Nature Communications - 11 May 2016

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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Correspondence     Correspondence: Reply to ‘Enhancing a phase measurement by sequentially probing a solid-state system’ OPEN 09 May 2016 | doi: 10.1038/ncomms11521     Correspondence: Enhancing a phase measurement by sequentially probing a solid-state system OPEN 09 May 2016 | doi: 10.1038/ncomms11520       Latest Articles View all Articles     Generation of stem cell-derived β-cells from patients with type 1 diabetes OPEN Jeffrey R. Millman, Chunhui Xie, Alana Van Dervort, Mads Gürtler, Felicia W. Pagliuca and Douglas A. Melton Pancreatic β cells can be generated from pluripotent stem cells. Here, the authors show that human induced pluripotent stem cells from patients with type 1 diabetes can be differentiated into β-like cells that have no detectable differences compared with cells from non-diabetic individuals. 10 May 2016 | doi: 10.1038/ncomms11463 Biological Sciences  Cell biology  Developmental biology  Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models OPEN Hermenegild J. Arevalo, Fijoy Vadakkumpadan, Eliseo Guallar, Alexander Jebb, Peter Malamas, Katherine C. Wu and Natalia A. Trayanova Sudden arrhythmic death is a leading cause of mortality, however approaches to identify at-risk patients are of low sensitivity and specificity. Here, the authors develop a personalized approach to assess arrhythmia risk in post-infarction patients based on cardiac imaging and computational modelling that significantly outperforms existing clinical metrics. 10 May 2016 | doi: 10.1038/ncomms11437 Biological Sciences  Medical research  Atomistic understanding of cation exchange in PbS nanocrystals using simulations with pseudoligands OPEN Zhaochuan Fan, Li-Chiang Lin, Wim Buijs, Thijs J. H. Vlugt and Marijn A. van Huis Cation exchange is a promising technique to modify ionic nanostructures by replacing the existing cations with those provided by the solution. Here, the authors use molecular dynamics to study cation exchange in PbS nanocrystals by combining solvent and ligand effects into a pseudoligand parameter. 10 May 2016 | doi: 10.1038/ncomms11503 Chemical Sciences  Nanotechnology  Physical chemistry  OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology OPEN Aleksandra Klimas, Christina M. Ambrosi, Jinzhu Yu, John C. Williams, Harold Bien and Emilia Entcheva The efficiency of preclinical drug testing and characterization of cellular function can be improved through the use of optogenetic tools. Here Klimas et al. present and validate OptoDyCE, a fully automated system for all-optical high-throughput cardiac electrophysiology. 10 May 2016 | doi: 10.1038/ncomms11542 Biological Sciences  Medical research  Predicting quantitative traits from genome and phenome with near perfect accuracy OPEN Kaspar Märtens, Johan Hallin, Jonas Warringer, Gianni Liti and Leopold Parts Heritability of complex traits can be finely dissected using yeast crosses. Here, Kaspar Märtens and colleagues show that quantitative traits in yeast can be predicted from genotype and phenotype data with an average coefficient of determination of 0.91, providing the most accurate predictions of complex traits to date. 10 May 2016 | doi: 10.1038/ncomms11512 Biological Sciences  Genetics  Giant photon bunching, superradiant pulse emission and excitation trapping in quantum-dot nanolasers OPEN Frank Jahnke, Christopher Gies, Marc Aßmann, Manfred Bayer, H. A. M. Leymann, Alexander Foerster, Jan Wiersig, Christian Schneider, Martin Kamp and Sven Höfling Classical light sources are characterized by their intensity and coherence, whereas quantum light sources are described by photon correlations. Here, the authors provide a connection between the two for the case of superradiant emission from quantum dots in a nanolaser. 10 May 2016 | doi: 10.1038/ncomms11540 Physical Sciences  Optical physics  Phosphatidylserine exposure is required for ADAM17 sheddase function OPEN Anselm Sommer, Felix Kordowski, Joscha Büch, Thorsten Maretzky, Astrid Evers, Jörg Andrä, Stefan Düsterhöft, Matthias Michalek, Inken Lorenzen, Prasath Somasundaram, Andreas Tholey, Frank D. Sönnichsen, Karl Kunzelmann, Lena Heinbockel, Christian Nehls, Thomas Gutsmann, Joachim Grötzinger, Sucharit Bhakdi and Karina Reiss ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its substrates. 10 May 2016 | doi: 10.1038/ncomms11523 Biological Sciences  Cell biology  Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors OPEN Shing-Hong Lin, Yuan-Ren Cheng, Robert W. Banks, Ming-Yuan Min, Guy S. Bewick and Chih-Cheng Chen Acid-sensing ion channel 3 (ASIC3) is known to play a role in nociception, but its role in low threshold neurosensory mechanotransduction is unclear. Here, the authors target ASIC3 expression in dorsal root ganglion parvalbumin positive neurons and find ASIC3 contributes to dynamic proprioception responses. 10 May 2016 | doi: 10.1038/ncomms11460 Biological Sciences  Neuroscience  An unforeseen polymorph of coronene by the application of magnetic fields during crystal growth OPEN Jason Potticary, Lui R. Terry, Christopher Bell, Alexandros N. Papanikolopoulos, Peter C. M. Christianen, Hans Engelkamp, Andrew M. Collins, Claudio Fontanesi, Gabriele Kociok-Köhn, Simon Crampin, Enrico Da Como and Simon R. Hall Polymorphism, the presence of different crystal structures of the same molecular system, provides an opportunity to discover new phenomena and properties. Here, the authors crystallize coronene in the presence of a magnetic field, forming a different polymorph, which remains stable under ambient conditions. 