Nature Reviews Molecular Cell Biology contents June 2016 Volume 17 Number 6 pp 329-394

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TABLE OF CONTENTS
June 2016 Volume 17 Number 6		Advertisement
Impact Factor 37.806 *	In this issue Research Highlights Comment Focus on: DNA damage repair Reviews Also this month  Featured article: Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers Petra Schwertman, Simon Bekker-Jensen & Niels Mailand  Focus on: DNA damage repair	Nature Index 2016 Saudi Arabia Saudi Arabia had the largest growth of its region in the production of high-quality research in 2015 tracked by the Nature Index, propelling the country into a leading position. Click here to see how strong and fruitful collaborations with international powerhouses have been integral to Saudi Arabia’s rapid rise. The country has now firmly set its sights on becoming a global player in science. Produced with support from: KACST
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RESEARCH HIGHLIGHTS Top DNA damage response: Controlling ubiquitylation at DNA lesions p329 | doi:10.1038/nrm.2016.59 Two studies now provide new insights into the complex and multi-level regulation of ubiquitylation in the DNA damage response. PDF Non-coding RNA: LINP1 joins ends with triple-negative effect p330 | doi:10.1038/nrm.2016.60 The long non-coding RNA LINP1 facilitates double-strand break repair in triple-negative breast cancer through non-homologous end joining, by recruiting DNA-PKcs to sites of damage. PDF Autophagy: Inflammatory pathology of Fanconi anaemia p330 | doi:10.1038/nrm.2016.64 The Fanconi anaemia DNA repair pathway also has cytoplasmic functions in selective autophagy that might contribute to Fanconi anaemia disease. PDF Ageing: The yin and yang of mitochondrial dysfunction p331 | doi:10.1038/nrm.2016.71 Three studies provide important insights into mitochondrial function during ageing – they reveal a connection to stem cell senescence and shed light on the epigenetic mechanisms underlying UPRmt activation and stress-induced longevity. PDF DNA Replication: Looping smoothens repetitive DNA replication p332 | doi:10.1038/nrm.2016.61 DNA supercoiling and the formation of loops suppresses the ATR checkpoint and is required for proper replication of centromeric DNA. PDF JOURNAL CLUB The rule of three p333 | doi:10.1038/nrm.2016.57 As far as James Haber is concerned, the big picture is all he wants of protein structures. This was not the case, however, with the structure of RecA, published in 2008. PDF Cytoskeleton: Microtubules set the beat p333 | doi:10.1038/nrm.2016.63 Microtubule detyrosination is shown to influence mechanical properties of cardiomyocytes, as detyrosinated microtubules resist the force of contraction by undergoing buckling. PDF IN BRIEF Genome engineering: Presenting Argonaute, the genome editor | Ion transporters: Potassium channel regulates ciliogenesis | DNA damage response: p53 curbs topological stress PDF Molecular Cell Biology JOBS of the week Postdoctoral / Senior Postdoctoral Fellow Positions Georgia Cancer Center, Center for Immuno-Oncolgy Postdoctoral Research Associate Position Available Upstate Medical University Post-Doctoral Fellow University of Oklahoma Health Sciences Center Postdoctoral Fellow Baylor College of Medicine (BCM) Postdoctoral Research Associate Benaroya Research Institute at Virginia Mason (BRI) More Science jobs from
Comment: The world of DNA in glycol solution Tomas Lindahl p335 | doi:10.1038/nrm.2016.66 Tomas Lindahl presents a case for keeping DNA in the organic solvent glycol, in which it keeps its activity and is better protected from contamination and, potentially, radiation. Abstract | Full Text | PDF
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Focus on: DNA damage repair REVIEWS Top The Fanconi anaemia pathway: new players and new functions Raphael Ceccaldi, Prabha Sarangi & Alan D. D'Andrea p337 | doi:10.1038/nrm.2016.48 Proteins of the Fanconi anaemia pathway are master regulators of genomic integrity through their interactions with other DNA repair pathways to repair interstrand crosslinks, stabilize replication forks and regulate cytokinesis. Abstract | Full Text | PDF Processing ribonucleotides incorporated during eukaryotic DNA replication Jessica S. Williams, Scott A. Lujan & Thomas A. Kunkel p350 | doi:10.1038/nrm.2016.37 Ribonucleotides are incorporated into DNA by various mechanisms, including by DNA polymerases during replication. Such ribonucleotides may have physiological functions, but their presence is typically associated with diverse structural aberrations and interferes with fundamental processes, including DNA replication, repair and transcription. Thus, efficient mechanisms of ribonucleotide removal are key to maintaining genomic integrity and functionality. Abstract | Full Text | PDF Stop pulling my strings – what telomeres taught us about the DNA damage response Eros Lazzerini-Denchi & Agnel Sfeir p364 | doi:10.1038/nrm.2016.43 Double-strand break (DSB) repair at telomeres – the ends of linear chromosomes – can cause chromosome end fusions and genomic instability, which drives tumorigenesis. As several mechanisms protect mammalian telomeres from the DNA damage response, telomeres have emerged as a system to uncover key steps in DSB repair. Abstract | Full Text | PDF Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers Petra Schwertman, Simon Bekker-Jensen & Niels Mailand p379 | doi:10.1038/nrm.2016.58 Signalling by ubiquitin, SUMO and other ubiquitin-like modifiers (UBLs), and crosstalk between these modifications, underlies cellular responses to DNA double-strand breaks (DSBs). Important insights have been gained into the mechanisms by which ubiquitin and UBLs regulate protein interactions at DSB sites to enable accurate repair in mammalian cells, thereby protecting genome integrity. Abstract | Full Text | PDF
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