Scientific Reports Biology Table of Contents e-alert: 7 June 2016

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07 June 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports       Biological Sciences               The alterations in the extracellular matrix composition guide the repair of damaged liver tissue ▶     Mariliis Klaas, Triin Kangur, Janeli Viil et al.     While the cellular mechanisms of liver regeneration have been thoroughly studied, the role of extracellular matrix (ECM) in liver regeneration is still poorly understood. We …             Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy ▶     Kaikai Wang, Yifan Zhang, Juan Wang et al.     Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two …             Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domains ▶     Zhenyong Wu, Sarah M. Auclair, Oscar Bello et al.     The initial, nanometer-sized connection between the plasma membrane and a hormone- or neurotransmitter-filled vesicle –the fusion pore– can flicker open and closed repeatedly …             Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development ▶     Manish Kumar, Nicole J. Camlin, Janet E. Holt et al.     All the major components of the WNT signalling pathway are expressed in female germ cells and embryos. However, their functional relevance in oocyte biology is currently unclear. …             MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment ▶     Si-Hyung Lee, Mi-Sun Lee, Tae-Ik Choi et al.     MCRS1 is involved in multiple cellular activities, including mitotic spindle assembly, mTOR signaling and tumorigenesis. Although MCRS1 has been reported to bind to the dynein …             Social apoptosis in honey bee superorganisms ▶     Paul Page, Zheguang Lin, Ninat Buawangpong et al.     Eusocial insect colonies form superorganisms, in which nestmates cooperate and use social immunity to combat parasites. However, social immunity may fail in case of emerging …             Identification of differentially expressed genes from multipotent epithelia at the onset of an asexual development ▶     Lorenzo Ricci, Ankita Chaurasia, Pascal Lapébie et al.     Organisms that have evolved alternative modes of reproduction, complementary to the sexual mode, are found across metazoans. The chordate Botryllus schlosseri is an emerging …             A sacrificial millipede altruistically protects its swarm using a drone blood enzyme, mandelonitrile oxidase ▶     Yuko Ishida, Yasumasa Kuwahara, Mohammad Dadashipour et al.     Soldiers of some eusocial insects exhibit an altruistic self-destructive defense behavior in emergency situations when attacked by large enemies. The swarm-forming invasive …             Identification and characterization of DcUCGalT1, a galactosyltransferase responsible for anthocyanin galactosylation in purple carrot (Daucus carota L.) taproots ▶     Zhi-Sheng Xu, Jing Ma, Feng Wang et al.     Purple carrots (Daucus carota ssp. sativus var. atrorubens Alef.) accumulate large amounts of cyanidin-based anthocyanins in their taproots. Cyanidin can be glycosylated with …             New Highly Oxygenated Germacranolides from Carpesium divaricatum and their Cytotoxic Activity ▶     Tao Zhang, Jin-Guang Si, Qiu-Bo Zhang et al.     Eight highly oxygenated germacranolides (1–8) including four new ones (2–5) were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative …             Nucleosomes determine their own patch size in base excision repair ▶     Rithy Meas, Michael J. Smerdon     Base excision repair (BER) processes non-helix distorting lesions (e.g., uracils and gaps) and is composed of two subpathways that differ in the number of nucleotides (nts) …             Identification of potent maturation inhibitors against HIV-1 clade C ▶     Uddhav Timilsina, Dibya Ghimire, Bivek Timalsina et al.     Antiretroviral therapy has led to a profound improvement in the clinical care of HIV-infected patients. However, drug tolerability and the evolution of drug resistance have …             Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission ▶     Kentaro Tokudome, Takahiro Okumura, Saki Shimizu et al.     Synaptic vesicle glycoprotein 2A (SV2A) is a prototype synaptic vesicle protein regulating action potential-dependent neurotransmitters release. SV2A also serves as a specific …             Clear-cut observation of clearance of sustainable upconverting nanoparticles from lymphatic system of small living mice ▶     Hye Sun Park, Sang Hwan Nam, Jongwoo Kim et al.     The significance of lymphatic system has gathered great attention for immunotechnology related to cancer metastasis and immunotherapy. To develop innovative immunodiagnostics and …             Triggering through NOD-2 Differentiates Bone Marrow Precursors to Dendritic Cells with Potent Bactericidal activity ▶     Nargis Khan, Mohammad Aqdas, Aurobind Vidyarthi et al.     Dendritic cells (DCs) play a crucial role in bridging innate and adaptive immunity by activating naïve T cells. The role of pattern recognition receptors like Toll-Like Receptors …             Synthetic long non-coding RNAs [SINEUPs] rescue defective gene expression in vivo ▶     Alessia Indrieri, Claudia Grimaldi, Silvia Zucchelli et al.     Non-coding RNAs provide additional regulatory layers to gene expression as well as the potential to being exploited as therapeutic tools. Non-coding RNA-based therapeutic …             Photoelectrochemical Immunosensor for Detection of Carcinoembryonic Antigen Based on 2D TiO2 Nanosheets and Carboxylated Graphitic Carbon Nitride ▶     Huan Wang, Yaoguang Wang, Yong Zhang et al.     Carcinoembryonic antigen (CEA) was used as the model, an ultrasensitive label-free photoelectrochemical immunosensor was developed using 2D TiO2 nanosheets and carboxylated …             Spirochaetes dominate the microbial community associated with the red coral Corallium rubrum on a broad geographic scale ▶     Jeroen A. J. M. van de Water, Rémy Melkonian, Howard Junca et al.     Mass mortality events in populations of the iconic red coral Corallium rubrum have been related to seawater temperature anomalies that may have triggered microbial disease …             Impaired interhemispheric synchrony in Parkinson’s disease with depression ▶     Yajing Zhu, Xiaopeng Song, Mingze Xu et al.     The alterations of interhemispheric resting-state functional connectivity (FC) in Parkinson’s disease (PD) with depression remain unclear, so we aimed to explore the differences …             Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice ▶     Aleix Sala-Vila, Inmaculada Navarro-Lérida, Miguel Sánchez-Alvarez et al.     The mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been …             Perceptual Modalities Guiding Bat Flight in a Native Habitat ▶     Zhaodan Kong, Nathan Fuller, Shuai Wang et al.     Flying animals accomplish high-speed navigation through fields of obstacles using a suite of sensory modalities that blend spatial memory with input from vision, tactile sensing, …             Induction of Germ Cell-like Cells from Porcine Induced Pluripotent Stem Cells ▶     Hanning Wang, Jinzhu Xiang, Wei Zhang et al.     The ability to generate germ cells from pluripotent stem cells (PSCs) is valuable for human regenerative medicine and animal breeding. Germ cell-like cells (GCLCs) have been …             IRESPred: Web Server for Prediction of Cellular and Viral Internal Ribosome Entry Site (IRES) ▶     Pandurang Kolekar, Abhijeet Pataskar, Urmila Kulkarni-Kale et al.     Cellular mRNAs are predominantly translated in a cap-dependent manner. However, some viral and a subset of cellular mRNAs initiate their translation in a cap-independent manner. …             Silica ecosystem for synergistic biotransformation ▶     Baris R. Mutlu, Jonathan K. Sakkos, Sujin Yeom et al.     Synergistical bacterial species can perform more varied and complex transformations of chemical substances than either species alone, but this is rarely used commercially because …             Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death ▶     Kai Wang, Chao Zhang, Jiaolin Bao et al.     Curcumin (CUR) and berberine (BBR) are renowned natural compounds that exhibit potent anticancer activities through distinct molecular mechanisms. However, the anticancer …             A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum ▶     Lichang Wu, Yu Sun, Liqiao Ma et al.     The Bestrophin family has been characterized as Cl− channels in mammals and Na+ channels in bacteria, but their exact physiological roles remian unknown. In this study, a natural …             An Automated High-throughput Array Microscope for Cancer Cell Mechanics ▶     Jeremy A. Cribb, Lukas D. Osborne, Kellie Beicker et al.     Changes in cellular mechanical properties correlate with the progression of metastatic cancer along the epithelial-to-mesenchymal transition (EMT). Few high-throughput …             Chalcone-based Selective Inhibitors of a C4 Plant Key Enzyme as Novel Potential Herbicides ▶     G. T. T. Nguyen, G. Erlenkamp, O. Jäck et al.     Weeds are a challenge for global food production due to their rapidly evolving resistance against herbicides. We have identified chalcones as selective inhibitors of …             Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα ▶     Lina Wunderle, Julia D. Knopf, Nathalie Kühnle et al.     Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little is known about their …             Lethal exposure: An integrated approach to pathogen transmission via environmental reservoirs ▶     Wendy C. Turner, Kyrre L. Kausrud, Wolfgang Beyer et al.     To mitigate the effects of zoonotic diseases on human and animal populations, it is critical to understand what factors alter transmission dynamics. Here we assess the risk of …             Imaging cellular structures in super-resolution with SIM, STED and Localisation Microscopy: A practical comparison ▶     Eva Wegel, Antonia Göhler, B. Christoffer Lagerholm et al.     Many biological questions require fluorescence microscopy with a resolution beyond the diffraction limit of light. Super-resolution methods such as Structured Illumination …             Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability ▶     Sabine Eva Dudek, Katja Nitzsche, Stephan Ludwig et al.     Infection with influenza A viruses (IAV) provokes activation of cellular defence mechanisms contributing to the innate immune and inflammatory response. In this process the …             Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease ▶     Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou et al.     Stem cell-based therapy is a potential treatment for neurodegenerative diseases, but its application to Alzheimer’s disease (AD) remains limited. Brain-derived neurotrophic …             An extra dimension in protein tagging by quantifying universal proteotypic peptides using targeted proteomics ▶     Giel Vandemoortele, An Staes, Giulia Gonnelli et al.     The use of protein tagging to facilitate detailed characterization of target proteins has not only revolutionized cell biology, but also enabled biochemical analysis through …             The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells ▶     Xin Wang, Magdalena Mazurkiewicz, Ellin-Kristina Hillert et al.     Inhibition of deubiquitinase (DUB) activity is a promising strategy for cancer therapy. VLX1570 is an inhibitor of proteasome DUB activity currently in clinical trials for …             A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury ▶     Juan Carlos García- Cañaveras, José V. Castell, M. Teresa Donato et al.     In preclinical stages of drug development, anticipating potential adverse drug effects such as toxicity is an important issue for both saving resources and preventing public …             Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure ▶     Yoko Iijima, Katharina Behr, Takatoshi Iijima et al.     Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders characterized by impairments in social interactions and stereotyped behaviors. Valproic …             Homoeologue expression insights into the basis of growth heterosis at the intersection of ploidy and hybridity in Cyprinidae ▶     Li Ren, Wuhui Li, Min Tao et al.     Hybridization and polyploidization are considered important driving forces that form new epigenetic regulations. To study the changing patterns of expression accompanying …             The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly ▶     Lidia Wrobel, Anna M. Sokol, Magdalena Chojnacka et al.     