10 May 2016 | doi: 10.1038/ncomms11555 Chemical Sciences  Materials science  Organic chemistry  Physical chemistry  Supramolecular metal-organic frameworks that display high homogeneous and heterogeneous photocatalytic activity for H2 production OPEN Jia Tian, Zi-Yue Xu, Dan-Wei Zhang, Hui Wang, Song-Hai Xie, Da-Wen Xu, Yuan-Hang Ren, Hao Wang, Yi Liu and Zhan-Ting Li Self-assembly is robust in creating advanced, homogeneous architectures under mild conditions. Here, the authors describe the generation of the first 3D metal-cored supramolecular organic framework using this strategy and illustrate its capacity in catalysing visible light-induced H2 production. 10 May 2016 | doi: 10.1038/ncomms11580 Chemical Sciences  Catalysis  Inorganic chemistry  Materials science  The role of collective motion in the ultrafast charge transfer in van der Waals heterostructures OPEN Han Wang, Junhyeok Bang, Yiyang Sun, Liangbo Liang, Damien West, Vincent Meunier and Shengbai Zhang Ultrafast charge transfer has been observed experimentally in van der Waals heterostructures. Here, Wang et al. study theoretically the collective exciton motion at the interface. They show that the oscillations lead to charge transfer, with a rate that depends critically on the coupling and on the layer stacking. 10 May 2016 | doi: 10.1038/ncomms11504 Physical Sciences  Condensed matter  Materials science  Nanotechnology  The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes OPEN Bernard Pereira, Suet-Feung Chin, Oscar M. Rueda, Hans-Kristian Moen Vollan, Elena Provenzano, Helen A. Bardwell, Michelle Pugh, Linda Jones, Roslin Russell, Stephen-John Sammut, Dana W. Y. Tsui, Bin Liu, Sarah-Jane Dawson, Jean Abraham, Helen Northen, John F. Peden, Abhik Mukherjee, Gulisa Turashvili, Andrew R. Green, Steve McKinney et al. Much effort has recently been devoted to understanding the genomics of breast cancer. In this study, the authors integrate somatic mutation data with previously published copy number aberration and gene expression information for nearly 2,500 breast cancer samples. 10 May 2016 | doi: 10.1038/ncomms11479 Biological Sciences  Cancer  Genetics  Medical research  Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism OPEN Xiaoming Wang, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, Sunil Kumar, Stephen D. Mague, Samuel W. Hulbert, Nisha Dutta, Volodya Hayrapetyan, Chunxiu Yu, Erin Gaidis, Shengli Zhao, Jin-Dong Ding, Qiong Xu, Leeyup Chung, Ramona M. Rodriguiz, Fan Wang et al. SHANK3 mutations have been linked to autism spectrum disorders, although the underlying mechanisms remain unclear. Here, the authors generate a complete knockout Shank3 mouse model, identifying ASD-like behaviours associated with impaired mGluR5-Homer scaffolding and abnormal brain connectivity. 10 May 2016 | doi: 10.1038/ncomms11459 Biological Sciences  Neuroscience  Tumour resistance in induced pluripotent stem cells derived from naked mole-rats OPEN Shingo Miyawaki, Yoshimi Kawamura, Yuki Oiwa, Atsushi Shimizu, Tsuyoshi Hachiya, Hidemasa Bono, Ikuko Koya, Yohei Okada, Tokuhiro Kimura, Yoshihiro Tsuchiya, Sadafumi Suzuki, Nobuyuki Onishi, Naoko Kuzumaki, Yumi Matsuzaki, Minoru Narita, Eiji Ikeda, Kazuo Okanoya, Ken-ichiro Seino, Hideyuki Saya, Hideyuki Okano et al. The naked mole-rat exhibits an exceptional resistance to cancer. Here, the authors show that induced pluripotent stem cells derived from the naked mole-rat lack teratoma-forming tumorigenicity due to a naked mole-rat-specific ARF-dependent tumour-suppression mechanism. 10 May 2016 | doi: 10.1038/ncomms11471 Biological Sciences  Cancer  Cell biology  Developmental biology  The complete local genotype–phenotype landscape for the alternative splicing of a human exon OPEN Philippe Julien, Belén Miñana, Pablo Baeza-Centurion, Juan Valcárcel and Ben Lehner Genotype–phenotype landscapes are an important characteristic for understanding the evolution of traits. Here the authors construct the local landscape for the alternative splicing of FAS/CD95 exon 6, revealing the regulation of splicing and the evolution of regulatory information between species. 10 May 2016 | doi: 10.1038/ncomms11558 Biological Sciences  Bioinformatics  Molecular biology  Tunable graphene micro-emitters with fast temporal response and controllable electron emission OPEN Gongtao Wu, Xianlong Wei, Song Gao, Qing Chen and Lianmao Peng Controlling the electron emission of microfabricated field emitters can be challenging. Here the authors report controllable and tunable graphene thermionic micro-emitters with well-defined turn-on voltages and switching times in the microsecond range and fabricate uniform micro-emitter arrays. 10 May 2016 | doi: 10.1038/ncomms11513 Physical Sciences  Applied physics  Materials science  Nanotechnology  Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits OPEN James E. Robinson, Kathryn M. Hastie, Robert W. Cross, Rachael E. Yenni, Deborah H. Elliott, Julie A. Rouelle, Chandrika B. Kannadka, Ashley A. Smira, Courtney E. Garry, Benjamin T. Bradley, Haini Yu, Jeffrey G. Shaffer, Matt L. Boisen, Jessica N. Hartnett, Michelle A. Zandonatti, Megan M. Rowland, Megan L. Heinrich, Luis Martínez-Sobrido, Benson Cheng, Juan C. de la Torre et al. Lassa virus can cause haemorrhagic fever for which no specific treatment currently exists. Here the authors have cloned 113 monoclonal antibodies from the survivors of Lassa infection and show that the majority of neutralizing antibodies target a complex of GP1 and GP2 viral proteins. 