Nature Communications -07 June 2016

Advertisement Check out CuriosityStream for the world's greatest documentaries, for unlimited access to hundreds of science, nature, history videos and more. With new content added weekly and starting at only $2.99/month, dive deep and get your free 30-day trial today: http:/bit.ly/1Z5Mc3O      Weekly Content Alert Nature Communications is now fully open access. Read more. 08 June 2016  Featured image: Yoon et al. use hair-like microstructures to facilitate transfer printing of flexible electronics onto textiles. Latest content: Review Articles Corrigenda Errata Advertisement   Submit your proposal: Seeking Safe Drug-like small organic molecules for Human Use with Negligible Biological Effects. Deadline; 26th June. $20,000 award offered. See the full details and enter here. Journal homepage Recommend to library Web feed   Advertisement MATERIALS FOR ENERGY 2016 Presented by: Wuhan University of Technology | Nature Energy | Nature Materials | Nature The conference will feature sessions on electrochemical energy storage, solar energy conversion, and emerging materials and devices. June 11-14, 2016 | Wuhan, China REGISTER NOW       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Review View all Reviews     Quantum mechanical effects in plasmonic structures with subnanometre gaps OPEN Wenqi Zhu, Ruben Esteban, Andrei G. Borisov, Jeremy J. Baumberg, Peter Nordlander, Henri J. Lezec, Javier Aizpurua and Kenneth B. Crozier Recent work has shown that quantum mechanical effects in plasmonic nanogap structures become important as the gap distances approach the subnanometre length-scale. Here, the authors review the major findings which challenge the classical picture of these structures and discuss future directions for the field. 03 June 2016 | doi: 10.1038/ncomms11495 Physical Sciences  Applied physics  Optical physics        Latest Articles View all Articles     Overfishing and nutrient pollution interact with temperature to disrupt coral reefs down to microbial scales OPEN Jesse R. Zaneveld, Deron E. Burkepile, Andrew A. Shantz, Catharine E. Pritchard, Ryan McMinds, Jérôme P. Payet, Rory Welsh, Adrienne M. S. Correa, Nathan P. Lemoine, Stephanie Rosales, Corinne Fuchs, Jeffrey A. Maynard and Rebecca Vega Thurber Overfishing and nutrient pollution can damage coral reefs in part by increasing coral-algal competition. Here the authors simulate these stressors in a three year field experiment, and show that they interact to enhance sensitivity to temperature, predation and bacterial opportunism. 07 June 2016 | doi: 10.1038/ncomms11833 Biological Sciences  Ecology  Th2 and eosinophil responses suppress inflammatory arthritis OPEN Zhu Chen, Darja Andreev, Katharina Oeser, Branislav Krljanac, Axel Hueber, Arnd Kleyer, David Voehringer, Georg Schett and Aline Bozec Type 2 immune responses are viewed as opposites of Type 1 and 17 responses. Here the authors show that activation of Type 2 immunity by helminth infection counteracts the development of inflammatory arthritis, a type 17-mediated pathology, via IL-4/IL-13- STAT6 signalling and eosinophil activation. 07 June 2016 | doi: 10.1038/ncomms11596 Biological Sciences  Immunology  Medical research  Human glia can both induce and rescue aspects of disease phenotype in Huntington disease OPEN Abdellatif Benraiss, Su Wang, Stephanie Herrlinger, Xiaojie Li, Devin Chandler-Militello, Joseph Mauceri, Hayley B. Burm, Michael Toner, Mikhail Osipovitch, Qiwu Jim Xu, Fengfei Ding, Fushun Wang, Ning Kang, Jian Kang, Paul C. Curtin, Daniela Brunner, Martha S. Windrem, Ignacio Munoz-Sanjuan, Maiken Nedergaard and Steven A. Goldman. The contribution of glia to Huntington's disease is unclear. The authors show that human glial progenitor cells (GPCs) expressing mutant huntingtin impair motor performance when engrafted into wild type mice, and wild type human GPCs ameliorate disease phenotypes when engrafted into an HD mouse model. 07 June 2016 | doi: 10.1038/ncomms11758 Biological Sciences  Neuroscience  Simultaneous optical and electrical in vivo analysis of the enteric nervous system OPEN Nikolai Rakhilin, Bradley Barth, Jiahn Choi, Nini L. Muñoz, Subhash Kulkarni, Jason S. Jones, David M. Small, Yu-Ting Cheng, Yingqiu Cao, Colleen LaVinka, Edwin Kan, Xinzhong Dong, Michael Spencer, Pankaj Pasricha, Nozomi Nishimura and Xiling Shen The enteric nervous system (ENS) plays a key role in regulating gut motility and homeostasis yet it remains a challenging system to record from. Here, the authors develop a novel abdominal window permitting simultaneous optical and electrical recording of mouse ENS system activity over prolonged time periods. 07 June 2016 | doi: 10.1038/ncomms11800 Biological Sciences  Neuroscience  The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing OPEN Cui-Jun Zhang, Xiao-Mei Hou, Lian-Mei Tan, Chang-Rong Shao, Huan-Wei Huang, Yong-Qiang Li, Lin Li, Tao Cai, She Chen and Xin-Jian He Transposons and repetitive sequences are typically subject to transcription silencing. Here, Zhang et al. find that the bromodomain-containing protein BRAT1 forms a complex with BRP1, recognizes histone acetylation and acts to prevent transcriptional silencing in Arabidopsis. 07 June 2016 | doi: 10.1038/ncomms11715 Biological Sciences  Molecular biology  Plant sciences  Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection OPEN Caitlin Bohannon, Ryan Powers, Lakshmipriyadarshini Satyabhama, Ang Cui, Christopher Tipton, Miri Michaeli, Ioanna Skountzou, Robert S. Mittler, Steven H. Kleinstein, Ramit Mehr, Francis Eun-Yun Lee, Ignacio Sanz and Joshy Jacob Long-lived IgG plasma cells develop in germinal centres and then home to the bone marrow and persist for a lifetime. Here the authors identify long-lived IgM plasma cells in the murine spleen, which carry IgH mutations but can develop independently of germinal centres, and confer protective antiviral immunity. 