Nature Cell Biology contents: September 2016 Volume 18 Number 9, pp 911 - 1024

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Advertisement Cell culture work, which includes seeding, cultivation, and analysis, holds a special place in the daily laboratory routine. Whenever cells are affected, experimental conditions are as different as the cells themselves. Check your expertise in cell handling and get some tips and tricks from the Eppendorf cell handling experts. Click here   TABLE OF CONTENTS September 2016 Volume 18, Issue 9 News and Views Articles Letter Advertisement   Free Naturejobs Career Expo London Registration is now open for the free Naturejobs Career Expo London on September 16, 2016. Be sure to attend this special 10 year anniversary of the London science career fair for your chance to meet employers face-to-face, attend all conferences and workshops, take part in our photo booth fun, win amazing prizes and so much more! Register Free today! Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement nature.com webcasts Nature Protocols presents an editorial webcast on: Practically implementing Förster resonance energy transfer (FRET). Tuesday 27th September 2016 9AM PDT, 12PM EDT, 5PM BST, 6PM CEST Join us to learn more about how to practically implement FRET techniques. Register free online: Produced with support from:  Olympus Corporation of the Americas Scientific Solutions Group     Advertisement nature.com webcasts Springer Nature presents a custom webcast on: FFPE Tissue and the HTG EdgeSeq Oncology Biomarker Panel: a Low-Input, Extraction-Free Gene Expression Pilot Study Date: Tuesday September 20, 2016 Time: 9AM PDT, 12PM EDT, 5PM BST, 6PM CEST Register for the webcast and live Q&A session Sponsored by: HTG Molecular Diagnostics     Advertisement Open for Submissions  npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.  Explore the benefits of submitting your manuscript >>   News and Views Top Melanosomes foster a tumour niche by activating CAFs   pp911 - 913 Susana García-Silva and Héctor Peinado doi:10.1038/ncb3404 Extracellular vesicles, such as exosomes, are important effectors in the formation of tumour-fostering niches. Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of miR-211. See also: Article by Dror et al. The persistent dynamic secrets of senescence   pp913 - 915 Clemens A. Schmitt doi:10.1038/ncb3403 While the beneficial versus detrimental implications of the senescence-associated secretome remain an issue of debate, time-resolved analyses of its composition, regulatory mechanisms and functional consequences have been largely missing. The dynamic activity of NOTCH is now shown to direct two distinct senescence phenotypes, by first promoting a pro-senescent TGF-β1-dependent secretome, followed by a second wave of pro-inflammatory, senescence-clearing cytokines. See also: Article by Hoare et al. Cell Biology JOBS of the week Tenure-Track Faculty Position (Open Rank) in Cell and Molecular Biology Dartmouth College Postdoctoral Fellow in Cell Biology and Medicine Washington University School of Medicine Assistant Professor in Developmental and Cell Biology Princeton University Postdoctoral Fellow; Developmental and Stem Cell Biology The Hospital for Sick Children, Research Institute Assistant Professor - Cryo-Electron Microscopy - Department of Molecular and Cell Biology University of California, Berkeley More Science jobs from Cell Biology EVENT From Metchnikoff to Systems Biology: The Role of Inflammation and Phagocytic Cells in Cancer 29.09.16 Maryland, USA More science events from Advertisement nature.com webcasts Nature Publishing Group presents a custom webcast on: Releasable purification of monocytes for human dendritic cell generation  Watch on-demand today Sponsored by: Quad Technologies   Articles Top Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation   pp917 - 929 Yi Tang, Tamar Feinberg, Evan T. Keller, Xiao-Yan Li and Stephen J. Weiss doi:10.1038/ncb3394 Weiss and colleagues report that the EMT transcription factors Snail and Slug control skeletal stem cell self-renewal and differentiation by forming transcriptional complexes with the co-activators YAP and TAZ. Sex hormones establish a reserve pool of adult muscle stem cells   pp930 - 940 Ji-Hoon Kim, Gi-Chan Han, Ji-Yun Seo, Inkuk Park, Wookjin Park et al. doi:10.1038/ncb3401 Kim et al. demonstrate that sex hormones induce Mib1 expression in myofibres during puberty, initiating the conversion of cycling juvenile satellite cells into adult quiescent satellite cells. Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation   pp941 - 953 Zhiqi Sun, Hui-Yuan Tseng, Steven Tan, Fabrice Senger, Laetitia Kurzawa et al. doi:10.1038/ncb3402 At sites of cell adhesion to the matrix, integrins are coupled to the actin cytoskeleton through proteins such as talin. Sun et al. now identify Kank2 as an activator of talin that reduces force transmission across focal adhesions. Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22   pp954 - 966 Aidong Zhou, Kangyu Lin, Sicong Zhang, Yaohui Chen, Nu Zhang et al. doi:10.1038/ncb3396 Zhou et al. show that GSK3β phosphorylates KDM1A and induces its deubiquitylation by USP22, leading to demethylation of histone H3K4 and glioblastoma progression. A single dividing cell population with imbalanced fate drives oesophageal tumour growth   pp967 - 978 Julia Frede, Philip Greulich, Tibor Nagy, Benjamin D. Simons and Philip H. Jones doi:10.1038/ncb3400 Frede et al. use a chemical carcinogenesis model and lineage tracing to show that oesophageal tumour growth is driven by a single proliferating cancer cell population, suggesting the absence of a hierarchy of proliferating cells in this cancer type. NOTCH1 mediates a switch between two distinct secretomes during senescence   pp979 - 992 Matthew Hoare, Yoko Ito, Tae-Won Kang, Michael P. Weekes, Nicholas J. Matheson et al. doi:10.1038/ncb3397 Hoare et al. find that NOTCH1 regulates the switch between two distinct senescence-associated secretomes—the TGF-β pathway and pro-inflammatory cytokines—and that its inhibition promotes clearance of oncogene-induced senescent liver cells. See also: News and Views by Schmitt G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway   pp993 - 1005 Shih-Ting Cha, Ching-Ting Tan, Cheng-Chi Chang, Chia-Yu Chu, Wei-Jiunn Lee et al. doi:10.1038/ncb3395 Cha et al. report that the G9a/RelB axis represses Let-7b through DNMT3A, and sustains K-RAS and β-catenin signalling, thereby controlling the maintenance and function of colorectal-cancer-initiating cells. Melanoma miRNA trafficking controls tumour primary niche formation   pp1006 - 1017 Shani Dror, Laureen Sander, Hila Schwartz, Danna Sheinboim, Aviv Barzilai et al. doi:10.1038/ncb3399 Dror et al. report that melanoma-derived melanosomes carry miRNAs that induce primary fibroblast reprogramming into cancer-associated fibroblasts, and also induce the formation of a pro-tumorigenic niche. See also: News and Views by García-Silva & Peinado Advertisement Experimental & Molecular Medicine is an open access journal to communicate experimental and translational research performed using molecular tools. Submit your manuscript.   Letter Top The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition   pp1018 - 1024 Vladislav Belyy, Max A. Schlager, Helen Foster, Armando E. Reimer, Andrew P. Carter et al. doi:10.1038/ncb3393 It has been unclear how the relatively weak dynein motor can counterbalance kinesin forces during microtubule-dependent transport. Belyy et al. find that binding of dynactin and BICD2 increases the strength of the dynein motor. Top Advertisement An online-only, open access journal publishing high-quality research on ways to help the human body repair, replace and regenerate damaged tissues and organs. Read the latest featured article:  An acellular biologic scaffold treatment for volumetric muscle loss: results of a 13-patient cohort study    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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