Nature Structural & Molecular Biology Contents: 2016 Volume #23 pp 619-697

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TABLE OF CONTENTS July 2016 Volume 23, Issue 7 News and Views Perspective Articles Resource Technical Report Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Experimental & Molecular Medicine is an open access journal to communicate experimental and translational research performed using molecular tools. Submit your manuscript.   News and Views Top Botulinum neurotoxin A1 likes it double sweet   pp619 - 621 Cesare Montecucco and Giuseppe Zanotti doi:10.1038/nsmb.3253 The pathogenesis of the nerve paralysis induced by botulinum neurotoxins begins with their specific and high-affinity binding to peripheral nerve terminals. The new crystal structure of the toxin bound to its glycosylated receptor, presented in this issue, represents a major step forward in the understanding of how botulinum neurotoxin type A1, the toxin used in human therapy and cosmetics, binds its protein receptor. See also: Article by Yao et al. Molecular chaperones: providing a safe place to weather a midlife protein-folding crisis   pp621 - 623 Patricia L Clark and Adrian H Elcock doi:10.1038/nsmb.3255 Contrary to conventional wisdom that molecular chaperones rely on hydrophobic interactions to bind a wide variety of client proteins in danger of misfolding, three recent studies reveal that the ATP-independent chaperone Spy exploits electrostatic interactions to bind its clients quickly, yet loosely enough to enable folding of the client while it is chaperone bound. See also: Technical Report by Horowitz et al. New DUBs on the block   p623 Inês Chen doi:10.1038/nsmb.3261 Structural & Molecular Biology JOBS of the week Postdoctoral Research Scientist Cancer Research UK Beatson Institute in Glasgow Postdoctoral Fellow The Scripps Research Institute (TSRI) 10 Postdoctoral Fellowships in Cancer Research Helmholtz Association More Science jobs from Perspective Top Toward the atomic structure of the nuclear pore complex: when top down meets bottom up   pp624 - 630 André Hoelz, Joseph S Glavy and Martin Beck doi:10.1038/nsmb.3244 This Perspective discusses how two complementary approaches, bottom-up in vitro and top-down in situ structural biology, have now converged to generate the first predictive structural models of the nuclear pore scaffold. Articles Top lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal   pp631 - 639 Pingping Zhu, Yanying Wang, Guanling Huang, Buqing Ye, Benyu Liu et al. doi:10.1038/nsmb.3235 The lncRNA lnc-β-Catm associates with β-catenin and the methyltransferase Ezh2, thereby promoting β-catenin methylation and stabilization, which in turn lead to activation of Wnt-β-catenin signaling and promote liver CSCs self-renewal. Direct observation of DNA threading in flap endonuclease complexes   pp640 - 646 Faizah A AlMalki, Claudia S Flemming, Jing Zhang, Min Feng, Svetlana E Sedelnikova et al. doi:10.1038/nsmb.3241 A new 'metal mimic' mutagenesis approach that captures a T5 flap endonuclease complex with an intact DNA substrate provides structural evidence that the single-stranded 5′ flap generated by Okazaki-fragment synthesis threads through the flap endonuclease enzyme. Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection   pp647 - 655 Ruth M Densham, Alexander J Garvin, Helen R Stone, Joanna Strachan, Robert A Baldock et al. doi:10.1038/nsmb.3236 The E3 ubiquitin ligase activity of the BRCA1-BARD1 complex is required to reposition 53BP1 on damaged chromatin and to promote DNA resection and repair via homologous recombination, in a mechanism involving the chromatin remodeler SMARCAD1. N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A   pp656 - 662 Guorui Yao, Sicai Zhang, Stefan Mahrhold, Kwok-ho Lam, Daniel Stern et al. doi:10.1038/nsmb.3245 BoNT/A1 invades motoneurons by binding to the neuronal receptor SV2. A combination of structural, biophysical and cellular analyses reveal that BoNT/A1 binding and uptake require glycosylation of SV2. See also: News and Views by Montecucco & Zanotti The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression   pp663 - 672 Xavier Rambout, Cecile Detiffe, Jonathan Bruyr, Emeline Mariavelle, Majid Cherkaoui et al. doi:10.1038/nsmb.3243 The canonical transcription factor ERG promotes degradation of a subset of mRNAs linked to mitotic progression by recruiting the CCR4-NOT deadenylation complex, thus revealing a new regulatory interplay between mRNA synthesis and degradation. Functional interdependence of BRD4 and DOT1L in MLL leukemia   pp673 - 681 Omer Gilan, Enid Y N Lam, Isabelle Becher, Dave Lugo, Ester Cannizzaro et al. doi:10.1038/nsmb.3249 The histone methyltransferase DOT1L and the chromatin reader BRD4 together facilitate transcription of genes critical to the molecular pathogenesis of MLL leukemia. Resource Top The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation   pp682 - 690 Susan L Kloet, Matthew M Makowski, H Irem Baymaz, Lisa van Voorthuijsen, Ino D Karemaker et al. doi:10.1038/nsmb.3248 Proteomic and genomic analysis of Polycomb group complexes in embryonic stem cells and neural progenitor cells identifies new PRC1 and PRC2 interaction partners and targets during neural lineage commitment. Technical Report Top Visualizing chaperone-assisted protein folding   pp691 - 697 Scott Horowitz, Loic Salmon, Philipp Koldewey, Logan S Ahlstrom, Raoul Martin et al. doi:10.1038/nsmb.3237 READ is a new crystallographic approach to visualize conformational ensembles of heterogeneous and dynamic molecules. READ is applied here to structurally characterize the various folding states of client Im7 bound to chaperone Spy. See also: News and Views by Clark & Elcock Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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