The EMBO Journal Table of Contents for 15 April 2016; Vol. 35, No. 8

15 April 2016 | Volume 35, Number 8 Submit Table of Contents News & Views Articles Corrigendum Volume 35, Number 8 News & Views Three in a row—how sodium ions cross the channel New structural work on the selectivity filter of voltage‐gated sodium channels explains their striking cation preferences. Werner Kühlbrandt Published online 21.03.2016 cGAS‐STING do it again: pivotal role in RNase H2 genetic disease A tractable new mouse model for Aicardi–Goutières syndrome (AGS) implicates the cGAS‐STING pathway for cytosolic nucleic acid sensing in this auto‐inflammatory disease. Matteo Gentili and Nicolas Manel Published online 23.03.2016 ER strikes again: Proteostasis Dysfunction In ALS A new study demonstrates the impact of disease‐linked PDI mutations on motoneuron function. Niran Maharjan and Smita Saxena Published online 11.03.2016 When Myc's asleep, embryonic stem cells are dormant c‐Myc and N‐Myc are dispensable for the control of pluripotency in embryonic stem cells and diapause—a state of suspension during embryonic development, but control reversible entry and exit from dormancy by governing biosynthesis and metabolism. Masato Nakagawa, Peter Karagiannis, and Shinya Yamanaka Published online 10.03.2016 Articles CPAP promotes timely cilium disassembly to maintain neural progenitor pool Mutations in centrosomal‐P4.1‐associated protein (CPAP) cause Seckel syndrome. CPAP defects prevent proper cilium disassembly in neural progenitor cells with cell cycle progression delay and premature differentiation, leading to the microcephaly associated with this syndrome. Elke Gabriel, Arpit Wason, Anand Ramani, Li Ming Gooi, Patrick Keller, Andrei Pozniakovsky, Ina Poser, Florian Noack, Narasimha Swamy Telugu, Federico Calegari, Tomo Šarić, Jürgen Hescheler, Anthony A Hyman, Marco Gottardo, Giuliano Callaini, Fowzan Sami Alkuraya, and Jay Gopalakrishnan Published online 29.02.2016 Molecular basis of ion permeability in a voltage‐gated sodium channel Structural localisation of sodium ions passing through the prokaryotic NavM channel selectivity filter explains this channel's strong sodium preference over other cations in electrochemical signalling across cell membranes. Claire E Naylor, Claire Bagnéris, Paul G DeCaen, Altin Sula, Antonella Scaglione, David E Clapham, and BA Wallace Published online 12.02.2016 Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response A new mouse model reveals the key nucleic acid‐sensing and signalling pathway in autoinflammatory Aicardi–Goutières syndrome caused by RNase H2 mutations. Karen J Mackenzie, Paula Carroll, Laura Lettice, Žygimantė Tarnauskaitė, Kaalak Reddy, Flora Dix, Ailsa Revuelta, Erika Abbondati, Rachel E Rigby, Björn Rabe, Fiona Kilanowski, Graeme Grimes, Adeline Fluteau, Paul S Devenney, Robert E Hill, Martin AM Reijns, and Andrew P Jackson Published online 22.02.2016 ALS‐linked protein disulfide isomerase variants cause motor dysfunction Disease phenotypes associated with expression of mutant PDIA1 and ERp57 show how impaired ER proteostasis can drive initial stages of amyotrophic lateral sclerosis pathology. Ute Woehlbier, Alicia Colombo, Mirva J Saaranen, Viviana Pérez, Jorge Ojeda, Fernando J Bustos, Catherine I Andreu, Mauricio Torres, Vicente Valenzuela, Danilo B Medinas, Pablo Rozas, Rene L Vidal, Rodrigo Lopez‐Gonzalez, Johnny Salameh, Sara Fernandez‐Collemann, Natalia Muñoz, Soledad Matus, Ricardo Armisen, Alfredo Sagredo, Karina Palma, Thergiory Irrazabal, Sandra Almeida, Paloma Gonzalez‐Perez, Mario Campero, Fen‐Biao Gao, Pablo Henny, Brigitte van Zundert, Lloyd W Ruddock, Miguel L Concha, Juan P Henriquez, Robert H Brown, and Claudio Hetz Published online 11.02.2016 USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin‐1 USP19 stabilizes Beclin‐1 by cleaving K11‐linked ubiquitin chains on Beclin‐1, thereby promoting autophagy and inhibiting the type I IFN signaling pathway. Shouheng Jin, Shuo Tian, Yamei Chen, Chuanxia Zhang, Weihong Xie, Xiaojun Xia, Jun Cui, and Rong‐Fu Wang Published online 17.03.2016 The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6 Expression of the master Tfh cell differentiation factor Bcl6 is controlled by Bob1 and Oct1/2 transcription factors, to fine‐tune B‐cell responses following antigen‐mediated immunization. Dennis Stauss, Cornelia Brunner, Friederike Berberich‐Siebelt, Uta E Höpken, Martin Lipp, and Gerd Müller Published online 08.03.2016 Corrigendum UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells Jin Zhang, Ivan Khvorostov, Jason S Hong, Yavuz Oktay, Laurent Vergnes, Esther Nuebel, Paulin N Wahjudi, Kiyoko Setoguchi, Geng Wang, Anna Do, Hea‐Jin Jung, J Michael McCaffery, Irwin J Kurland, Karen Reue, Wai‐Nang P Lee, Carla M Koehler, and Michael A Teitell Published online 15.04.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.