Scientific Reports Biology Table of Contents e-alert: 12 April 2016

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12 April 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports       Biological Sciences               Microsaccades enable efficient synchrony-based coding in the retina: a simulation study ▶     Timothée Masquelier, Geoffrey Portelli, Pierre Kornprobst     It is now reasonably well established that microsaccades (MS) enhance visual perception, although the underlying neuronal mechanisms are unclear. Here, using numerical …             A Recombinant Secondary Antibody Mimic as a Target-specific Signal Amplifier and an Antibody Immobilizer in Immunoassays ▶     Junseon Min, Eun Kyung Song, Hansol Kim et al.     We construct a novel recombinant secondary antibody mimic, GST-ABD, which can bind to the Fc regions of target-bound primary antibodies and acquire multiple HRPs simultaneously. …             Dissociating the neural correlates of tactile temporal order and simultaneity judgements ▶     Makoto Miyazaki, Hiroshi Kadota, Kozue S. Matsuzaki et al.     Perceiving temporal relationships between sensory events is a key process for recognising dynamic environments. Temporal order judgement (TOJ) and simultaneity judgement (SJ) are …             Trading in cooperativity for specificity to maintain uracil-free DNA ▶     Judit E. Szabó, Enikő Takács, Gábor Merényi et al.     Members of the dUTPase superfamily play an important role in the maintenance of the pyrimidine nucleotide balance and of genome integrity. dCTP deaminases and the bifunctional …             A stochastic model for immunotherapy of cancer ▶     Martina Baar, Loren Coquille, Hannah Mayer et al.     We propose an extension of a standard stochastic individual-based model in population dynamics which broadens the range of biological applications. Our primary motivation is …             Ectomycorrhizal fungal communities associated with Populus simonii and Pinus tabuliformis in the hilly-gully region of the Loess Plateau, China ▶     Dongfeng Long, Jianjun Liu, Qisheng Han et al.     The Loess Plateau region of northwestern China has unique geological and dry/semi-dry climate characteristics. However, knowledge about ectomycorrhizal fungal (EMF) communities …             Construction of recombinant baculoviruses expressing hemagglutinin of H5N1 avian influenza and research on the immunogenicity ▶     Jingping Ge, Qi An, Dongni Gao et al.     Recombinant baculoviruses with different promoter and regulatory elements were constructed to enhance the expression of target protein and boost the efficacies of avian influenza …             Hydrolases of the ILR1-like family of Arabidopsis thaliana modulate auxin response by regulating auxin homeostasis in the endoplasmic reticulum ▶     Ana Paula Sanchez Carranza, Aparajita Singh, Karoline Steinberger et al.     Amide-linked conjugates of indole-3-acetic acid (IAA) have been identified in most plant species. They function in storage, inactivation or inhibition of the growth regulator …             Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth ▶     Chih-Wen Chu, Olga Ossipova, Andriani Ioannou et al.     PCP proteins maintain planar polarity in many epithelial tissues and have been implicated in cilia development in vertebrate embryos. In this study we examine Prickle3 (Pk3), a …             Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity ▶     Kuo-Hsing Lin, Li-Sheng Chang, Chun-Yuan Tian et al.     Flagellin has the capacity to activate both Toll-like receptor 5 (TLR5) and Nod-like receptor C4 (NLRC4)/neuronal apoptosis inhibitory protein 5 (NAIP5) inflammasome signaling. …             Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system ▶     Mingming Wu, Caihong Wei, Zhengxing Lian et al.     Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed …             Accurate quantification of supercoiled DNA by digital PCR ▶     Lianhua Dong, Hee-Bong Yoo, Jing Wang et al.     Digital PCR (dPCR) as an enumeration-based quantification method is capable of quantifying the DNA copy number without the help of standards. However, it can generate false …             Generation of Hprt-disrupted rat through mouse←rat ES chimeras ▶     Ayako Isotani, Kazuo Yamagata, Masaru Okabe et al.     We established rat embryonic stem (ES) cell lines from a double transgenic rat line which harbours CAG-GFP for ubiquitous expression of GFP in somatic cells and Acr3-EGFP for …             Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain ▶     Teemu Haikarainen, Lari Lehtiö     ADP-ribosylation is a ubiquitous protein modification utilized by both prokaryotes and eukaryotes for several cellular functions, such as DNA repair, proliferation, and cell …             Multimodal Image Analysis in Alzheimer’s Disease via Statistical Modelling of Non-local Intensity Correlations ▶     Marco Lorenzi, Ivor J. Simpson, Alex F. Mendelson et al.     The joint analysis of brain atrophy measured with magnetic resonance imaging (MRI) and hypometabolism measured with positron emission tomography with fluorodeoxyglucose (FDG-PET) …             Lipid-mediated Protein-protein Interactions Modulate Respiration-driven ATP Synthesis ▶     Tobias Nilsson, Camilla Rydström Lundin, Gustav Nordlund et al.     