Disulfide bond formation is crucial for the biogenesis and structure of many proteins that are localized in the intermembrane space of mitochondria. The importance of disulfide …             Range expansion of the Bluetongue vector, Culicoides imicola, in continental France likely due to rare wind-transport events ▶     Stéphanie Jacquet, Karine Huber, Nonito Pagès et al.     The role of the northward expansion of Culicoides imicola Kieffer in recent and unprecedented outbreaks of Culicoides-borne arboviruses in southern Europe has been a significant …             Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia ▶     Eun-Taex Oh, Chan Woo Kim, Soo Jung Kim et al.     HIF-1 (hypoxia-inducible factor-1) regulates the expression of more than 70 genes involved in angiogenesis, tumor growth, metastasis, chemoresistance, and radioresistance. Thus, …             Mangrove succession enriches the sediment microbial community in South China ▶     Quan Chen, Qian Zhao, Jing Li et al.     Sediment microorganisms help create and maintain mangrove ecosystems. Although the changes in vegetation during mangrove forest succession have been well studied, the changes in …             IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly ▶     Javier García-Nafría, Jake F. Watson, Ingo H. Greger     In vivo homologous recombination holds the potential for optimal molecular cloning, however, current strategies require specialised bacterial strains or laborious protocols. …             Shedding light on Aspergillus niger volatile exometabolome ▶     Carina Pedrosa Costa, Diogo Gonçalves Silva, Alisa Rudnitskaya et al.     An in-depth exploration of the headspace content of Aspergillus niger cultures was performed upon different growth conditions, using a methodology based on advanced …             Postoperative improvement in DASH score, clinical findings, and nerve conduction velocity in patients with cubital tunnel syndrome ▶     Yoshikazu Ido, Shigeharu Uchiyama, Koichi Nakamura et al.     We investigated a recovery pattern in subjective and objective measures among 52 patients with cubital tunnel syndrome after anterior subcutaneous transposition of the ulnar …             Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas ▶     B. Pouyatos, C. Nemoz, T. Chabrol et al.     Synchrotron-generated X-ray (SRX) microbeams deposit high radiation doses to submillimetric targets whilst minimizing irradiation of neighboring healthy tissue. We developed a …             High-resolution biophysical analysis of the dynamics of nucleosome formation ▶     Akiko Hatakeyama, Brigitte Hartmann, Andrew Travers et al.     We describe a biophysical approach that enables changes in the structure of DNA to be followed during nucleosome formation in in vitro reconstitution with either the canonical …             Novel MRI Contrast Agent from Magnetotactic Bacteria Enables In Vivo Tracking of iPSC-derived Cardiomyocytes ▶     Morteza Mahmoudi, Atsushi Tachibana, Andrew B. Goldstone et al.     Therapeutic delivery of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iCMs) represents a novel clinical approach to regenerate the injured myocardium. …             The SDF-1 rs1801157 Polymorphism is Associated with Cancer Risk: An Update Pooled Analysis and FPRP Test of 17,876 Participants ▶     Xiang Tong, Yao Ma, Huajiang Deng et al.     The stromal cell derived factor-1 (SDF-1) rs1801157 gene polymorphism has been implicated in susceptibility to cancer, but the results were inconclusive. The current study was to …             Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium ▶     Qianpeng Zhang, Yanqiu Wu, Jing Wang et al.     Butyrate-producing bacteria (BPB) are potential probiotic candidates for inflammatory bowel diseases as they are often depleted in the diseased gut microbiota. However, here we …             Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression ▶     Corinna Hintermair, Kirsten Voß, Ignasi Forné et al.     Dynamic phosphorylation of Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 heptad-repeats in the C-terminal domain (CTD) of the large subunit coordinates progression of RNA polymerase (Pol) …             Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion ▶     S. Ramaswamy, C. Grace, A. A. Mattei et al.     Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine …             Genome-wide DNA methylation profiles changes associated with constant heat stress in pigs as measured by bisulfite sequencing ▶     Yue Hao, Yanjun Cui, Xianhong Gu     Heat stress affects muscle development and meat quality in food animals; however, little is known regarding its regulatory mechanisms at the epigenetic level, such as via DNA …             Quantifying promoter activity during the developmental cycle of Chlamydia trachomatis ▶     Yanguang Cong, Leiqiong Gao, Yan Zhang et al.     Chlamydia trachomatis is an important human pathogen that undergoes a characteristic development cycle correlating with stage-specific gene expression profiles. Taking advantage …             Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9 ▶     Yuta Morisaki, Mamiko Niikura, Mizuho Watanabe et al.     Differential vulnerability among motor neuron (MN) subtypes is a fundamental feature of amyotrophic lateral sclerosis (ALS): fast-fatigable (FF) MNs are more vulnerable than fast …             A carnosine intervention study in overweight human volunteers: bioavailability and reactive carbonyl species sequestering effect ▶     Luca Regazzoni, Barbora de Courten, Davide Garzon et al.     Carnosine is a natural dipeptide able to react with reactive carbonyl species, which have been recently associated with the onset and progression of several human diseases. …             Mycobacteria emulsified in olive oil-in-water trigger a robust immune response in bladder cancer treatment ▶     Estela Noguera-Ortega, Núria Blanco-Cabra, Rosa Maria Rabanal et al.     The hydrophobic composition of mycobacterial cell walls leads to the formation of clumps when attempting to resuspend mycobacteria in aqueous solutions. Such aggregation may …             A Material Conferring Hemocompatibility ▶     William Everett, David J Scurr, Anna Rammou et al.     There is a need for biomimetic materials for use in blood-contacting devices. Blood contacting surfaces maintain their patency through physico-chemical properties of a functional …             Metabolic rates of giant pandas inform conservation strategies ▶     Yuxiang Fei, Rong Hou, James R. Spotila et al.     The giant panda is an icon of conservation and survived a large-scale bamboo die off in the 1980s in China. Captive breeding programs have produced a large population in zoos and …             Flow cytometry may allow microscope-independent detection of holocentric chromosomes in plants ▶     František Zedek, Pavel Veselý, Lucie Horová et al.     Two chromosomal structures, known as monocentric and holocentric chromosomes, have evolved in eukaryotes. Acentric fragments of monocentric chromosomes are unequally distributed …             Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae ▶     Ulrike Grienke, Martina Richter, Elisabeth Walther et al.     Influenza virus neuraminidase (NA) is the primary target for influenza therapeutics. Severe complications are often related to secondary pneumonia caused by Streptococcus …             Remarkable preservation of Ca2+ homeostasis and inhibition of apoptosis contribute to anti-muscle atrophy effect in hibernating Daurian ground squirrels ▶     Weiwei Fu, Huanxin Hu, Kai Dang et al.     The underlying mechanisms that hibernators deviated from muscle atrophy during prolonged hibernating inactivity remain elusive. This study tested the hypothesis that the …             Drosophila cells use nanotube-like structures to transfer dsRNA and RNAi machinery between cells ▶     Margot Karlikow, Bertsy Goic, Vanesa Mongelli et al.     Tunnelling nanotubes and cytonemes function as highways for the transport of organelles, cytosolic and membrane-bound molecules, and pathogens between cells. During viral …             Insights into the role of sulfated glycans in cancer cell adhesion and migration through use of branched peptide probe ▶     Jlenia Brunetti, Lorenzo Depau, Chiara Falciani et al.     The tetra-branched peptide NT4 selectively binds to different human cancer cells and tissues. NT4 specifically binds to sulfated glycosaminoglycans on cancer cell membranes. …             A screen for constituents of motor control and decision making in Drosophila reveals visual distance-estimation neurons ▶     Tilman Triphan, Aljoscha Nern, Sonia F. Roberts et al.     Climbing over chasms larger than step size is vital to fruit flies, since foraging and mating are achieved while walking. Flies avoid futile climbing attempts by processing …             Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice ▶     Jingjing Zhang, Romain Bedel, S. Harsha Krovi et al.     Invariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, …             Discovery of a rhamnose utilization pathway and rhamnose-inducible promoters in Pichia pastoris ▶     Bo Liu, Yuwei Zhang, Xue Zhang et al.     The rhamnose utilization pathway in Pichia pastoris has not been clarified although this strain can grow well on rhamnose as a sole carbon source. In this study, four genes, …             Multisite electrophysiological recordings by self-assembled loose-patch-like junctions between cultured hippocampal neurons and mushroom-shaped microelectrodes ▶     Nava Shmoel, Noha Rabieh, Silviya M. Ojovan et al.     Substrate integrated planar microelectrode arrays is the “gold standard” method for millisecond-resolution, long-term, large-scale, cell-noninvasive electrophysiological …             Heritability and Reversibility of DNA Methylation Induced by in vitro Grafting between Brassica juncea and B. oleracea ▶     Liwen Cao, Ningning Yu, Junxing Li et al.     Grafting between tuber mustard and red cabbage produced a chimeric shoot apical meristem (SAM) of TTC, consisting of Layers I and II from Tuber mustard and Layer III from red C…             Effects of bioirrigation of non-biting midges (Diptera: Chironomidae) on lake sediment respiration ▶     Viktor Baranov, Jörg Lewandowski, Paul Romeijn et al.     Bioirrigation or the transport of fluids into the sediment matrix due to the activities of organisms such as bloodworms (larvae of Diptera, Chironomidae), has substantial impacts …             A novel recombinant 6Aβ15-THc-C chimeric vaccine (rCV02) mitigates Alzheimer’s disease-like pathology, cognitive decline and synaptic loss in aged 3 × Tg-AD mice ▶     Yun-Zhou Yu, Si Liu, Hai-Chao Wang et al.     Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs memory and cognition. Targeting amyloid-β (Aβ) may be currently the most promising immunotherapeutic …             The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth ▶     Lu Xing, Yang Zhao, Jinghui Gao et al.     Abscisic acid is a phytohormone regulating plant growth, development and stress responses. PYR1/PYL/RCAR proteins are ABA receptors that function by inhibiting PP2Cs to activate …             Direct repeat-mediated DNA deletion of the mating type MAT1-2 genes results in unidirectional mating type switching in Sclerotinia trifoliorum ▶     Liangsheng Xu, Teresa M. Jardini, Weidong Chen     The necrotrophic fungal pathogen Sclerotinia trifoliorum exhibits ascospore dimorphism and unidirectional mating type switching - self-fertile strains derived from large …             Detection of RNA-DNA association by a proximity ligation-based method ▶     Svetlana Petruk, Tyler K. Fenstermaker, Kathryn L. Black et al.     We describe a proximity ligation assay (PLA)-based method of assessing association of DNA and RNA in single cells during the cell cycle. Pulse-labeling of DNA with Ed and RNA …             Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway ▶     Cédric Chaveroux, Carmen Sarcinelli, Virginie Barbet et al.     The hexosamine biosynthetic pathway (HBP) is a nutrient-sensing metabolic pathway that produces the activated amino sugar UDP-N-acetylglucosamine, a critical substrate for …             Functional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3 ▶     Hyo Jin Park, Tae Hee Kim, So Won Kim et al.     Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates …             Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein ▶     Shi-Cong Tao, You-Shui Gao, Hong-Yi Zhu et al.     The pH of extracellular fluids is a basic property of the tissue microenvironment and is normally maintained at 7.40 ± 0.05 in humans. Many pathological circumstances, such as …             Uncovering the composition of microbial community structure and metagenomics among three gut locations in pigs with distinct fatness ▶     Hui Yang, Xiaochang Huang, Shaoming Fang et al.     Uncovering the phylogenetic composition of microbial community and the potential functional capacity of microbiome in different gut locations is of great importance to pig …             Discovery of Novel Splice Variants and Regulatory Mechanisms for Microsomal Triglyceride Transfer Protein in Human Tissues ▶     Takashi Suzuki, Larry L. Swift     Microsomal triglyceride transfer protein (MTP) is a unique lipid transfer protein essential for the assembly of triglyceride-rich lipoproteins by the liver and intestine. …             Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells ▶     Teresa Rayon, Sergio Menchero, Isabel Rollán et al.     The first intercellular differences during mammalian embryogenesis arise in the blastocyst, producing the inner cell mass and the trophectoderm. The trophectoderm is the first …             Non-random distribution of homo-repeats: links with biological functions and human diseases ▶     Michail Yu. Lobanov, Petr Klus, Igor V. Sokolovsky et al.     The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 …             Deletion of Brg1 causes abnormal hair cell planer polarity, hair cell anchorage, and scar formation in mouse cochlea ▶     Yecheng Jin, Naixia Ren, Shiwei Li et al.     Hair cells (HCs) are mechanosensors that play crucial roles in perceiving sound, acceleration, and fluid motion. The precise architecture of the auditory epithelium and its …             A novel suicide shuttle plasmid for Streptococcus suis serotype 2 and Streptococcus equi ssp. zooepidemicus gene mutation ▶     Rui Liu, Ping Zhang, Yiqi Su et al.     The mariner-based Himar1 system has been utilized for creating mutant libraries of many Gram-positive bacteria. Streptococcus suis serotype 2 (SS2) and Streptococcus equi ssp. …             An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice ▶     Shintaro Minegishi, Tomoaki Ishigami, Tabito Kino et al.     Epithelial sodium channels (ENaCs) play critical roles in the maintenance of fluid and electrolyte homeostasis, and their genetic abnormalities cause one type of hereditary …             Mammalian metabolic rates in the hottest fish on earth ▶     Chris M. Wood, Kevin V. Brix, Gudrun De Boeck et al.     The Magadi tilapia, Alcolapia grahami, a small cichlid fish of Lake Magadi, Kenya lives in one of the most challenging aquatic environments on earth, characterized by very high …             Extensive coronavirus-induced membrane rearrangements are not a determinant of pathogenicity ▶     Helena J. Maier, Benjamin W. Neuman, Erica Bickerton et al.     Positive-strand RNA (+RNA) viruses rearrange cellular membranes during replication, possibly in order to concentrate and arrange viral replication machinery for efficient viral …             A 3D in vitro model to explore the inter-conversion between epithelial and mesenchymal states during EMT and its reversion ▶     S. J. Bidarra, P. Oliveira, S. Rocha et al.     Epithelial-to-mesenchymal transitions (EMT) are strongly implicated in cancer dissemination. Intermediate states, arising from inter-conversion between epithelial (E) and …             The roles of RelA/(p)ppGpp in glucose-starvation induced adaptive response in the zoonotic Streptococcus suis ▶     Tengfei Zhang, Jiawen Zhu, Shun Wei et al.     The (p)ppGpp signal molecules play a central role in the stringent response (SR) to adapt to nutrient starvation in bacteria, yet the carbohydrate starvation induced adaptive …             Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man ▶     Anthony L. Gotter, Mark S. Forman, Charles M. Harrell et al.     Orexin neuropeptides regulate sleep/wake through orexin receptors (OX1R, OX2R); OX2R is the predominant mediator of arousal promotion. The potential for single OX2R antagonism to …             Using metabarcoding to reveal and quantify plant-pollinator interactions ▶     André Pornon, Nathalie Escaravage, Monique Burrus et al.     Given the ongoing decline of both pollinators and plants, it is crucial to implement effective methods to describe complex pollination networks across time and space in a …             Disturbed flow mediated modulation of shear forces on endothelial plane: A proposed model for studying endothelium around atherosclerotic plaques ▶     Uma Maheswari Balaguru, Lakshmikirupa Sundaresan, Jeganathan Manivannan et al.     Disturbed fluid flow or modulated shear stress is associated with vascular conditions such as atherosclerosis, thrombosis, and aneurysm. In vitro simulation of the fluid flow …             The effector AWR5 from the plant pathogen Ralstonia solanacearum is an inhibitor of the TOR signalling pathway ▶     Crina Popa, Liang Li, Sergio Gil et al.     Bacterial pathogens possess complex type III effector (T3E) repertoires that are translocated inside the host cells to cause disease. However, only a minor proportion of these …             An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca2+-dependent regulation ▶     Worawan B. Limpitikul, Ivy E. Dick, Manu Ben-Johny et al.     CaV1.3 channels are a major class of L-type Ca2+ channels which contribute to the rhythmicity of the heart and brain. In the brain, these channels are vital for …             Purifying selection shapes the coincident SNP distribution of primate coding sequences ▶     Chia-Ying Chen, Li-Yuan Hung, Chan-Shuo Wu et al.     Genome-wide analysis has observed an excess of coincident single nucleotide polymorphisms (coSNPs) at human-chimpanzee orthologous positions, and suggested that this is due to …             TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis ▶     Jun-Hao Zhou, Tong-Tong Zhang, Dan-Dan Song et al.     Previous study showed that TIGAR (TP53-induced glycolysis and apoptosis regulator) protected ischemic brain injury via enhancing pentose phosphate pathway (PPP) flux and …             Populations of the Minor α-Conformation in AcGXGNH2 and the α-Helical Nucleation Propensities ▶     Yanjun Zhou, Liu He, Wenwen Zhang et al.     Intrinsic backbone conformational preferences of different amino acids are important for understanding the local structure of unfolded protein chains. Recent evidence suggests …             A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin ▶     Lisa Leon Gallegos, Mei Rosa Ng, Mathew E. Sowa et al.     Cell-cell adhesion is central to morphogenesis and maintenance of epithelial cell state. We previously identified 27 candidate cell-cell adhesion regulatory proteins (CCARPs) …             Optical diffraction for measurements of nano-mechanical bending ▶     Rodolfo I. Hermans, Benjamin Dueck, Joseph Wafula Ndieyira et al.     We explore and exploit diffraction effects that have been previously neglected when modelling optical measurement techniques for the bending of micro-mechanical transducers such …             IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma ▶     Matthew N. Svalina, Ken Kikuchi, Jinu Abraham et al.     Risk or presence of metastasis in medulloblastoma causes substantial treatment-related morbidity and overall mortality. Through the comparison of cytokines and growth factors in …             Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7 ▶     Menachem J. Gunzburg, Ketav Kulkarni, Gabrielle M. Watson et al.     The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new …             Riems influenza a typing array (RITA): An RT-qPCR-based low density array for subtyping avian and mammalian influenza a viruses ▶     Bernd Hoffmann, Donata Hoffmann, Dinah Henritzi et al.     Rapid and sensitive diagnostic approaches are of the utmost importance for the detection of humans and animals infected by specific influenza virus subtype(s). Cascade-like …             The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria ▶     Estela Shabani, Robert O. Opoka, Paul Bangirana et al.     The endothelial protein C receptor (EPCR) appears to play an important role in Plasmodium falciparum endothelial cell binding in severe malaria (SM). Despite consistent findings …             Whole-genome resequencing of honeybee drones to detect genomic selection in a population managed for royal jelly ▶     David Wragg, Maria Marti-Marimon, Benjamin Basso et al.     Four main evolutionary lineages of A. mellifera have been described including eastern Europe (C) and western and northern Europe (M). Many apiculturists prefer bees from the C …             Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells ▶     Rong Fan, Travis Emery, Yongguo Zhang et al.     During cancer metastasis, circulating tumor cells constantly experience hemodynamic shear stress in the circulation. Cellular responses to shear stress including cell viability …             Differential effects of conifer and broadleaf litter inputs on soil organic carbon chemical composition through altered soil microbial community composition ▶     Hui Wang, Shi-Rong Liu, Jing-Xin Wang et al.     A strategic selection of tree species will shift the type and quality of litter input, and subsequently magnitude and composition of the soil organic carbon (SOC) through soil …             T cells expressing CD19-specific Engager Molecules for the Immunotherapy of CD19-positive Malignancies ▶     Mireya Paulina Velasquez, David Torres, Kota Iwahori et al.     T cells expressing chimeric antigen receptors (CARs) or the infusion of bispecific T-cell engagers (BITEs) have shown antitumor activity in humans for CD19-positive malignancies. …             Dietary fruit, vegetable, fat, and red and processed meat intakes and Barrett’s esophagus risk: a systematic review and meta-analysis ▶     Zhanwei Zhao, Zhongshu Pu, Zifang Yin et al.     The relationships between dietary fruit, vegetable, fat, and red and processed meat intakes and Barrett’s esophagus (BE) risk remain inconclusive. We conducted a systematic …             Identification of key metabolic changes in renal interstitial fibrosis rats using metabonomics and pharmacology ▶     Liangcai Zhao, Minjian Dong, Shixian Liao et al.     Renal fibrosis is one of the important pathways involved in end-stage renal failure. Investigating the metabolic changes in the progression of disease may enhance the …             Cryo-thermal therapy elicits potent anti-tumor immunity by inducing extracellular Hsp70-dependent MDSC differentiation ▶     Jun Zhu, Yan Zhang, Aili Zhang et al.     Achieving control of metastatic disease is a long-sought goal in cancer therapy. Treatments that encourage a patient’s own immune system are bringing new hopes in reaching such a …             CNV analysis in Chinese children of mental retardation highlights a sex differentiation in parental contribution to de novo and inherited mutational burdens ▶     Binbin Wang, Taoyun Ji, Xueya Zhou et al.     Rare copy number variations (CNVs) are a known genetic etiology in neurodevelopmental disorders (NDD). Comprehensive CNV analysis was performed in 287 Chinese children with …             Divergence and Conservation of the Major UPR Branch IRE1-bZIP Signaling Pathway across Eukaryotes ▶     Lingrui Zhang, Changwei Zhang, Aiming Wang     The unfolded protein response (UPR) is crucial to life by regulating the cellular response to the stress in the endoplasmic reticulum (ER) imposed by abiotic and biotic cues such …             Alpha fetoprotein antagonizes apoptosis induced by paclitaxel in hepatoma cells in vitro ▶     Mingyue Zhu, Wei Li, Yan Lu et al.     Hepatocellular carcinoma (HCC) cell resistance to the effects of paclitaxel has not been adequately addressed. In this study, we found that paclitaxel significantly inhibited the …             Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis ▶     Qin Bian, Amit Jain, Xin Xu et al.     