Nature Reviews Genetics Contents July 2016 Volume 17 Number 7 pp373-433

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TABLE OF CONTENTS
July 2016 Volume 17 Number 7
Impact Factor 36.978 *	In this issue Research Highlights Reviews Also this month  Featured article: Determinants of genetic diversity Hans Ellegren & Nicolas Galtier
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RESEARCH HIGHLIGHTS Top Translation: Live stream: translation at single-mRNA resolution p373 | doi:10.1038/nrg.2016.79 PDF Population genetics: Bursts of male-lineage expansions p374 | doi:10.1038/nrg.2016.63 PDF Cancer genetics: Evading antitumour immunity p374 | doi:10.1038/nrg.2016.77 PDF Technique: CRISP(e)R genetic mapping p375 | doi:10.1038/nrg.2016.68 PDF Chromatin: Cracking the nucleosome code p376 | doi:10.1038/nrg.2016.70 PDF Evolution: Duplicate gene co-regulation slows evolution p376 | doi:10.1038/nrg.2016.75 PDF Regulatory elements: Putting enhancers into context p377 | doi:10.1038/nrg.2016.74 PDF Cancer genomics: A catalogue of somatic mutations p378 | doi:10.1038/nrg.2016.65 PDF Metagenomics: Pathogen diagnostics for the masses p378 | doi:10.1038/nrg.2016.76 PDF IN BRIEF Cancer genetics: Oncohistone pathology explained | Genetic engineering: A new player in genome editing | Genetic variation: Genetic associations with a social science outcome PDF Genetics JOBS of the week wiss. Mitarbeiter / in / Doktorand / in TU Dresden Junior Group Leader Position, Tenure Track: Neural Basis of Animal Behavior Friedrich Miescher Institute for Biomedical Research (FMI) PhD Candidate / Student Uniklinik Koln Postdoctoral Scientists Cedars-Sinai Postdoctoral Fellow The Scripps Research Institute (TSRI) More Science jobs from Genetics EVENT Advances in the Neurobiology of Mental Illness 07.10.16 New York, USA More science events from
REVIEWS		Top
Evolution by gene loss Ricard Albalat & Cristian Cañestro p379 | doi:10.1038/nrg.2016.39 Gene loss is emerging as a pervasive source of genetic variation. The authors review the mechanisms by which gene loss has influenced evolution of different species and discuss insights from comparative population genomics studies of gene loss. Further, they highlight future directions for the study of gene losses and their relevance in evolutionary biology and biomedicine. Abstract | Full Text | PDF | Supplementary information
Developing and evaluating polygenic risk prediction models for stratified disease prevention Nilanjan Chatterjee, Jianxin Shi & Montserrat García-Closas p392 | doi:10.1038/nrg.2016.27 Common diseases have complex aetiology involving the interplay of genetic susceptibility and environmental risk factors. Here, the authors describe methods for building and evaluating models for the prediction of disease risk based on information from genetic testing and environmental factors, and use case studies to illustrate the potential of such models in the prevention of diseases. Abstract | Full Text | PDF | Supplementary information
Lessons from non-canonical splicing Christopher R. Sibley, Lorea Blazquez & Jernej Ule p407 | doi:10.1038/nrg.2016.46 Advances in transcriptomics and analysis have identified thousands of previously unknown non-canonical splicing events. In this Review, the authors discuss the mechanisms and functions of these events and their roles in a variety of diseases. They explain how non-canonical splicing mechanisms can be targeted or exploited for therapeutic strategies. Abstract | Full Text | PDF
Determinants of genetic diversity Hans Ellegren & Nicolas Galtier p422 | doi:10.1038/nrg.2016.58 The degree of genetic diversity differs greatly among species and across genomic loci within genomes. The wide ranges in genetic diversity have important implications, including for evolution, conservation and management of wild and domesticated species. In this Review, the authors discuss how genome-scale sequencing strategies are providing insight into the varied determinants of genetic variation both among species and across genomic regions. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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