Nature Communications -15 June 2016

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Journal homepage Recommend to library Web feed   Advertisement npj Clean Water: open for submissions  An open access, online-only journal, dedicated to publishing high-quality papers that describe the significant and cutting-edge research that continues to ensure the supply of clean water to populations. Explore the benefits of submitting your next manuscript.       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Neonatal face-to-face interactions promote later social behaviour in infant rhesus monkeys OPEN Amanda M. Dettmer, Stefano S. K. Kaburu, Elizabeth A. Simpson, Annika Paukner, Valentina Sclafani, Kristen L. Byers, Ashley M. Murphy, Michelle Miller, Neal Marquez, Grace M. Miller, Stephen J. Suomi and Pier F. Ferrari Like humans, neonatal primates engage in face-to-face interactions with their mothers from an early age. Dettmer and colleagues demonstrate that in monkeys, increasing neonatal face-to-face interactions enhances social interest in infants of two and five months. 14 June 2016 | doi: 10.1038/ncomms11940 Biological Sciences  Neuroscience  Zoology  Male care and life history traits in mammals OPEN Hannah E. R. West and Isabella Capellini Males help care for offspring in about 10% of mammal species. Here, West and Capellini perform phylogenetic comparative analyses on a sample of 529 mammal species and find that male care is associated with shorter lactation periods by females, larger litters of offspring, and more frequent breeding events. 14 June 2016 | doi: 10.1038/ncomms11854 Biological Sciences  Evolution  Zoology  A new type of solar-system material recovered from Ordovician marine limestone OPEN B. Schmitz, Q. -Z. Yin, M. E. Sanborn, M. Tassinari, C. E. Caplan and G. R. Huss Meteorites falling on Earth today are believed to represent 100–150 parent bodies. Within 470  Myr ago sediments at a limestone quarry in Sweden, Schmitz et al. have found and identified a new type of meteorite based on chromium and oxygen isotopes sourced from a previously unknown parental body. 14 June 2016 | doi: 10.1038/ncomms11851 Earth Sciences  Geology and geophysics  Planetary sciences  Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics OPEN Eloy F. Robles, Maria Mena-Varas, Laura Barrio, Sara V. Merino-Cortes, Péter Balogh, Ming-Qing Du, Takashi Akasaka, Anton Parker, Sergio Roa, Carlos Panizo, Idoia Martin-Guerrero, Reiner Siebert, Victor Segura, Xabier Agirre, Laura Macri-Pellizeri, Beatriz Aldaz, Amaia Vilas-Zornoza, Shaowei Zhang, Sarah Moody, Maria Jose Calasanz et al. The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes. Here, the authors show that NKX2-3 is a bona fide oncogenic driver in marginal-zone B-cell lymphoma and that it promotes lymphomagenesis by shaping lymphocyte dynamics and promoting BCR signalling. 14 June 2016 | doi: 10.1038/ncomms11889 Biological Sciences  Cancer  Immunology  Failure mechanisms of single-crystal silicon electrodes in lithium-ion batteries OPEN Feifei Shi, Zhichao Song, Philip N. Ross, Gabor A. Somorjai, Robert O. Ritchie and Kyriakos Komvopoulos Long-term durability is crucial for heavy-duty usage of lithium ion batteries; however, electrode failure mechanisms are still unknown. Here, the authors reveal the fracture mechanisms of single crystal silicon electrodes over extended cycling, and show how electrolyte additives can heal electrode cracks. 14 June 2016 | doi: 10.1038/ncomms11886 Chemical Sciences  Materials science  Physical chemistry  Polymorphism in magic-sized Au144(SR)60 clusters OPEN Kirsten M.Ø. Jensen, Pavol Juhas, Marcus A. Tofanelli, Christine L. Heinecke, Gavin Vaughan, Christopher J. Ackerson and Simon J. L. Billinge Gold nanoclusters are important nanomaterials but their structural assignment can be challenging if single crystals can’t be grown. Here, the authors use pair distribution function analysis of X-ray powder diffraction data for Au144(SR)60 nanoclusters, and show that they exhibit polymorphism. 14 June 2016 | doi: 10.1038/ncomms11859 Chemical Sciences  Inorganic chemistry  Nanotechnology  Physical chemistry  A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging OPEN Takahiro Kuchimaru, Satoshi Iwano, Masahiro Kiyama, Shun Mitsumata, Tetsuya Kadonosono, Haruki Niwa, Shojiro Maki and Shinae Kizaka-Kondoh D-luciferin is the standard bioluminescent substrate for in vitro and in vivo imaging. Here the authors introduce AkaLumine-HCl, a soluble luciferin analogue with a near-infrared emission maximum, which allows deep tissue imaging at lower concentrations than D-luciferin. 14 June 2016 | doi: 10.1038/ncomms11856 Biological Sciences  Biotechnology  Calredoxin represents a novel type of calcium-dependent sensor-responder connected to redox regulation in the chloroplast OPEN Ana Karina Hochmal, Karen Zinzius, Ratana Charoenwattanasatien, Philipp Gäbelein, Risa Mutoh, Hideaki Tanaka, Stefan Schulze, Gai Liu, Martin Scholz, André Nordhues, Jan Niklas Offenborn, Dimitris Petroutsos, Giovanni Finazzi, Christian Fufezan, Kaiyao Huang, Genji Kurisu and Michael Hippler Calcium and redox signalling have important roles in acclimation processes. Here, the authors characterise a protein from Chlamydomonas reinhardtii that can integrate calcium and redox-related signalling. 