07 June 2016 | doi: 10.1038/ncomms11826 Biological Sciences  Immunology  Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1 OPEN Frederick C. Nucifora, Leslie G. Nucifora, Chee-Hoe Ng, Nicolas Arbez, Yajuan Guo, Elaine Roby, Vered Shani, Simone Engelender, Dong Wei, Xiao-Fang Wang, Tianxia Li, Darren J. Moore, Olga Pletnikova, Juan C. Troncoso, Akira Sawa, Ted M. Dawson, Wanli Smith, Kah-Leong Lim and Christopher A. Ross Mutations in LRRK2 are linked to Parkinson’s Disease. Here, the authors identify WSB1 as a LRRK2 interacting protein and find that it promotes LRRK2 aggregation in primary neurons and drosophila models via ubiquitin K27 and K29 linkages. 07 June 2016 | doi: 10.1038/ncomms11792 Biological Sciences  Neuroscience  Spin-orbit-driven magnetic structure and excitation in the 5d pyrochlore Cd2Os2O7 OPEN S. Calder, J. G. Vale, N. A. Bogdanov, X. Liu, C. Donnerer, M. H. Upton, D. Casa, A. H. Said, M. D. Lumsden, Z. Zhao, J. -Q. Yan, D. Mandrus, S. Nishimoto, J. van den Brink, J. P. Hill, D. F. McMorrow and A. D. Christianson Strong electronic correlations in 5d materials such as osmates may combine with spin-orbit coupling to yield novel order. Here, the authors demonstrate how spin-orbit coupling in pyrochlore Cd2Os2O7 generates magnetic order and excitations associated with a magnetic metal-insulator transition. 07 June 2016 | doi: 10.1038/ncomms11651 Physical Sciences  Condensed matter  Critical length scale controls adhesive wear mechanisms OPEN Ramin Aghababaei, Derek H. Warner and Jean-Francois Molinari Adhesive wear can proceed through qualitatively different mechanisms, with conflicting results in the literature. Here the authors observe a transition between two regimes in simulations using model interatomic potentials, allowing development of a simple analytical theory to describe past results. 06 June 2016 | doi: 10.1038/ncomms11816 Physical Sciences  Applied physics  Materials science  Unravelling the structural plasticity of stretched DNA under torsional constraint OPEN Graeme A. King, Erwin J. G. Peterman and Gijs J. L. Wuite Cellular DNA is often torsionally constrained, but the topologies that such DNA can adopt under tensile strain have remained largely untested. Here, the authors use single-molecule optical tweezers to illustrate the structural plasticity of torsionally constrained DNA under mechanical force. 06 June 2016 | doi: 10.1038/ncomms11810 Physical Sciences  Biophysics  Molecular biology  Nanotechnology  A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels OPEN Maria Ángeles Martínez-Martínez, Camino De Juan Romero, Virginia Fernández, Adrián Cárdenas, Magdalena Götz and Víctor Borrell The outer subventricular zone (OSVZ) contains basal radial glial cells (bRGC) involved in cortical expansion in gyrencephalic mammals. Here the authors identify a developmental time window with marked production of bRGCs required to found the OSVZ that is dependent on coincident downregulation of Cdh1 and Trnp1. 06 June 2016 | doi: 10.1038/ncomms11812 Biological Sciences  Neuroscience  111 oriented gold nanoplatelets on multilayer graphene as visible light photocatalyst for overall water splitting OPEN Diego Mateo, Iván Esteve-Adell, Josep Albero, Juan F. Sánchez Royo, Ana Primo and Hermenegildo Garcia A plethora of photocatalysts have been investigated in order to obtain solar fuels but the photon-to-hydrogen molecule conversion is generally remains low. Here the authors show that 111 facet oriented gold nanoplatelets on multilayer graphene films is an active photocatalyst for overall water splitting. 06 June 2016 | doi: 10.1038/ncomms11819 Chemical Sciences  Catalysis  Materials science  Nanotechnology  Avoiding short circuits from zinc metal dendrites in anode by backside-plating configuration OPEN Shougo Higashi, Seok Woo Lee, Jang Soo Lee, Kensuke Takechi and Yi Cui Zinc-based aqueous battery chemistries allow for attractive cost and energy densities, but are susceptible to zinc dendrite formation during plating and internal shorting. Here, the authors show that by plating only on the side away from the counter-electrode, internal shorts can be circumvented. 06 June 2016 | doi: 10.1038/ncomms11801 Physical Sciences  Materials science  Physical chemistry  PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery OPEN Yi Zhao, Wei Wang, Shutao Guo, Yuhua Wang, Lei Miao, Yang Xiong and Leaf Huang The anti-diabetic drug Metformin also possesses anti-tumour activity. Here, the authors synthesize polymeric Metformin-based nanoparticles that still exert intrinsic biological activity through AMPK and mTOR regulation and can systematically deliver VEGF siRNA, significantly reducing lung cancer growth in mice. 06 June 2016 | doi: 10.1038/ncomms11822 Biological Sciences  Cancer  Medical research  Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia OPEN Henrik Lilljebjörn, Rasmus Henningsson, Axel Hyrenius-Wittsten, Linda Olsson, Christina Orsmark-Pietras, Sofia von Palffy, Maria Askmyr, Marianne Rissler, Martin Schrappe, Gunnar Cario, Anders Castor, Cornelis J. H. Pronk, Mikael Behrendtz, Felix Mitelman, Bertil Johansson, Kajsa Paulsson, Anna K. Andersson, Magnus Fontes and Thoas Fioretos The fusion of two genes during the pathogenesis of cancer can create oncogenes. In this study, the authors screen pediatric B-cell precursor acute lymphoblastic leukaemia samples for the presence of fusion genes and describe fusion genes that define new molecular subtypes of the disease 06 June 2016 | doi: 10.1038/ncomms11790 Biological Sciences  Cancer  Genetics  Correlation detection as a general mechanism for multisensory integration OPEN Cesare V. Parise and Marc O. Ernst The human brain integrates inputs across multiple sensory streams into a unified percept. Here Parise and Ernst present a model that assesses the correlation, lag and synchrony of multisensory stimuli, and predicts psychophysical performance on multisensory temporal and spatial tasks. 