Narrowed intervertebral disc (IVD) space is a characteristic of IVD degeneration. EP sclerosis is associated with IVD, however the pathogenesis of EP hypertrophy is poorly …             Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue ▶     Camilla Natasha Cederbye, Jesper Andreas Palshof, Tine Plato Hansen et al.     Overexpression of the ATP-dependent drug efflux pump ABCG2 is a major molecular mechanism of multidrug resistance in cancer and might be a predictive biomarker for drug response. …             Electrical Oscillations in Two-Dimensional Microtubular Structures ▶     María del Rocío Cantero, Paula L. Perez, Mariano Smoler et al.     Microtubules (MTs) are unique components of the cytoskeleton formed by hollow cylindrical structures of αβ tubulin dimeric units. The structural wall of the MT is interspersed by …             Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers ▶     Nicole O. McPherson, Tod Fullston, Wan Xian Kang et al.     There is an ever increasing body of evidence that demonstrates that paternal over-nutrition prior to conception programs impaired metabolic health in offspring. Here we examined …             MALDI-Imaging Mass Spectrometry: a step forward in the anatomopathological characterization of stenotic aortic valve tissue ▶     Laura Mourino-Alvarez, Ibon Iloro, Fernando de la Cuesta et al.     Aortic stenosis (AS) is the most common form of valve disease. Once symptoms develop, there is an inexorable deterioration with a poor prognosis; currently there are no therapies …             Gigapixel surface imaging of radical prostatectomy specimens for comprehensive detection of cancer-positive surgical margins using structured illumination microscopy ▶     Mei Wang, David B. Tulman, Andrew B. Sholl et al.     Achieving cancer-free surgical margins in oncologic surgery is critical to reduce the need for additional adjuvant treatments and minimize tumor recurrence; however, there is a …             Gene switching rate determines response to extrinsic perturbations in the self-activation transcriptional network motif ▶     Sebastiano de Franciscis, Giulio Caravagna, Giancarlo Mauri et al.     Gene switching dynamics is a major source of randomness in genetic networks, also in the case of large concentrations of the transcription factors. In this work, we consider a …             Pro-apoptotic Bax molecules densely populate the edges of membrane pores ▶     Tomomi Kuwana, Norman H. Olson, William B. Kiosses et al.     How the pro-apoptotic Bax protein permeabilizes the mitochondrial outer membrane is not fully understood. Previously, using cryo-electron microscopy (cryo-EM), we showed that …             The changing shape of vaccination: improving immune responses through geometrical variations of a microdevice for immunization ▶     Michael Lawrence Crichton, David Alexander Muller, Alexandra Christina Isobel Depelsenaire et al.     Micro-device use for vaccination has grown in the past decade, with the promise of ease-of-use, painless application, stable solid formulations and greater immune response …             Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida ▶     Yinfeng Lyu, Yang Yang, Xiting Lyu et al.     Antimicrobial peptides (AMPs) have recently attracted a great deal of attention as promising antibiotic candidates, but some obstacles such as toxicity and high synthesis cost …             Corrigendum: Intrinsic challenges in ancient microbiome reconstruction using 16S rRNA gene amplification ▶     Kirsten A. Ziesemer, Allison E. Mann, Krithivasan Sankaranarayanan et al.                 The rise of angiosperm-dominated herbaceous floras: Insights from Ranunculaceae ▶     Wei Wang, Li Lin, Xiao-Guo Xiang et al.     The rise of angiosperms has been regarded as a trigger for the Cretaceous revolution of terrestrial ecosystems. However, the timeframe of the rise angiosperm-dominated herbaceous …             Macrophage-mediated inflammatory response decreases mycobacterial survival in mouse MSCs by augmenting NO production ▶     Kun Yang, Yongjian Wu, Heping Xie et al.     Mycobacterium tuberculosis (MTB) is a hard-to-eradicate intracellular microbe, which escapes host immune attack during latent infection. Recent studies reveal that mesenchymal …             Principal components analysis and the reported low intrinsic dimensionality of gene expression microarray data ▶     Michael Lenz, Franz-Josef Müller, Martin Zenke et al.     Principal components analysis (PCA) is a common unsupervised method for the analysis of gene expression microarray data, providing information on the overall structure of the …             Anomalous uptake and circulatory characteristics of the plant-based small RNA MIR2911 ▶     Jian Yang, Tremearne Hotz, LaCassidy Broadnax et al.     Inconsistent detection of plant-based dietary small RNAs in circulation has thwarted the use of dietary RNA therapeutics. Here we demonstrate mice consuming diets rich in …             Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and Function ▶     Jocelyn F. Krey, Meghan Drummond, Sarah Foster et al.     The phospholipid- and Ca2+-binding protein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse vestibular hair bundles, the inner ear’s sensory …             Single-trial prediction of reaction time variability from MEG brain activity ▶     Ryu Ohata, Kenji Ogawa, Hiroshi Imamizu     Neural activity prior to movement onset contains essential information for predictive assistance for humans using brain-machine-interfaces (BMIs). Even though previous studies …             Transcriptome profiles of metamorphosis in the ornamented pygmy frog Microhyla fissipes clarify the functions of thyroid hormone receptors in metamorphosis ▶     Lanying Zhao, Lusha Liu, Shouhong Wang et al.     Anuran metamorphosis is an excellent system in which to study postembryonic development. Studies on Xenopus (Mesobatrachia) show that thyroid hormone receptors (TRs) regulate …             The N-terminal zinc finger domain of Tgf2 transposase contributes to DNA binding and to transposition activity ▶     Xia-Yun Jiang, Fei Hou, Xiao-Dan Shen et al.     Active Hobo/Activator/Tam3 (hAT) transposable elements are rarely found in vertebrates. Previously, goldfish Tgf2 was found to be an autonomously active vertebrate transposon …             Flt1/VEGFR1 heterozygosity causes transient embryonic edema ▶     Yasunori Otowa, Kazumasa Moriwaki, Keigo Sano et al.     Vascular endothelial growth factor-A is a major player in vascular development and a potent vascular permeability factor under physiological and pathological conditions by …             Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis ▶     Ting Wang, Jia Liu, Junran Zhang et al.     Many functional neuroimaging studies have reported differential patterns of spontaneous brain activity in posttraumatic stress disorder (PTSD), but the findings are inconsistent …             Genomic structure analysis of a set of Oryza nivara introgression lines and identification of yield-associated QTLs using whole-genome resequencing ▶     Xin Ma, Yongcai Fu, Xinhui Zhao et al.     Oryza nivara, an annual wild AA-genome species of rice, is an important gene pool for broadening the genetic diversity of cultivated rice (O. sativa L.). Towards identifying and …             Dengue Specific Immunoglobulin A Antibody is Present in Urine and Associated with Disease Severity ▶     Hui Zhao, Shuang Qiu, Wen-Xin Hong et al.     The kinetics of dengue virus (DENV)-specific IgA antibody in urine and the potential correlation with disease severity remain elusive. In this study, 262 serial urine samples …             Bone scaffolds loaded with siRNA-Semaphorin4d for the treatment of osteoporosis related bone defects ▶     Yufeng Zhang, Lingfei Wei, Richard J. Miron et al.     Osteoporosis is a prominent disorder affecting over 200 million people worldwide. Recently, semaphorins have been implicated in the cell-cell communication between osteoclasts …             Hypoxia induced CCL28 promotes angiogenesis in lung adenocarcinoma by targeting CCR3 on endothelial cells ▶     Guichun Huang, Leilei Tao, Sunan Shen et al.     Tumor hypoxia is one of the important features of lung adenocarcinoma. Chemokines might mediate the effects caused by tumor hypoxia. As confirmed in tumor tissue and serum of …             TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107 combined with irradiation in glioma cells ▶     Xiaoli Li, Yanyan Cen, Yongqing Cai et al.     Synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides (CpG ODN) function as potential radiosensitizers for glioma treatment, although the underlying mechanism …             Functional analysis of thioredoxin from the desert lichen-forming fungus, Endocarpon pusillum Hedwig, reveals its role in stress tolerance ▶     Hui Li, Jiang-Chun Wei     Endocarpon pusillum is a lichen-forming fungus with an outstanding stress resistance property closely related to its antioxidant system. In this study, thioredoxin (Trx), one of …             CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking ▶     Pei-Hsuan Weng, Jen-Hau Chen, Ta-Fu Chen et al.     α7 nicotinic acetylcholine receptor (α7nAChR, encoded by CHRNA7) is involved in dementia pathogenesis through cholinergic neurotransmission, neuroprotection and interactions with …             Predictive value of the composition of the vaginal microbiota in bacterial vaginosis, a dynamic study to identify recurrence-related flora ▶     Bingbing Xiao, Xiaoxi Niu, Na Han et al.     Bacterial vaginosis (BV) is a highly prevalent disease in women, and increases the risk of pelvic inflammatory disease. It has been given wide attention because of the high …             Dissecting the role of transforming growth factor-β1 in topmouth culter immunobiological activity: a fundamental functional analysis ▶     Pengzhi Qi, Congxin Xie, Baoying Guo et al.     Transforming growth factor-β1 (TGF-β1) has been proven to function primarily in mammalian immunobiological activity, but information regarding the immune role of TGF-β1 in …             Rethinking spontaneous giving: Extreme time pressure and ego-depletion favor self-regarding reactions ▶     Valerio Capraro, Giorgia Cococcioni     Previous experimental studies suggest that cooperation in one-shot anonymous interactions is, on average, spontaneous, rather than calculative. To explain this finding, it has …             4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate ▶     Shida Miao, Wei Zhu, Nathan J. Castro et al.     Photocurable, biocompatible liquid resins are highly desired for 3D stereolithography based bioprinting. Here we solidified a novel renewable soybean oil epoxidized acrylate, …             A Lipid Based Antigen Delivery System Efficiently Facilitates MHC Class-I Antigen Presentation in Dendritic Cells to Stimulate CD8+ T Cells ▶     Mithun Maji, Saumyabrata Mazumder, Souparno Bhattacharya et al.     The most effective strategy for protection against intracellular infections such as Leishmania is vaccination with live parasites. Use of recombinant proteins avoids the risks …             Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication ▶     Daria Trabattoni, Federica Gnudi, Salomè V. Ibba et al.     Nitazoxanide (Alinia®, NTZ) and tizoxanide (TIZ), its active circulating metabolite, belong to a class of agents known as thiazolides (TZD) endowed with broad anti-infective …             Eyes wide shut: Transcranial alternating current stimulation drives alpha rhythm in a state dependent manner ▶     Philipp Ruhnau, Toralf Neuling, Marco Fuscá et al.     Transcranial alternating current stimulation (tACS) is used to modulate brain oscillations to measure changes in cognitive function. It is only since recently that brain activity …             Cooperation Survives and Cheating Pays in a Dynamic Network Structure with Unreliable Reputation ▶     Alberto Antonioni, Angel Sánchez, Marco Tomassini     In a networked society like ours, reputation is an indispensable tool to guide decisions about social or economic interactions with individuals otherwise unknown. Usually, …             RNA-Seq reveals 10 novel promising candidate genes affecting milk protein concentration in the Chinese Holstein population ▶     Cong Li, Wentao Cai, Chenghao Zhou et al.     Paired-end RNA sequencing (RNA-Seq) was used to explore the bovine transcriptome from the mammary tissue of 12 Chinese Holstein cows with 6 extremely high and 6 low phenotypic …             Role of Histidine 547 of Human Dopamine Transporter in Molecular Interaction with HIV-1 Tat and Dopamine Uptake ▶     Yaxia Yuan, Pamela M. Quizon, Wei-Lun Sun et al.     