14 June 2016 | doi: 10.1038/ncomms11847 Biological Sciences  Biochemistry  Plant sciences  High-flexibility combinatorial peptide synthesis with laser-based transfer of monomers in solid matrix material OPEN Felix F. Loeffler, Tobias C. Foertsch, Roman Popov, Daniela S. Mattes, Martin Schlageter, Martyna Sedlmayr, Barbara Ridder, Florian-Xuan Dang, Clemens von Bojničić-Kninski, Laura K. Weber, Andrea Fischer, Juliane Greifenstein, Valentina Bykovskaya, Ivan Buliev, F. Ralf Bischoff, Lothar Hahn, Michael A. R. Meier, Stefan Bräse, Annie K. Powell, Teodor Silviu Balaban et al. Peptide arrays are used in areas such as measuring protein-protein interactions, but achieving high density in synthesis is challenging. Here, the authors report a method for the combinatorial synthesis of high density peptides arrays by laser driven sequential transfer of monomers onto acceptor surfaces. 14 June 2016 | doi: 10.1038/ncomms11844 Chemical Sciences  Chemical biology  Materials science  Organic chemistry  Fast nanoscale addressability of nitrogen-vacancy spins via coupling to a dynamic ferromagnetic vortex OPEN M. S. Wolf, R. Badea and J. Berezovsky Nitrogen vacancies in diamond present single spin defects which may be used as nanoscale magnetic sensors. Here, Wolf et al. demonstrate how a ferromagnetic vortex in an adjacent micromagnet allows for fast nanoscale addressability of individual defect spins in nanodiamonds. 14 June 2016 | doi: 10.1038/ncomms11584 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis OPEN Shuke Wu, Yi Zhou, Tianwen Wang, Heng-Phon Too, Daniel I. C. Wang and Zhi Li Biocatalysis can perform highly selective multi-step synthesis in one pot, but with a limited range of non-natural reactions and products. Here, the authors report regio- and enantioselective bio-cascades, able to convert styrenes into a number of nitrogen and oxygen containing chiral molecules. 14 June 2016 | doi: 10.1038/ncomms11917 Chemical Sciences  Biotechnology  Catalysis  Organic chemistry  Full circumpolar migration ensures evolutionary unity in the Emperor penguin OPEN Robin Cristofari, Giorgio Bertorelle, André Ancel, Andrea Benazzo, Yvon Le Maho, Paul J. Ponganis, Nils Chr Stenseth, Phil N. Trathan, Jason D. Whittington, Enrico Zanetti, Daniel P. Zitterbart, Céline Le Bohec and Emiliano Trucchi Delimiting populations is crucial for conserving threatened species. Using genome-wide data from the whole of Antarctica, Cristofari et al. show that Emperor penguins are organised into a single global population that have shared demography since the late Quarternary. 14 June 2016 | doi: 10.1038/ncomms11842 Biological Sciences  Ecology  Evolution  Genetics  Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity OPEN Rouven Hoefflin, Bernd Lahrmann, Gregor Warsow, Daniel Hübschmann, Cathleen Spath, Britta Walter, Xin Chen, Luisa Hofer, Stephan Macher-Goeppinger, Yanis Tolstov, Nina Korzeniewski, Anette Duensing, Carsten Grüllich, Dirk Jäger, Sven Perner, Gita Schönberg, Joanne Nyarangi-Dix, Sanjay Isaac, Gencay Hatiboglu, Dogu Teber et al. It has been increasingly recognised that tumours are not made up of a homogeneous population of cells. Here, the authors show heterogeneous expression of five protein markers in renal cell cancer and demonstrate that the progression of the tumour does not influence the degree of heterogeneity in the tumour. 13 June 2016 | doi: 10.1038/ncomms11845 Biological Sciences  Cancer  Genetics  Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation OPEN Jun Li, Cancan Chen, Xiancai Ma, Guannan Geng, Bingfeng Liu, Yijun Zhang, Shaoyang Zhang, Fudi Zhong, Chao Liu, Yue Yin, Weiping Cai and Hui Zhang Long noncoding RNAs have a wide range of physiological functions, though their role in viral infection and latency is poorly understood. Here the authors show a lncRNA NRON can induce degradation of HIV-1 protein Tat, potentially contributing to latent infection. 13 June 2016 | doi: 10.1038/ncomms11730 Biological Sciences  Immunology  Molecular biology  Laboratory analogue of a supersonic accretion column in a binary star system OPEN J. E. Cross, G. Gregori, J. M. Foster, P. Graham, J. -M. Bonnet-Bidaud, C. Busschaert, N. Charpentier, C. N. Danson, H. W. Doyle, R. P. Drake, J. Fyrth, E. T. Gumbrell, M. Koenig, C. Krauland, C. C. Kuranz, B. Loupias, C. Michaut, M. Mouchet, S. Patankar, J. Skidmore et al. Stationary radiative shocks are expected to form above the surface of highly-magnetized white dwarves in binary systems, but this cannot be resolved by telescopes. Here, the authors report a laboratory experiment showing the evolution of a reverse shock when both ionization and radiative losses are important. 13 June 2016 | doi: 10.1038/ncomms11899 Physical Sciences  Astronomy  Fluids and plasma physics  Stabilizing lithium metal using ionic liquids for long-lived batteries OPEN A. Basile, A. I. Bhatt and A. P. O’Mullane Suppressing dendrite formation at lithium anodes during cycling is critical to development of lithium battery technology. Here, the authors show that immersion of lithium electrodes in ionic liquid electrolytes prior to battery assembly produces a durable and lithium ion permeable solid-electrolyte interphase. 13 June 2016 | doi: 10.1038/ncomms11794 Chemical Sciences  Materials science  Physical chemistry  Mesoscale atmosphere ocean coupling enhances the transfer of wind energy into the ocean OPEN D. Byrne, M. Münnich, I. Frenger and N. Gruber The precise mechanism for wind energy input into the ocean at mesoscales remains uncertain. Here, using a high-resolution atmosphere-ocean model of the South Atlantic, the authors show that a mesoscale conduit associated with oceanic eddies is responsible for up to 10% of kinetic energy transfer. 