10 May 2016 | doi: 10.1038/ncomms11544 Biological Sciences  Immunology  Medical research  Virology  Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation OPEN Nicholas Collins, Xiaodong Jiang, Ali Zaid, Bethany L. Macleod, Jane Li, Chang Ook Park, Ashraful Haque, Sammy Bedoui, William R. Heath, Scott N. Mueller, Thomas S. Kupper, Thomas Gebhardt and Francis R. Carbone Memory T cells are vital responders to skin inflammation, but cell localization and dynamics of exchange with the bloodstream are not clear. Here the authors use parabiosis and intravital microscopy to show that CD4+ memory T cells equilibrate with the circulation and cluster around hair follicles in response to CCL5-dependent responses to viral infection or contact sensitization. 10 May 2016 | doi: 10.1038/ncomms11514 Biological Sciences  Immunology  Medical research  The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes OPEN Tobias Ritterhoff, Hrishikesh Das, Götz Hofhaus, Rasmus R. Schröder, Annette Flotho and Frauke Melchior Continuous cycles of nucleo-cytoplasmic transport require disassembly of transport receptor-Ran-GTP complexes in the cytoplasm. Here the authors elucidate the specific function of the RanBP2 complex in the disassembly process. 10 May 2016 | doi: 10.1038/ncomms11482 Biological Sciences  Biochemistry  Molecular biology  Direct electronic measurement of Peltier cooling and heating in graphene OPEN I. J. Vera-Marun, J. J. van den Berg, F. K. Dejene and B. J. van Wees The interaction of electric and thermal transport phenomena at the nanoscale leads to Seebeck and Peltier thermoelectric effects. Here, the authors directly detect the Peltier effect in graphene, and show that it can be reversed by controlling the type and density of the majority carriers using a back gate. 10 May 2016 | doi: 10.1038/ncomms11525 Physical Sciences  Applied physics  Materials science  Nanotechnology  Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity OPEN Arne Battefeld, Jan Klooster and Maarten H. P. Kole Satellite oligodendrocytes (s-OLs) are characterised by their close proximity to neocortical pyramidal cells. Here, the authors find that s-OLs myelinate axons and activity of host neurons evokes inward K+ currents in s-OLs which may work to modulate action potential burst firing by buffering extracellular K+ levels. 10 May 2016 | doi: 10.1038/ncomms11298 Biological Sciences  Cell biology  Neuroscience  Intrinsic correlation between β-relaxation and spatial heterogeneity in a metallic glass OPEN F. Zhu, H. K. Nguyen, S. X. Song, Daisman P. B. Aji, A. Hirata, H. Wang, K. Nakajima and M. W. Chen Beta-relaxation in glasses is commonly attributed to the confined motions of constituent atoms in nanosized domains, but there is no direct evidence so far. Here, Zhu et al. show the correlation between the evolution of spatial heterogeneity at nanoscale and beta-relaxation below glass transition point. 09 May 2016 | doi: 10.1038/ncomms11516 Physical Sciences  Condensed matter  Materials science  Superior visible light hydrogen evolution of Janus bilayer junctions via atomic-level charge flow steering OPEN Jie Li, Guangming Zhan, Ying Yu and Lizhi Zhang The efficiency of photocatalytic hydrogen evolution is impeded by the inability of semiconductors to precisely steer the charge flow. Here, the authors address this issue by designing conceptually new Janus bilayer junctions. 09 May 2016 | doi: 10.1038/ncomms11480 Physical Sciences  Catalysis  Materials science  Nanotechnology  Nonlocality-driven supercontinuum white light generation in plasmonic nanostructures OPEN A. V. Krasavin, P. Ginzburg, G. A. Wurtz and A. V. Zayats A theoretical description of the nonlinear response of metals is complicated due to their complex electron behavior. Here, Krasavin et al. use a hydrodynamic model coupled with Maxwell's equations and demonstrate higher harmonics and supercontinuum generation from metal Archimedean spiral shapes 09 May 2016 | doi: 10.1038/ncomms11497 Physical Sciences  Nanotechnology  Optical physics  Visualizing non-equilibrium lithiation of spinel oxide via in situ transmission electron microscopy OPEN Kai He, Sen Zhang, Jing Li, Xiqian Yu, Qingping Meng, Yizhou Zhu, Enyuan Hu, Ke Sun, Hongseok Yun, Xiao-Qing Yang, Yimei Zhu, Hong Gan, Yifei Mo, Eric A. Stach, Christopher B. Murray and Dong Su Non-equilibrium intercalation reactions may determine the performance of lithium-ion battery materials undergoing lithiation, but it is difficult to probe in real time. Here, the authors use in situ electron microscopy to identify kinetically-driven phase evolution in magnetite single nanoparticles. 09 May 2016 | doi: 10.1038/ncomms11441 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  Sampling the structure and chemical order in assemblies of ferromagnetic nanoparticles by nuclear magnetic resonance OPEN Yuefeng Liu, Jingjie Luo, Yooleemi Shin, Simona Moldovan, Ovidiu Ersen, Anne Hébraud, Guy Schlatter, Cuong Pham-Huu and Christian Meny As nanoparticles possess technological applications from catalysis to medical therapies, methods to probe their structural properties are crucial. Here, the authors extend a nuclear magnetic resonance method to extract such properties for specific size ranges of noninteracting magnetic particles. 