06 June 2016 | doi: 10.1038/ncomms11543 Biological Sciences  Neuroscience  The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells OPEN Xiaomu Li, Kenneth K. Y. Cheng, Zhuohao Liu, Jin-Kui Yang, Baile Wang, Xue Jiang, Yawen Zhou, Philip Hallenborg, Ruby L. C. Hoo, Karen S. L. Lam, Yasuhiro Ikeda, Xin Gao and Aimin Xu Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate carboxylase, thereby inhibiting insulin secretion. 06 June 2016 | doi: 10.1038/ncomms11740 Biological Sciences  Cell biology  Medical research  Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress OPEN Emilien Nicolas, Pascaline Parisot, Celina Pinto-Monteiro, Roxane de Walque, Christophe De Vleeschouwer and Denis L. J. Lafontaine The nucleolus is a specialized functional domain of the nucleus where ribosome biogenesis is initiated and also implicated in a p53-dependent anti-tumor surveillance. Here the authors use a quantitative imaging approach to detail the role of each ribosomal protein on the structural integrity of the nucleolus and p53 homeostasis. 06 June 2016 | doi: 10.1038/ncomms11390 Biological Sciences  Biochemistry  Cancer  Cell biology  Ligand-induced substrate steering and reshaping of [Ag2(H)]+ scaffold for selective CO2 extrusion from formic acid OPEN Athanasios Zavras, George N. Khairallah, Marjan Krstić, Marion Girod, Steven Daly, Rodolphe Antoine, Philippe Maitre, Roger J. Mulder, Stefanie-Ann Alexander, Vlasta Bonačić-Koutecký, Philippe Dugourd and Richard A. J. O’Hair Designing catalysts and understanding the influence of ligands for particular transformations remains a highly challenging task. Here, the authors show that bisphosphine ligands can alter the geometry of the active site in silver catalysts, driving protonation and ultimately extrusion of carbon dioxide from formic acid. 06 June 2016 | doi: 10.1038/ncomms11746 Chemical Sciences  Catalysis  Inorganic chemistry  Organic chemistry  Controlling thermal emission with refractory epsilon-near-zero metamaterials via topological transitions OPEN P. N. Dyachenko, S. Molesky, A. Yu Petrov, M. Störmer, T. Krekeler, S. Lang, M. Ritter, Z. Jacob and M. Eich The ability to control thermal radiation at high temperatures is of interest for thermal photovoltaics. Here, Dyachenko et al. engineer the epsilon-near-zero frequency of a metamaterial and connected optical topological transition to selectively enhance and suppress the thermal emission in the near-infrared spectrum. 06 June 2016 | doi: 10.1038/ncomms11809 Physical Sciences  Applied physics  Materials science  Optical physics  Freestanding three-dimensional core–shell nanoarrays for lithium-ion battery anodes OPEN Guoqiang Tan, Feng Wu, Yifei Yuan, Renjie Chen, Teng Zhao, Ying Yao, Ji Qian, Jianrui Liu, Yusheng Ye, Reza Shahbazian-Yassar, Jun Lu and Khalil Amine Degradation and low conductivity of transition metal oxide anodes cause capacity fading in lithium ion batteries. Here the authors make freestanding 3D copper oxide/carbon nitride core-shell nanoarrays which accommodate volume change, provide electro-active zones and facilitate rapid charge transport. 03 June 2016 | doi: 10.1038/ncomms11774 Physical Sciences  Inorganic chemistry  Materials science  Photoelectrochemical water splitting enhanced by self-assembled metal nanopillars embedded in an oxide semiconductor photoelectrode OPEN Seiji Kawasaki, Ryota Takahashi, Takahisa Yamamoto, Masaki Kobayashi, Hiroshi Kumigashira, Jun Yoshinobu, Fumio Komori, Akihiko Kudo and Mikk Lippmaa Nanoscale designs are known to increase the energy conversion efficiency of photoelectrochemical water splitting. Here, the authors report a self-organized nanocomposite formed by embedding self-assembled metal nanopillars in a semiconductor thin film, for enhanced photocarrier separation efficiency. 03 June 2016 | doi: 10.1038/ncomms11818 Chemical Sciences  Catalysis  Materials science  Nanotechnology  Large-scale ordering of nanoparticles using viscoelastic shear processing OPEN Qibin Zhao, Chris E. Finlayson, David R. E. Snoswell, Andrew Haines, Christian Schäfer, Peter Spahn, Goetz P. Hellmann, Andrei V. Petukhov, Lars Herrmann, Pierre Burdet, Paul A. Midgley, Simon Butler, Malcolm Mackley, Qixin Guo and Jeremy J. Baumberg Packing nanoparticles into ordered superstructures finds applications in photonic materials, but fabrication over large scales is challenging. Zhao et al. show a roll-to-roll approach to prepare flexible films of ordered polymer nanoparticles via an oscillatory shear-induced structural transition. 03 June 2016 | doi: 10.1038/ncomms11661 Physical Sciences  Applied physics  Materials science  A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins OPEN Maofeng Jing, Baodian Guo, Haiyang Li, Bo Yang, Haonan Wang, Guanghui Kong, Yao Zhao, Huawei Xu, Yan Wang, Wenwu Ye, Suomeng Dong, Yongli Qiao, Brett M. Tyler, Wenbo Ma and Yuanchao Wang Phytophthora pathogens manipulate host plant immune responses by secreting effector proteins into plant cells. Here, Jing et al. show that the Phytophthora sojae Avh262 effector negatively regulates plant resistance by binding to host BiP proteins and suppressing ER-stress induced cell death 03 June 2016 | doi: 10.1038/ncomms11685 Biological Sciences  Plant sciences  Rebalancing gene haploinsufficiency in vivo by targeting chromatin OPEN Filomena Gabriella Fulcoli, Monica Franzese, Xiangyang Liu, Zhen Zhang, Claudia Angelini and Antonio Baldini Deficit in transcription factor Tbx1 causes heart defects in humans