13 June 2016 | doi: 10.1038/ncomms11867 Earth Sciences  Atmospheric science  Oceanography  Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1 OPEN Shigeru Matsumura, Tomoko Kojidani, Yuji Kamioka, Seiichi Uchida, Tokuko Haraguchi, Akatsuki Kimura and Fumiko Toyoshima Studies imply that cell adhesion geometry during interphase dictates the orientation of the cell division axis. Here the authors show that accumulation of caveolin-1 to rapidly retracting regions during cell rounding sets the spindle orientation by recruiting Gαi1-LGN-NuMA to the cortex. 13 June 2016 | doi: 10.1038/ncomms11858 Biological Sciences  Cell biology  Vacuum Rabi splitting in a plasmonic cavity at the single quantum emitter limit OPEN Kotni Santhosh, Ora Bitton, Lev Chuntonov and Gilad Haran Strong coupling at the limit of a single quantum emitter has not been reported. Here, Santhosh et al. show a transparency dip is observed in the scattering spectra of individual silver bowties with one to a few quantum dots, placing the plasmonic bowtie-quantum dot constructs close to the strong coupling regime. 13 June 2016 | doi: 10.1038/ncomms11823 Physical Sciences  Nanotechnology  Optical physics  In vivo imaging of clock gene expression in multiple tissues of freely moving mice OPEN Toshiyuki Hamada, Kenneth Sutherland, Masayori Ishikawa, Naoki Miyamoto, Sato Honma, Hiroki Shirato and Ken-ichi Honma The circadian rhythms of peripheral clocks are difficult to study. Here the authors demonstrate a technique to image clock gene expression simultaneously in various tissues of freely moving mice, and use it to show that a long duration light pulse resets the rhythms in the olfactory bulb faster than other tissues. 10 June 2016 | doi: 10.1038/ncomms11705 Biological Sciences  Biotechnology  Neuroscience  First wide-angle view of channelized turbidity currents links migrating cyclic steps to flow characteristics OPEN John E. Hughes Clarke The basal structure of turbidity currents and their association with crescent-shaped bedforms has not been observed at the field scale. Here, the author presents views of turbidity currents moving over and modifying such bedforms in a manner consistent with theoretical and laboratory studies of cyclic steps. 10 June 2016 | doi: 10.1038/ncomms11896 Earth Sciences  Geology and geophysics  DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis OPEN Kunlun Li, Renbo Yu, Liu-Min Fan, Ning Wei, Haodong Chen and Xing Wang Deng Gibberellins (GA) negatively regulate light-mediated suppression of hypocotyl elongation in plants. Here, Li et al. show that GA-mediated destabilization of DELLA proteins promotes accumulation of the light-regulated PIF transcription factors thus contributing to the crosstalk between light and GA signalling. 10 June 2016 | doi: 10.1038/ncomms11868 Biological Sciences  Plant sciences  First-principles quantum dynamical theory for the dissociative chemisorption of H2O on rigid Cu(111) OPEN Zhaojun Zhang, Tianhui Liu, Bina Fu, Xueming Yang and Dong H. Zhang Dissociative chemisorption dynamics of polyatomic molecules on surfaces are still challenging to probe quantitatively. Here, the authors report the 9-dimensional quantum dynamics of H2O dissociative chemisorption on Cu(111), with the highest level of accuracy yet seen for this prototypical reaction. 10 June 2016 | doi: 10.1038/ncomms11953 Chemical Sciences  Catalysis  Physical chemistry  Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway OPEN Ruud H. Wijdeven, Hans Janssen, Leila Nahidiazar, Lennert Janssen, Kees Jalink, Ilana Berlin and Jacques Neefjes Autophagy requires transport of autophagosomes to the perinuclear region. Here, the authors show that ORP1L localizes to autophagosomes and mediates formation of ER contact sites that prevent autophagosome transport and fusion with endocytic vesicles when cholesterol levels are low. 10 June 2016 | doi: 10.1038/ncomms11808 Biological Sciences  Cell biology  Lasting mantle scars lead to perennial plate tectonics OPEN Philip J. Heron, Russell N. Pysklywec and Randell Stephenson The causes of intraplate deformation remain poorly constrained. Heron et al. use numerical models to show that ancient plate tectonic processes produce mantle lithosphere structures that may be reactivated to generate intraplate deformation. 10 June 2016 | doi: 10.1038/ncomms11834 Earth Sciences  Geology and geophysics  Interfacial control of oxygen vacancy doping and electrical conduction in thin film oxide heterostructures OPEN Boyd W. Veal, Seong Keun Kim, Peter Zapol, Hakim Iddir, Peter M. Baldo and Jeffrey A. Eastman Oxygen vacancies near the interface in oxide heterostructures can lead to large changes in properties, including metal–insulator transition temperatures or catalytic activity. Here, the authors demonstrate a way to reversibly control the oxygen-vacancy concentration and distribution in oxide heterostructures. 10 June 2016 | doi: 10.1038/ncomms11892 Physical Sciences  Condensed matter  Materials science  Massive subsurface ice formed by refreezing of ice-shelf melt ponds OPEN Bryn Hubbard, Adrian Luckman, David W. Ashmore, Suzanne Bevan, Bernd Kulessa, Peter Kuipers Munneke, Morgane Philippe, Daniela Jansen, Adam Booth, Heidi Sevestre, Jean-Louis Tison, Martin O’Leary and Ian Rutt The influence of surface ponding on the interior of ice shelves is currently unknown. Here, the authors combine surface and borehole geophysics on the Larsen C Ice Shelf, Antarctica, with remote sensing and modelling and show how pond refreezing increases ice shelf density and temperature. 