09 May 2016 | doi: 10.1038/ncomms11532 Physical Sciences  Condensed matter  Controlling the volatility of the written optical state in electrochromic DNA liquid crystals OPEN Kai Liu, Justin Varghese, Jennifer Y. Gerasimov, Alexey O. Polyakov, Min Shuai, Juanjuan Su, Dong Chen, Wojciech Zajaczkowski, Alessio Marcozzi, Wojciech Pisula, Beatriz Noheda, Thomas T. M. Palstra, Noel A. Clark and Andreas Herrmann Electrochromism, the dependence of light absorption upon electronic control, finds a wide range of applications in smart materials. Here, Liu et al. show an electrochromic DNA–surfactant liquid crystal system that exhibits electrically tunable optical absorption and thermally tunable memory. 09 May 2016 | doi: 10.1038/ncomms11476 Physical Sciences  Applied physics  Materials science  Multimodal two-photon imaging using a second harmonic generation-specific dye OPEN Mutsuo Nuriya, Shun Fukushima, Atsuya Momotake, Takanori Shinotsuka, Masato Yasui and Tatsuo Arai Current dyes for second harmonic generation (SHG) imaging strongly fluoresce, limiting their application. Here the authors develop a SHG-specific dye, Ap3, that partitions into cell membranes, displays sensitivity to membrane potential and has virtually no fluorescence emission at SHG imaging wavelengths. 09 May 2016 | doi: 10.1038/ncomms11557 Biological Sciences  Biotechnology  Cell biology  Spontaneous helix formation in non-chiral bent-core liquid crystals with fast linear electro-optic effect OPEN Sithara P. Sreenilayam, Yuri P. Panarin, Jagdish K. Vij, Vitaly P. Panov, Anne Lehmann, Marco Poppe, Marko Prehm and Carsten Tschierske Liquid crystals that consist of rod-like molecules currently dominate the materials used in industry for display and photonic applications. Here, the authors demonstrate electro-optic grey-scale switching based on the spontaneous formation of a short-pitch helix in a tilted smectic phase of achiral bent-core molecules. 09 May 2016 | doi: 10.1038/ncomms11369 Physical Sciences  Condensed matter  Materials science  Plasticity within non-cerebellar pathways rapidly shapes motor performance in vivo OPEN Diana E. Mitchell, Charles C. Della Santina and Kathleen E. Cullen The extent to which non-cerebellar pathways can refine motor performance is debated. Here, the authors demonstrate behaviourally relevant patterns of activation evoke rapid plasticity within direct and indirect vestibulo-ocular reflex pathways in vivo, leading to changes in evoked eye movements. 09 May 2016 | doi: 10.1038/ncomms11238 Biological Sciences  Neuroscience  Radiocarbon constraints on the extent and evolution of the South Pacific glacial carbon pool OPEN T. A. Ronge, R. Tiedemann, F. Lamy, P. Köhler, B. V. Alloway, R. De Pol-Holz, K. Pahnke, J. Southon and L. Wacker On glacial/interglacial timescales CO2 might have been sequestered from the atmosphere and stored within the deep ocean. Here, the authors show that an old and CO2-rich water mass occupied the glacial South Pacific between ∼2,000 and 4,300 m water depth and was influenced by volcanic CO2 from mid-ocean ridges. 09 May 2016 | doi: 10.1038/ncomms11487 Earth Sciences  Climate science  Oceanography  Viscoelastic lithography for fabricating self-organizing soft micro-honeycomb structures with ultra-high aspect ratios OPEN Gi Seok Jeong, Da Yoon No, JaeSeo Lee, Junghyo Yoon, Seok Chung and Sang-Hoon Lee Tissue engineering applications call for controllable micro-structural units as a platform, but their fabrication remains challenging. Here, Jeong et al. show a method that enables soft materials to self-organize into highly packed micro-honeycomb structures with aspect ratios up to 500, and tunable shapes. 09 May 2016 | doi: 10.1038/ncomms11269 Physical Sciences  Bioengineering  Materials science  Nanotechnology  Quantum coding with finite resources OPEN Marco Tomamichel, Mario Berta and Joseph M. Renes The maximal rate at which quantum information can be reliably communicated through many uses of a memoryless quantum channel is determined by its quantum channel capacity. Here, the authors demonstrate that such an asymptotic characterization is insufficient in practical scenarios. 09 May 2016 | doi: 10.1038/ncomms11419 Physical Sciences  Theoretical physics  Determination of the spin-lifetime anisotropy in graphene using oblique spin precession OPEN Bart Raes, Jeroen E. Scheerder, Marius V. Costache, Frédéric Bonell, Juan F. Sierra, Jo Cuppens, Joris Van de Vondel and Sergio O. Valenzuela Studying the spin lifetime anisotropy in graphene, which provides information on spin-orbit interaction and is relevant to spintronic applications, poses important experimental challenges. Here, the authors study the spin lifetime anisotropy using spin precession under oblique magnetic fields. 09 May 2016 | doi: 10.1038/ncomms11444 Physical Sciences  Condensed matter  Single-shot read-out of a superconducting qubit using a Josephson parametric oscillator OPEN Philip Krantz, Andreas Bengtsson, Michaël Simoen, Simon Gustavsson, Vitaly Shumeiko, W. D. Oliver, C. M. Wilson, Per Delsing and Jonas Bylander Efficient qubit readout is essential for quantum information technology, which requires sufficient recognition of signal from noise. Here, Krantz et al. propose a simplified technique using a Josephson parametric oscillator, demonstrating single-shot readout performance of a superconducting qubit. 