncomms12548 | | |
| Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole OPEN | | | Yuki Tsuchiya, Satoko Yoshiba, Akshari Gupta, Koki Watanabe and Daiju Kitagawa | | | Newly formed centrioles mature into functional mother centrioles. Here the authors show that the scaffolding protein Cep295 is recruited to the procentriole assembly site and assists daughter centriole assembly and daughter-to-mother centriole conversion. | | | 26 August 2016 | doi: 10.1038/ncomms12567 | | |
| Reaction-induced rheological weakening enables oceanic plate subduction OPEN | | | Ken-ichi Hirauchi, Kumi Fukushima, Masanori Kido, Jun Muto and Atsushi Okamoto | | | Plate subduction initiation requires weak boundaries between tectonic plates, but how weaknesses develop is unclear. Here, using high-pressure friction experiments on peridotite gouge material, the authors show that hydration reactions contribute to the weak mantle shear zones leading to subduction initiation. | | | 26 August 2016 | doi: 10.1038/ncomms12550 | | |
| Automated optogenetic feedback control for precise and robust regulation of gene expression and cell growth OPEN | | | Andreas Milias-Argeitis, Marc Rullan, Stephanie K. Aoki, Peter Buchmann and Mustafa Khammash | | | Optogenetics has emerged as a promising means to achieve gene expression control in bioprocess engineering, but current systems cannot respond to fluctuations in growth conditions. Here the authors overcome this limitation and develop an automated optogenetic feedback control system for precise and robust control of protein production in E. coli. | | | 26 August 2016 | doi: 10.1038/ncomms12546 | | |
| A moving contact line as a rheometer for nanometric interfacial layers OPEN | | | Romain Lhermerout, Hugo Perrin, Etienne Rolley, Bruno Andreotti and Kristina Davitt | | | The characterisation of interfacial layers, whose rheology can differ from the bulk, is important for the design of new materials. Here, Lhermerout et al. use the dynamics of a moving contact line to quantify the mechanical properties of a polymer thin film. | | | 26 August 2016 | doi: 10.1038/ncomms12545 | | |
| Simultaneous atomic-resolution electron ptychography and Z-contrast imaging of light and heavy elements in complex nanostructures OPEN | | | H. Yang, R. N. Rutte, L. Jones, M. Simson, R. Sagawa, H. Ryll, M. Huth, T. J. Pennycook, M.L.H. Green, H. Soltau, Y. Kondo, B. G. Davis and P. D. Nellist | | | The use of ptychography with electrons has been limited. Here, Yang et al. demonstrate that the combination of Z-contrast and phase imaging reveals the structure of complex nanomaterials. This practical tool can be used to solve the structure of a beam-sensitive carbon nanostructure at atomic-resolution. | | | 26 August 2016 | doi: 10.1038/ncomms12532 | | |
| Colloidal cholesteric liquid crystal in spherical confinement OPEN | | | Yunfeng Li, Jeffrey Jun-Yan Suen, Elisabeth Prince, Egor M. Larin, Anna Klinkova, Héloïse Thérien-Aubin, Shoujun Zhu, Bai Yang, Amr S. Helmy, Oleg D. Lavrentovich and Eugenia Kumacheva | | | Confinement-induced organization of nanoparticles is utilized to generate new structures with novel optical or magnetic properties. Here, Li et al. show that colloidal liquid crystals formed by rod-like nanoparticles self-assemble into various geometries depending on the degree of spherical confinement in droplets. | | | 26 August 2016 | doi: 10.1038/ncomms12520 | | |
| Prediction of allosteric sites and mediating interactions through bond-to-bond propensities OPEN | | | B. R. C. Amor, M. T. Schaub, S. N. Yaliraki and M. Barahona | | | Allostery is a key molecular mechanism underpinning control and modulation in a variety of cellular processes. Here, the authors present a method that can be used to predict allosteric sites and the mediating interactions that connect them to the active site of the protein. | | | 26 August 2016 | doi: 10.1038/ncomms12477 | | |