10 June 2016 | doi: 10.1038/ncomms11897 Earth Sciences  Climate science  Geology and geophysics  Evidence for a chemical clock in oscillatory formation of UiO-66 OPEN M. G. Goesten, M. F. de Lange, A. I. Olivos-Suarez, A. V. Bavykina, P. Serra-Crespo, C. Krywka, F. M. Bickelhaupt, F. Kapteijn and Jorge Gascon Reactions with non-linear kinetics, such as chemical clocks, are reasonably common but only well understood in the liquid phase. Here, the authors report and rationalize a chemical clock reaction taking place in a solidifying metal-organic framework. 10 June 2016 | doi: 10.1038/ncomms11832 Chemical Sciences  Inorganic chemistry  Materials science  Plasma optical modulators for intense lasers OPEN Lu-Le Yu, Yao Zhao, Lie-Jia Qian, Min Chen, Su-Ming Weng, Zheng-Ming Sheng, D. A. Jaroszynski, W. B. Mori and Jie Zhang Optical modulators are easily damaged by high-intensity pulses. Here, the authors propose a method for directly modulating high-power laser light across a broad spectral range using a wave generated in a sub-millimetre-scale underdense plasma by a second laser. 10 June 2016 | doi: 10.1038/ncomms11893 Physical Sciences  Fluids and plasma physics  Optical physics  Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens OPEN Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea C. Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard and Paul J. Lehner CRISPR/Cas9-mediated forward genetic screens and gene-trap mutagenesis screens in haploid cells are both powerful techniques to examine gene function. Here, the authors show the two approaches have high concordance and identify an uncharacterized gene, TXNDC11, which is involved in endoplasmic reticulum-associated degradation. 10 June 2016 | doi: 10.1038/ncomms11786 Biological Sciences  Cell biology  Molecular biology  Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation OPEN Jonathan Latham, Jean-Marc Henry, Humera H. Sharif, Binuraj R. K. Menon, Sarah A. Shepherd, Michael F. Greaney and Jason Micklefield Biocatalysis and metal catalysis often provide complimentary reactivities and selectivities. Here, the authors exploit the regioselectivity of an enzymatic C–H activation followed by palladium catalysed carbon-carbon bond formation in one pot, with membrane compartmentalization used to isolate the two chemistries. 10 June 2016 | doi: 10.1038/ncomms11873 Chemical Sciences  Catalysis  Chemical biology  Organic chemistry  Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients OPEN Jacob J. Chabon, Andrew D. Simmons, Alexander F. Lovejoy, Mohammad S. Esfahani, Aaron M. Newman, Henry J. Haringsma, David M. Kurtz, Henning Stehr, Florian Scherer, Chris A. Karlovich, Thomas C. Harding, Kathleen A. Durkin, Gregory A. Otterson, W. Thomas Purcell, D. Ross Camidge, Jonathan W. Goldman, Lecia V. Sequist, Zofia Piotrowska, Heather A. Wakelee, Joel W. Neal et al. EGFR-mutant non-small cell lung cancer is routinely treated with EGFR inhibitors, although resistance inevitably develops. Here, the authors sequence circulating tumour DNA and show that resistance to the third-generation inhibitor rociletinib is heterogeneous and recurrently involves somatic alterations of MET, EGFR, PIK3CA, ERRB2, and KRAS. 10 June 2016 | doi: 10.1038/ncomms11815 Biological Sciences  Cancer  Genetics  Efficient hydrogen evolution in transition metal dichalcogenides via a simple one-step hydrazine reaction OPEN Dustin R. Cummins, Ulises Martinez, Andriy Sherehiy, Rajesh Kappera, Alejandro Martinez-Garcia, Roland K. Schulze, Jacek Jasinski, Jing Zhang, Ram K. Gupta, Jun Lou, Manish Chhowalla, Gamini Sumanasekera, Aditya D. Mohite, Mahendra K. Sunkara and Gautam Gupta Transition metal dichalcogenides are promising hydrogen evolution catalysts however they can require expensive processing steps to enhance their activity. Here, the authors report a one-step activation step in which room temperature hydrazine treatment results in much enhanced electrocatalytic performance. 10 June 2016 | doi: 10.1038/ncomms11857 Chemical Sciences  Catalysis  Inorganic chemistry  Materials science  Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes OPEN Rizi Ai, Deepa Hammaker, David L. Boyle, Rachel Morgan, Alice M. Walsh, Shicai Fan, Gary S. Firestein and Wei Wang Rheumatoid arthritis is an inflammatory disease that selectively affects different joints. Here the authors show that gene expression and DNA methylation patterns of fibroblast-like synoviocytes differ between hip and knee joints in patients with RA, thus providing epigenetic and transcriptomic evidence for this anatomic selectivity of inflammation. 10 June 2016 | doi: 10.1038/ncomms11849 Biological Sciences  Medical research  Integration of metal-organic frameworks into an electrochemical dielectric thin film for electronic applications OPEN Wei-Jin Li, Juan Liu, Zhi-Hua Sun, Tian-Fu Liu, Jian Lü, Shui-Ying Gao, Chao He, Rong Cao and Jun-Hua Luo The integration of porous metal-organic frameworks into devices for electronic applications is in its infancy. Here, the authors deposit metal-organic framework films onto conductive metal plate electrodes, and show that the resulting films exhibit enhanced dielectric properties. 10 June 2016 | doi: 10.1038/ncomms11830 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  Palladium/N-heterocyclic carbene catalysed regio and diastereoselective reaction of ketones with allyl reagents via inner-sphere mechanism OPEN Da-Chang Bai, Fei-Le Yu, Wan-Ying Wang, Di Chen, Hao Li, Qing-Rong Liu, Chang-Hua Ding, Bo Chen and Xue-Long Hou Palladium catalyzed allylic substitution reactions typically proceed via an outer sphere mechanism, yielding predominately linear products. Here, the authors report an inner sphere process for the allylic substitution of ketone enolates, giving branched products with up to three contiguous stereocentres. 