HIV-1 Tat plays an important role in HIV-associated neurocognitive disorders (HAND) by disrupting neurotransmission including dopamine uptake by human dopamine transporter …             Erythrocyte intracellular Mg2+ concentration as an index of recognition and memory ▶     Wenxiang Xiong, Yaru Liang, Xue Li et al.     Magnesium (Mg2+) plays an important role in the neural system, and yet scarcely any research has quantitatively analyzed the link between endogenous Mg2+ level and memory. Using …             Handedness is related to neural mechanisms underlying hemispheric lateralization of face processing ▶     Stefan Frässle, Sören Krach, Frieder Michel Paulus et al.     While the right-hemispheric lateralization of the face perception network is well established, recent evidence suggests that handedness affects the cerebral lateralization of …             Evaluating the responses of a territorial solitary carnivore to potential mates and competitors ▶     Maximilian L. Allen, Veronica Yovovich, Christopher C. Wilmers     Successful communication is critical to the fitness of individuals and maintenance of populations, but less is known regarding the social contexts and reactions to scent marking …             The response of an egg parasitoid to substrate-borne semiochemicals is affected by previous experience ▶     Ezio Peri, Gianandrea Salerno, Takoua Slimani et al.     Animals can adjust their behaviour according to previous experience gained during foraging. In parasitoids, experience plays a key role in host location, a hierarchical process …             Immuno-targeting the multifunctional CD38 using nanobody ▶     Ting Li, Shali Qi, Mandy Unger et al.     CD38, as a cell surface antigen is highly expressed in several hematologic malignancies including multiple myeloma (MM) and has been proven to be a good target for immunotherapy …             Molecular mechanism and functional significance of acid generation in the Drosophila midgut ▶     Gayle Overend, Yuan Luo, Louise Henderson et al.     The gut of Drosophila melanogaster includes a proximal acidic region (~pH 2), however the genome lacks the H+/K+ ATPase characteristic of the mammalian gastric parietal cell, and …             DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways ▶     Meijuan Zou, Yongtao Duan, Pengfei Wang et al.     Astrocyte elevated gene-1 (AEG-1) has been explored as a novel target for human glioma therapy, thus reflecting its potential contribution to gliomagenesis. In the present study, …             The CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity ▶     Samuel Jourdan, Isolde Maria Francis, Min Jung Kim et al.     Streptomyces scabies is an economically important plant pathogen well-known for damaging root and tuber crops by causing scab lesions. Thaxtomin A is the main causative agent …             Corrigendum: Prognostic role of Gli1 expression in solid malignancies: a meta-analysis ▶     Ji Cheng, Jinbo Gao, Kaixiong Tao                 The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery ▶     Yunbin Xu, Fei Liu, Juan Liu et al.     Cdc37, as a kinase-specific co-chaperone of the chaperone Hsp90AA1 (Hsp90), actively aids with the maturation, stabilization and activation of the cellular or viral …             A Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes ▶     Xi-Jing Qian, Xiao-Lian Zhang, Ping Zhao et al.     Despite recent progress in the development of hepatitis C virus (HCV) inhibitors, cost-effective antiviral drugs, especially among the patients receiving liver transplantations, …             Overexpression of a Chimeric Gene, OsDST-SRDX, Improved Salt Tolerance of Perennial Ryegrass ▶     Huifang Cen, Wenxing Ye, Yanrong Liu et al.     The Drought and Salt Tolerance gene (DST) encodes a C2H2 zinc finger transcription factor, which negatively regulates salt tolerance in rice (Oryza sativa). Phylogenetic analysis …             Viable offspring obtained from Prm1-deficient sperm in mice ▶     Naoki Takeda, Kazuya Yoshinaga, Kenryo Furushima et al.     Protamines are expressed in the spermatid nucleus and allow denser packaging of DNA compared with histones. Disruption of the coding sequence of one allele of either protamine 1 (…             Global gene expression analysis using RNA-seq uncovered a new role for SR1/CAMTA3 transcription factor in salt stress ▶     Kasavajhala V. S. K. Prasad, Amira A. E. Abdel-Hameed, Denghui Xing et al.     Abiotic and biotic stresses cause significant yield losses in all crops. Acquisition of stress tolerance in plants requires rapid reprogramming of gene expression. SR1/CAMTA3, a …             Peripheral Brain Derived Neurotrophic Factor Precursor Regulates Pain as an Inflammatory Mediator ▶     Cong Luo, Xiao-Lin Zhong, Fiona H. Zhou et al.     The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene product, binds to its receptors and exerts the opposing biologic functions of mature BDNF. …             Vibrio vulnificus VvhA induces autophagy-related cell death through the lipid raft-dependent c-Src/NOX signaling pathway ▶     Eun Ju Song, Sei-Jung Lee, Hyeon Su Lim et al.     VvhA, a virulent factor of Vibrio (V.) vulnificus, induces acute cell death in a destructive manner. Autophagy plays an important role in cell death, but the functional role of …             Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine ▶     Joanna Y. Ip, Masamitsu Sone, Chieko Nashiki et al.     The long noncoding RNA Gomafu/MIAT/Rncr2 is thought to function in retinal cell specification, stem cell differentiation and the control of alternative splicing. To further …             14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression ▶     Amitabha Mukhopadhyay, Lalit Sehgal, Arunabha Bose et al.     More than 80% of malignant tumors show centrosome amplification and clustering. Centrosome amplification results from aberrations in the centrosome duplication cycle, which is …             Cotesia vestalis teratocytes express a diversity of genes and exhibit novel immune functions in parasitism ▶     Fei Gao, Qi-juan Gu, Jing Pan et al.     Some endoparasitoid wasps lay eggs that produce cells called teratocytes. In this study, we sequenced and analyzed the transcriptome of teratocytes from the solitary …             High hydrostatic pressure adaptive strategies in an obligate piezophile Pyrococcus yayanosii ▶     Grégoire Michoud, Mohamed Jebbar     Pyrococcus yayanosii CH1, as the first and only obligate piezophilic hyperthermophilic microorganism discovered to date, extends the physical and chemical limits of life on …             Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody ▶     Kenji Sugata, Jun-ichirou Yasunaga, Michi Miura et al.     Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia and inflammatory diseases. Because anti-HTLV-1 immune responses are critical for suppressing infected …             Transmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigs ▶     Weili Kong, Qinfang Liu, Yipeng Sun et al.     Given the present extensive co-circulation in pigs of Eurasian avian-like (EA) swine H1N1 and 2009 pandemic (pdm/09) H1N1 viruses, reassortment between them is highly plausible …             The phosphatidylethanolamine derivative diDCP-LA-PE mimics intracellular insulin signaling ▶     Tomoyuki Nishizaki, Akinobu Gotoh, Tadashi Shimizu et al.     Insulin facilitates glucose uptake into cells by translocating the glucose transporter GLUT4 towards the cell surface through a pathway along an insulin receptor (IR)/IR …             Tracing the locality of prisoners and workers at the Mausoleum of Qin Shi Huang: First Emperor of China (259-210 BC) ▶     Ying Ma, Benjamin T. Fuller, Weigang Sun et al.     The mausoleum complex of the First Emperor of China, Qin Shi Huang (259-210 BC), is one of the most famous and important archaeological sites in China, yet questions remain as to …             Identification of Changes in Gene expression of rats after Sensory and Motor Nerves Injury ▶     Yu Wang, Zhi-Yuan Guo, Xun Sun et al.     Wallerian degeneration is a sequence of events in the distal stump of axotomized nerves. Despite large numbers of researches concentrating on WD, the biological mechanism still …             Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice ▶     Qixue Wang, Lei Sun, Xiaoxiao Yang et al.     We previously reported that LXR ligand, T0901317, inhibited the growth of inoculated Lewis lung carcinoma in C57BL/6 mice by activating IFN-γ production. However, the effects of …             In vivo Magnetic Resonance Microscopy and Hypothermic Anaesthesia of a Disease Model in Medaka ▶     Tomohiro Ueno, Hirokazu Suzuki, Masahiro Hiraishi et al.     In medical and pharmacological research, various human disease models in small fish, such as medaka (Oryzias latipes), have been created. To investigate these disease models …             Robust Statistical Detection of Power-Law Cross-Correlation ▶     Duncan A. J. Blythe, Vadim V. Nikulin, Klaus-Robert Müller     We show that widely used approaches in statistical physics incorrectly indicate the existence of power-law cross-correlations between financial stock market fluctuations measured …             MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells ▶     Aihong Mao, Qiuyue Zhao, Xin Zhou et al.     MicroRNAs (miRNAs) have been reported to be involved in DNA damage response induced by ionizing radiation (IR). c-Myc is reduced when cells treated with IR or other DNA damaging …             miR-146a is essential for lipopolysaccharide (LPS)-induced cross-tolerance against kidney ischemia/reperfusion injury in mice ▶     Yan Dai, Ping Jia, Yi Fang et al.     MicroRNA-146a is one of most important microRNAs involved in development of endotoxin tolerance via (toll-like receptors) TLRs/ NF-κB pathway. In this study, we sought to …             The Critical Role Of VP1 In Forming The Necessary Cavities For Receptor-mediated Entry Of FMDV To The Host Cell ▶     Jahanshah Ashkani, D. J. G. Rees     The antigenic inconsistency of the foot-and-mouth disease virus (FMDV) is very broad, such that a vaccine made from one isolate will not offer protection against infection with …             miR-200 family promotes podocyte differentiation through repression of RSAD2 ▶     Zhigui Li, Hongqiang Yin, Shuang Hao et al.     Mature podocytes are highly differentiated cells with several characteristic phenotypic features that are involved in the glomerular filtration function. During kidney …             Glacial melting: an overlooked threat to Antarctic krill ▶     Verónica Fuentes, Gastón Alurralde, Bettina Meyer et al.     Strandings of marine animals are relatively common in marine systems. However, the underlying mechanisms are poorly understood. We observed mass strandings of krill in Antarctica …             EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta ▶     Inn-Inn Chen, Arianna Caprioli, Hidetaka Ohnuki et al.     Adult-type intraembryonic hematopoiesis arises from specialized endothelial cells of the dorsal aorta (DA). Despite the critical importance of this specialized endothelium for …             Defense pattern of Chinese cork oak across latitudinal gradients: influences of ontogeny, herbivory, climate and soil nutrients ▶     Xiao-Fei Wang, Jian-Feng Liu, Wen-Qiang Gao et al.     Knowledge of latitudinal patterns in plant defense and herbivory is crucial for understanding the mechanisms that govern ecosystem functioning and for predicting their responses …             Inhibition of Osteoclast Differentiation and Bone Resorption by Bisphosphonate-conjugated Gold Nanoparticles ▶     Donghyun Lee, Dong Nyoung Heo, Han-Jun Kim et al.     In recent years, gold nanoparticles (GNPs) have been reported to affect the regeneration of bone tissue. The goal of this study was to improve bone tissue regeneration by using …             Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric ▶     Manpreet Kaur Rawal, Atanu Banerjee, Abdul Haseeb Shah et al.     An analysis of Candida albicans ABC transporters identified conserved related α-helical sequence motifs immediately C-terminal of each Walker A sequence. Despite the occurrence …             Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods ▶     Feng He, Melina A. Agosto, Ivan A. Anastassov et al.     Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, …             Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV ▶     Haruna Onoyama, Mako Kamiya, Yugo Kuriki et al.     Early detection of esophageal squamous cell carcinoma (ESCC) is an important prognosticator, but is difficult to achieve by conventional endoscopy. Conventional lugol …             Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking ▶     Eugenia Butkevich, Wolfgang Härtig, Miroslav Nikolov et al.     Adapters bind motor proteins to cargoes and therefore play essential roles in Kinesin-1 mediated intracellular transport. The regulatory mechanisms governing adapter functions …             SCF/c-kit transactivates CXCR4-serine 339 phosphorylation through G protein-coupled receptor kinase 6 and regulates cardiac stem cell migration ▶     Ke Zuo, Dong Kuang, Ying Wang et al.     C-kit positive cardiac stem cells (CSCs) have been shown to contribute to myocardial regeneration after infarction. Previously, we have shown that the c-kit ligand stem cell …             The origin of the cooperativity in the streptavidin-biotin system: A computational investigation through molecular dynamics simulations ▶     Fengjiao Liu, John Z. H. Zhang, Ye Mei     Previous experimental study measuring the binding affinities of biotin to the wild type streptavidin (WT) and three mutants (S45A, D128A and S45A/D128A double mutant) has shown …             ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells ▶     Christopher D. Scharer, Emily L. Blalock, Benjamin G. Barwick et al.     Biobanking is a widespread practice for storing biological samples for future studies ranging from genotyping to RNA analysis. However, methods that probe the status of the …             Prediction of miRNA-disease associations with a vector space model ▶     Claude Pasquier, Julien Gardès     MicroRNAs play critical roles in many physiological processes. Their dysregulations are also closely related to the development and progression of various human diseases, …             Quantifying intrinsic and extrinsic control of single-cell fates in cancer and stem/progenitor cell pedigrees with competing risks analysis ▶     J. A. Cornwell, R. M. Hallett, S. Auf der Mauer et al.     The molecular control of cell fate and behaviour is a central theme in biology. Inherent heterogeneity within cell populations requires that control of cell fate is studied at …             Timing of population peaks of Norway lemming in relation to atmospheric pressure: A hypothesis to explain the spatial synchrony ▶     Vidar Selås     Herbivore cycles are often synchronized over larger areas than what could be explained by dispersal. In Norway, the 3–4 year lemming cycle usually show no more than a one-year …             Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells ▶     Jun Ma, Nan Zhao, Donghui Zhu     Bioabsorbable metal zinc (Zn) is a promising new generation of implantable scaffold for cardiovascular and orthopedic applications. In cardiovascular stent applications, zinc ion …             Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors ▶     Eva Hedlund, Laure Belnoue, Spyridon Theofilopoulos et al.     Degeneration of dopamine neurons in the midbrain causes symptoms of the movement disorder, Parkinson disease. Dopamine neurons are generated from proliferating progenitor cells …             Alteration of the Intra- and Cross- Hemisphere Posterior Default Mode Network in Frontal Lobe Glioma Patients ▶     Haosu Zhang, Yonghong Shi, Chengjun Yao et al.     Patients with frontal lobe gliomas often experience neurocognitive dysfunctions before surgery, which affects the default mode network (DMN) to different degrees. This study …             Overcoming inter-subspecific hybrid sterility in rice by developing indica-compatible japonica lines ▶     Jie Guo, Xiaomei Xu, Wentao Li et al.     Rice (Oryza sativa L.) is an important staple crop. The exploitation of the great heterosis that exists in the inter-subspecific crosses between the indica and japonica rice has …             Cholesterol Depletion from a Ceramide/Cholesterol Mixed Monolayer: A Brewster Angle Microscope Study ▶     Pritam Mandal, Pakiza Noutsi, Sahraoui Chaieb     Cholesterol is crucial to the mechanical properties of cell membranes that are important to cells’ behavior. Its depletion from the cell membranes could be dramatic. Among …             Neuronal activity in dorsomedial and dorsolateral striatum under the requirement for temporal credit assignment ▶     Eun Sil Her, Namjung Huh, Jieun Kim et al.     To investigate neural processes underlying temporal credit assignment in the striatum, we recorded neuronal activity in the dorsomedial and dorsolateral striatum (DMS and DLS, …             Proteomic Response and Quality Maintenance in Postharvest Fruit of Strawberry (Fragaria × ananassa) to Exogenous Cytokinin ▶     Li Li, Dongdong Li, Zisheng Luo et al.     The limitations in current understanding of the molecular mechanisms underlying fruit response to the application of plant growth regulators have increasingly become major …             A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67 ▶     Sijia Wang, Gereon Hüttmann, Thomas Scholzen et al.     Using nanotechnology for optical manipulation of molecular processes in cells with high spatial and temporal precision promises new therapeutic options. Especially tumor therapy …             Small groups and long memories promote cooperation ▶     Alexander J. Stewart, Joshua B. Plotkin     Complex social behaviors lie at the heart of many of the challenges facing evolutionary biology, sociology, economics, and beyond. For evolutionary biologists the question is …             Polymorphisms in the XPC gene affect urinary bladder cancer risk: a case-control study, meta-analyses and trial sequential analyses ▶     Monica Sankhwar, Satya Narayan Sankhwar, Sandeep Kumar Bansal et al.     Compromised activity of the DNA repair enzymes may raise the risk of a number of cancers. We analyzed polymorphisms in the Xeroderma Pigmentosum, Complementation Group C (XPC) …             A neuron-in-capillary platform for facile collection and mass spectrometric characterization of a secreted neuropeptide ▶     Chang Young Lee, Yi Fan, Stanislav S. Rubakhin et al.     The integration of microfluidic devices—which efficiently handle small liquid volumes—with separations/mass spectrometry (MS) is an effective approach for profiling the …             Hyperlipidemia-associated gene variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models ▶     Zhen Wang, Jifeng Zhang, Hong Li et al.     The rabbit (Oryctolagus cuniculus) is an important experimental animal for studying human diseases, such as hypercholesterolemia and atherosclerosis. Despite this, genetic …             Microsomal membrane proteome of low grade diffuse astrocytomas: Differentially expressed proteins and candidate surveillance biomarkers ▶     Ravindra Varma Polisetty, Poonam Gautam, Manoj Kumar Gupta et al.     Diffuse astrocytoma (DA; WHO grade II) is a low-grade, primary brain neoplasm with high potential of recurrence as higher grade malignant form. We have analyzed differentially …             Differences in DNA Repair Capacity, Cell Death and Transcriptional Response after Irradiation between a Radiosensitive and a Radioresistant Cell Line ▶     Mireia Borràs-Fresneda, Joan-Francesc Barquinero, Maria Gomolka et al.     Normal tissue toxicity after radiotherapy shows variability between patients, indicating inter-individual differences in radiosensitivity. Genetic variation probably contributes …             Seven wood-inhabiting new species of the genus Trichoderma (Fungi, Ascomycota) in Viride clade ▶     Wen-Tao Qin, Wen-Ying Zhuang     More than 200 recent collections of Trichoderma from China were examined and 16 species belonging to the Viride clade were identified based on integrated studies of phenotypic …             Longitudinal, label-free, quantitative tracking of cell death and viability in a 3D tumor model with OCT ▶     Yookyung Jung, Oliver J. Klein, Hequn Wang et al.     Three-dimensional in vitro tumor models are highly useful tools for studying tumor growth and treatment response of malignancies such as ovarian cancer. Existing viability and …             Establishment and application of a real-time loop-mediated isothermal amplification system for the detection of CYP2C19 polymorphisms ▶     Chao Zhang, Yao Yao, Juan-Li Zhu et al.     Single-nucleotide polymorphisms (SNPs) represent the most widespread type of genetic variation (approximately 90%) in the human genome, and the demand to overcome such variation …             The Sp1-mediaded allelic regulation of MMP13 expression by an ESCC susceptibility SNP rs2252070 ▶     Meng Shi, Jianhong Xia, Huaixin Xing et al.     Metallopeptidase 13 (MMP13), a well-known and highly regulated zinc-dependent MMP collagenase, plays a crucial part in development and progression of esophageal squamous cell …             The Wheat GT Factor TaGT2L1D Negatively Regulates Drought Tolerance and Plant Development ▶     Xin Zheng, Haipei Liu, Hongtao Ji et al.     GT factors are trihelix transcription factors that specifically regulate plant development and stress responses. Recently, several GT factors have been characterized in different …             Non integrative strategy decreases chromosome instability and improves endogenous pluripotency genes reactivation in porcine induced pluripotent-like stem cells ▶     Annabelle Congras, Harmonie Barasc, Kamila Canale-Tabet et al.     The pig is an emerging animal model, complementary to rodents for basic research and for biomedical and agronomical purposes. However despite the progress made on mouse and rat …             Tomato 26S Proteasome subunit RPT4a regulates ToLCNDV transcription and activates hypersensitive response in tomato ▶     Pranav Pankaj Sahu, Namisha Sharma, Swati Puranik et al.     Involvement of 26S proteasomal subunits in plant pathogen-interactions, and the roles of each subunit in independently modulating the activity of many intra- and inter-cellular …             Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain ▶     Patrick Kanju, Yong Chen, Whasil Lee et al.     TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression. One of the critical functions of TRPV4 in this spectrum is its …             Threatened by mining, polymetallic nodules are required to preserve abyssal epifauna ▶     Ann Vanreusel, Ana Hilario, Pedro A. Ribeiro et al.     Polymetallic nodule mining at abyssal depths in the Clarion Clipperton Fracture Zone (Eastern Central Pacific) will impact one of the most remote and least known environments on …             PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis ▶     Yuchen Zhang, Emilie Viennois, Mingzhen Zhang et al.     In the jejunum, PepT1 is particularly enriched in the well-differentiated absorptive epithelial cells in the villi. Studies of expression and function of PepT1 along the …             Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis ▶     Jung-Yeon Lim, Keon-Il Im, Eun-Sol Lee et al.     Mesenchymal stem cells (MSCs) possess immunomodulatory properties and have potential, however, there have been conflicting reports regarding their effects in rheumatoid arthritis …             Genetic Variation in the TAS2R38 Bitter Taste Receptor and Gastric Cancer Risk in Koreans ▶     Jeong-Hwa Choi, Jeonghee Lee, Il Ju Choi et al.     The human TAS2R38 gene encodes a bitter taste receptor that regulates the bitterness perception and differentiation of ingested nutritional/poisonous compounds in the oral cavity …             Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity ▶     Chao-Shun Yang, Kung-Yen Chang, Jason Dang et al.     The polycomb repressive complex 1 (PRC1) is a multi-subunit complex that plays critical roles in the epigenetic modulation of gene expression. Here, we show that the PRC1 …             Multiple host switching events shape the evolution of symbiotic palaemonid shrimps (Crustacea: Decapoda) ▶     Ivona Horká, Sammy De Grave, Charles H. J. M. Fransen et al.     The majority of the almost 1,000 species of Palaemonidae, the most speciose family of caridean shrimp, largely live in symbioses with marine invertebrates of different phyla. …             The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC ▶     Chunbo Wang, Huan Nie, Yiqun Li et al.     