| Immune modulation enables a specialist insect to benefit from antibacterial withanolides in its host plant OPEN | | | Andrea Barthel, Heiko Vogel, Yannick Pauchet, Gerhard Pauls, Grit Kunert, Astrid T. Groot, Wilhelm Boland, David G. Heckel and Hanna M. Heidel-Fischer | | | Certain plants in the nightshade family contain withanolides, defensive chemicals known to be harmful to most insect herbivores. Here, Barthel et al. show that a moth species that is a specialist herbivore of these plants benefits from the compounds by gaining increased immunity to a pathogen. | | | 26 August 2016 | doi: 10.1038/ncomms12530 | | |
| Asymmetric cryo-EM reconstruction of phage MS2 reveals genome structure in situ OPEN | | | Roman I Koning, Josue Gomez-Blanco, Inara Akopjana, Javier Vargas, Andris Kazaks, Kaspars Tars, José María Carazo and Abraham J. Koster | | | MS2 is a single-stranded RNA bacteriophage that infects its host via adsorption to bacterial pili. Here the authors visualize the MS2 virion with asymmetric cryo-EM reconstruction, revealing that the genome of MS2 adopts a specific structure of asymmetrically distributed stem-loops connected to the capsid. | | | 26 August 2016 | doi: 10.1038/ncomms12524 | | |
| The tumour suppressor CYLD regulates the p53 DNA damage response OPEN | | | Vanesa Fernández-Majada, Patrick-Simon Welz, Maria A. Ermolaeva, Michael Schell, Alexander Adam, Felix Dietlein, David Komander, Reinhard Büttner, Roman K. Thomas, Björn Schumacher and Manolis Pasparakis | | | CYLD is a deubiquitinase known to act as a tumour suppressor in different models of carcinogenesis. Here, the authors show that CYLD suppresses carcinogen-induced tumorigenesis by deubiquitinating p53 and promoting its stabilization and activation in response to DNA damage. | | | 26 August 2016 | doi: 10.1038/ncomms12508 | | |
| Mapping surface charge density of lipid bilayers by quantitative surface conductivity microscopy OPEN | | | Lasse Hyldgaard Klausen, Thomas Fuhs and Mingdong Dong | | | Surface charges on lipid bilayers deeply influence the way proteins interact with cellular membranes, yet their precise quantification has proven challenging. Here, the authors report on a quantitative method to map and evaluate surface charge densities under physiological conditions. | | | 26 August 2016 | doi: 10.1038/ncomms12447 | | |
| Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit OPEN | | | Francesco Meghini, Torcato Martins, Xavier Tait, Kazuyuki Fujimitsu, Hiroyuki Yamano, David M. Glover and Yuu Kimata | | | The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C activity towards its centrosomal substrate Aurora A. | | | 25 August 2016 | doi: 10.1038/ncomms12607 | | |
| Comparative genomics reveals convergent rates of evolution in ant–plant mutualisms OPEN | | | Benjamin E. R. Rubin and Corrie S. Moreau | | | Mutualisms in which ants protect plants in exchange for food and shelter have arisen independently multiple times. Here, Rubin and Moreau sequence the genomes of three mutualistic ant species and four of their non-mutualistic relatives and show that the transition to mutualism is associated with elevated evolutionary rates across the genome | | | 25 August 2016 | doi: 10.1038/ncomms12679 | | |
| A strategy to discover new organizers identifies a putative heart organizer OPEN | | | Claire Anderson, Mohsin A. F. Khan, Frances Wong, Tatiana Solovieva, Nidia M. M. Oliveira, Richard A. Baldock, Cheryll Tickle, Dave W. Burt and Claudio D. Stern | | | Organizers are regions in the embryo that induce cell fate and impart pattern on neighbouring regions. Here, the authors search for new organizers based on a common gene signature, and show that the Anterior Intestinal Portal endoderm induces cardiac identity, specifies ventricle and inhibits atrial character. | | | 25 August 2016 | doi: 10.1038/ncomms12656 | | |
| Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5 OPEN | | | Yang Duan, Dawei Huo, Jie Gao, Heng Wu, Zheng Ye, Zhe Liu, Kai Zhang, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Xiang Ding, Lei Shi, Yan Wang, Yongfeng Shang and Chenghao Xuan | | | Eg5 has a role in spindle assembly and has been associated with tumorigenesis but it is not clear how its activity is regulated. Here, the authors show that the E3 ligase RNF20/40 regulates mitotic spindle assembly by regulating the stability of Eg5 through mono-ubiquitination of K745. | | | 25 August 2016 | doi: 10.1038/ncomms12648 | | |
| RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation OPEN | | | Kiran Kumar Naidu Guturi, Miyuki Bohgaki, Toshiyuki Bohgaki, Tharan Srikumar, Deborah Ng, Ramya Kumareswaran, Samah El Ghamrasni, Justin Jeon, Parasvi Patel, Mohamed Saad Eldin, Rob Bristow, Peter Cheung, Grant S. Stewart, Brian Raught, Anne Hakem and Razqallah Hakem | | | The E3 ligase RNF168 is essential for the signalling of DNA double strand break and its mutations are associated with the RIDDLE syndrome. Here the authors identify TOP2a as substrate for RNF168 and USP10; providing a link between the RNF168/USP10 axis, TOP2a and the response to anti-cancer drugs that target TOP2. | | | 25 August 2016 | doi: 10.1038/ncomms12638 | | |
| Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility OPEN | | | Ian Linsmeier, Shiladitya Banerjee, Patrick W. Oakes, Wonyeong Jung, Taeyoon Kim and Michael P. Murrell | | | The interaction between myosin motors and F-actin is well described, but the impact of actin organization on contractility is not well described. Here the authors use a 2D biomimetic system and computational modelling to show that contractility of isotropic actomyosin is cooperative, and contraction velocity scales with myosin activation area. | | | 25 August 2016 | doi: 10.1038/ncomms12615 | | |
| Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA OPEN | | | Yi Zhang, Zhen Liang, Yuan Zong, Yanpeng Wang, Jinxing Liu, Kunling Chen, Jin-Long Qiu and Caixia Gao | | | Plant genome editing typically relies upon transgenic intermediates, which is a concern given the current regulatory requirements concerning GMOs. Here, Zhang et al. describe a method to edit wheat genomes by transiently expressing CRISPR/Cas9 DNA or RNA, and are able to generate mutant plants with no detectable transgenes. | | | 25 August 2016 | doi: 10.1038/ncomms12617 | | |
| Shaping polymersomes into predictable morphologies via out-of-equilibrium self-assembly OPEN | | | R. S. M. Rikken, H. Engelkamp, R. J. M. Nolte, J. C. Maan, J. C. M. van Hest, D. A. Wilson and P. C. M. Christianen | | | Polymersomes are used in many applications, ranging from drug delivery to microfluidics, but controlling their shape is difficult. Here, Christianen and co-workers have precisely controlled polymersome shape via an out-of-equilibrium process and fully understood the mechanism of this procedure. | | | 25 August 2016 | doi: 10.1038/ncomms12606 | | |
| A possible four-phase coexistence in a single-component system OPEN | | | Kenji Akahane, John Russo and Hajime Tanaka | | | Gibbs' phase rule states that the maximum number of coexisting phases in a one-component system, and in absence of external fields, is three. Here, the authors show that directly controlling the Hamiltonian allows the extension of this rule to four phases. | | | 25 August 2016 | doi: 10.1038/ncomms12599 | | |
| Universal shape and pressure inside bubbles appearing in van der Waals heterostructures OPEN | | | E. Khestanova, F. Guinea, L. Fumagalli, A. K. Geim and I. V. Grigorieva | | | The interface between vertically stacked 2D materials can host contaminants trapped within bubbles. Here, the authors show that such nano-bubbles can be used as a platform to explore the van der Waals pressure and elasticity in atomically thin films, in a previously inaccessible confined environment. | | | 25 August 2016 | doi: 10.1038/ncomms12587 | | |