and mice. Here the authors show that Tbx1 regulates gene expression by recruiting histone methyltransferases that affect chromatin marks, and that a drug inhibiting histone demethylation ameliorates the cardiovascular phenotype in Tbx1 haploinsufficient or hypomorphic mice. 03 June 2016 | doi: 10.1038/ncomms11688 Biological Sciences  Developmental biology  Medical research  Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk OPEN Rastislav Tamaskovic, Martin Schwill, Gabriela Nagy-Davidescu, Christian Jost, Dagmar C. Schaefer, Wouter P. R. Verdurmen, Jonas V. Schaefer, Annemarie Honegger and Andreas Plückthun Targeted therapy of ErbB2-dependent tumours often provokes an adaptive response leading to reactivation of the PI3K/AKT pathway. Here the authors identify an ErbB3-independent compensatory mechanism comprising Ras/PI3K activation directly by ErbB2, and develop biparatopic panErbB inhibitors to block this mode of resistance. 03 June 2016 | doi: 10.1038/ncomms11672 Biological Sciences  Biotechnology  Cancer  Synthetic mixed-signal computation in living cells OPEN Jacob R. Rubens, Gianluca Selvaggio and Timothy K. Lu Digital and analogue gene circuits each have distinct advantages in natural and engineered cells. Here, Rubens et al. engineer synthetic gene circuits that implement mixed-signal digital and analogue computations in living cells. 03 June 2016 | doi: 10.1038/ncomms11658 Biological Sciences  Biotechnology  A two-neuron system for adaptive goal-directed decision-making in Lymnaea OPEN Michael Crossley, Kevin Staras and György Kemenes Integrating information from both the external environment and an organism's internal state is an important aspect of feeding-related decision making. Here, the authors identify a two neuron circuit within the mollusc Lymnaea that adapts feeding behaviour according to food availability and motivational state. 03 June 2016 | doi: 10.1038/ncomms11793 Biological Sciences  Neuroscience  Tenascin-C drives persistence of organ fibrosis OPEN Swati Bhattacharyya, Wenxia Wang, Luisa Morales-Nebreda, Gang Feng, Minghua Wu, Xiaodong Zhou, Robert Lafyatis, Jungwha Lee, Monique Hinchcliff, Carol Feghali-Bostwick, Katja Lakota, G. R. Scott Budinger, Kirtee Raparia, Zenshiro Tamaki and John Varga Systemic sclerosis (SSc) is a fibrotic disease affecting multiple organs. Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease. 03 June 2016 | doi: 10.1038/ncomms11703 Biological Sciences  Medical research  Engineering skyrmions in transition-metal multilayers for spintronics OPEN B. Dupé, G. Bihlmayer, M. Böttcher, S. Blügel and S. Heinze Materials possessing anisotropic spin exchange interactions can support skyrmion quasiparticle spin textures, which may be exploited in nanomagnetic devices. Here, the authors predict the appearance of skyrmions in multilayered thin films of biatomic Fe sandwiched between 4d and 5d transition metals. 03 June 2016 | doi: 10.1038/ncomms11779 Physical Sciences  Condensed matter  Nanotechnology  Theoretical physics  Interface strain in vertically stacked two-dimensional heterostructured carbon-MoS2 nanosheets controls electrochemical reactivity OPEN Landon Oakes, Rachel Carter, Trevor Hanken, Adam P. Cohn, Keith Share, Benjamin Schmidt and Cary L. Pint Two-dimensional materials are promising for electrochemical energy storage, conversion, catalysis, and sensing. Here the authors leverage strain engineering using a two-dimensional stacked carbon-MoS2 material to control chemical storage pathways in MoS2 upon lithium metal insertion. 03 June 2016 | doi: 10.1038/ncomms11796 Physical Sciences  Materials science  Nanotechnology  Physical chemistry  North Atlantic Deep Water Production during the Last Glacial Maximum OPEN Jacob N. W. Howe, Alexander M. Piotrowski, Taryn L. Noble, Stefan Mulitza, Cristiano M. Chiessi and Germain Bayon The nature of the overturning circulation in the Atlantic Ocean during the Last Glacial Maximum remains a topic of contention. Here, using neodymium isotope measurements, the authors demonstrate that North Atlantic Deep Water was produced under glacial climate conditions. 03 June 2016 | doi: 10.1038/ncomms11765 Earth Sciences  Climate science  Oceanography  Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells OPEN Congping Lin, Martin Schuster, Sofia Cunha Guimaraes, Peter Ashwin, Michael Schrader, Jeremy Metz, Christian Hacker, Sarah Jane Gurr and Gero Steinberg The mechanisms underlying the positioning of eukaryotic organelles remain elusive. Here Lin et al. use imaging and a mathematical model to show that microtubule-based transport and active diffusion and actin-based polar drift act together to facilitate even distribution of peroxisomes in filamentous fungi. 02 June 2016 | doi: 10.1038/ncomms11814 Biological Sciences  Biophysics  Cell biology  Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases OPEN Urszula M. McCaughan, Uma Jayachandran, Vadim Shchepachev, Zhuo Angel Chen, Juri Rappsilber, David Tollervey and Atlanta G. Cook Tsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribosomal maturation to be drawn. 02 June 2016 | doi: 10.1038/ncomms11789 Biological Sciences  Biochemistry  Molecular biology  Demonstration of a positron beam-driven hollow channel plasma wakefield accelerator OPEN Spencer Gessner, Erik Adli, James M. Allen, Weiming An, Christine I. Clarke, Chris E. Clayton, Sebastien Corde, J. P. Delahaye, Joel Frederico, Selina Z. Green, Carsten Hast, Mark J. Hogan, Chan Joshi, Carl A. Lindstrøm, Nate Lipkowitz, Michael Litos, Wei Lu, Kenneth A. Marsh, Warren B. Mori, Brendan O’Shea et al. Plasma wakefield accelerators produce gradients that are orders of magnitude larger than in conventional particle accelerator, but beams tend to be disrupted by transverse forces. Here the authors create an extended hollow plasma channel, which accelerates positrons without generating transverse forces. 