Energy conversion in biological systems is underpinned by membrane-bound proton transporters that generate and maintain a proton electrochemical gradient across the membrane …             Direct bone marrow HSC transplantation enhances local engraftment at the expense of systemic engraftment in NSG mice ▶     Kathryn Futrega, William B. Lott, Michael R. Doran     Direct bone marrow (BM) injection has been proposed as a strategy to bypass homing inefficiencies associated with intravenous (IV) hematopoietic stem cell (HSC) transplantation. …             High magnetic field induced otolith fusion in the zebrafish larvae ▶     Patricia Pais-Roldán, Ajeet Pratap Singh, Hildegard Schulz et al.     Magnetoreception in animals illustrates the interaction of biological systems with the geomagnetic field (geoMF). However, there are few studies that identified the impact of …             Population Dynamics of Bulking and Foaming Bacteria in a Full-scale Wastewater Treatment Plant over Five Years ▶     Xiao-Tao Jiang, Feng Guo, Tong Zhang     Bulking and foaming are two notorious problems in activated sludge wastewater treatment plants (WWTPs), which are mainly associated with the excessive growth of bulking and …             Histone H4 lysine 20 acetylation is associated with gene repression in human cells ▶     Jun-Ya Kaimori, Kazumitsu Maehara, Yoko Hayashi-Takanaka et al.     Histone acetylation is generally associated with gene activation and chromatin decondensation. Recent mass spectrometry analysis has revealed that histone H4 lysine 20, a major …             Architectural plasticity of AMPK revealed by electron microscopy and X-ray crystallography ▶     Yan Ouyang, Li Zhu, Yifang Li et al.     Mammalian AMP-activated protein kinase (AMPK) acts as an important sensor of cellular energy homeostasis related with AMP/ADP to ATP ratio. The overall architecture of AMPK has …             TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells ▶     Yonggang Ren, Lu Qiu, Fenglin Lü et al.     The full-length Nrf1α is processed into distinct isoforms, which together regulate genes essential for maintaining cellular homeostasis and organ integrity, and liver-specific …             FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition ▶     Mika Pietilä, Geraldine V. Vijay, Rama Soundararajan et al.     Cancer cells with stem cell properties (CSCs) underpin the chemotherapy resistance and high therapeutic failure of triple-negative breast cancers (TNBCs). Even though CSCs are …             IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity ▶     Mohd Shahid, Ammar A. Javed, David Chandra et al.     Chronic inflammation plays a crucial role in the pathogenesis of obesity and insulin resistance. However, the primary mediators that affect energy homeostasis remain ill defined. …             Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration ▶     Sandra Gómez-López, Ana Valeria Martínez-Silva, Teresa Montiel et al.     Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder, characterised by the progressive loss of midbrain dopaminergic neurons and a variety of motor symptoms. …             Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis ▶     Santosh Karnewar, Sathish Babu Vasamsetti, Raja Gopoju et al.     Mitochondria-targeted compounds are emerging as a new class of drugs that can potentially alter the pathophysiology of those diseases where mitochondrial dysfunction plays a …             Genetic dissection of seed-iron and zinc concentrations in chickpea ▶     Hari D. Upadhyaya, Deepak Bajaj, Shouvik Das et al.     The SNP-based high-resolution QTL mapping mapped eight major genomic regions harbouring robust QTLs governing seed-Fe and Zn concentrations (39.4% combined phenotypic variation …             Nonmuscle Myosin IIA Regulates Intestinal Epithelial Barrier in vivo and Plays a Protective Role During Experimental Colitis ▶     Nayden G. Naydenov, Alex Feygin, Dongdong Wang et al.     The actin cytoskeleton is a critical regulator of intestinal mucosal barrier permeability, and the integrity of epithelial adherens junctions (AJ) and tight junctions (TJ). Non …             Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells ▶     Huiyin Lan, Zaiming Tang, Hongchuan Jin et al.     MLN4924 is a recently discovered small molecule inhibitor of NEDD8-Activating Enzyme (NAE). Because cullin RING ligase (CRL), the largest family of E3 ubiquitin ligase, requires …             Bidens pilosa and its active compound inhibit adipogenesis and lipid accumulation via down-modulation of the C/EBP and PPARγ pathways ▶     Yu-Chuan Liang, Meng-Ting Yang, Chuan-Ju Lin et al.     Obesity and its complications are a major global health problem. In this study, we investigated the anti-obesity effect and mechanism of an edible plant, Bidens pilosa, and its …             The Brain Metabolome of Male Rats across the Lifespan ▶     Xiaojiao Zheng, Tianlu Chen, Aihua Zhao et al.     Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome …             Engineering formation of multiple recombinant Eut protein nanocompartments in E. coli ▶     Mark Held, Alexander Kolb, Sarah Perdue et al.     Compartmentalization of designed metabolic pathways within protein based nanocompartments has the potential to increase reaction efficiency in multi-step biosynthetic reactions. …             Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing ▶     C. Voellenkle, J. M. Garcia-Manteiga, S. Pedrotti et al.     Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the …             Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens ▶     Yan He, Jun Tian, Xintao Chen et al.     Four naphtho-γ-pyrones (fonsecinones A and C and aurasperones A and E) were identified as potential antibacterial agents against Escherichia coli, extended-spectrum β-lactamase …             Comparative genetic characterization of Enteroaggregative Escherichia coli strains recovered from clinical and non-clinical settings ▶     Rong Zhang, Dan-xia Gu, Yong-lu Huang et al.     The origin of pathogenic Enteroaggregative Escherichia coli (EAEC), a major causative agent of childhood diarrhea worldwide, remains ill-defined. The objective of this study was …             An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase ▶     Encarna Pucheta-Martínez, Giorgio Saladino, Maria Agnese Morando et al.     Phosphorylation of the activation loop is a fundamental step in the activation of most protein kinases. In the case of the Src tyrosine kinase, a prototypical kinase due to its …             C7 genotype of the donor may predict early bacterial infection after liver transplantation ▶     Lin Zhong, Hao Li, Zhiqiang Li et al.     Post-transplantation infection causes high mortality and remains a significant challenge. High clinical risk factors for bacterial infection in recipients are often found in …             Effects of anthropogenic sound on digging behavior, metabolism, Ca2+/Mg2+ ATPase activity, and metabolism-related gene expression of the bivalve Sinonovacula constricta ▶     Chao Peng, Xinguo Zhao, Saixi Liu et al.     Anthropogenic sound has increased significantly in the past decade. However, only a few studies to date have investigated its effects on marine bivalves, with little known about …             Inhibition of HSV-1 Replication by Gene Editing Strategy ▶     Pamela C. Roehm, Masoud Shekarabi, Hassen S. Wollebo et al.     HSV-1 induced illness affects greater than 85% of adults worldwide with no permanent curative therapy. We used RNA-guided CRISPR/Cas9 gene editing to specifically target for …             Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage ▶     Marilina Piemontese, Melda Onal, Jinhu Xiong et al.     Autophagy maintains cell function and homeostasis by recycling intracellular components. This process is also required for morphological changes associated with maturation of …             Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth ▶     M. Endo, M. Hattori, H. Toriyabe et al.     Growth cones of extending axons navigate to correct targets by sensing a guidance cue gradient via membrane protein receptors. Although most signaling mechanisms have been …             Enoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei ▶     Guiming Liu, Shuangfeng Cai, Jing Hou et al.     Although polyhydroxyalkanoate (PHA) accumulation and mobilization are one of the most general mechanisms for haloarchaea to adapt to the hypersaline environments with changeable …             Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme ▶     Saken Sherkhanov, Tyler P. Korman, Steven G Clarke et al.     Most biodiesel currently in use consists of fatty acid methyl esters (FAMEs) produced by transesterification of plant oils with methanol. To reduce competition with food …             Erratum: Mating dynamics in a nematode with three sexes and its evolutionary implications ▶     Jyotiska Chaudhuri, Neelanjan Bose, Sophie Tandonnet et al.                 Corrigendum: Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages ▶     Philippe Abdel-Sayed, Ariane Kaeppeli, Thissa Siriwardena et al.                 Concentration Dependent Ion-Protein Interaction Patterns Underlying Protein Oligomerization Behaviours ▶     Helena Batoulis, Thomas H. Schmidt, Pascal Weber et al.     Salts and proteins comprise two of the basic molecular components of biological materials. Kosmotropic/chaotropic co-solvation and matching ion water affinities explain basic …             In vivo imaging demonstrates dendritic spine stabilization by SynCAM 1 ▶     Nils Körber, Valentin Stein     Formation and stability of synapses are required for proper brain function. While it is well established that synaptic adhesion molecules are important regulators of synapse …             Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing ▶     Wataru Kobayashi, Motoki Takaku, Shinichi Machida et al.     In eukaryotes, genomic DNA is compacted as chromatin, in which histones and DNA form the nucleosome as the basic unit. DMC1 and RAD51 are essential eukaryotic recombinases that …             The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating emotional behavior and amygdala function ▶     Sooyoung Chung, Il Hwan Kim, Dongmin Lee et al.     Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a molecule enriched in the brain and neurons that regulates intracellular calcium levels via signaling through the inositol …             Knots cascade detected by a monotonically decreasing sequence of values ▶     Xin Liu, Renzo L. Ricca     Due to reconnection or recombination of neighboring strands superfluid vortex knots and DNA plasmid torus knots and links are found to undergo an almost identical cascade …             A novel therapeutic strategy of lipidated promiscuous peptide against Mycobacterium tuberculosis by eliciting Th1 and Th17 immunity of host ▶     Pradeep K Rai, Sathi Babu Chodisetti, Sajid Nadeem et al.     Regardless of the fact that potent drug-regimen is currently available, tuberculosis continues to kill 1.5 million people annually. Tuberculosis patients are not only inflicted …             Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network ▶     Yue-Yue Wang, Xiao-Sheng Zhang, Hong-Dou Luo et al.     Phosphopantetheinyl transferases (PPTases) play essential roles in both primary metabolisms and secondary metabolisms via post-translational modification of acyl carrier proteins …             Bioinspired Immobilization of Glycerol Dehydrogenase by Metal Ion-Chelated Polyethyleneimines as Artificial Polypeptides ▶     Yonghui Zhang, Hong Ren, Yali Wang et al.     In this study, a novel, simple and generally applicable strategy for multimeric oxidoreductase immobilization with multi-levels interactions was developed and involved activity …             Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway ▶     Akio Tsuru, Yasutaka Imai, Michiko Saito et al.     Mammalian inositol-requiring enzyme 1α (IRE1α) is the most conserved of all endoplasmic reticulum (ER) stress sensors, which includes activating transcription factor (ATF) 6 and …             Differential coding of uncertain reward in rat insular and orbitofrontal cortex ▶     Suhyun Jo, Min Whan Jung     Anterior insular and orbitofrontal cortex (AIC and OFC, respectively) are known to play important roles in decision making under risk. However, risk-related AIC neural activity …             Vesicle Size Regulates Nanotube Formation in the Cell ▶     Qian Peter Su, Wanqing Du, Qinghua Ji et al.     Intracellular membrane nanotube formation and its dynamics play important roles for cargo transportation and organelle biogenesis. Regarding the regulation mechanisms, while much …             Improving the catalytic activity of isopentenyl phosphate kinase through protein coevolution analysis ▶     Ying Liu, Zhihui Yan, Xiaoyun Lu et al.     Protein rational design has become more and more popular for protein engineering with the advantage of biological big-data. In this study, we described a method of rational …             A dual drug regimen synergistically blocks human parainfluenza virus infection ▶     Benjamin Bailly, Larissa Dirr, Ibrahim M. El-Deeb et al.     Human parainfluenza type-3 virus (hPIV-3) is one of the principal aetiological agents of acute respiratory illness in infants worldwide and also shows high disease severity in …             Deletion and low expression of NFKBIA are associated with poor prognosis in lower-grade glioma patients ▶     Gabriela Sarti Kinker, Andrew Maltez Thomas, Vinicius Jardim Carvalho et al.     Lower-grade gliomas (LGGs), which are uniformly fatal in young adults, are classified as grades II-III tumors according to their histological features. The NFκB transcription …             Swimming performance of Bradyrhizobium diazoefficiens is an emergent property of its two flagellar systems ▶     J. Ignacio Quelas, M. Julia Althabegoiti, Celia Jimenez-Sanchez et al.     Many bacterial species use flagella for self-propulsion in aqueous media. In the soil, which is a complex and structured environment, water is found in microscopic channels where …             Evidence for subjective values guiding posture and movement coordination in a free-endpoint whole-body reaching task ▶     P. M. Hilt, B. Berret, C. Papaxanthis et al.     When moving, humans must overcome intrinsic (body centered) and extrinsic (target-related) redundancy, requiring decisions when selecting one motor solution among several …             Redirection of pyruvate flux toward desired metabolic pathways through substrate channeling between pyruvate kinase and pyruvate-converting enzymes in Saccharomyces cerevisiae ▶     Sujin Kim, Sang-Jeong Bae, Ji-Sook Hahn     Spatial organization of metabolic enzymes allows substrate channeling, which accelerates processing of intermediates. Here, we investigated the effect of substrate channeling on …             Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer ▶     Hitesh Kulhari, Deep Pooja, Shweta Shrivastava et al.     Approximately 20% of breast cancer cases are human epidermal growth factor receptor 2 (HER2)-positive. This type of breast cancer is more aggressive and tends to reoccur more …             PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon ▶     Lulu Li, Ping Zhang, Zhengxi Bao et al.     