| The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner OPEN | | | Bisrat T. Woldemichael, Ali Jawaid, Eloïse A. Kremer, Niharika Gaur, Jacek Krol, Antonin Marchais and Isabelle M. Mansuy | | | Protein phosphatase1 (PP1), a signalling and transcriptional regulator, and epigenetic modulator is known to be a memory suppressor. Here the authors show that memory control by PP1 involves the microRNA cluster miR-183/96/182, and that this cluster is selectively regulated during memory formation in mice. | | | 25 August 2016 | doi: 10.1038/ncomms12594 | | |
| Metal-responsive promoter DNA compaction by the ferric uptake regulator OPEN | | | Davide Roncarati, Simone Pelliciari, Nicola Doniselli, Stefano Maggi, Andrea Vannini, Luca Valzania, Luca Mazzei, Barbara Zambelli, Claudio Rivetti and Alberto Danielli | | | The Fur protein regulates transcription of bacterial genes in response to metal ions. Here, the authors show that the Fur protein from Helicobacter pylori represses transcription by iron-responsive oligomerization and DNA compaction, encasing the transcriptional start site in a macromolecular complex. | | | 25 August 2016 | doi: 10.1038/ncomms12593 | | |
| Intermediate magnetization state and competing orders in Dy2Ti2O7 and Ho2Ti2O7 OPEN | | | R. A. Borzi, F. A. Gómez Albarracín, H. D. Rosales, G. L. Rossini, A. Steppke, D. Prabhakaran, A. P. Mackenzie, D. C. Cabra and S. A. Grigera | | | A classical Hamiltonian captures key properties of spin ice materials such as residual entropy and fractionalized excitations. Here, the authors present experimental results of the polarization transition that motivate a Hamiltonian with lattice distortions, which predicts an intermediate magnetization state and competing ground state orders. | | | 25 August 2016 | doi: 10.1038/ncomms12592 | | |
| Sensory input attenuation allows predictive sexual response in yeast OPEN | | | Alvaro Banderas, Mihaly Koltai, Alexander Anders and Victor Sourjik | | | Cells of the yeast Saccharomyces cerevisiae can mate with other cells of opposite mating type. Here, the authors show that the combination of a pheromone and a pheromone-degrading enzyme allows yeast cells to monitor relative mate abundance within a population and adjust their commitment to sexual reproduction. | | | 25 August 2016 | doi: 10.1038/ncomms12590 | | |
| Emergent nanoscale superparamagnetism at oxide interfaces OPEN | | | Y. Anahory, L. Embon, C. J. Li, S. Banerjee, A. Meltzer, H. R. Naren, A. Yakovenko, J. Cuppens, Y. Myasoedov, M. L. Rappaport, M. E. Huber, K. Michaeli, T. Venkatesan, Ariando and E. Zeldov | | | Interfaces between complex oxides can exhibit diverse emergent phenomena, such as magnetic and superconducting order. Here, the authors evidence the emergence of nanoislands with a thickness dependent transition from superparamagnetic to ferromagnetic behaviour at LaMnO3/SrTiO3 thin film interfaces. | | | 25 August 2016 | doi: 10.1038/ncomms12566 | | |
| Performance of arsenene and antimonene double-gate MOSFETs from first principles OPEN | | | Giovanni Pizzi, Marco Gibertini, Elias Dib, Nicola Marzari, Giuseppe Iannaccone and Gianluca Fiori | | | The family of two-dimensional materials is ever growing, and theoretical calculations are a useful tool to predict the suitability of emerging monolayers for electronic applications. Here, the authors perform accurate simulations of complete field-effect devices based on arsenene and antimonene. | | | 25 August 2016 | doi: 10.1038/ncomms12585 | | |
| Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution OPEN | | | Krishna C Mudumbi, Eric C Schirmer and Weidong Yang | | | Nuclear envelope transmembrane proteins (NETs) can reside in the outer or inner nuclear membrane, but distinguishing which membrane they reside in, and their translocation rate, is technically challenging. Here the authors develop a FRAP-based super-resolution microscopy method to obtain this information for several NETs. | | | 25 August 2016 | doi: 10.1038/ncomms12562 | | |
| Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma OPEN | | | Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh et al. | | | Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2 occur in vemurafenib-induced and sporadic cutaneous squamous cell carcinomas. | | | 25 August 2016 | doi: 10.1038/ncomms12493 | | |
