EMBO reports Table of Contents for June 2016; Vol. 17, No. 6

June 2016 | Volume 17, Number 6 Submit Table of Contents News & Views Science & Society Scientific Reports Articles Volume 17, Number 6 News & Views HUWE1 comes to the rescue at stalled replication forks A study in this issue shows that the HUWE1 E3 ligase is recruited to stalled replication forks by PCNA, promotes fork restart, and mitigates replication stress. Kate E Coleman and Tony T Huang Published online 04.05.2016 The cohesin REC8 prevents illegitimate inter‐sister synaptonemal complex assembly A study in this issue shows that densely arranged REC8 cohesin complexes prevent local separation of sister chromatid axes and illegitimate synaptonemal complex assembly. Kei‐ichiro Ishiguro and Yoshinori Watanabe Published online 11.05.2016 Science & Society Future directions in analytics for infectious disease intelligence: Toward an integrated warning system for emerging pathogens Anticipating the emergence of infectious diseases would be more effective in reducing their toll, rather than reacting to an outbreak. Machine learning and simulation tools that use environmental, epidemiological and molecular data could help manage and analyse the flow or risks, and inform appropriate actions by public health authorities. Barbara A Han and John M Drake Published online 11.05.2016 The animal experimentation quandary: stuck between legislation and scientific freedom: More research and engagement by scientists is needed to help to improve animal welfare without hampering biomedical research Existing national and EU regulations and laws to protect animal welfare are being challenged by the increasing importance and use of genetically modified animals in biomedical research. Scientists, veterinarians, lawyers and regulatory authorities need to adapt these laws to improve animal welfare in research while not hindering medical progress. Bettina Bert, Justyna Chmielewska, Andreas Hensel, Barbara Grune, and Gilbert Schönfelder Published online 22.04.2016 The FBI and biohackers: an unusual relationship: The FBI has had some success reaching out to the DIY biology community in the USA, but European biohackers remain skeptical of the intentions of US law enforcement The biohacking movement raises security concerns for some law enforcement officials. However, while attempts at outreach from the FBI to the US community have been successful, others in the biohacking movement remain cautious of government interference. Howard Wolinsky Published online 22.04.2016 New migraine therapies promise prevention: A new generation of drugs could avert migraine attacks rather than merely relieve symptoms Migraines afflict millions of people, generating considerable economic costs in terms of treatment and lost work time. Even though research has not yet uncovered the molecular basis for migraines, it has nonetheless yielded a new generation of drug treatment and non‐drug intervention, which could help ward‐off migraine attacks rather than help sufferers manage the headaches. Philip Hunter Published online 06.05.2016 Scientific Reports ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function This study provides evidence for a novel localization of the PS lipid transfer proteins ORP5 and ORP8 at ER–mitochondria contact sites, in addition to ER–PM contacts. Depletion of ORP5 and ORP8 leads to defects in mitochondria morphology and respiratory function. Romain Galmes, Audrey Houcine, Alexander R van Vliet, Patrizia Agostinis, Catherine L Jackson, and Francesca Giordano Published online 13.04.2016 SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense This study shows that SIRT5 desuccinylates and deglutarylates IDH2 and G6PD, respectively, and activates both enzymes to maintain cellular NADPH homeostasis and to enhance cellular antioxidant defense. Lisha Zhou, Fang Wang, Renqiang Sun, Xiufei Chen, Mengli Zhang, Qi Xu, Yi Wang, Shiwen Wang, Yue Xiong, Kun‐Liang Guan, Pengyuan Yang, Hongxiu Yu, and Dan Ye Published online 09.04.2016 Articles Folliculin directs the formation of a Rab34–RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes This study shows how the renal tumour suppressor folliculin couples the lysosomal nutrient signaling network to the cellular machinery that controls the intracellular distribution of the organelle itself. Georgina P Starling, Yan Y Yip, Anneri Sanger, Penny E Morton, Emily R Eden, and Mark P Dodding Published online 13.04.2016 UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation This study shows that the BAG6‐binding factor UBQLN4 is essential for the elimination of mislocalized cytosolic transmembrane domain proteins that have failed to reach their correct destination at the ER membrane. Rigel Suzuki and Hiroyuki Kawahara Published online 22.04.2016 A role for septin 2 in Drp1‐mediated mitochondrial fission This study provides evidence that septins, conserved components of the cytoskeleton, are involved in Drp1‐mediated mitochondrial fission. Alessandro Pagliuso, To Nam Tham, Julia K Stevens, Thibault Lagache, Roger Persson, Audrey Salles, Jean‐Christophe Olivo‐Marin, Stéphane Oddos, Anne Spang, Pascale Cossart, and Fabrizia Stavru Published online 23.05.2016 HUWE1 interacts with PCNA to alleviate replication stress The HUWE1 ubiquitin ligase is recruited to stalled replication forks by the replication factor PCNA. HUWE1 ubiquitinates H2AX to promote restart of stalled replication forks and mitigate replication stress. Katherine N Choe, Claudia M Nicolae, Daniel Constantin, Yuka Imamura Kawasawa, Maria Rocio Delgado‐Diaz, Subhajyoti De, Raimundo Freire, Veronique AJ Smits, and George‐Lucian Moldovan Published online 04.05.2016 The AS‐RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation The lncRNA AS‐RBM15 is transcriptionally upregulated by RUNX1 and enhances RBM15 protein translation via its overlapping region with the RBM15 5′UTR. Ngoc‐Tung Tran, Hairui Su, Alireza Khodadadi‐Jamayran, Shan Lin, Li Zhang, Dewang Zhou, Kevin M Pawlik, Tim M Townes, Yabing Chen, James C Mulloy, and Xinyang Zhao Published online 26.04.2016 High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation This study shows that randomly distributed but densely arranged REC8 cohesin complexes prevent local separation of sister chromatid axes and illegitimate synaptonemal complex assembly. Ana Agostinho, Otto Manneberg, Robin van Schendel, Abrahan Hernández‐Hernández, Anna Kouznetsova, Hans Blom, Hjalmar Brismar, and Christer Höög Published online 11.05.2016 The paracaspase MALT1 mediates CARD14‐induced signaling in keratinocytes This study shows that the paracaspase MALT1 is indispensable for CARD14‐induced NF‐κB and MAP kinase signaling. Pharmacological inhibition of MALT1 prevents pro‐inflammatory gene expression in primary keratinocytes induced by psoriasis‐associated mutation of CARD14. Inna S Afonina, Elien Van Nuffel, Griet Baudelet, Yasmine Driege, Marja Kreike, Jens Staal, and Rudi Beyaert Published online 25.04.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.