02 June 2016 | doi: 10.1038/ncomms11785 Physical Sciences  Fluids and plasma physics  Particle physics  The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2) OPEN Yujin Jeong, Ji-Nu Kim, Min Woo Kim, Giselda Bucca, Suhyung Cho, Yeo Joon Yoon, Byung-Gee Kim, Jung-Hye Roe, Sun Chang Kim, Colin P. Smith and Byung-Kwan Cho Bacteria of the genus Streptomyces produce a great variety of natural products, the biosynthesis of which is subject to complex regulatory networks. Here the authors present a high-resolution, genome-wide analysis of the transcriptome and translatome of Streptomyces coelicolor under various growth conditions. 02 June 2016 | doi: 10.1038/ncomms11605 Biological Sciences  Genetics  Microbiology  Systems biology  Fast, greener and scalable direct coupling of organolithium compounds with no additional solvents OPEN Erik B. Pinxterhuis, Massimo Giannerini, Valentín Hornillos and Ben L. Feringa Cross-coupling reactions typically are carried out under dilute conditions of ethereal solvents. Here, the authors report a method for palladium catalysed cross-coupling of organolithium reagents that avoids the use of any added solvent with reaction times of only minutes. 02 June 2016 | doi: 10.1038/ncomms11698 Chemical Sciences  Catalysis  Organic chemistry  Wafer-scale fabrication and growth dynamics of suspended graphene nanoribbon arrays OPEN Hiroo Suzuki, Toshiro Kaneko, Yasushi Shibuta, Munekazu Ohno, Yuki Maekawa and Toshiaki Kato Shaping atomically thin materials in suspended structures may provide a viable platform for nanoscale mechanical oscillators. Here, the authors demonstrate wafer-scale, high-yield synthesis of suspended graphene nanoribbon arrays using a bottom-up approach and shed light into their growth dynamics. 02 June 2016 | doi: 10.1038/ncomms11797 Physical Sciences  Applied physics  Materials science  Nanotechnology  ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation OPEN Luise Hartmann, Sayantanee Dutta, Sabrina Opatz, Sebastian Vosberg, Katrin Reiter, Georg Leubolt, Klaus H. Metzeler, Tobias Herold, Stefanos A. Bamopoulos, Kathrin Bräundl, Evelyn Zellmeier, Bianka Ksienzyk, Nikola P. Konstandin, Stephanie Schneider, Karl-Peter Hopfner, Alexander Graf, Stefan Krebs, Helmut Blum, Jan Moritz Middeke, Friedrich Stölzel et al. The t(8;21) translocation is often found in acute myeloid leukaemia but is not sufficient for development of the disease. In this study, the authors identify frequent mutations in the transcriptional repressor, ZBTB7A, in these patients and show that the mutations reduce DNA binding activity. 02 June 2016 | doi: 10.1038/ncomms11733 Biological Sciences  Cancer  Genetics  Molecular biology  Initialized decadal prediction for transition to positive phase of the Interdecadal Pacific Oscillation OPEN Gerald A. Meehl, Aixue Hu and Haiyan Teng The phase of the Interdecadal Pacific Oscillation (IPO) impacts global temperatures. Here, the authors show that a build-up of off-equatorial western tropical Pacific heat content allows ENSO events to trigger IPO phase changes, with a predicted switch to a positive IPO for 2015–2019 and larger warming trends. 02 June 2016 | doi: 10.1038/ncomms11718 Earth Sciences  Climate science  Oceanography  Synergetic electrode architecture for efficient graphene-based flexible organic light-emitting diodes OPEN Jaeho Lee, Tae-Hee Han, Min-Ho Park, Dae Yool Jung, Jeongmin Seo, Hong-Kyu Seo, Hyunsu Cho, Eunhye Kim, Jin Chung, Sung-Yool Choi, Taek-Soo Kim, Tae-Woo Lee and Seunghyup Yoo Replacing indium tin oxide with graphene in organic light-emitting diodes is a promising approach to enhance the flexibility of displays and light sources. Here, the authors combine graphene, TiO2 and low-index hole-injection layers to achieve high external quantum efficiency and good bendability. 02 June 2016 | doi: 10.1038/ncomms11791 Physical Sciences  Applied physics  Materials science  Optical physics  Fluorescence microscopy as an alternative to electron microscopy for microscale dispersion evaluation of organic–inorganic composites OPEN Weijiang Guan, Si Wang, Chao Lu and Ben Zhong Tang Imaging of inorganic dispersions in organic-inorganic composites is typically performed using electron microscopy. Here, the authors show that surfactants with attached aggregation-induced emission fluorophores allow simple fluorescence imaging of the spatial distribution of the inorganic filler dispersion. 02 June 2016 | doi: 10.1038/ncomms11811 Chemical Sciences  Analytical chemistry  Materials science  Organic chemistry  Shifting El Niño inhibits summer Arctic warming and Arctic sea-ice melting over the Canada Basin OPEN Chundi Hu, Song Yang, Qigang Wu, Zhenning Li, Junwen Chen, Kaiqiang Deng, Tuantuan Zhang and Chengyang Zhang Teleconnections between different flavours of El Niño and Arctic climate change are inherently uncertain in the context of warming. Here, the authors show that Central Pacific El Niño contributes to summer Arctic cooling and sea-ice increase via an Equator-Arctic teleconnection on interannual timescales. 02 June 2016 | doi: 10.1038/ncomms11721 Earth Sciences  Atmospheric science  Climate science  Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations OPEN Elisa Varela, Miguel A. Muñoz-Lorente, Agueda M. Tejera, Sagrario Ortega and Maria A. Blasco Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing-associated cellular damage and have accelerated wound-healing. 