10 June 2016 | doi: 10.1038/ncomms11806 Chemical Sciences  Catalysis  Organic chemistry  Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex OPEN Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani and Isao Hasegawa Episodic or declarative memory is thought to be encoded in the ensemble firing of spatially distributed neurons. Here the authors use high-density electrical recordings to show that some areas in the primate temporal cortex develop patterns of theta activity that are similar for pairs of remembered objects. 10 June 2016 | doi: 10.1038/ncomms11827 Biological Sciences  Neuroscience  Activity-dependent plasticity of hippocampal place maps OPEN Philipp Schoenenberger, Joseph O’Neill and Jozsef Csicsvari Place cells in hippocampus encode a map of space, however the role of activity in place map stability is not known. Schoenenberger and colleagues optogenetically manipulate hippocampal firing rates within place fields and show lasting changes in spatial firing patterns through two separate mechanisms. 10 June 2016 | doi: 10.1038/ncomms11824 Biological Sciences  Neuroscience  Crystal structure of NOD2 and its implications in human disease OPEN Sakiko Maekawa, Umeharu Ohto, Takuma Shibata, Kensuke Miyake and Toshiyuki Shimizu NOD2 has a role in host innate immune responses, activating the NF-κB signalling pathway and mutations have been associated with chronic inflammatory disorders. Here, Maekawa et al. solved the structure of NOD2 in its inactive form, suggesting a mechanism for autoinhibition. 10 June 2016 | doi: 10.1038/ncomms11813 Biological Sciences  Biochemistry  Immunology  Imaging of room-temperature ferromagnetic nano-domains at the surface of a non-magnetic oxide OPEN T. Taniuchi, Y. Motoyui, K. Morozumi, T. C. Rödel, F. Fortuna, A. F. Santander-Syro and S. Shin The surfaces of transition metal oxides exhibit a wide range of functional behaviours, from magnetism to superconductivity. Here, the authors use high-resolution microscopy to image the temperature dependent development of nanoscale ferromagnetic domains on an oxygen-deficient SrTiO3 surface. 10 June 2016 | doi: 10.1038/ncomms11781 Physical Sciences  Condensed matter  Brillouin scattering self-cancellation OPEN O. Florez, P. F. Jarschel, Y. A. V. Espinel, C. M. B. Cordeiro, T. P. Mayer Alegre, G. S. Wiederhecker and P. Dainese The interaction between light and acoustic phonons is radically modified in sub-wavelength photonic structures. Here, the authors engineer the optical and acoustic modes to perfectly cancel the two interaction mechanisms—the photo-elastic and moving-boundary effects—which leads to Brillouin self-cancellation. 10 June 2016 | doi: 10.1038/ncomms11759 Physical Sciences  Optical physics  Atom-economic catalytic amide synthesis from amines and carboxylic acids activated in situ with acetylenes OPEN Thilo Krause, Sabrina Baader, Benjamin Erb and Lukas J. Gooßen Amide formation is a ubiquitous reaction in organic chemistry, but suffers from the problem of generating large amounts of waste. Here, the authors report a catalytic amide synthesis by the ruthenium catalysed addition of carboxylic acids to acetylenes, followed by reaction with primary or secondary amines. 10 June 2016 | doi: 10.1038/ncomms11732 Chemical Sciences  Catalysis  Organic chemistry  Age differences in learning emerge from an insufficient representation of uncertainty in older adults OPEN Matthew R. Nassar, Rasmus Bruckner, Joshua I. Gold, Shu-Chen Li, Hauke R. Heekeren and Ben Eppinger The ability to learn decreases with old age especially in a dynamically changing environment, however the precise nature of this decline is not understood. Nassar and colleagues report that older adults show a reduced ability to learn from uncertain outcomes compared to younger adults. 10 June 2016 | doi: 10.1038/ncomms11609 Biological Sciences  Neuroscience  Internal guide RNA interactions interfere with Cas9-mediated cleavage OPEN Summer B. Thyme, Laila Akhmetova, Tessa G. Montague, Eivind Valen and Alexander F. Schier While the CRISPR-Cas9 system has revolutionised molecular biology, it is still a mystery why not every guide RNA elicits target DNA cleavage. Here the authors show that genomic context and internal gRNA interactions can inhibit cleavage. 10 June 2016 | doi: 10.1038/ncomms11750 Biological Sciences  Molecular biology  Ambiphilic boron in 1,4,2,5-diazadiborinine OPEN Baolin Wang, Yongxin Li, Rakesh Ganguly, Hajime Hirao and Rei Kinjo Boranes are archetypal Lewis acids owing to an empty p-orbital on the boron, although Lewis basic tricoordinate boranes have been developed too. Here, the authors report an annulated 1,4,2,5-diazadiborinine derivative with boron atoms that exhibit both Lewis acidic and basic properties. 09 June 2016 | doi: 10.1038/ncomms11871 Chemical Sciences  Inorganic chemistry  Directed percolation identified as equilibrium pre-transition towards non-equilibrium arrested gel states OPEN M. Kohl, R. F. Capellmann, M. Laurati, S. U. Egelhaaf and M. Schmiedeberg Gels exhibit very slow dynamics, for which a structural reason remains elusive. Here, Kohl et al. show the gel formation is accompanied by a succession of continuous and directed percolation, with only the latter found to lead to the arrested dynamics. 