To analyze the relation between SNPs in DNA repair pathway-related genes and sensitivity of tumor radio-chemotherapy, 26 SNPs in 20 DNA repair genes were genotyped on 176 …             Development and Evaluation of a Rapid and Sensitive EBOV-RPA Test for Rapid Diagnosis of Ebola Virus Disease ▶     Mingjuan Yang, Yuehua Ke, Xuesong Wang et al.     Confirming Ebola virus disease (EVD), a deadly infectious disease, requires real-time RT-PCR, which takes up to a few hours to yield results. Therefore, a rapid diagnostic assay …             A synthetic kisspeptin analog that triggers ovulation and advances puberty ▶     C. Decourt, V. Robert, K. Anger et al.     The neuropeptide kisspeptin and its receptor, KiSS1R, govern the reproductive timeline of mammals by triggering puberty onset and promoting ovulation by stimulating …             Polyamine transporter in Streptococcus pneumoniae is essential for evading early innate immune responses in pneumococcal pneumonia ▶     Aswathy N. Rai, Justin A. Thornton, John Stokes et al.     Streptococcus pneumoniae is the most common bacterial etiology of pneumococcal pneumonia in adults worldwide. Genomic plasticity, antibiotic resistance and extreme capsular …             Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients ▶     H. Al-momani, A. Perry, C. J. Stewart et al.     Gastro-Oesophageal Reflux (GOR) is a key problem in Cystic Fibrosis (CF), but the relationship between lung and gastric microbiomes is not well understood. We hypothesised that …             Attractiveness of volatiles from different body parts to the malaria mosquito Anopheles coluzzii is affected by deodorant compounds ▶     Niels O. Verhulst, Berhane T. Weldegergis, David Menger et al.     Mosquitoes display biting preferences among different sites of the human body. In addition to height or convection currents, body odour may play a role in the selection of these …             Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes ▶     Xin Chen, Jun Guo, Tao Cai et al.     Ossification of the posterior longitudinal ligament of the spine (OPLL), which is characterized by ectopic bone formation in the spinal ligaments, can cause spinal-cord …             Proteomic analysis of Plasmodium falciparum parasites from patients with cerebral and uncomplicated malaria ▶     Gwladys I. Bertin, Audrey Sabbagh, Nicolas Argy et al.     Plasmodium falciparum is responsible of severe malaria, including cerebral malaria (CM). During its intra-erythrocytic maturation, parasite-derived proteins are expressed, …             HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide ▶     Nan Feng, Haiying Chen, Sengwang Fu et al.     Thalidomide is used in clinical practice to treat gastrointestinal vascular malformation (GIVM), but the pathogenesis of GIVM is not clear. Hypoxia inducible factor 1 alpha …             Endogenous sulfur dioxide is a novel adipocyte-derived inflammatory inhibitor ▶     Heng Zhang, Yaqian Huang, Dingfang Bu et al.     The present study was designed to determine whether sulfur dioxide (SO2) could be endogenously produced in adipocyte and served as a novel adipocyte-derived inflammatory …             Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress ▶     Carman K. M. Ip, Shan-Shan Li, Matthew Y. H. Tang et al.     One of greatest challenges to the successful treatment of cancer is drug resistance. An exciting approach is the eradication of cancer stem cells (CSCs). However, little is known …             Cytotoxicity and genotoxicity of bacterial magnetosomes against human retinal pigment epithelium cells ▶     Lei Qi, Xiujuan Lv, Tongwei Zhang et al.     A variety of nanomaterials have been developed for ocular diseases. The ability of these nanomaterials to pass through the blood-ocular barrier and their biocompatibility are …             The hydrogen sulfide metabolite trimethylsulfonium is found in human urine ▶     Bassam Lajin, Kevin A. Francesconi     Hydrogen sulfide is the third and most recently discovered gaseous signaling molecule following nitric oxide and carbon monoxide, playing important roles both in normal …             Pharmacological inhibition of MyD88 homodimerization counteracts renal ischemia reperfusion-induced progressive renal injury in vivo and in vitro ▶     Li-Min Zhang, Jian-Hua Liu, Cheng-Biao Xue et al.     The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to ischemia reperfusion (I/R) induced acute kidney injury (AKI) and chronic kidney …             GC Preps: Fast and Easy Extraction of Stable Yeast Genomic DNA ▶     Benjamin A. Blount, Maureen R. M. Driessen, Tom Ellis     Existing yeast genomic DNA extraction methods are not ideally suited to extensive screening of colonies by PCR, due to being too lengthy, too laborious or yielding poor quality …             Regulating the effects of GPR21, a novel target for type 2 diabetes ▶     Siobhán Leonard, Gemma K. Kinsella, Elisa Benetti et al.     Type 2 diabetes is a chronic metabolic disorder primarily caused by insulin resistance to which obesity is a major contributor. Expression levels of an orphan G protein-coupled …             A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative ▶     Boglárka H. Várkuti, Miklós Képiró, István Ádám Horváth et al.     Blebbistatin is a commonly used molecular tool for the specific inhibition of various myosin II isoforms both in vitro and in vivo. Despite its popularity, the use of …             Mitogenomics of southern hemisphere blue mussels (Bivalvia: Pteriomorphia): Insights into the evolutionary characteristics of the Mytilus edulis complex ▶     Juan Diego Gaitán-Espitia, Julian F. Quintero-Galvis, Andres Mesas et al.     Marine blue mussels (Mytilus spp.) are widespread species that exhibit an antitropical distribution with five species occurring in the Northern Hemisphere (M. trossulus, M. edulis…             Exploring flavour-producing core microbiota in multispecies solid-state fermentation of traditional Chinese vinegar ▶     Zong-Min Wang, Zhen-Ming Lu, Jin-Song Shi et al.     Multispecies solid-state fermentation (MSSF), a natural fermentation process driven by reproducible microbiota, is an important technique to produce traditional fermented foods. …             Soil fungal community development in a high Arctic glacier foreland follows a directional replacement model, with a mid-successional diversity maximum ▶     Ke Dong, Binu Tripathi, Itumeleng Moroenyane et al.     Directional replacement and directional non-replacement models are two alternative paradigms for community development in primary successional environments. The first model …             Analysis of the dynamic co-expression network of heart regeneration in the zebrafish ▶     Sophie Rodius, Ganna Androsova, Lou Götz et al.     The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully …             Corrigendum: Computational Approach Towards Exploring Potential Anti-Chikungunya Activity of Selected Flavonoids ▶     Seyedeh Somayeh Seyedi, Munirah Shukri, Pouya Hassandarvish et al.                 Corrigendum: Genetic Variations of NLR family genes in Behcet’s Disease ▶     Lin Li, Hongsong Yu, Yanni Jiang et al.                 Corrigendum: Neuronal activity controls transsynaptic geometry ▶     Oleg O. Glebov, Susan Cox, Lawrence Humphreys et al.                 Corrigendum: Mapping the small-world properties of brain networks in deception with functional near-infrared spectroscopy ▶     Jiang Zhang, Xiaohong Lin, Genyue Fu et al.                 Differential effects of Cytomegalovirus carriage on the immune phenotype of middle-aged males and females ▶     Marieke van der Heiden, Menno C. van Zelm, Sophinus J. W. Bartol et al.     The elderly population is more susceptible to infections as a result of an altered immune response, commonly referred to as immunosenescence. Cytomegalovirus (CMV)-infection …             The Statistical Value of Raw Fluorescence Signal in Luminex xMAP Based Multiplex Immunoassays ▶     Edmond J. Breen, Woei Tan, Alamgir Khan     Tissue samples (plasma, saliva, serum or urine) from 169 patients classified as either normal or having one of seven possible diseases are analysed across three 96-well plates …             Treatment of Rats with Apocynin Has Considerable Inhibitory Effects on Arylamine N-Acetyltransferase Activity in the Liver ▶     Sheena Francis, Nicola Laurieri, Chukwuemeka Nwokocha et al.     The effect of apocynin on the activity of arylamine N-acetyltransferases (NATs) in excised liver samples was examined using eighteen Sprague-Dawley rats. Three groups of six …             Fatty acid profile in the seeds and seed tissues of Paeonia L. species as new oil plant resources ▶     Shuiyan Yu, Shaobo Du, Junhui Yuan et al.     Most common plant oils have little α-linolenic acid (C18:3Δ9,12,15, ALA) and an unhealthy ω6/ω3 ratio. Here, fatty acids (FAs) in the seeds of 11 species of Paeonia L., including …             Protective efficacy and safety of liver stage attenuated malaria parasites ▶     Hirdesh Kumar, Julia Magdalena Sattler, Mirko Singer et al.     During the clinically silent liver stage of a Plasmodium infection the parasite replicates from a single sporozoite into thousands of merozoites. Infection of humans and rodents …             A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo ▶     Constantin C. Paun, Yara T. E. Lechanteur, Joannes M. M. Groenewoud et al.     The complement system is the first line of defense against foreign intruders, and deregulation of this system has been described in multiple diseases. In age-related macular …             An electric generator using living Torpedo electric organs controlled by fluid pressure-based alternative nervous systems ▶     Yo Tanaka, Shun-ichi Funano, Yohei Nishizawa et al.     Direct electric power generation using biological functions have become a research focus due to their low cost and cleanliness. Unlike major approaches using glucose fuels or …             Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8+ T Cells ▶     Cheng Yang, Asma Khanniche, Joanna R. DiSpirito et al.     Memory T cells (TM) play a prominent role in protection and auto-immunity due to their ability to mount a more effective response than naïve T cells (TN). However, the molecular …             Identification of a reticulocyte-specific binding domain of Plasmodium vivax reticulocyte-binding protein 1 that is homologous to the PfRh4 erythrocyte-binding domain ▶     Jin-Hee Han, Seong-Kyun Lee, Bo Wang et al.     The Plasmodium vivax reticulocyte-binding protein (RBP) family was identified based on the annotation of adhesive ligands in the P. vivax genome. Reticulocyte-specific …             Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis ▶     Kuan-Hung Lin, Ya-Hsuan Ho, Jui-Chung Chiang et al.     Lysophosphatidic acid (LPA), a growth factor-like phospholipid, regulates numerous physiological functions, including cell proliferation and differentiation. In a previous study, …             Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces ▶     Boris Zacchetti, Joost Willemse, Brand Recter et al.     Streptomycetes are filamentous bacteria that produce numerous valuable compounds, including the majority of clinically used antibiotics. At an industrial scale, most of these …             Pcdh19 Loss-of-Function Increases Neuronal Migration In Vitro but is Dispensable for Brain Development in Mice ▶     Daniel T. Pederick, Claire C. Homan, Emily J. Jaehne et al.     Protocadherin 19 (Pcdh19) is an X-linked gene belonging to the protocadherin superfamily, whose members are predominantly expressed in the central nervous system and have been …             Proteasome activity is required for the initiation of precancerous pancreatic lesions ▶     Takaki Furuyama, Shinji Tanaka, Shu Shimada et al.     Proteasome activity is significantly increased in advanced cancers, but its role in cancer initiation is not clear, due to difficulties in monitoring this process in vivo. We …             Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration ▶     Christoph Schreiber, Felix J. Segerer, Ernst Wagner et al.     Quantification and discrimination of pharmaceutical and disease-related effects on cell migration requires detailed characterization of single-cell motility. In this context, …             A TonB-dependent receptor regulates antifungal HSAF biosynthesis in Lysobacter ▶     Ruping Wang, Huiyong Xu, Liangcheng Du et al.     