09 May 2016 | doi: 10.1038/ncomms11417 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Survival trade-offs in plant roots during colonization by closely related beneficial and pathogenic fungi OPEN Stéphane Hacquard, Barbara Kracher, Kei Hiruma, Philipp C. Münch, Ruben Garrido-Oter, Michael R. Thon, Aaron Weimann, Ulrike Damm, Jean-Félix Dallery, Matthieu Hainaut, Bernard Henrissat, Olivier Lespinet, Soledad Sacristán, Emiel Ver Loren van Themaat, Eric Kemen, Alice C. McHardy, Paul Schulze-Lefert and Richard J. O’Connell Colletotrichum tofieldiae is a beneficial root endophyte, whereas the closely related C. incanum is pathogenic. Here the authors compare the genomes and transcriptomes during host plant interaction and demonstrate that the host plant can respond differently to the beneficial endophyte according to phosphate status. 06 May 2016 | doi: 10.1038/ncomms11362 Biological Sciences  Genetics  Microbiology  Plant sciences  Plate tectonics drive tropical reef biodiversity dynamics OPEN Fabien Leprieur, Patrice Descombes, Théo Gaboriau, Peter F. Cowman, Valeriano Parravicini, Michel Kulbicki, Carlos J. Melián, Charles N. de Santana, Christian Heine, David Mouillot, David R. Bellwood and Loïc Pellissier Over a geological timescale, plate tectonics are thought to promote biodiversity, but this link remained descriptive. Here, Leprieur et al. model dynamically how plate tectonics shaped species diversification and movement of hotspots on tropical reefs over the past 140 million years. 06 May 2016 | doi: 10.1038/ncomms11461 Earth Sciences  Ecology  Geology and geophysics  Palaeontology  The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate OPEN Zhiguang Chang, Ning Jiang, Yuanyuan Zhang, Huijun Lu, Jigang Yin, Mats Wahlgren, Xunjia Cheng, Yaming Cao and Qijun Chen Neutrophil extracellular traps (NETs), composed of DNA and proteases, contribute to the innate immune response by capturing pathogens. Here, Chang et al. identify a NET-degrading DNase in Plasmodium parasites and show that immunization with this protein provides protective immunity in a malaria mouse model. 06 May 2016 | doi: 10.1038/ncomms11537 Biological Sciences  Cell biology  Immunology  Microbiology  14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila OPEN Thao Phuong Le, Linh Thuong Vuong, Ah-Ram Kim, Ya-Chieh Hsu and Kwang-Wook Choi 14-3-3 proteins regulate several signalling pathways but often act redundantly; however, the molecular mechanisms behind such redundancy are unclear. Here, the authors show that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, Tctp and Rheb, disrupting organ development. 06 May 2016 | doi: 10.1038/ncomms11501 Biological Sciences  Cell biology  Developmental biology  Giant photoluminescence enhancement in tungsten-diselenide–gold plasmonic hybrid structures OPEN Zhuo Wang, Zhaogang Dong, Yinghong Gu, Yung-Huang Chang, Lei Zhang, Lain-Jong Li, Weijie Zhao, Goki Eda, Wenjing Zhang, Gustavo Grinblat, Stefan A. Maier, Joel K. W. Yang, Cheng-Wei Qiu and Andrew T. S. Wee Two-dimensional materials have excellent electrical properties, but poor luminescence limits their application in optoelectronics. Here, the authors demonstrate a plasmon-induced 20,000-fold enhancement in photoluminescence from tungsten diselenide suspended across a nanometre-scale gap. 06 May 2016 | doi: 10.1038/ncomms11283 Physical Sciences  Materials science  Nanotechnology  Optical physics  MNase titration reveals differences between nucleosome occupancy and chromatin accessibility OPEN Jakub Mieczkowski, April Cook, Sarah K. Bowman, Britta Mueller, Burak H. Alver, Sharmistha Kundu, Aimee M. Deaton, Jennifer A. Urban, Erica Larschan, Peter J. Park, Robert E. Kingston and Michael Y. Tolstorukov Nucleosome positioning and chromatin accessibility are important contributors to the regulation of gene expression. Here the authors describe a method that allows the simultaneous measurement of nucleosome occupancy and chromatin accessibility in the same assay, revealing new features of chromatin organization linked to gene regulation. 06 May 2016 | doi: 10.1038/ncomms11485 Biological Sciences  Genetics  Molecular biology  The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages OPEN Yunlong Yang, Patrik Andersson, Kayoko Hosaka, Yin Zhang, Renhai Cao, Hideki Iwamoto, Xiaojuan Yang, Masaki Nakamura, Jian Wang, Rujie Zhuang, Hiromasa Morikawa, Yuan Xue, Harald Braun, Rudi Beyaert, Nilesh Samani, Susumu Nakae, Emily Hams, Steen Dissing, Padraic G. Fallon, Robert Langer et al. Elevated IL-33 levels have been correlated with metastasis and poor prognosis. Here the authors show in mouse tumour xenograft models that PDGF-BB produced by tumour cells induces IL-33 via Sox7 in tumour pericytes, and IL-33 promotes metastasis through its effects on tumour-associated macrophages. 06 May 2016 | doi: 10.1038/ncomms11385 Biological Sciences  Cancer  Immunology  Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease OPEN Simon J. Beck, Lan Guo, Aarron Phensy, Jing Tian, Lu Wang, Neha Tandon, Esha Gauba, Lin Lu, Juan M. Pascual, Sven Kroener and Heng Du F1FO ATP synthase is a critical enzyme for the maintenance of mitochondrial function. Here the authors demonstrate that loss of the F1FO-ATP synthase subunit OSCP and the interaction of OSCP with Aβ peptide in Alzheimer’s disease patients and mouse models lead to F1FO-ATP synthase deregulation and disruption of synaptic mitochondrial function. 