Excess ammonia is produced during fasting when amino acids are used for glucogenesis. Together with ureagenesis, glucogenesis occurs in periportal hepatocytes mediated mainly …             Both overexpression and suppression of an Oryza sativa NB-LRR-like gene OsLSR result in autoactivation of immune response and thiamine accumulation ▶     Liangchao Wang, Ye, Huachun Liu et al.     Tight and accurate regulation of immunity and thiamine biosynthesis is critical for proper defence mechanisms and several primary metabolic cycles in plants. Although thiamine is …             Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity ▶     Qing Zhong, Jan H. Rüschoff, Tiannan Guo et al.     Recent large-scale genome analyses of human tissue samples have uncovered a high degree of genetic alterations and tumour heterogeneity in most tumour entities, independent of …             A systematic analysis of the role of GGDEF-EAL domain proteins in virulence and motility in Xanthomonas oryzae pv. oryzicola ▶     Chao Wei, Wendi Jiang, Mengran Zhao et al.     The second messenger c-di-GMP is implicated in regulation of various aspects of the lifestyles and virulence of Gram-negative bacteria. Cyclic di-GMP is formed by diguanylate …             Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections ▶     Robert Y. L. Wang, Kuo-Feng Weng, Yhu-Chering Huang et al.     Human enterovirus 71 (EV71) is a major causative agent of hand, foot, and, mouth disease, accounting for more than 65% of recent outbreaks. Following enteroviral infection, the …             A Tricholoma matsutake Peptide with Angiotensin Converting Enzyme Inhibitory and Antioxidative Activities and Antihypertensive Effects in Spontaneously Hypertensive Rats ▶     Xueran Geng, Guoting Tian, Weiwei Zhang et al.     Hypertension is a major risk factor for cardiovascular disease. A crude water extract of the fruiting bodies of a highly prized mushroom Tricholoma matsutakei exerted an …             Multiple oligomeric structures of a bacterial small heat shock protein ▶     Nandini Mani, Spraha Bhandari, Rodolfo Moreno et al.     Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress …             Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation ▶     Yoshikazu Hirate, Hitomi Suzuki, Miyuri Kawasumi et al.     Embryonic implantation comprises a dynamic and complicated series of events, which takes place only when the maternal uterine endometrium is in a receptive state. Blastocysts …             Characterization of a temperature-responsive two component regulatory system from the Antarctic archaeon, Methanococcoides burtonii ▶     T. Najnin, K. S. Siddiqui, Taha et al.     Cold environments dominate the Earth’s biosphere and the resident microorganisms play critical roles in fulfilling global biogeochemical cycles. However, only few studies have …             A Novel SRP Recognition Sequence in the Homeostatic Control Region of Heat Shock Transcription Factor σ32 ▶     Ryoji Miyazaki, Takashi Yura, Takehiro Suzuki et al.     Heat shock response (HSR) generally plays a major role in sustaining protein homeostasis. In Escherichia coli, the activity and amount of the dedicated transcription factor σ32 …             82-kDa choline acetyltransferase and SATB1 localize to β-amyloid induced matrix attachment regions ▶     Warren Winick-Ng, Fabiana A. Caetano, Jennifer Winick-Ng et al.     The M-transcript of human choline acetyltransferase (ChAT) produces an 82-kDa protein (82-kDa ChAT) that concentrates in nuclei of cholinergic neurons. We assessed the effects of …             Potential use of bacterial community succession for estimating post-mortem interval as revealed by high-throughput sequencing ▶     Juanjuan Guo, Xiaoliang Fu, Huidan Liao et al.     Decomposition is a complex process involving the interaction of both biotic and abiotic factors. Microbes play a critical role in the process of carrion decomposition. In this …             Procaspase-9 induces its cleavage by transnitrosylating XIAP via the Thioredoxin system during cerebral ischemia-reperfusion in rats ▶     Dengyue Zhang, Ningjun Zhao, Bin Ma et al.     Transnitrosylation is an important mechanism by which nitric oxide (NO) modulates cell signaling pathways. For instance, SNO-caspase-3 can transnitrosylate the X-linked inhibitor …             A deformation energy-based model for predicting nucleosome dyads and occupancy ▶     Guoqing Liu, Yongqiang Xing, Hongyu Zhao et al.     Nucleosome plays an essential role in various cellular processes, such as DNA replication, recombination, and transcription. Hence, it is important to decode the mechanism of …             Behavioral and neural correlates of self-referential processing deficits in bipolar disorder ▶     Yanli Zhao, Wenbo Luo, Jingxu Chen et al.     Self-referential processing is a core component of social cognition. However, few studies have focused on whether self-referential processing deficits present in bipolar …             Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin ▶     Stephen Verespy III, Akul Y. Mehta, Daniel Afosah et al.     