Nature Reviews Microbiology contents June 2016 Volume 14 Number 6 pp 331-400

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TABLE OF CONTENTS
June 2016 Volume 14 Number 6		Advertisement
Impact Factor 23.574 *	In this issue Research Highlights News and Analysis Reviews Also this month Article : Microbiome  Featured article: Viral evasion of intracellular DNA and RNA sensing Ying Kai Chan & Michaela U. Gack	Immune Profiling in Health and Disease Presented by: Adaptive Biotechnologies | Nature Immunology | Nature Medicine | Nature Biotechnology | Nature Genetics October 3-5, 2016 | Bell Harbor International Conference Center, Seattle, WA, USA Register now!
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RESEARCH HIGHLIGHTS Top Bacterial pathogenesis: Bacterial effectors skip a few steps p331 | doi:10.1038/nrmicro.2016.61 Members of the SidE effector family of Legionella pneumophila directly ubiquitylate RAB small GTPases, independent of E1 and E2 enzymes, during infection. PDF Bacterial evolution: CPR breathes new air into the tree of life p332 | doi:10.1038/nrmicro.2016.63 A metagenomics-based tree of life reveals a remarkable prominence for the recently described Candidate Phyla Radiation (CPR) in the diversity of life on Earth. PDF Bacterial physiology: Persisters are under the pump p332 | doi:10.1038/nrmicro.2016.72 This studies shows that in addition to passive dormancy, bacterial persisters use active efflux to pump antibiotics out of the cell to survive. PDF Biofilms: Have exploding cells blown up MV dogma? p334 | doi:10.1038/nrmicro.2016.68 Membrane vesicles in Pseudomonas aeruginosa biofilms are not produced by blebbing of the outer membrane but instead by explosive cell lysis, which also releases extracellular DNA into the biofilm matrix. PDF Microbiome: Is LPS the key to the hygiene hypothesis? p334 | doi:10.1038/nrmicro.2016.74 A large study investigating the gut microbiome in infants identifies poorly immunogenic LPS as a risk factor for the development of autoimmunity. PDF IN BRIEF Microbiome: Salmonella breathe out Clostridia | Structural biology: Expanding the pilus family | Systems biology: 'Cache-ing' in on PAS domains | Bacterial genomics: A time to gather chromosomes together | Epidemiology: Which regions are vulnerable to Zika virus? | Structural biology: How Cpf1 cuts its CRISPR targets PDF
NEWS AND ANALYSIS		Top
GENOME WATCH Antibiotics, gut bugs and the young Hilary Browne p336 | doi:10.1038/nrmicro.2016.73 Two recent studies have investigated the effects of antibiotic use on the intestinal microbiota of preterm infants and young children. PDF
REVIEWS		Top
Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model Suguru Okuda, David J. Sherman, Thomas J. Silhavy, Natividad Ruiz & Daniel Kahne p337 | doi:10.1038/nrmicro.2016.25 In this Review, Kahne and colleagues discuss how lipopolysaccharide (LPS) is transported across the cellular envelope and inserted into the outer membrane of Gram-negative bacteria. They propose a new model, which explains how energy from the cytoplasm is used to power LPS transport to the cell surface. Abstract | Full Text | PDF
Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses Mary K. Stewart & Brad T. Cookson p346 | doi:10.1038/nrmicro.2016.50 The initial sensing of an infection is mediated by innate pattern recognition receptors, which detect pathogens, such as bacteria and viruses. In this Review, Stewart and Cookson discuss the molecular mechanisms by which microorganisms evade or inhibit intracellular detection that is coupled to pro-inflammatory caspase-dependent protective responses, thus delaying protective host responses. Abstract | Full Text | PDF
Viral evasion of intracellular DNA and RNA sensing Ying Kai Chan & Michaela U. Gack p360 | doi:10.1038/nrmicro.2016.45 Pattern recognition receptors (PRRs) detect conserved molecular features of viral pathogens and initiate signalling that results in the expression of antiviral genes. In this Review, Chan and Gack highlight the major classes of intracellular viral RNA and DNA sensors and discuss the viral strategies that are used to escape immune surveillance by those sensors. Abstract | Full Text | PDF
Article series: Microbiome Gut microbial communities of social bees Waldan K. Kwong & Nancy A. Moran p374 | doi:10.1038/nrmicro.2016.43 The gut of honey bees is inhabited by a small group of highly host-adapted bacteria. In this Review, Kwong and Moran detail the composition and functions of the microbiota of honey bees and highlight similarities and differences to the human microbiota. Abstract | Full Text | PDF
Chlamydia cell biology and pathogenesis Cherilyn Elwell, Kathleen Mirrashidi & Joanne Engel p385 | doi:10.1038/nrmicro.2016.30 Chlamydia spp. are intracellular bacteria that depend on the host for their metabolic requirements, while hiding from host immune defences. In this Review, Elwell, Mirrashidi and Engel detail the molecular mechanisms that enable these pathogens to shape and thrive in their niche in host cells. Abstract | Full Text | PDF
Corrigendum: Splitsville: structural and functional insights into the dynamic bacterial Z ring Daniel P. Haeusser & William Margolin p400 | doi:10.1038/nrmicro.2016.64 Full Text | PDF
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