09 June 2016 | doi: 10.1038/ncomms11817 Physical Sciences  Applied physics  Condensed matter  Materials science  Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD OPEN Wei Lin, Jing Zhang, Haiyan Lin, Zexing Li, Xiaofeng Sun, Di Xin, Meng Yang, Liwei Sun, Lin Li, Hongmei Wang, Dahua Chen and Qinmiao Sun Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RIG-I ubiquitination. 09 June 2016 | doi: 10.1038/ncomms11848 Biological Sciences  Immunology  Molecular biology  The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway OPEN Carla F. Bento, Avraham Ashkenazi, Maria Jimenez-Sanchez and David C. Rubinsztein Mutations in ATP13A2 are associated with lysosomal dysfunction and early onset Parkinson’s disease. Here Bento et al. show that ATP13A2 depletion negatively regulates SYT11, at both transcriptional and post-translational levels, which in turn impairs function of the autophagy-lysosome pathway. 09 June 2016 | doi: 10.1038/ncomms11803 Biological Sciences  Cell biology  Neuroscience  Dynamic protein coronas revealed as a modulator of silver nanoparticle sulphidation in vitro OPEN Teodora Miclăuş, Christiane Beer, Jacques Chevallier, Carsten Scavenius, Vladimir E. Bochenkov, Jan J. Enghild and Duncan S. Sutherland The biomolecule layer adsorbed at the nanoparticle surface and defined as protein corona affects the nanoparticle biophysical properties and functions. Here, the authors suggest that rapidly-exchanging proteins on the outermost layer of the corona modulate sulphidation of silver nanoparticles in vitro. 09 June 2016 | doi: 10.1038/ncomms11770 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  Plexciton Dirac points and topological modes OPEN Joel Yuen-Zhou, Semion K. Saikin, Tony Zhu, Mehmet C. Onbasli, Caroline A. Ross, Vladimir Bulovic and Marc A. Baldo Ultraviolet-visible molecular excited states (excitons) may couple to collective excitations in metals (plasmons) to form plexitons, which transfers energy ballistically over tens of microns. Here, the authors propose a plexitonic system which exhibits Dirac points and topologically nontrivial band structure. 09 June 2016 | doi: 10.1038/ncomms11783 Physical Sciences  Condensed matter  Theoretical physics  The structure of slip-pulses and supershear ruptures driving slip in bimaterial friction OPEN Hadar Shlomai and Jay Fineberg Friction commonly involves different material types (bimaterials) at their sliding interface. Here, in laboratory experiments Shlomai and Fineberg reveal effects uniquely due to biomaterial coupling, with slip-pulses and crack-like supershear fronts dominating opposing propagation directions. 09 June 2016 | doi: 10.1038/ncomms11787 Earth Sciences  Geology and geophysics  Materials science  Structural identification of electron transfer dissociation products in mass spectrometry using infrared ion spectroscopy OPEN Jonathan Martens, Josipa Grzetic, Giel Berden and Jos Oomens Mass spectrometry is a leading method used for sequencing peptides and proteins by fragmentation followed by analysis of the sequence fragments. Here, the authors use infrared spectroscopy to characterize the structures of peptide fragments formed during electron transfer dissociation. 09 June 2016 | doi: 10.1038/ncomms11754 Chemical Sciences  Analytical chemistry  Chemical biology  Physical chemistry  Golgi-localized STELLO proteins regulate the assembly and trafficking of cellulose synthase complexes in Arabidopsis OPEN Yi Zhang, Nino Nikolovski, Mathias Sorieul, Tamara Vellosillo, Heather E. McFarlane, Ray Dupree, Christopher Kesten, René Schneider, Carlos Driemeier, Rahul Lathe, Edwin Lampugnani, Xiaolan Yu, Alexander Ivakov, Monika S. Doblin, Jenny C. Mortimer, Steven P. Brown, Staffan Persson and Paul Dupree Cellulose is produced in plants by cellulose synthase complexes (CSCs) that are assembled in the endomembrane system and then trafficked to the plasma membrane. Here Zhang et al. show that the Golgi-localized STELLO1 and 2 proteins are required for the proper assembly and distribution of CSCs in plant cells. 09 June 2016 | doi: 10.1038/ncomms11656 Biological Sciences  Cell biology  Plant sciences  Multiple-stable anisotropic magnetoresistance memory in antiferromagnetic MnTe OPEN D. Kriegner, K. Výborný, K. Olejník, H. Reichlová, V. Novák, X. Marti, J. Gazquez, V. Saidl, P. Němec, V. V. Volobuev, G. Springholz, V. Holý and T. Jungwirth Contrary to ferromagnets, antiferromagnets possess no net magnetic moment, which has limited their applicability as magnetic memory media. Here, the authors demonstrate a heat-assisted multiple-stable memory based on epitaxial thin films of antiferromagnet MnTe with three-fold symmetric anisotropy. 09 June 2016 | doi: 10.1038/ncomms11623 Physical Sciences  Applied physics  Nanotechnology  Arctic cut-off high drives the poleward shift of a new Greenland melting record OPEN M. Tedesco, T. Mote, X. Fettweis, E. Hanna, J. Jeyaratnam, J. F. Booth, R. Datta and K. Briggs Atmospheric circulation controls the mass and energy balance of the Greenland ice sheet, yet the exact dynamics remain unknown. Here, the authors show that record conditions over Greenland during the summer of 2015 were associated with the formation and persistency of an Arctic cut-off high. 09 June 2016 | doi: 10.1038/ncomms11723 Earth Sciences  Atmospheric science  Climate science  A stable room-temperature sodium–sulfur battery OPEN Shuya Wei, Shaomao Xu, Akanksha Agrawral, Snehashis Choudhury, Yingying Lu, Zhengyuan Tu, Lin Ma and Lynden A. Archer Rechargeable sodium-sulfur batteries able to operate stably at room temperature are sought-after platforms as they can achieve high storage capacity from inexpensive electrode materials. Here, the authors use rationally selected cathode and electrolyte materials to design a room temperature Na-S battery. 