Nature Reviews Cancer contents June 2016 Volume 16 Number 6 pp341-408

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Immune Profiling in Health and Disease Presented by: Adaptive Biotechnologies | Nature Immunology | Nature Medicine | Nature Biotechnology | Nature Genetics October 3-5, 2016 | Bell Harbor International Conference Center, Seattle, WA, USA Register now!
TABLE OF CONTENTS
June 2016 Volume 16 Number 6		Advertisement
Impact Factor 37.4 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Cancer origins  Featured article: From melanocytes to melanomas A. Hunter Shain & Boris C. Bastian	Precision Research Models of Human Immune Function The development of animal models to mimic human immune responses is crucial to study the pathophysiology of cancer. Taconic Biosciences, in partnership with the Central Institute for Experimental Animals, has developed a variety of next generation immune deficient mouse lines that are suitable and highly effective at modeling the diverse mechanistic functions of human immunity.  Click to Learn More
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RESEARCH HIGHLIGHTS Top Tumour microenvironment: Genotype puts tension on a tumour p341 | doi:10.1038/nrc.2016.57 SMAD4-mutant pancreatic ductal adenocarcinomas (PDACs) with impaired transforming growth factor-β (TGFβ) signalling initiate a signal transducer and activator of transcription 3 (STAT3)-dependent signalling pathway that leads to increased stromal stiffening and aggressive disease. PDF Tumour microenvironment: As time goes by p342 | doi:10.1038/nrc.2016.53 Kaur et al. show that in older patients, fibroblasts in the melanoma microenvironment produce the WNT-β-catenin inhibitor secreted frizzled-related protein 2 (SFRP2), which increases oxidative stress in melanoma cells, driving metastasis and therapeutic resistance. PDF Targeted therapy: RAS mimetic revealed p342 | doi:10.1038/nrc.2016.59 The small-molecule inhibitor rigosertib acts as a RAS mimetic — by disrupting the association of RAS with RAF and other effector proteins, it inactivates RAS downstream signalling. PDF Chemotherapy: Clocking up resistance p343 | doi:10.1038/nrc.2016.50 Paek et al. report that the level of p53 required to induce apoptosis in human colon cancer cells increases with time following treatment with DNA damage-inducing agents. PDF Cancer JOBS of the week Bioinformatics / computational biology | Non-coding alterations in cancer University of Gothenburg (GU) Postdoctoral Fellowships in Cancer Immunotherapy and Drug Delivery Vanderbilt University National Cancer Institute (NCI) Postdoc: Cancer Prevention Fellowship Program National Cancer Institue Senior Project Manager, AACR Cancer Progress Report American Association for Cancer Research (AACR) Postdoctoral / Senior Postdoctoral Fellow Positions Georgia Cancer Center, Center for Immuno-Oncolgy More Science jobs from Cancer EVENT Horizons of Cancer Biology and Therapy Inaugural Symposium 07.09.16 Lausanne, Switzerland More science events from
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BJC collections: Cancer Immunotherapy Immunotherapies have revolutionised therapy for some cancers. In parallel with therapeutic trials, many other mechanisms and pathways are being investigated in optimising these treatments.  Access this collection from British Journal of Cancer - free online for six months Produced with support from: EMD Serono
REVIEWS		Top
Article series: Cancer origins From melanocytes to melanomas A. Hunter Shain & Boris C. Bastian p345 | doi:10.1038/nrc.2016.37 This Review proposes evolutionary models of tumour progression for melanomas on sun-exposed skin by integrating genetic, epidemiological, clinical and histopathological information. Abstract | Full Text | PDF
Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape Fan Liu, Lan Wang, Fabiana Perna & Stephen D. Nimer p359 | doi:10.1038/nrc.2016.41 The interplay between cellular signalling pathways and chromatin modifications adds another layer of complexity to the already complex regulation of the epigenome. This Review discusses how signalling connections to epigenetics contribute to the molecular pathogenesis of neoplasia. Abstract | Full Text | PDF
Bone metastasis: the importance of the neighbourhood Peter I. Croucher, Michelle M. McDonald & T. John Martin p373 | doi:10.1038/nrc.2016.44 This Review summarizes progress in our understanding of the mechanisms by which different bone cell types support tumour cell dormancy and reactivation, and highlights new therapeutic approaches to control dormancy and bone metastasis by targeting the bone microenvironment. Abstract | Full Text | PDF
Mechanisms of human lymphoid chromosomal translocations Michael R. Lieber p387 | doi:10.1038/nrc.2016.40 This Review discusses the mechanisms underlying 'hot-spot' translocations, which frequently occur in human lymphomas. Discussion of the role of activation-induced deaminase (AID) and the recombination activating gene (RAG) complex provides insights into these mechanisms. Some aspects may also apply to translocations that occur in non-lymphoid neoplasms. Abstract | Full Text | PDF | Supplementary information
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PERSPECTIVES		Top
OPINION Mechanisms of cancer dissemination along nerves Moran Amit, Shorook Na'ara & Ziv Gil p399 | doi:10.1038/nrc.2016.38 Nerve invasion frequently occurs in tumours and has traditionally been viewed as a passive process; however, recent studies have revealed active migration of cancer cells along axons (neural tracking). This Opinion article describes possible molecular mechanisms of neural tracking. Abstract | Full Text | PDF | Supplementary information
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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