Lysobacter species are Gram-negative bacteria that are emerging as new sources of antibiotics, including HSAF (Heat Stable Antifungal Factor), which was identified from L. …             Identification of metal species by ESI-MS/MS through release of free metals from the corresponding metal-ligand complexes ▶     Munkhtsetseg Tsednee, Yu-Chen Huang, Yet-Ran Chen et al.     Electrospray ionization-mass spectrometry (ESI-MS) is used to analyze metal species in a variety of samples. Here, we describe an application for identifying metal species by …             An Improved Method for High Quality Metagenomics DNA Extraction from Human and Environmental Samples ▶     Satyabrata Bag, Bipasa Saha, Ojasvi Mehta et al.     To explore the natural microbial community of any ecosystems by high-resolution molecular approaches including next generation sequencing, it is extremely important to develop a …             Metagenomic sequencing reveals the relationship between microbiota composition and quality of Chinese Rice Wine ▶     Xutao Hong, Jing Chen, Lin Liu et al.     Chinese Rice Wine (CRW) is a common alcoholic beverage in China. To investigate the influence of microbial composition on the quality of CRW, high throughput sequencing was …             A Microfabricated Platform for Generating Physiologically-Relevant Hepatocyte Zonation ▶     William J. McCarty, O. Berk Usta, Martin L. Yarmush     In vitro liver models have been important tools for more than 40 years for academic research and preclinical toxicity screening by the pharmaceutical industry. Hepatocytes, the …             Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion ▶     Joshua L. Heuslein, Kelsey P. Murrell, Ryan J. Leiphart et al.     Arteriogenesis, or the lumenal expansion of pre-existing arterioles in the presence of an upstream occlusion, is a fundamental vascular growth response. Though alterations in …             Corrigendum: Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch ▶     Nassim Dali-Youcef, Karim Hnia, Sébastien Blaise et al.                 Erratum: CAP2 in cardiac conduction, sudden cardiac death and eye development ▶     Jeffrey Field, Diana Z. Ye, Manasi Shinde et al.                 Corrigendum: Generation of a monoclonal antibody recognizing the CEACAM glycan structure and inhibiting adhesion using cancer tissue-originated spheroid as an antigen ▶     Yumi Sato, Hiroaki Tateno, Jun Adachi et al.                 Corrigendum: Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation ▶     Tien-Jyun Chang, Hsing-Chi Tseng, Meng-Wei Liu et al.                 ALG-2 interacting protein-X (Alix) is essential for clathrin-independent endocytosis and signaling ▶     Vincent Mercier, Marine H. Laporte, Olivier Destaing et al.     The molecular mechanisms and the biological functions of clathrin independent endocytosis (CIE) remain largely elusive. Alix (ALG-2 interacting protein X), has been assigned …             Dissolved Organic Carbon in the North Atlantic Meridional Overturning Circulation ▶     Marcos Fontela, Maribel I. García-Ibáñez, Dennis A. Hansell et al.     The quantitative role of the Atlantic Meridional Overturning Circulation (AMOC) in dissolved organic carbon (DOC) export is evaluated by combining DOC measurements with observed …             Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice ▶     Vir B. Singh, Meera V. Singh, Santhi Gorantla et al.     Human Immunodeficiency Virus type-1 (HIV)-associated neurocognitive disorder is characterized by recruitment of activated/infected leukocytes into the CNS via disrupted Blood …             The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion ▶     Martijn J. Kool, Jolet E. van de Bree, Hanna E. Bodde et al.     Genetic approaches using temporal and brain region-specific restricted gene deletions have provided a wealth of insight in the brain regions and temporal aspects underlying …             Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation ▶     N. Arecco, C. J. Clarke, F. K. Jones et al.     In Duchenne muscular dystrophy, progressive loss of muscle tissue is accompanied by fibrosis, chronic inflammation and reduced muscle regenerative capacity. Although much is …             A Phytophthora sojae effector PsCRN63 forms homo-/hetero-dimers to suppress plant immunity via an inverted association manner ▶     Qi Li, Meixiang Zhang, Danyu Shen et al.     Oomycete pathogens produce a large number of effectors to promote infection. Their mode of action are largely unknown. Here we show that a Phytophthora sojae effector, PsCRN63, …             Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer ▶     Eva Pigna, Emanuele Berardi, Paola Aulino et al.     Recent studies have correlated physical activity with a better prognosis in cachectic patients, although the underlying mechanisms are not yet understood. In order to identify …             Analysis of tigecycline resistance development in clinical Acinetobacter baumannii isolates through a combined genomic and transcriptomic approach ▶     Lin Liu, Yujun Cui, Beiwen Zheng et al.     Tigecycline (Tgc) is considered a last-resort antibiotic for the treatment of multi-drug resistant bacteria. To study Tgc resistance development in the important nosocomial …             Changing ideas about others’ intentions: updating prior expectations tunes activity in the human motor system ▶     Pierre O. Jacquet, Alice C. Roy, Valérian Chambon et al.     Predicting intentions from observing another agent’s behaviours is often thought to depend on motor resonance – i.e., the motor system’s response to a perceived movement by the …             Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes ▶     Su Mei Yew, Chai Ling Chan, Yun Fong Ngeow et al.     Cladosporium sphaerospermum, a dematiaceous saprophytic fungus commonly found in diverse environments, has been reported to cause allergy and other occasional diseases in humans. …             Non-thermal Plasma Exposure Rapidly Attenuates Bacterial AHL-Dependent Quorum Sensing and Virulence ▶     Padrig B. Flynn, Alessandro Busetti, Ewa Wielogorska et al.     The antimicrobial activity of atmospheric pressure non-thermal plasma has been exhaustively characterised, however elucidation of the interactions between biomolecules produced …             Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract ▶     Alison J. Carey, Jason B. Weinberg, Suzanne R. Dawid et al.     Postpartum women are at increased risk of developing puerperal sepsis caused by group A Streptococcus (GAS). Specific GAS serotypes, including M1 and M28, are more commonly …             Bioengineered kidney tubules efficiently excrete uremic toxins ▶     J. Jansen, M. Fedecostante, M. J. Wilmer et al.     The development of a biotechnological platform for the removal of waste products (e.g. uremic toxins), often bound to proteins in plasma, is a prerequisite to improve current …             The Analysis of the Influence of Odorant’s Complexity on Fractal Dynamics of Human Respiration ▶     Hamidreza Namazi, Amin Akrami, Vladimir V. Kulish     One of the major challenges in olfaction research is to relate the structural features of the odorants to different features of olfactory system. However, no relationship has …             Understory herb layer exerts strong controls on soil microbial communities in subtropical plantations ▶     Kai Yin, Lei Zhang, Dima Chen et al.     The patterns and drivers of soil microbial communities in forest plantations remain inadequate although they have been extensively studied in natural forest and grassland …             Global methylation, oxidative stress, and relative telomere length in biliary atresia patients ▶     Wanvisa Udomsinprasert, Nakarin Kitkumthorn, Apiwat Mutirangura et al.     Alu and LINE-1 elements are retrotransposons with a ubiquitous presence in the human genome that can cause genomic instability, specifically relating to telomere length. …             Exogenous NAD+ decreases oxidative stress and protects H2O2-treated RPE cells against necrotic death through the up-regulation of autophagy ▶     Ying Zhu, Ke-ke Zhao, Yao Tong et al.     Increased oxidative stress, which can lead to the retinal pigment epithelium (RPE) cell death by inducing ATP depletion and DNA repair, is believed to be a prominent pathology in …             Lanthanum induced B-to-Z transition in self-assembled Y-shaped branched DNA structure ▶     Ashok K. Nayak, Aseem Mishra, Bhabani S. Jena et al.     Controlled conversion of right-handed B-DNA to left-handed Z-DNA is one of the greatest conformational transitions in biology. Recently, the B-Z transition has been explored from …             Early pancreatic islet fate and maturation is controlled through RBP-Jκ ▶     Corentin Cras-Méneur, Megan Conlon, Yaqing Zhang et al.     Notch signaling is known to control early pancreatic differentiation through Ngn3 repression. In later stages, downstream of Notch, the Presenilins are still required to maintain …             Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway ▶     Ran Wang, Qian Zhang, Xin Peng et al.     Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC). Marine organisms are rich source of novel compounds with …             LPS/TLR4 Signaling Enhances TGF-β Response Through Downregulating BAMBI During Prostatic Hyperplasia ▶     Yao He, Zhenyu Ou, Xiang Chen et al.     Compelling evidence suggests that benign prostatic hyperplasia (BPH) development involves accumulation of mesenchymal-like cells derived from the prostatic epithelium by …             Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart ▶     Vanessa M. Mahoney, Valeria Mezzano, Gary R. Mirams et al.     Studies have demonstrated non-myocytes, including fibroblasts, can electrically couple to myocytes in culture. However, evidence demonstrating current can passively spread across …             Plasma β-amyloid in Alzheimer’s disease and vascular disease ▶     Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist et al.     Implementation of amyloid biomarkers in clinical practice would be accelerated if such biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a …             The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways ▶     Huili Zhu, Yusheng Zhang, Zhongshan Shi et al.     Glucagon-like peptide-1 (GLP-1) is an incretin hormone that increases glucose-dependent insulin secretion to reduce the glucose level. Liraglutide, a long-acting GLP-1 analogue, …             Variation in serum biomarkers with sex and female hormonal status: implications for clinical tests ▶     Jordan M. Ramsey, Jason D. Cooper, Brenda W. J. H. Penninx et al.     Few serum biomarker tests are implemented in clinical practice and recent reports raise concerns about poor reproducibility of biomarker studies. Here, we investigated the …             Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus ▶     Joon W. Shim, Johanna Sandlund, Mustafa Q. Hameed et al.     Heparin binding epidermal growth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the developing forebrain, while vascular endothelial …             Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates ▶     Yuhei Kirita, Daisuke Kami, Ryo Ishida et al.     Reconstitution of total nephron segments after resection in the adult kidney has not been achieved; however, whether the neonatal kidney can maintain the capacity for …               • Careers & Jobs         naturejobs.com Science jobs of the week       Research Technician     Roskamp Institute            Research Associate (Assistant Professor)     University of Chicago            Associate Research Fellow     University of Exeter            Early Career Development Fellowships     Manchester Cancer Research Centre            Group Leaders     European Molecular Biology Laboratory (EMBL)            Postdoctoral Research Assistant     University of Dundee            Doctoral student positions     University of Oulu            Postdoctoral Training Fellow     Institute of Cancer Research (ICR)            Diabetes UK RD Lawrence Fellowships     Diabetes UK            Associate Research Scientist     Herbert Irving Comprehensive Cancer Center          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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