02 June 2016 | doi: 10.1038/ncomms11739 Biological Sciences  Medical research  The channel catfish genome sequence provides insights into the evolution of scale formation in teleosts OPEN Zhanjiang Liu, Shikai Liu, Jun Yao, Lisui Bao, Jiaren Zhang, Yun Li, Chen Jiang, Luyang Sun, Ruijia Wang, Yu Zhang, Tao Zhou, Qifan Zeng, Qiang Fu, Sen Gao, Ning Li, Sergey Koren, Yanliang Jiang, Aleksey Zimin, Peng Xu, Adam M. Phillippy et al. Catfish represent 6.3% of all vertebrate species, and occupy a phylogenetic position close to the common ancestor of bony fish. Liu et al. present a reference genome of the channel catfish, and reveal a genomic basis for the evolutionary loss of scales in these species. 02 June 2016 | doi: 10.1038/ncomms11757 Biological Sciences  Genetics  LRP6 acts as a scaffold protein in cardiac gap junction assembly OPEN Jun Li, Changming Li, Dandan Liang, Fei Lv, Tianyou Yuan, Erlinda The, Xiue Ma, Yahan Wu, Lixiao Zhen, Duanyang Xie, Shiyi Wang, Yuan Liu, Jian Huang, Jingyi Shi, Yi Liu, Dan Shi, Liang Xu, Li Lin, Luying Peng, Jianmin Cui et al. LRP6 is known for its role as a Wnt co-receptor essential for the canonical Wnt/β-catenin signaling. Here, Li et al. show that LRP6 exerts a Wnt-independent scaffold function and regulates connexin 43 gap junction formation and coupling of cardiomyocytes in mouse hearts. 02 June 2016 | doi: 10.1038/ncomms11775 Biological Sciences  Cell biology  Medical research  Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow OPEN James C. Wright, Jonathan Mudge, Hendrik Weisser, Mitra P. Barzine, Jose M. Gonzalez, Alvis Brazma, Jyoti S. Choudhary and Jennifer Harrow Identifying and annotating functional elements in the human genome remains a challenging but important task. Here the authors propose a priority annotation score to rank identifications and suggest how proteogenomics evidence can be interpreted and what additional information substantiates protein-coding potential for annotation. 02 June 2016 | doi: 10.1038/ncomms11778 Biological Sciences  Bioinformatics  Systems biology  aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis OPEN Renuka Raman, Indraneel Damle, Rahul Rote, Shamik Banerjee, Chaitanya Dingare and Mahendra Sonawane Squamous epithelia present actin-rich microridges on the apical surface, but the mechanism of their formation is not known. Here the authors show that, in zebrafish epidermis, the exclusion of the basolateral regulator Lgl from the apical domain by atypical protein kinase C prevents precocious elongation and fusion of microridges. 01 June 2016 | doi: 10.1038/ncomms11643 Biological Sciences  Cell biology  A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution OPEN Jörg Schönfelder, Raul Perez-Jimenez and Victor Muñoz Previous investigations have indicated that the model protein CspB folds in a simple two-state fashion. Here, the authors provide direct experimental evidence for that the energy landscape of two-state folding proteins is highly heterogeneous and that unfolding can occur via multiple pathways. 01 June 2016 | doi: 10.1038/ncomms11777 Biological Sciences  Biophysics  Conventional methanotrophs are responsible for atmospheric methane oxidation in paddy soils OPEN Yuanfeng Cai, Yan Zheng, Paul L. E. Bodelier, Ralf Conrad and Zhongjun Jia Atmospheric methane may be consumed by microorganisms in soil, but the mechanisms behind high-affinity methane oxidization remain poorly understood. Here, Jia et al. show that known methanotrophic bacteria are responsible for atmospheric methane uptake in periodically drained wetland ecosystems. 01 June 2016 | doi: 10.1038/ncomms11728 Earth Sciences  Biogeochemistry  Geology and geophysics  Microbiology  In vivo modulation of endothelial polarization by Apelin receptor signalling OPEN Hyouk-Bum Kwon, Shengpeng Wang, Christian S. M. Helker, S. Javad Rasouli, Hans-Martin Maischein, Stefan Offermanns, Wiebke Herzog and Didier Y. R. Stainier Endothelial cells align in the direction of flow in response to shear stress. Here the authors describe a zebrafish model for visualization of endothelial polarization and demonstrate that endothelial cell alignment depends on blood flow and Apelin signalling. 01 June 2016 | doi: 10.1038/ncomms11805 Biological Sciences  Developmental biology  Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement OPEN Lawrence S. Hsieh, John H. Wen, Kumiko Claycomb, Yuegao Huang, Felicia A. Harrsch, Janice R. Naegele, Fahmeed Hyder, Gordon F. Buchanan and Angelique Bordey The etiology of focal cortical dysplasia (FCD) is not fully understood. Here authors generate an mTORC1 overactivation mouse model that recapitulates hallmarks of type II FCDs, including spontaneous seizures, and suggest that neuronal defects, rather than macrostructural changes, lead to seizures. 01 June 2016 | doi: 10.1038/ncomms11753 Biological Sciences  Neuroscience  Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice OPEN Hongsheng Zhang, Eunchai Kang, Yaqing Wang, Chaojuan Yang, Hui Yu, Qin Wang, Zheyu Chen, Chen Zhang, Kimberly M. Christian, Hongjun Song, Guo-li Ming and Zhiheng Xu The in vivo function of CRMP2 is unclear. Zhang et al. generate and characterize brain-specific Crmp2 knockout mice. These mice show impairments in hippocampal neurogenesis, neuronal maturation and synaptic transmission, and exhibit schizophrenia-related behavioral deficits. 01 June 2016 | doi: 10.1038/ncomms11773 Biological Sciences  Neuroscience  Topological protection of multiparticle dissipative transport OPEN Johannes Loehr, Michael Loenne, Adrian Ernst, Daniel de las Heras and Thomas M. Fischer Transport of a collection of classical particles involves thermal ratchet effect or adiabatic motion, which brings complexity to control multiparticle transport. Here, Loehr et al. show topologically protected multiparticle transport of diamagnetic and paramagnetic colloids, driven by periodic modulation loops of an external magnetic field. 