| Long-term time-lapse microscopy of C. elegans post-embryonic development OPEN | | | Nicola Gritti, Simone Kienle, Olga Filina and Jeroen Sebastiaan van Zon | | | Long-term time-lapse imaging of motile developing organisms at the single cell level is challenging. Here the authors culture free-moving C. elegans larvae in hydrogel chambers containing a food source, and use fast image acquisition to follow developmental processes. | | | 25 August 2016 | doi: 10.1038/ncomms12500 | | |
| Microglia contact induces synapse formation in developing somatosensory cortex OPEN | | | Akiko Miyamoto, Hiroaki Wake, Ayako Wendy Ishikawa, Kei Eto, Keisuke Shibata, Hideji Murakoshi, Schuichi Koizumi, Andrew J. Moorhouse, Yumiko Yoshimura and Junichi Nabekura | | | Microglia contribute to shaping neural circuits in the developing brain. Here, the authors show that microglial contact with pyramidal neuron dendrites induces synapse formation in the developing somatosensory cortex, and ablation of microglia reduces synaptic connections from L4 to L2/3 neurons. | | | 25 August 2016 | doi: 10.1038/ncomms12540 | | |
| A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4 OPEN | | | Brian J. Galletta, Carey J. Fagerstrom, Todd A. Schoborg, Tiffany A. McLamarrah, John M. Ryniawec, Daniel W. Buster, Kevin C. Slep, Gregory C. Rogers and Nasser M. Rusan | | | The centrosome is a large intracellular structure that serves as the microtubule-organising center, but how it is accurately assembled is not known. Here the authors generate a ‘domain-level’ centrosome interactome and show that Plk4 positions the essential centriole component Asterless by phosphorylating Cep135. | | | 25 August 2016 | doi: 10.1038/ncomms12476 | | |
| Palladium-catalysed formation of vicinal all-carbon quaternary centres via propargylation OPEN | | | Xin Huang, Shangze Wu, Wangteng Wu, Pengbin Li, Chunling Fu and Shengming Ma | | | Formation of vicinal, quaternary stereocentres is challenging, but such products are commonly encountered in nature. Here, the authors report a palladium catalysed process to form vicinal quaternary carbons via propargylation, including in enantiopure form when optically active starting materials are employed. | | | 25 August 2016 | doi: 10.1038/ncomms12382 | | |
| Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells OPEN | | | Jung-Lin Wu, Hsin-Yi Wu, Dong-Yan Tsai, Ming-Feng Chiang, Yi-Ju Chen, Shijay Gao, Chun-Cheng Lin, Chun-Hung Lin, Kay-Hooi Khoo, Yu-Ju Chen and Kuo-I. Lin | | | B cell receptor (BCR) activation can trigger signalling causing apoptosis in order to eliminate auto-reactive B cells. Here the authors show that the O-GlcNAcylation and phosphorylation of lymphocyte-specific protein-1 are involved in a switch that regulates the initiation of apoptosis induced by BCR cross-linking. | | | 24 August 2016 | doi: 10.1038/ncomms12526 | | |
| A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria OPEN | | | Paul Murima, Michael Zimmermann, Tarun Chopra, Florence Pojer, Giulia Fonti, Matteo Dal Peraro, Sylvie Alonso, Uwe Sauer, Kevin Pethe and John D. McKinney | | | Microbes survive in dynamic environments by modulating their intracellular metabolism. Here, the authors reveal that mycobacteria employ a rheostat-like mechanism to regulate carbon flux between the oxidative TCA cycle and the glyoxylate shunt during glucose-acetate diauxic shift. | | | 24 August 2016 | doi: 10.1038/ncomms12527 | | |
| No complexity–stability relationship in empirical ecosystems OPEN | | | Claire Jacquet, Charlotte Moritz, Lyne Morissette, Pierre Legagneux, François Massol, Philippe Archambault and Dominique Gravel | | | A long-standing ecological hypothesis is that complexity should decrease stability in food webs. Here, Jacquet and colleagues analyse over 100 real-world food webs and show that complexity does not decrease stability, but that a high frequency of weak species interactions stabilizes complex food webs. | | | 24 August 2016 | doi: 10.1038/ncomms12573 | | |