06 May 2016 | doi: 10.1038/ncomms11483 Biological Sciences  Biochemistry  Cell biology  Neuroscience  Perspective on the phase diagram of cuprate high-temperature superconductors OPEN Damian Rybicki, Michael Jurkutat, Steven Reichardt, Czesław Kapusta and Jürgen Haase Cuprate superconductors show critical temperatures over 100 K, below which current flows without resistance. Here, the authors show how this temperature is set by material chemistry, leading to a reinterpretation of the cuprate phase diagram and suggestions of how to raise this temperature in the future. 06 May 2016 | doi: 10.1038/ncomms11413 Physical Sciences  Condensed matter  Phytochrome and retrograde signalling pathways converge to antagonistically regulate a light-induced transcriptional network OPEN Guiomar Martín, Pablo Leivar, Dolores Ludevid, James M. Tepperman, Peter H. Quail and Elena Monte Retrograde signals from dysfunctional chloroplasts influence plant response to light. Here the authors show that the GUN1 retrograde signalling pathway acts antagonistically to the phytochrome-mediated red light perception pathway to control the expression of GLK1, a key transcriptional regulator of photomorphogenesis. 06 May 2016 | doi: 10.1038/ncomms11431 Biological Sciences  Plant sciences  Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling OPEN Shin-ichiro Honda, Kazuki Sato, Naoya Totsuka, Satoshi Fujiyama, Manabu Fujimoto, Kensuke Miyake, Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka, Kazuko Shibuya and Akira Shibuya Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mouse model of sepsis. 05 May 2016 | doi: 10.1038/ncomms11498 Biological Sciences  Immunology  Coral snakes predict the evolution of mimicry across New World snakes OPEN Alison R. Davis Rabosky, Christian L. Cox, Daniel L. Rabosky, Pascal O. Title, Iris A. Holmes, Anat Feldman and Jimmy A. McGuire Toxic and venomous species often have conspicuous warning colouration that is mimicked by harmless species. Here, Davis Rabosky et al. combine phylogenetic and biogeographic analyses to reveal that mimicry of venomous coral snakes has been a major driver of snake colour evolution in the New World. 05 May 2016 | doi: 10.1038/ncomms11484 Biological Sciences  Ecology  Evolution  Zoology  Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis OPEN Islam El-Awaad, Marco Bocola, Till Beuerle, Benye Liu and Ludger Beerhues Xanthones are pharmacologically and biosynthetically intriguing compounds. Here, the authors identify two cytochrome P450 enzymes, which hydroxylate and cyclize the benzophenone precursor to either 1,3,7- or 1,3,5-trihydroxyxanthones, and pinpoint residues that determine the alternative regioselectivities. 05 May 2016 | doi: 10.1038/ncomms11472 Biological Sciences  Biochemistry  Molecular biology  Plant sciences  Active mode locking of quantum cascade lasers in an external ring cavity OPEN D. G. Revin, M. Hemingway, Y. Wang, J. W. Cockburn and A. Belyanin Compact, integrated mode-locked lasers can produce ultrashort pulses of light in the visible and near infrared, but are more difficult to achieve in the mid-infrared. Here, the authors demonstrate active mode locking of an external-cavity quantum cascade laser emitting at 5.2 micrometres at room temperature. 05 May 2016 | doi: 10.1038/ncomms11440 Physical Sciences  Optical physics  Repeated quantum error correction on a continuously encoded qubit by real-time feedback OPEN J. Cramer, N. Kalb, M. A. Rol, B. Hensen, M. S. Blok, M. Markham, D. J. Twitchen, R. Hanson and T. H. Taminiau Large-scale quantum information processing requires the continuous protection of quantum states against errors. Here, the authors demonstrate active quantum error correction that improves the dephasing time of quantum states using a diamond quantum processor. 05 May 2016 | doi: 10.1038/ncomms11526 Physical Sciences  Applied physics  Efficient quantum walk on a quantum processor OPEN Xiaogang Qiang, Thomas Loke, Ashley Montanaro, Kanin Aungskunsiri, Xiaoqi Zhou, Jeremy L. O’Brien, Jingbo B. Wang and Jonathan C. F. Matthews Quantum walks are a potential framework for developing quantum algorithms, but have so far been limited to analogue quantum-simulation approaches that do not scale. Here, the authors provide a protocol for simulating exponentially large quantum walks using a polynomial number of quantum gates and qubits. 05 May 2016 | doi: 10.1038/ncomms11511 Physical Sciences  Theoretical physics  The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation OPEN Nadia Martinez-Martin, Sree R. Ramani, Jason A. Hackney, Irene Tom, Bernd J. Wranik, Michelle Chan, Johnny Wu, Maciej T. Paluch, Kentaro Takeda, Philip E. Hass, Hilary Clark and Lino C. Gonzalez Viruses interact with their hosts via secreted and membrane-bound proteins to affect host immune responses and virulence. Here the authors contribute to our understanding of this relationship with an extracellular interaction map of human and adenoviral E3 immunomodulatory proteins. 05 May 2016 | doi: 10.1038/ncomms11473 Biological Sciences  Immunology  Virology  miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint OPEN Shaohua Xu, Zhen Tao, Bo Hai, Huagen Liang, Ying Shi, Tao Wang, Wen Song, Yong Chen, Jun OuYang, Jinhong Chen, Fanfei Kong, Yishan Dong, Shi-Wen Jiang, Weiyong Li, Ping Wang, Zhiyong Yuan, Xiaoping Wan, Chenguang Wang, Wencheng Li, Xiaoping Zhang et al. Resistance to chemotherapy occurs in many ovarian cancer cases. Here, the authors show that mir-424(322) expression restores the sensitivity of ovarian cancer cells to chemotherapy by blocking the PD-L1 immune checkpoint, and find that combining immunotherapy and chemotherapy has a synergistic effect. 