01 June 2016 | doi: 10.1038/ncomms11745 Physical Sciences  Applied physics  Condensed matter  Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice OPEN V. Beglopoulos, J. Tulloch, A. D. Roe, S. Daumas, L. Ferrington, R. Watson, Z. Fan, B. T. Hyman, P. A. T. Kelly, F. Bard and R. G. M. Morris Identifying early signs of Alzheimer’s disease is important when it comes to diagnosis and treatment. Here, the authors identify subtle memory retrieval deficits and associated brain glucose uptake impairments in very young mouse models of Alzheimer’s, prior to plaque development. 01 June 2016 | doi: 10.1038/ncomms11761 Biological Sciences  Neuroscience  Geometrical assembly of ultrastable protein templates for nanomaterials OPEN Dominic J. Glover, Lars Giger, Steve S. Kim, Rajesh R. Naik and Douglas S. Clark Protein nanotechnology for the fabrication of protein-based nanoscale devices is gaining momentum but assembling well-defined three-dimensional shapes is still challenging. Here, the authors use an existing prefoldin assembled system to design a template for the construction of geometrically constrained structures. 01 June 2016 | doi: 10.1038/ncomms11771 Biological Sciences  Bioengineering  Materials science  Nanotechnology  The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling OPEN Yan-Xiao Ji, Peng Zhang, Xiao-Jing Zhang, Yi-Chao Zhao, Ke-Qiong Deng, Xi Jiang, Pi-Xiao Wang, Zan Huang and Hongliang Li TRAF6 is a ubiquitin E3 ligase regulating a number of biological processes. Here the authors show that ROS, generated during pathological cardiac stress, induces TRAF6 auto-ubiquitination and activation, promoting its interaction with and ubiquitination of TAK1 that contributes to development of cardiac hypertrophy. 01 June 2016 | doi: 10.1038/ncomms11267 Biological Sciences  Cell biology  Medical research  Observation of coherent delocalized phonon-like modes in DNA under physiological conditions OPEN Mario González-Jiménez, Gopakumar Ramakrishnan, Thomas Harwood, Adrian J. Lapthorn, Sharon M. Kelly, Elizabeth M. Ellis and Klaas Wynne Terahertz-frequency vibrational modes are thought to play a key role for DNA biological functions, yet observation of these fluctuations in solution has proven difficult so far. Here, the authors use femtosecond optical Kerr-effect spectroscopy to demonstrate their existence in physiologically relevant conditions. 01 June 2016 | doi: 10.1038/ncomms11799 Physical Sciences  Biophysics  Molecular biology  Physical chemistry  Fast escape of a quantum walker from an integrated photonic maze OPEN Filippo Caruso, Andrea Crespi, Anna Gabriella Ciriolo, Fabio Sciarrino and Roberto Osellame Studying quantum transport in biological systems is difficult so developing an artificial platform that can be used to understand quantum transport is desirable. Here, Caruso, et al. demonstrate how a quantum walker can quickly reach the output of a maze by partially suppressing the presence of interference. 01 June 2016 | doi: 10.1038/ncomms11682 Physical Sciences  Optical physics  Theoretical physics  Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10 OPEN Wang-Yong Yang, Rui Gao, Mark Southern, Partha S. Sarkar and Matthew D. Disney Expanded RNA repeats in non-coding region of a gene represent a hallmark of several diseases. Here, the authors identify two small molecules that selectively bind AU repeats and use them to design a compound that targets the pathogenic RNA associated with spinocerebellar ataxia type 10. 01 June 2016 | doi: 10.1038/ncomms11647 Biological Sciences  Biochemistry  Chemical biology  Medicinal chemistry  Robust and stretchable indium gallium zinc oxide-based electronic textiles formed by cilia-assisted transfer printing OPEN Jongwon Yoon, Yunkyung Jeong, Heeje Kim, Seonggwang Yoo, Hoon Sun Jung, Yonghun Kim, Youngkyu Hwang, Yujun Hyun, Woong-Ki Hong, Byoung Hun Lee, Sung-Hoon Choa and Heung Cho Ko The fabrication of smart textiles is currently relying on the printing of ultrathin electronics on fabric, which is subject to the poor adhesion between electronics and textile. Here, Yoon et al. propose the use of cilia-like structure to improve adhesion in addition to release mechanical stress. 01 June 2016 | doi: 10.1038/ncomms11477 Physical Sciences  Applied physics  Nanotechnology  Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy OPEN Ke-Qiong Deng, Aibing Wang, Yan-Xiao Ji, Xiao-Jing Zhang, Jing Fang, Yan Zhang, Peng Zhang, Xi Jiang, Lu Gao, Xue-Yong Zhu, Yichao Zhao, Lingchen Gao, Qinglin Yang, Xue-Hai Zhu, Xiang Wei, Jun Pu and Hongliang Li Identifying pathways that cause pathological cardiac hypertrophy holds great therapeutic potential. Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modulating the TBK1/AKT signalling in rodents and monkeys. 01 June 2016 | doi: 10.1038/ncomms11432 Biological Sciences  Cell biology  Medical research  Characterizing the boundary lateral to the shear direction of deformation twins in magnesium OPEN Y. Liu, N. Li, S. Shao, M. Gong, J. Wang, R. J. McCabe, Y. Jiang and C. N. Tomé Twin propagation involves three-dimensional normal, forward and lateral motion of twin interfaces with respect to the twinning shear direction. Here, the authors combine electron microscopy and atomistic simulations to study the until now unknown lateral structure of tensile deformation twins in magnesium. 01 June 2016 | doi: 10.1038/ncomms11577 Physical Sciences  Materials science  Shaping nanoscale magnetic domain memory in exchange-coupled ferromagnets by field cooling OPEN Karine Chesnel, Alex Safsten, Matthew Rytting and Eric E. Fullerton The extent to which a material revisits previously accessed magnetization states under a cycling applied magnetic field has important implications for its use in memory technology. Here, the authors demonstrate the effects of field-cooling on magnetic domain memory in exchange-biased Co/Pd thin films. 