The EDGE

Inside the USCAP Journals

2016 96: 934-935; 10.1038/labinvest.2016.92

Mini Review

A survey of changing trends in modelling radiation lung injury in mice: bringing out the good, the bad, and the uncertain

An extensive review of the literature that deals with the utilization of mouse models of radiation-induced pulmonary injury and how the treatments and effects compare with radiation exposure to the human lung reveals that diverse responses among different mouse strains are found. The most clinically relevant models have been identified and summarized to aid in future research.

Mohamad B Dabjan, Carolyn MS Buck, Isabel L Jackson, Zeljko Vujaskovic, Brian Marples and Julian D Down

2016 96: 936-949; advance online publication, August 1, 2016; 10.1038/labinvest.2016.76

Reaearch Articles

GENITOURINARY AND REPRODUCTIVE SYSTEMS

Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway

This study shows that expression of both isoforms of Musashi-2 (Msi2) are elevated in bladder cancer cells and tissues, and that Msi2 promotes bladder cancer cell migration and invasion via the JAK2/STAT3 pathway. Moreover, Msi2 expression correlates with clinical features and prognosis of bladder cancer patients. Thus, Msi2 may play a fundamental role in the development of bladder cancer.

Chenlu Yang, Weijing Zhang, Longwang Wang, Gallina Kazobinka, Xiaomin Han, Bin Li and Teng Hou

2016 96: 950-958; advance online publication, June 20, 2016; 10.1038/labinvest.2016.71

Functional expression of aryl hydrocarbon receptor on mast cells populating human endometriotic tissues

The authors found a population of aryl hydrocarbon receptor (AhR)-expressing mast cells that are both interleukin (IL)-17 and IL-10-positive in endometriotic tissues and also rich in tryptophan-metabolizing enzymes as well as the AhR-ligand kynurenine. Endometriotic tissue was susceptible to treatment with an AhR antagonist, and endometrial stromal cell growth was improved by soluble factors released by mast cells upon AhR activation.

Laura Mariuzzi, Rossana Domenis, Maria Orsaria, Stefania Marzinotto, Ambrogio P Londero, Michela Bulfoni, Veronica Candotti, Andrea Zanello, Maurizio Ballico, Maria C Mimmi, Angelo Calcagno, Diego Marchesoni, Carla Di Loreto, Antonio P Beltrami, Daniela Cesselli and Giorgia Gri

2016 96: 959-971; advance online publication, June 27, 2016; 10.1038/labinvest.2016.74

HEPATIC AND PANCREATIC SYSTEMS

Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation

The implication of Notch signaling in lipid and glucose metabolism is unclear. The authors show that Notch1 depletion impairs glucose-6-phosphatase and perilipin-5 expression and is associated with diabetic phenotype and hepatic steatosis. These results confirm the metabolic role of Notch1 and suggest Notch1 as a new player in the physiopathology of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease.

Christine Bernsmeier, Michael T Dill, Angela Provenzano, Zuzanna Makowska, Ilona Krol, Giovanna Muscogiuri, David Semela, Luigi Tornillo, Fabio Marra, Markus H Heim and François H T Duong

2016 96: 972-980; advance online publication, July 18, 2016; 10.1038/labinvest.2016.75

HEAD AND NECK

Denervation of nasal mucosa induced by posterior nasal neurectomy suppresses nasal secretion, not hypersensitivity, in an allergic rhinitis rat model

In this study, the authors developed a rat model of posterior nasal neurectomy, which is characterized by the depletion of nerve fibers, choline acetyltransferase, and neuropeptides in the nasal respiratory mucosa. Denervation of the nasal mucosa induced by posterior nasal neurectomy suppresses nasal secretion, not hypersensitivity, in an allergic rhinitis model.

Hironobu Nishijima, Kenji Kondo, Makiko Toma-Hirano, Shinichi Iwasaki, Shu Kikuta, Chisato Fujimoto, Rumi Ueha, Ryoji Kagoya and Tatsuya Yamasoba

2016 96: 981-993; advance online publication, June 20, 2016; 10.1038/labinvest.2016.72

Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment

The authors investigated phagocytic potential of tumor-associated macrophages (TAM) subsets in relation to CD47 expression, the “don't eat me” signal, in oral squamous cell carcinoma (OSCC). Engulfment by immunostimulatory macrophages, but not immunoregulatory macrophages, increase in a CD47-dependent manner. CD47 expression and TAM are associated with shorter survivals by immunohistochemical analysis.

Koichi Sakakura, Hideyuki Takahashi, Kyoichi Kaira, Minoru Toyoda, Takaaki Murata, Hiroshi Ohnishi, Tetsunari Oyama and Kazuaki Chikamatsu

2016 96: 994-1003; advance online publication, June 20, 2016; 10.1038/labinvest.2016.70

ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS

Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI

Metastasis underlies non-small cell lung cancer (NSCLC) cancer morbidity and accounts for disease progression. In the current study, the authors demonstrate that inhibition of eIF4E/eIF4GI translation initiation factors reduce migration and epithelial to mesenchymal transition, both essential for metastasis. These findings highlight the potential of translation initiation targeting in NSCLC therapy.

Oshrat Attar-Schneider, Liat Drucker and Maya Gottfried

2016 96: 1004-1015; advance online publication, August 8, 2016; 10.1038/labinvest.2016.77

MODELS AND TECHNIQUES

Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement

This manuscript compares three different methods of estrogen receptor detection and assessment on two retrospective cohorts of breast cancer cases. The advantages and disadvantages of conventional 3,3′-diaminobenzidine-based immunohistochemistry with two different reading methods and of quantitative immunofluorescence are illustrated. Quantitative immunofluorescence offers better sensitivity and reproducibility than conventional immunohistochemistry.

Elizabeth R Zarrella, Madeline Coulter, Allison W Welsh, Daniel E Carvajal, Kurt A Schalper, Malini Harigopal, David L Rimm and Veronique M Neumeister

2016 96: 1016-1025; advance online publication, June 27, 2016; 10.1038/labinvest.2016.73

Letters to the Editor

Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells

Lykke Sylow

2016 96: 1026; 10.1038/labinvest.2016.58

Response to: Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells

Ta-Chun Yuan

2016 96: 1027; 10.1038/labinvest.2016.81

Neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson’s disease

Andrew R Cook, Philip A Botham, Charles B Breckenridge, Daniel J Minnema, Nicholas C Sturgess and Kim Z Travis

2016 96: 1028-1029; 10.1038/labinvest.2016.80

Response to: Neurotoxicity of paraquat and paraquat-induced Parkinson's disease

Mark D Thompson and Xiao feng Zhang

2016 96: 1030-1034; 10.1038/labinvest.2016.83

Corrigendum

Hypoxia-stimulated cardiac fibroblast production of IL-6 promotes myocardial fibrosis via the TGF-β1 signaling pathway

Jia-Hong Wang, Lan Zhao, Xin Pan, Nan-Nan Chen, Jian Chen, Qun-Lin Gong, Feng Su, Jian Yan, Yan Zhang and Shao-Heng Zhang

2016 96: 1035; 10.1038/labinvest.2016.84