05 May 2016 | doi: 10.1038/ncomms11406 Biological Sciences  Cancer  Immunology  Dchs1–Fat4 regulation of polarized cell behaviours during skeletal morphogenesis OPEN Yaopan Mao, Anna Kuta, Ivan Crespo-Enriquez, Danielle Whiting, Tina Martin, Joanna Mulvaney, Kenneth D. Irvine and Philippa Francis-West How the shape of the sternum is regulated is unclear. Here, the authors identify the Dchs1-Fat4-planar cell polarity pathway as controlling cell orientation and cell intercalation of mesenchymal cells that form skeletal condensations for the mouse sternum, which defines the relative dimensions of the sternum. 05 May 2016 | doi: 10.1038/ncomms11469 Biological Sciences  Cell biology  Developmental biology  Incorrect interpretation of carbon mass balance biases global vegetation fire emission estimates OPEN N. C. Surawski, A. L. Sullivan, S. H. Roxburgh, C.P. Mick Meyer and P. J. Polglase Vegetation fires contribute to global carbon emissions, but uncertainty exists due to inconsistencies in the treatment of post-burn combustion. Here, it is shown that the ‘consumed biomass’ approach overestimates emissions by 4%, which can be corrected using an alternative ‘burnt carbon’ method. 05 May 2016 | doi: 10.1038/ncomms11536 Earth Sciences  Atmospheric science  Climate science  Common genetic variation in ETV6 is associated with colorectal cancer susceptibility OPEN Meilin Wang, Dongying Gu, Mulong Du, Zhi Xu, Suzhan Zhang, Lingjun Zhu, Jiachun Lu, Rui Zhang, Jinliang Xing, Xiaoping Miao, Haiyan Chu, Zhibin Hu, Lei Yang, Cuiju Tang, Lei Pan, Haina Du, Jian Zhao, Jiangbo Du, Na Tong, Jielin Sun et al. Genome-wide association studies have been performed to identify genetic variants that are associated with susceptibility to colorectal cancer. Here, the authors expand on these studies and identify a variant that regulates the expression of ETV6 and find that over-expression of ETV6 blocks cell proliferation in vitro. 05 May 2016 | doi: 10.1038/ncomms11478 Biological Sciences  Cancer  Genetics  Magnetic field controlled charge density wave coupling in underdoped YBa2Cu3O6+x OPEN J. Chang, E. Blackburn, O. Ivashko, A. T. Holmes, N. B. Christensen, M. Hücker, Ruixing Liang, D. A. Bonn, W. N. Hardy, U. Rütt, M. v. Zimmermann, E. M. Forgan and S M Hayden The interplay between competing orders in high-temperature superconductors can be tuned by the application of magnetic fields. Here, Chang et al. report high field induced three-dimensional charge density wave in underdoped YBa2Cu3O6.67, which suggests Fermi surface reconstruction due to competing orders. 05 May 2016 | doi: 10.1038/ncomms11494 Physical Sciences  Condensed matter  Materials science  Integrating a dual-silicon photoelectrochemical cell into a redox flow battery for unassisted photocharging OPEN Shichao Liao, Xu Zong, Brian Seger, Thomas Pedersen, Tingting Yao, Chunmei Ding, Jingying Shi, Jian Chen and Can Li Technologies for in situ capture and storage of intermittent solar energy are an important research goal. Here the authors report a solar rechargeable flow cell based on a dual-silicon photoelectrochemical cell and a quinone/bromine redox flow battery for in situ solar energy conversion and storage. 04 May 2016 | doi: 10.1038/ncomms11474 Chemical Sciences  Catalysis  Physical chemistry  Quantum transport of two-species Dirac fermions in dual-gated three-dimensional topological insulators OPEN Yang Xu, Ireneusz Miotkowski and Yong P. Chen Novel physics of topological aspects are obscured due to lack of effective way to manipulate topological particles. Here, Xu et al. demonstrate independent control of Dirac fermions on top and bottom surfaces of BiSbTeSe2 flakes by dual-gating, which suggests a way to manipulate exotic particles. 04 May 2016 | doi: 10.1038/ncomms11434 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Structure and transformation of tactoids in cellulose nanocrystal suspensions OPEN Pei-Xi Wang, Wadood Y. Hamad and Mark J. MacLachlan Cellulose nanocrystals suspensions self-assemble into cholesteric liquid crystalline droplets, namely tactoids, which then condense into helical structures upon drying. Here, Wang et al. capture the structural evolution of this nucleation process by trapping and protecting tactoids in a polymer matrix. 04 May 2016 | doi: 10.1038/ncomms11515 Chemical Sciences  Materials science  Physical chemistry  TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis OPEN Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike and Yoshiharu Matsuura A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immature core protein mediated by the E3 ubiquitin ligase TRC8. 04 May 2016 | doi: 10.1038/ncomms11379 Biological Sciences  Cell biology  Virology  Enhanced spin Seebeck effect signal due to spin-momentum locked topological surface states OPEN Zilong Jiang, Cui-Zu Chang, Massoud Ramezani Masir, Chi Tang, Yadong Xu, Jagadeesh S. Moodera, Allan H. MacDonald and Jing Shi Future spintronic devices may exploit topological insulators, bulk insulators with unique spin-momentum locked conductive surface states. Here, the authors demonstrate the detection of thermally-generated spin currents in a ferromagnetic-insulator/topological-insulator heterostructure. 