Allosteric partial inhibition of soluble, monomeric proteases can offer major regulatory advantages, but remains a concept on paper to date; although it has been routinely …             Vegetation and Cold Trapping Modulating Elevation-dependent Distribution of Trace Metals in Soils of a High Mountain in Eastern Tibetan Plateau ▶     Haijian Bing, Yanhong Wu, Jun Zhou et al.     Trace metals adsorbed onto fine particles can be transported long distances and ultimately deposited in Polar Regions via the cold condensation effect. This study indicated the …             Altitudinal patterns and controls of plant and soil nutrient concentrations and stoichiometry in subtropical China ▶     Xianjin He, Enqing Hou, Yang Liu et al.     Altitude is a determining factor of ecosystem properties and processes in mountains. This study investigated the changes in the concentrations of carbon (C), nitrogen (N), and …             Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response ▶     Anouk Wezel, Margreet R. de Vries, Johanna M. Maassen et al.     Venous grafts are often used to bypass occlusive atherosclerotic lesions; however, poor patency leads to vein graft disease. Deficiency of TLR4, an inflammatory regulator, …             A novel approach for modelling vegetation distributions and analysing vegetation sensitivity through trait-climate relationships in China ▶     Yanzheng Yang, Qiuan Zhu, Changhui Peng et al.     Increasing evidence indicates that current dynamic global vegetation models (DGVMs) have suffered from insufficient realism and are difficult to improve, particularly because …             Central transthyretin acts to decrease food intake and body weight ▶     Fenping Zheng, Yonwook J. Kim, Timothy H. Moran et al.     Transthyretin (TTR) is a blood and cerebrospinal fluid transporter of thyroxine and retinol. Gene expression profiling revealed an elevation of Ttr expression in the dorsomedial …             Quantifying the role of motor imagery in brain-machine interfaces ▶     Silvia Marchesotti, Michela Bassolino, Andrea Serino et al.     Despite technical advances in brain machine interfaces (BMI), for as-yet unknown reasons the ability to control a BMI remains limited to a subset of users. We investigate whether …             PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway ▶     Yuan Wang, Feng Yan, Qing Ye et al.     Promoting endothelial cell (EC) migration is important not only for therapeutic angiogenesis, but also for accelerating re-endothelialization after vessel injury. Several recent …             Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3 ▶     Jun-Ling Zhang, Xiang-Zheng Liu, Peng-Yuan Wang et al.     The human cervical cancer oncogene (HCCR) has been found to be overexpressed in a variety of human cancers. However, the level of expression of HCCR and its biological function …             Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction ▶     Jianzhong Li, Yuan Gui, Jiafa Ren et al.     Metformin, one of the most common prescriptions for patients with type 2 diabetes, is reported to protect the kidney from gentamicin-induced nephrotoxicity. However, the role and …             Empirical insights into the stochasticity of small RNA sequencing ▶     Li-Xuan Qin, Thomas Tuschl, Samuel Singer     The choice of stochasticity distribution for modeling the noise distribution is a fundamental assumption for the analysis of sequencing data and consequently is critical for the …             Predicting the response of olfactory sensory neurons to odor mixtures from single odor response ▶     Addolorata Marasco, Alessandro De Paris, Michele Migliore     The response of olfactory receptor neurons to odor mixtures is not well understood. Here, using experimental constraints, we investigate the mathematical structure of the odor …             Clinicopathological Characteristics and Survival Outcomes in Invasive Papillary Carcinoma of the Breast: A SEER Population-Based Study ▶     Yi-Zi Zheng, Xin Hu, Zhi-Ming Shao     To investigate the clinicopathological characteristics and survival outcomes of invasive papillary carcinoma (IPC), we identified 233,171 female patients in the Surveillance, …             Association between TP53 Arg72Pro polymorphism and leukemia risk: a meta-analysis of 14 case-control studies ▶     Xin Tian, Shundong Dai, Jing Sun et al.     The relationship between the TP53 Arg72Pro polymorphism (rs1042522) and the risk of leukemia remains controversial. Consequently, we performed a meta-analysis to accurately …             Loss-of-function Mutation in PMVK Causes Autosomal Dominant Disseminated Superficial Porokeratosis ▶     Jiuxiang Wang, Ying Liu, Fei Liu et al.     Disseminated superficial porokeratosis (DSP) is a rare keratinization disorder of the epidermis. It is characterized by keratotic lesions with an atrophic center encircled by a …             Effects of Morphology Constraint on Electrophysiological Properties of Cortical Neurons ▶     Geng Zhu, Liping Du, Lei Jin et al.     There is growing interest in engineering nerve cells in vitro to control architecture and connectivity of cultured neuronal networks or to build neuronal networks with …             RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers ▶     Kyong Nyon Nam, Anais Mounier, Nicholas F. Fitz et al.     