The early stages of development of the human embryo are studied in culture for up to 10–13 days in two separate studies published in Nature and Nature Cell Biology this week. Both studies show that, even in a petri dish, human embryos can self-organize — a process involving cell divisions and shape rearrangements — and that the changes they undergo are similar to those that occur in the presence of maternal cues. In a Comment piece also published in Nature this week, Insoo Hyun, Amy Wilkerson and Josephine Johnston explain that the 14-day rule has been effective at permitting research on embryos within strict constraints in part because, until now, it has been technologically challenging for scientists to break it. Access the news article, Nature paper, Nature Cell Biology paper and News & Views article online. |
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