09 June 2016 | doi: 10.1038/ncomms11722 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  High-efficiency and air-stable P3HT-based polymer solar cells with a new non-fullerene acceptor OPEN Sarah Holliday, Raja Shahid Ashraf, Andrew Wadsworth, Derya Baran, Syeda Amber Yousaf, Christian B. Nielsen, Ching-Hong Tan, Stoichko D. Dimitrov, Zhengrong Shang, Nicola Gasparini, Maha Alamoudi, Frédéric Laquai, Christoph J. Brabec, Alberto Salleo, James R. Durrant and Iain McCulloch In organic photovoltaics, the best performing devices usually involve low-bandgap polymers whose limited solubility and stability constrain the scalability of organic solar cells. Here, Holliday et al. develop a new acceptor and pair it with canonical P3HT to obtain 6.4% efficient and stable devices. 09 June 2016 | doi: 10.1038/ncomms11585 Chemical Sciences  Applied physics  Materials science  Physical chemistry  SURVIV for survival analysis of mRNA isoform variation OPEN Shihao Shen, Yuanyuan Wang, Chengyang Wang, Ying Nian Wu and Yi Xing Clinical RNA-seq datasets can predict clinical outcomes. Here, Shen et al. report a statistical method for survival analysis of mRNA isoform variation using clinical RNA-seq datasets, and the identified isoform based survival predictors outperform gene expression based survival predictors using TCGA data on six cancer types. 09 June 2016 | doi: 10.1038/ncomms11548 Biological Sciences  Bioinformatics  Cancer  Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification OPEN Wim Dejonghe, Sabine Kuenen, Evelien Mylle, Mina Vasileva, Olivier Keech, Corrado Viotti, Jef Swerts, Matyáš Fendrych, Fausto Andres Ortiz-Morea, Kiril Mishev, Simon Delang, Stefan Scholl, Xavier Zarza, Mareike Heilmann, Jiorgos Kourelis, Jaroslaw Kasprowicz, Le Son Long Nguyen, Andrzej Drozdzecki, Isabelle Van Houtte, Anna-Mária Szatmári et al. Plant cells maintain strict proton gradients over different membranes. Here, Dejonghe et al. show that several protonophores, including the known tyrosine kinase inhibitor TyrphostinA23, inhibit clathrin-mediated endocytosis by disturbing these gradients and causing cytoplasmic acidification. 08 June 2016 | doi: 10.1038/ncomms11710 Biological Sciences  Cell biology  Plant sciences  GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis OPEN Jian Wang, Alton B. Farris, Kaiming Xu, Ping Wang, Xiangming Zhang, Duc M. Duong, Hong Yi, Hui-Kuo Shu, Shi-Yong Sun and Ya Wang GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis. 08 June 2016 | doi: 10.1038/ncomms11795 Biological Sciences  Cancer  Cell biology  Western Pacific hydroclimate linked to global climate variability over the past two millennia OPEN Michael L. Griffiths, Alena K. Kimbrough, Michael K. Gagan, Russell N. Drysdale, Julia E. Cole, Kathleen R. Johnson, Jian-Xin Zhao, Benjamin I. Cook, John C. Hellstrom and Wahyoe S. Hantoro Interdecadal modes of tropical Pacific ocean-atmosphere circulation have a strong influence on global temperature. Here, the authors present a 2000-year hydroclimate record from the Indo-Pacific, which suggests that century-scale variations in these modes are also linked with global temperature variability. 08 June 2016 | doi: 10.1038/ncomms11719 Earth Sciences  Climate science  Weyl fermions and spin dynamics of metallic ferromagnet SrRuO3 OPEN Shinichi Itoh, Yasuo Endoh, Tetsuya Yokoo, Soshi Ibuka, Je-Geun Park, Yoshio Kaneko, Kei S. Takahashi, Yoshinori Tokura and Naoto Nagaosa Whilst Weyl fermions have characteristic effects in magnetotransport measurements in condensed matter systems, their effects on other properties remain unexplored. Here, the authors use neutron Brillouin scattering to evidence the interaction of Weyl fermions with the spin wave dynamics in SrRuO3. 08 June 2016 | doi: 10.1038/ncomms11788 Physical Sciences  Condensed matter  Nanodiamond-based nanostructures for coupling nitrogen-vacancy centres to metal nanoparticles and semiconductor quantum dots OPEN Jianxiao Gong, Nat Steinsultz and Min Ouyang The coupling of nitrogen-vacancy centres with plasmonic and photonic nanostructures is usually studied by top-down preparation. Here, Gong et al. use a bottom-up approach to grow metallic and semiconducting nanoparticles on nanodiamonds, controlling the nanoparticle coverage, size and composition. 08 June 2016 | doi: 10.1038/ncomms11820 Chemical Sciences  Applied physics  Materials science  Nanotechnology  A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells OPEN Ya Zhang, Liang Huang, Haiqing Fu, Owen K. Smith, Chii Mei Lin, Koichi Utani, Mishal Rao, William C. Reinhold, Christophe E. Redon, Michael Ryan, RyangGuk Kim, Yang You, Harlington Hanna, Yves Boisclair, Qiaoming Long and Mirit I. Aladjem Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins. 08 June 2016 | doi: 10.1038/ncomms11748 Biological Sciences  Molecular biology  The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1 OPEN Emilio Boada-Romero, Inmaculada Serramito-Gómez, María P. Sacristán, David L. Boone, Ramnik J. Xavier and Felipe X. Pimentel-Muiños The T300A substitution in ATG16L is associated with Crohn’s disease risk and disrupts clearance of intracellular pathogens by autophagy. Here the authors show that the mutation impairs interaction of ATG16L with TMEM59 and disrupts unconventional TMEM-induced autophagy, an aspect of innate immunity. 