Bexarotene, a selective agonist for Retinoid X receptors (RXR) improves cognitive deficits and amyloid-β (Aβ) clearance in mice. Here we examine if the effect of bexarotene on …             Designing synthetic RNAs to determine the relevance of structural motifs in picornavirus IRES elements ▶     Javier Fernandez-Chamorro, Gloria Lozano, Juan Antonio Garcia-Martin et al.     The function of Internal Ribosome Entry Site (IRES) elements is intimately linked to their RNA structure. Viral IRES elements are organized in modular domains consisting of one …             SHEsisPlus, a toolset for genetic studies on polyploid species ▶     Jiawei Shen, Zhiqiang Li, Jianhua Chen et al.     Currently, algorithms and softwares for genetic analysis of diploid organisms with bi-allelic markers are well-established, while those for polyploids are limited. Here, we …             Surface energetics and protein-protein interactions: analysis and mechanistic implications ▶     Claudio Peri, Giulia Morra, Giorgio Colombo     Understanding protein-protein interactions (PPI) at the molecular level is a fundamental task in the design of new drugs, the prediction of protein function and the clarification …             Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils ▶     Yuriko Tanaka, Sachiko Ito, Ken-ichi Isobe     Inflammatory bowel disease confers an increased risk of developing colitis-associated colon cancer (CAC). During the active colitis or developing tumor stage, commensal bacteria …             Determinants of emigration and their impact on survival during dispersal in fox and jackal populations ▶     Dror Kapota, Amit Dolev, Gilad Bino et al.     Animals disperse in response to poor resource conditions as a strategy of escaping harsh competition and stress, but may also disperse under good resource conditions, as these …             A wild Indo-Pacific bottlenose dolphin adopts a socially and genetically distant neonate ▶     Mai Sakai, Yuki F. Kita, Kazunobu Kogi et al.     Alloparental behaviour and adoption have been reported in many mammals and birds. Such behaviours are energetically costly, and their causes and functions remain unclear. We …             Immunization with a novel Clostridium perfringens epsilon toxin mutant rETXY196E-C confers strong protection in mice ▶     Wenwu Yao, Jingjing Kang, Lin Kang et al.     Epsilon toxin (ETX) is produced by toxinotypes B and D of Clostridium perfringens. It can induce lethal enterotoxemia in domestic animals, mainly in sheep, goats and cattle, …             Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice ▶     Lihua Zhao, Xinhua Du, Kun Huang et al.     The size of the primordial follicle pool determines the reproductive potential of mammalian females, and establishment of the pool is highly dependent on specific genes …             Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population ▶     Aditi Chandra, Anirudhya Lahiri, Swapan Senapati et al.     HLA-Cw6 is one of the most associated alleles in psoriasis. Recently, Late Cornified Envelop 3 (LCE3) genes were identified as a susceptibility factor for psoriasis. Some …             Production and characterization of tearless and non-pungent onion ▶     Masahiro Kato, Noriya Masamura, Jinji Shono et al.     The onion lachrymatory factor (LF) is produced from trans-S-1-propenyl-L-cysteine sulfoxide (PRENCSO) through successive reactions catalyzed by alliinase (EC 4.4.1.4) and …             Growth resumption from stationary phase reveals memory in Escherichia coli cultures ▶     Arvi Jõers, Tanel Tenson     Frequent changes in nutrient availability often result in repeated cycles of bacterial growth and dormancy. The timing of growth resumption can differ among isogenic cells and …             Spinal cord lesions shrink peripersonal space around the feet, passive mobilization of paraplegic limbs restores it ▶     Michele Scandola, Salvatore Maria Aglioti, Claudio Bonente et al.     Peripersonal space (PPS) is the space surrounding us within which we interact with objects. PPS may be modulated by actions (e.g. when using tools) or sense of ownership (e.g. …             Targeted mutagenesis in chicken using CRISPR/Cas9 system ▶     Isao Oishi, Kyoko Yoshii, Daichi Miyahara et al.     The CRISPR/Cas9 system is a simple and powerful tool for genome editing in various organisms including livestock animals. However, the system has not been applied to poultry …             Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes ▶     F. Ebstein, K. Textoris-Taube, C. Keller et al.     Proteasome-catalyzed peptide splicing represents an additional catalytic activity of proteasomes contributing to the pool of MHC-class I-presented epitopes. We here biochemically …             Insights into the adaptive response of the plant-pathogenic oomycete Phytophthora capsici to the fungicide flumorph ▶     Zhili Pang, Lei Chen, Wenjun Mu et al.     Phytophthora capsici is an important oomycete plant pathogen that causes significant losses worldwide. The carboxylic acid amide fungicide flumorph has shown excellent activity …             Comparison of DNA Quantification Methods for Next Generation Sequencing ▶     Jérôme D. Robin, Andrew T. Ludlow, Ryan LaRanger et al.     