Thursday, May 19, 2016

Nature Reviews Neuroscience contents June 2016 Volume 17 Number 6 pp 333 - 395

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Nature Reviews Neuroscience

 
TABLE OF CONTENTS
 
June 2016 Volume 17 Number 6
Nature Reviews Neuroscience cover
Impact Factor 31.427 *
In this issue
Research Highlights
Reviews

Also this month
 Featured article:
The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease
Aaron R. Haeusler, Christopher J. Donnelly & Jeffrey D. Rothstein


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RESEARCH HIGHLIGHTS
Top

Neural repair: Not such a scar on regrowth
p333 | doi:10.1038/nrn.2016.54
A new study shows that astrocytic scars facilitate the regrowth of axons following spinal cord injury in mice.

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Synaptic transmission: Go, go, glycolysis!
p334 | doi:10.1038/nrn.2016.55
During periods of energy stress, glycolytic enzymes become localized near synaptic release sites and are crucial for maintaining energy levels, the synaptic vesicle cycle and behaviour in Caenorhabditis elegans.

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Techniques: Spinning organoids shed light on Zika
p334 | doi:10.1038/nrn.2016.66
A miniaturized spinning bioreactor is used to generate cerebral organoids that mimic key aspects of human cortical development and that can be used to investigate the effects of Zika virus infection on neural development.

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Neurodegenerative disease: Complement mediates pathological pruning
p336 | doi:10.1038/nrn.2016.52
Components of the complement cascade induce microglial engulfment of synapses to mediate synapse loss in mouse models of Alzheimer disease.

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IN BRIEF

Language: Mapping meaning | Spatial processing: Motion replay | Neurodegenerative disease: Repeating mistakes | Gut-brain communication: Gut reaction | Synaptic transmission: Taking back what you owe | Cognitive neuroscience: Getting over yourself | Systems neuroscience: Neural bypass
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REVIEWS
Top
Synaptic AMPA receptor composition in development, plasticity and disease
Jeremy M. Henley & Kevin A. Wilkinson
p337 | doi:10.1038/nrn.2016.37
AMPA receptor (AMPAR) subunit composition is thought to influence trafficking, but recent findings have challenged previously accepted models for how this might occur. In this Review, Henley and Wilkinson provide an overview of how different receptor subunits affect AMPAR assembly, trafficking and function under normal and pathological conditions.
Abstract | Full Text | PDF

Synaptic mechanisms underlying persistent cocaine craving
Marina E. Wolf
p351 | doi:10.1038/nrn.2016.39
One of the greatest challenges in treating addiction is preventing relapse during abstinence. In this Review, Marina Wolf discusses rodent models of cocaine craving that reveal the synaptic plasticity that occurs in reward-related brain regions during the abstinence phase.
Abstract | Full Text | PDF | Supplementary information

The neuronal code for number
Andreas Nieder
p366 | doi:10.1038/nrn.2016.40
Primates have a functional network in frontal and parietal cortices that allows them to quantify the number of elements in a stimulus; that is, its numerosity or cardinality. In this Review, Andreas Nieder examines how neurons in this network process cardinal numbers.
Abstract | Full Text | PDF

The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease
Aaron R. Haeusler, Christopher J. Donnelly & Jeffrey D. Rothstein
p383 | doi:10.1038/nrn.2016.38
A nucleotide repeat expansion (NRE) within the chromosome 9 open reading frame 72 (C9orf72) gene is linked to multiple neurological conditions. Rothstein and colleagues evaluate the evidence indicating that the NRE causes a loss of C9orf72 function or drives toxic gain-of-function mechanisms and consider the cellular defects through which the mutation drives disease pathology.
Abstract | Full Text | PDF | Supplementary information

Erratum: Neural correlates of consciousness: progress and problems
Christof Koch, Marcello Massimini, Melanie Boly & Giulio Tononi
p395 | doi:10.1038/nrn.2016.61
Full Text | PDF
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