08 June 2016 | doi: 10.1038/ncomms11821 Biological Sciences  Cell biology  Medical research  Molecular biology  Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis OPEN Megan K. Ruhland, Andrew J. Loza, Aude-Helene Capietto, Xianmin Luo, Brett L. Knolhoff, Kevin C. Flanagan, Brian A. Belt, Elise Alspach, Kathleen Leahy, Jingqin Luo, Andras Schaffer, John R. Edwards, Gregory Longmore, Roberta Faccio, David G. DeNardo and Sheila A. Stewart The risk of developing cancer increases with age. Here, the authors address the contribution of age-dependent accumulation of senescent cells within the tumour stroma compartment and show that senescent cells increase the infiltration of myeloid-derived suppressor cells that inhibit cytotoxic T-cells, thus facilitating tumour outgrowth. 08 June 2016 | doi: 10.1038/ncomms11762 Biological Sciences  Cancer  Immunology  Direct effects dominate responses to climate perturbations in grassland plant communities OPEN Chengjin Chu, Andrew R. Kleinhesselink, Kris M. Havstad, Mitchel P. McClaran, Debra P. Peters, Lance T. Vermeire, Haiyan Wei and Peter B. Adler Environmental change can have indirect effects on populations by altering the outcome of competitive interactions. Here, Chu et al. show that although direct effects dominate the responses of grassland species to climate perturbations, indirect effects could be greater among species with smaller niche differences. 08 June 2016 | doi: 10.1038/ncomms11766 Biological Sciences  Ecology  Optical modulation of nano-gap tunnelling junctions comprising self-assembled monolayers of hemicyanine dyes OPEN Parisa Pourhossein, Ratheesh K. Vijayaraghavan, Stefan C. J. Meskers and Ryan C. Chiechi Flow of electricity between two electrodes can be tuned by monolayers of organic compounds. Here, Pourhossein et al. show that the tunnelling current of such molecular junctions can be modulated rapidly by illumination, using nanoskived gold wires separated by a self-assembled monolayer of hemicyanine dyes. 08 June 2016 | doi: 10.1038/ncomms11749 Physical Sciences  Nanotechnology  Physical chemistry    Nature Communications JOBS of the week Senior Scientist The Allen Institute for Brain Science Research Associate The University of Sheffield PhD Student Position Georg-August-Universität Göttingen Postdoctoral Researcher Columbia University Medical Center Research Fellow University of Edinburgh Staff Scientist National Institutes of Health (NIH) Group Leader Institut de Génomique Fonctionnelle de Lyon (IGFL) Postdoctoral Fellow The Scripps Research Institute (TSRI) Research Investigator Cold Spring Harbor Laboratory (CSHL) Post Doctoral Position University of Texas at El Paso More Science jobs from Nature Communications EVENT Cancer Stem Cell Conference 2016 23.09.16 Cleveland, USA More science events from       Latest Corrigenda     Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation OPEN Benjamin Lacar, Sara B. Linker, Baptiste N. Jaeger, Suguna Rani Krishnaswami, Jerika J. Barron, Martijn J. E. Kelder, Sarah L. Parylak, Apuã C. M. Paquola, Pratap Venepally, Mark Novotny, Carolyn O’Connor, Conor Fitzpatrick, Jennifer A. Erwin, Jonathan Y. Hsu, David Husband, Michael J. McConnell, Roger Lasken and Fred H. Gage 14 June 2016 | doi: 10.1038/ncomms12020 Biological Sciences  Neuroscience      Corrigendum: Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures OPEN Yi Lu, Cheng Zhong, Lulu Wang, Pengfei Wei, Wei He, Kang Huang, Yi Zhang, Yang Zhan, Guoping Feng and Liping Wang 14 June 2016 | doi: 10.1038/ncomms12019 Biological Sciences  Neuroscience      Corrigendum: Iron-catalysed cross-coupling of organolithium compounds with organic halides OPEN Zhenhua Jia, Qiang Liu, Xiao-Shui Peng and Henry N. C. Wong 14 June 2016 | doi: 10.1038/ncomms11955 Chemical Sciences  Catalysis  Organic chemistry      Corrigendum: Alternative futures for Borneo show the value of integrating economic and conservation targets across borders OPEN Rebecca K. Runting, Erik Meijaard, Nicola K. Abram, Jessie A. Wells, David L. A. Gaveau, Marc Ancrenaz, Hugh P. Possingham, Serge A. Wich, Fitrian Ardiansyah, Melvin T. Gumal, Laurentius N. Ambu and Kerrie A. Wilson 14 June 2016 | doi: 10.1038/ncomms12018 Biological Sciences  Ecology        Latest Errata     Erratum: Elastic spheres can walk on water OPEN Jesse Belden, Randy C. Hurd, Michael A. Jandron, Allan F. Bower and Tadd T. Truscott 10 June 2016 | doi: 10.1038/ncomms11679 Physical Sciences  Fluids and plasma physics      Erratum: Genetic link between renal birth defects and congenital heart disease OPEN Jovenal T. San Agustin, Nikolai Klena, Kristi Granath, Ashok Panigrahy, Eileen Stewart, William Devine, Lara Strittmatter, Julie A. Jonassen, Xiaoqin Liu, Cecilia W. Lo and Gregory J. Pazour 08 June 2016 | doi: 10.1038/ncomms11910 Biological Sciences  Developmental biology  Genetics      Advertisement Launching in 2017: Nature Human Behaviour Now Open for Submissions! The journal will publish research of outstanding significance into any aspect of human behaviour: its psychological, biological, and social bases, as well as its origins, development, and disorders. The journal aims to enhance the visibility of research into human behaviour, strengthening its societal reach and impact.  Click here to find out more and to submit your paper.     Advertisement Nature Chemistry in the community Nature Chemistry is now on Facebook. Like our page to keep up to date with developments in the field and links to the latest research.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. 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