| Hydrogel microphones for stealthy underwater listening OPEN | | | Yang Gao, Jingfeng Song, Shumin Li, Christian Elowsky, You Zhou, Stephen Ducharme, Yong Mei Chen, Qin Zhou and Li Tan | | | Conventional ceramic SONAR suffers from large acoustic impedance mismatch with water, rendering them easily detectable. Here, Gao et al. report a new design using a hydrogel filled with stimuli-responsive metal nanoparticles, which detects low-frequency sound with a high-sensitivity and zero-reflection. | | | 24 August 2016 | doi: 10.1038/ncomms12316 | | |
| Stability and complexity in model meta-ecosystems OPEN | | | Dominique Gravel, François Massol and Mathew A. Leibold | | | The mechanisms allowing highly biodiverse ecosystems to remain stable are poorly understood. Here, Gravel and colleagues provide theoretical evidence that dispersal of organisms and material modifies species interactions and thus enables highly biodiverse communities to exist. | | | 24 August 2016 | doi: 10.1038/ncomms12457 | | |
| Electrolysis of a molten semiconductor OPEN | | | Huayi Yin, Brice Chung and Donald R. Sadoway | | | Conventional metal extraction processes rely on energy intensive pyro- or hydrometallurgical methods which generate pollutants. Here, the authors reveal a high-throughput electro-desulfurization process to convert molten stibnite to pure antimony in a single step, reducing emissions and energy consumption. | | | 24 August 2016 | doi: 10.1038/ncomms12584 | | |
| Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis OPEN | | | Seshiru Nakazawa, Daisuke Oikawa, Ryohei Ishii, Takashi Ayaki, Hirotaka Takahashi, Hiroyuki Takeda, Ryuichiro Ishitani, Kiyoko Kamei, Izumi Takeyoshi, Hideshi Kawakami, Kazuhiro Iwai, Izuho Hatada, Tatsuya Sawasaki, Hidefumi Ito, Osamu Nureki and Fuminori Tokunaga | | | Mutations in optineurin are associated with neurodegenerative diseases, including amyotrophic lateral sclerosis. Here, the authors report the structure of the ubiquitin binding domain of optineurin, which binds linear ubiquitin with homology to NEMO, and explore the function of this domain. | | | 24 August 2016 | doi: 10.1038/ncomms12547 | | |
| Variation in helper effort among cooperatively breeding bird species is consistent with Hamilton’s Rule OPEN | | | Jonathan P. Green, Robert P. Freckleton and Ben J. Hatchwell | | | Non-parental helpers contribute to offspring care in many species; however, the amount of care provided varies considerably across species. Here, Green et al. perform a phylogenetic comparative analysis of helping behavior in 36 cooperatively-breeding bird species and find that helper effort increases with relatedness to the recipient of care. | | | 24 August 2016 | doi: 10.1038/ncomms12663 | | |
| Crystal structure and functional characterization of a light-driven chloride pump having an NTQ motif OPEN | | | Kuglae Kim, Soon-Kyeong Kwon, Sung-Hoon Jun, Jeong Seok Cha, Hoyoung Kim, Weontae Lee, Jihyun F. Kim and Hyun-Soo Cho | | | The atypical rhodopsin ClR from flavobacterium Nonlabens marinus is a light-driven chloride-pumping protein. Here, the authors show that ClR crystal structure presents two chloride ion-binding sites, proposing a molecular pathway for ion transport by this light-driven pump. | | | 24 August 2016 | doi: 10.1038/ncomms12677 | | |
| Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation OPEN | | | Franck Martin, Jean-François Ménétret, Angelita Simonetti, Alexander G. Myasnikov, Quentin Vicens, Lydia Prongidi-Fix, S. Kundhavai Natchiar, Bruno P. Klaholz and Gilbert Eriani | | | Prokaryotic translation initiation involves mRNA-ribosomal RNA base pairing interactions. Here, the authors provide evidence for a similar base pairing interactions occurring between the human h4 mRNA and helix 16 of the small subunit rRNA to position the correct AUG codon in the decoding site. | | | 24 August 2016 | doi: 10.1038/ncomms12622 | | |