01 June 2016 | doi: 10.1038/ncomms11648 Physical Sciences  Condensed matter  Nanotechnology  Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross OPEN Matthew B. Taylor, Joann Phan, Jonathan T. Lee, Madelyn McCadden and Ian M. Ehrenreich Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the genetic bases of 17 independent occurrences of a phenotype that arises due to combinations of epistatically interacting cryptic variants. 01 June 2016 | doi: 10.1038/ncomms11669 Biological Sciences  Evolution  Genetics    Nature Communications JOBS of the week Research Assistant University of Edinburgh Postdoctoral Fellow The Scripps Research Institute (TSRI) PhD Student German Cancer Research Center (DKFZ). Postdoctoral Research Fellow Mayo Clinic Florida Post Doctoral Position University of Texas at El Paso Research Fellow The University of Warwick Postdoctoral Research Associate University of Reading Team Leader Position Fondation Toulouse Cancer Sante Researchers The Velux Foundations Research Fellow University of Aberdeen More Science jobs from Nature Communications EVENT Cancer Stem Cell Conference 2016 23.09.16 Cleveland, USA More science events from       Latest Corrigenda     Corrigendum: Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway OPEN Wai Shun Mak, Stephen Tran, Ryan Marcheschi, Steve Bertolani, James Thompson, David Baker, James C. Liao and Justin B. Siegel 07 June 2016 | doi: 10.1038/ncomms11912 Chemical Sciences  Biochemistry  Bioinformatics  Chemical biology      Corrigendum: Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4 OPEN Petra Hartmann, Zhe Zhou, Lucia Natarelli, Yuanyuan Wei, Maliheh Nazari-Jahantigh, Mengyu Zhu, Jochen Grommes, Sabine Steffens, Christian Weber and Andreas Schober 07 June 2016 | doi: 10.1038/ncomms11907 Biological Sciences  Cell biology  Medical research      Corrigendum: Analysing black phosphorus transistors using an analytic Schottky barrier MOSFET model OPEN Ashish V. Penumatcha, Ramon B. Salazar and Joerg Appenzeller 06 June 2016 | doi: 10.1038/ncomms11913 Physical Sciences  Applied physics  Materials science  Nanotechnology      Corrigendum: The solvation of electrons by an atmospheric-pressure plasma OPEN Paul Rumbach, David M. Bartels, R. Mohan Sankaran and David B. Go 06 June 2016 | doi: 10.1038/ncomms11911 Physical Sciences  Fluids and plasma physics  Physical chemistry      Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma OPEN Jane E. Freedman, Mark Gerstein, Eric Mick, Joel Rozowsky, Daniel Levy, Robert Kitchen, Saumya Das, Ravi Shah, Kirsty Danielson, Lea Beaulieu, Fabio C. P. Navarro, Yaoyu Wang, Timur R. Galeev, Alex Holman, Raymond Y. Kwong, Venkatesh Murthy, Selim E. Tanriverdi, Milka Koupenova, Ekaterina Mikhalev and Kahraman Tanriverdi. 03 June 2016 | doi: 10.1038/ncomms11902 Biological Sciences  Genetics  Molecular biology      Corrigendum: Radiocarbon constraints on the extent and evolution of the South Pacific glacial carbon pool OPEN T. A. Ronge, R. Tiedemann, F. Lamy, P. Köhler, B. V. Alloway, R. De Pol-Holz, K. Pahnke, J. Southon and L. Wacker 03 June 2016 | doi: 10.1038/ncomms11885 Earth Sciences  Climate science  Oceanography        Latest Errata     Erratum: Observation of an evolving magnetic flux rope before and during a solar eruption Jie Zhang, Xin Cheng and Ming-de Ding 07 June 2016 | doi: 10.1038/ncomms11959 Physical Sciences  Astronomy  Fluids and plasma physics  Planetary sciences      Erratum: Correspondence: Reply to ‘Enhancing a phase measurement by sequentially probing a solid-state system’ OPEN Liu Gang-Qin, Zhang Yu-Ran, Chang Yan-Chun, Yue Jie-Dong, Fan Heng and Pan Xin-Yu 07 June 2016 | doi: 10.1038/ncomms11865 Physical Sciences  Optical physics      Erratum: Correspondence: Enhancing a phase measurement by sequentially probing a solid-state system OPEN P. A. Knott, W. J. Munro and J. A. Dunningham 07 June 2016 | doi: 10.1038/ncomms11864 Physical Sciences  Optical physics      Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes OPEN Bernard Pereira, Suet-Feung Chin, Oscar M. Rueda, Hans-Kristian Moen Vollan, Elena Provenzano, Helen A. Bardwell, Michelle Pugh, Linda Jones, Roslin Russell, Stephen-John Sammut, Dana W. Y. Tsui, Bin Liu, Sarah-Jane Dawson, Jean Abraham, Helen Northen, John F. Peden, Abhik Mukherjee, Gulisa Turashvili, Andrew R. Green, Steve McKinney et al. 06 June 2016 | doi: 10.1038/ncomms11908 Biological Sciences  Cancer  Genetics  Medical research      Erratum: Nanoelectronic primary thermometry below 4 mK OPEN D. I. Bradley, R. E. George, D. Gunnarsson, R. P. Haley, H. Heikkinen, Yu A. Pashkin, J. Penttilä, J. R. Prance, M. Prunnila, L. Roschier and M. Sarsby 03 June 2016 | doi: 10.1038/ncomms11678 Physical Sciences  Condensed matter      Erratum: Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis OPEN Shu-Yi Yin, Feng-Yin Jian, Yung-Hsiang Chen, Shih-Chang Chien, Mao-Chih Hsieh, Pei-Wen Hsiao, Wen-Hwa Lee, Yueh-Hsiung Kuo and Ning-Sun Yang 03 June 2016 | doi: 10.1038/ncomms11909 Biological Sciences  Cancer  Immunology  Medical research      Advertisement Call for Cover Images Wanted - eye-catching images to feature on the 2017 covers of the clinical Nature Reviews titles. Submit your image for the opportunity for it to appear on the cover for 2017! PLUS we'll send the chosen author a print of the cover as a thank you.  Details of how to submit here     Advertisement Nature Outlook: Irritable Bowel Syndrome Irritable bowel syndrome is one of the most common gastrointestinal disorders. As research slowly progresses, there is increased hope for treating, or perhaps preventing, this always unpleasant and in some cases severe condition.  Access the Outlook free online for six months. Produced with support from Allergan plc     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.