04 May 2016 | doi: 10.1038/ncomms11458 Physical Sciences  Condensed matter  Highly efficient baculovirus-mediated multigene delivery in primary cells OPEN Maysam Mansouri, Itxaso Bellon-Echeverria, Aurélien Rizk, Zahra Ehsaei, Chiara Cianciolo Cosentino, Catarina S. Silva, Ye Xie, Frederick M. Boyce, M. Wayne Davis, Stephan C. F. Neuhauss, Verdon Taylor, Kurt Ballmer-Hofer, Imre Berger and Philipp Berger Current viral gene delivery systems are limited in the amount of foreign DNA they can deliver to cells. Here the authors develop MultiPrime, a baculovirus-based vector system capable of multigene delivery into a wide variety of cells, and use Multiprime for genome engineering by CRISPR/Cas9. 04 May 2016 | doi: 10.1038/ncomms11529 Biological Sciences  Biotechnology  Cell biology  Molecular biology  A 14 × 14 μm2 footprint polarization-encoded quantum controlled-NOT gate based on hybrid waveguide OPEN S. M. Wang, Q. Q. Cheng, Y. X. Gong, P. Xu, C. Sun, L. Li, T. Li and S. N. Zhu Photonic circuits often require separate components to manipulate light with orthogonal polarization, but this increases the chip size. Here, the authors create a polarization-dependent beam-splitter that uses dielectric loaded plasmonic waveguides to handle both polarizations in the same component. 04 May 2016 | doi: 10.1038/ncomms11490 Physical Sciences  Applied physics  Optical physics  Seawater usable for production and consumption of hydrogen peroxide as a solar fuel OPEN Kentaro Mase, Masaki Yoneda, Yusuke Yamada and Shunichi Fukuzumi The generation and storage of energy from renewable sources with robust and accessible technology is of significant and growing concern. Here, the authors demonstrate the solar generation of hydrogen peroxide from seawater as a viable route towards this important goal. 04 May 2016 | doi: 10.1038/ncomms11470 Chemical Sciences  Catalysis  Materials science  Physical chemistry  Tunnel electroresistance through organic ferroelectrics OPEN B. B. Tian, J. L. Wang, S. Fusil, Y. Liu, X. L. Zhao, S. Sun, H. Shen, T. Lin, J. L. Sun, C. G. Duan, M. Bibes, A. Barthélémy, B. Dkhil, V. Garcia, X. J. Meng and J. H. Chu Ferroelectric organic materials can be used for tunnel barriers in memory devices as a cheaper and eco-friendly replacement of their inorganic counterparts. Here, Tian et al. use poly(vinylidene fluoride) with 1–2 layer thickness to achieve giant tunnel electroresistance of 1,000% at room temperature. 04 May 2016 | doi: 10.1038/ncomms11502 Physical Sciences  Applied physics  Materials science  Nanotechnology  Converging prefrontal pathways support associative and perceptual features of conditioned stimuli OPEN James D. Howard, Thorsten Kahnt and Jay A. Gottfried Animals often need to form specific associations between perceptually similar stimuli and the different outcomes they may predict. Howard et al. find that the human brain accomplishes this via enhanced coupling between stable codes of sensory features and flexible codes of stimulus reward value. 04 May 2016 | doi: 10.1038/ncomms11546 Biological Sciences  Neuroscience  Analytic framework for peptidomics applied to large-scale neuropeptide identification OPEN Anna Secher, Christian D. Kelstrup, Kilian W. Conde-Frieboes, Charles Pyke, Kirsten Raun, Birgitte S. Wulff and Jesper V. Olsen Neuropeptide research is challenged by technical difficulties in identifying new bioactive peptides. Here the authors present an analytical pipeline for large-scale peptidomics applied to the rat hypothalamus, identifying thousands of endogenous neuropeptides and their post-translational modifications. 04 May 2016 | doi: 10.1038/ncomms11436 Biological Sciences  Biochemistry  Biotechnology  Neuroscience    Nature Communications JOBS of the week Postdoctoral Training Fellow (x2) Institute of Cancer Research (ICR) Postdoctoral Associate Medical University of South Carolina Research Group Leader University of Cambridge - Sainsbury Laboratory PhD position Max-Planck Institute for Molecular Genetics Postdoctoral Research Associate Texas A&M University Student Positions University Hospital Institute (IHU) Postdoctoral Scientist UCSF Bioinformatics Postdoctoral Associate Baylor College of Medicine (BCM) Postdoctoral Associate University of Minnesota Postdoctoral Research Assistant University of Dundee More Science jobs from Nature Communications EVENT Genomic Medicine Conference 08.08.16 Huntsville, USA More science events from       Latest Corrigendum     Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants OPEN Helen A. Fletcher, Margaret A. Snowden, Bernard Landry, Wasima Rida, Iman Satti, Stephanie A. Harris, Magali Matsumiya, Rachel Tanner, Matthew K. O’Shea, Veerabadran Dheenadhayalan, Leah Bogardus, Lisa Stockdale, Leanne Marsay, Agnieszka Chomka, Rachel Harrington-Kandt, Zita-Rose Manjaly-Thomas, Vivek Naranbhai, Elena Stylianou, Fatoumatta Darboe, Adam Penn-Nicholson et al. 06 May 2016 | doi: 10.1038/ncomms11633 Biological Sciences  Immunology  Medical research        Latest Erratum     Erratum: Damage-free vibrational spectroscopy of biological materials in the electron microscope OPEN Peter Rez, Toshihiro Aoki, Katia March, Dvir Gur, Ondrej L. Krivanek, Niklas Dellby, Tracy C. Lovejoy, Sharon G. Wolf and Hagai Cohen 04 May 2016 | doi: 10.1038/ncomms11592 Physical Sciences  Optical physics      Advertisement Free naturejobs webcast From bench to business: Top tips from experts and entrepreneurs on how to take your research all the way from idea to product. 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