| Graft-infiltrating host dendritic cells play a key role in organ transplant rejection OPEN | | | Quan Zhuang, Quan Liu, Sherrie J. Divito, Qiang Zeng, Karim M. Yatim, Andrew D. Hughes, Darling M. Rojas-Canales, A. Nakao, William J. Shufesky, Amanda L. Williams, Rishab Humar, Rosemary A. Hoffman, Warren D. Shlomchik, Martin H. Oberbarnscheidt, Fadi G. Lakkis and Adrian E. Morelli | | | Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes. | | | 24 August 2016 | doi: 10.1038/ncomms12623 | | |
| Anisotropic etching of platinum electrodes at the onset of cathodic corrosion OPEN | | | Thomas J. P. Hersbach, Alexei I. Yanson and Marc T. M. Koper | | | The corrosion mechanism of metals at cathodic potentials is still poorly understood. Here the authors report the cathodic corrosion onset potential of platinum in concentrated sodium hydroxide, showing etching anisotropy, and present a framework to determine such characteristics for other metals/solutions. | | | 24 August 2016 | doi: 10.1038/ncomms12653 | | |
| Assembled molecular face-rotating polyhedra to transfer chirality from two to three dimensions OPEN | | | Xinchang Wang, Yu Wang, Huayan Yang, Hongxun Fang, Ruixue Chen, Yibin Sun, Nanfeng Zheng, Kai Tan, Xin Lu, Zhongqun Tian and Xiaoyu Cao | | | Protein subunits on the capsids of icosahedral viruses can form patterns with rotational symmetry, which are difficult to recreate in the laboratory. Here the authors report a strategy to construct 3D chiral polyhedra with rotational faces from 2D chiral truxene-based units through dynamic covalent chemistry. | | | 24 August 2016 | doi: 10.1038/ncomms12469 | | |
| Spontaneous perception of numerosity in humans OPEN | | | Guido Marco Cicchini, Giovanni Anobile and David C. Burr | | | Humans as well as many other species have the ability to perceive the number of items, numerosity, but the mechanism by which this is achieved is unclear. Here the authors provide strong evidence in support of a spontaneous perception of numerosity without reliance on density and area estimation. | | | 24 August 2016 | doi: 10.1038/ncomms12536 | | |
| The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis OPEN | | | Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger and Andreas Wack | | | Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands. | | | 24 August 2016 | doi: 10.1038/ncomms12652 | | |
| Stratification and therapeutic potential of PML in metastatic breast cancer OPEN | | | Natalia Martín-Martín, Marco Piva, Jelena Urosevic, Paula Aldaz, James D. Sutherland, Sonia Fernández-Ruiz, Leire Arreal, Verónica Torrano, Ana R. Cortazar, Evarist Planet, Marc Guiu, Nina Radosevic-Robin, Stephane Garcia, Iratxe Macías, Fernando Salvador, Giacomo Domenici, Oscar M. Rueda, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Patricia Zúñiga-García et al. | | | Targeting PML in acute promyelocytic leukaemia has changed the outcome of patients with this disease. Here, the authors demonstrated that PML is also a potential therapeutic target in breast cancer where it specifically regulates cancer initiating cells and tumour progression through the transcriptional regulation of SOX9. | | | 24 August 2016 | doi: 10.1038/ncomms12595 | | |
| Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals OPEN | | | Qian Zhao, Jiqin Zhang, Ruoyu Chen, Lina Wang, Bo Li, Hao Cheng, Xiaoya Duan, Haijun Zhu, Wei Wei, Jiwen Li, Qihan Wu, Jing-Dong J. Han, Wenqiang Yu, Shaorong Gao, Guohong Li and Jiemin Wong | | | There is crosstalk between the maintenance of DNA methylation and histone methylation. Here, the authors create an Uhrf1 knockin mouse model that abolishes the H3K9me2/3-binding activity of Uhrf1, and show that DNA maintenance methylation in mammals is largely independent of H3K9 methylation. | | | 24 August 2016 | doi: 10.1038/ncomms12464 | | | | | | | | | | | | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
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