Next Generation Sequencing (NGS) is a powerful tool that depends on loading a precise amount of DNA onto a flowcell. NGS strategies have expanded our ability to investigate …             Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain ▶     Dipali Patel, Jolanta Kopec, Fiona Fitzpatrick et al.     The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme …             Combined Population Dynamics and Entropy Modelling Supports Patient Stratification in Chronic Myeloid Leukemia ▶     Marc Brehme, Steffen Koschmieder, Maryam Montazeri et al.     Modelling the parameters of multistep carcinogenesis is key for a better understanding of cancer progression, biomarker identification and the design of individualized therapies. …             Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimer’s disease mice ▶     Lifeng Qiu, Gandi Ng, Eng King Tan et al.     Cerebral hypoperfusion and impaired autophagy are two etiological factors that have been identified as being associated with the development of Alzheimer’s disease (AD). …             Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver ▶     Natalie J. Foot, Kelly M. Gembus, Kimberly Mackenzie et al.     The regulation of divalent metal ion transporter DMT1, the primary non-heme iron importer in mammals, is critical for maintaining iron homeostasis. Previously we identified …             Trim69 regulates zebrafish brain development by ap-1 pathway ▶     Ruiqin Han, Renxian Wang, Qing Zhao et al.     Proteins belonging to the TRIM family have been implicated in a variety of cellular processes such as apoptosis, differentiation, neurogenesis, muscular physiology and innate …             3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors ▶     Yajing Fang, Yulin Lu, Xixi Zang et al.     Flavonoids are potential antibacterial agents. However, key substituents and mechanism for their antibacterial activity have not been fully investigated. The quantitative …             Identification and characterization of histone lysine methylation modifiers in Fragaria vesca ▶     Tingting Gu, Yuhui Han, Ruirui Huang et al.     The diploid woodland strawberry (Fragaria vesca) is an important model for fruit crops because of several unique characteristics including the small genome size, an …             Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors ▶     Ce Shi, Ayaka Iura, Masahiko Terajima et al.     We previously found that disruption of two type I BMP receptors, Bmpr1a and Acvr1, respectively, in an osteoblast-specific manner, increased bone mass in mice. BMPR1B, another …             Integrated Metabolomics Study of the Milk of Heat-stressed Lactating Dairy Cows ▶     He Tian, Nan Zheng, Weiyu Wang et al.     Heat stress (HS) damages the global dairy industry by reducing milk yields and quality, harming health, and damaging the reproduction of dairy cows, causing huge economic losses …             Three-dimensional direct measurement of cardiomyocyte volume, nuclearity, and ploidy in thick histological sections ▶     Jonathan Guy Bensley, Robert De Matteo, Richard Harding et al.     Quantitative assessment of myocardial development and disease requires accurate measurement of cardiomyocyte volume, nuclearity (nuclei per cell), and ploidy (genome copies per …             Optical phase conjugation assisted scattering lens: variable focusing and 3D patterning ▶     Jihee Ryu, Mooseok Jang, Tae Joong Eom et al.     Variable light focusing is the ability to flexibly select the focal distance of a lens. This feature presents technical challenges, but is significant for optical interrogation …             On hybrid circuits exploiting thermistive properties of slime mould ▶     Xavier Alexis Walter, Ian Horsfield, Richard Mayne et al.     Slime mould Physarum polycephalum is a single cell visible by the unaided eye. Let the slime mould span two electrodes with a single protoplasmic tube: if the tube is heated to …             Calcium oxalate crystals increased enolase-1 secretion from renal tubular cells that subsequently enhanced crystal and monocyte invasion through renal interstitium ▶     Wararat Chiangjong, Visith Thongboonkerd     Calcium oxalate monohydrate (COM) crystals cause kidney stone disease by still unclear mechanisms. The present study aimed to characterize changes in secretion of proteins from …             Revealing a new activity of the human Dicer DUF283 domain in vitro ▶     Anna Kurzynska-Kokorniak, Maria Pokornowska, Natalia Koralewska et al.     The ribonuclease Dicer is a multidomain enzyme that plays a fundamental role in the biogenesis of small regulatory RNAs (srRNAs), which control gene expression by targeting …             Breeding Young as a Survival Strategy during Earth’s Greatest Mass Extinction ▶     Jennifer Botha-Brink, Daryl Codron, Adam K. Huttenlocker et al.     Studies of the effects of mass extinctions on ancient ecosystems have focused on changes in taxic diversity, morphological disparity, abundance, behaviour and resource …             Resilient help to switch and overlap hierarchical subsystems in a small human group ▶     K. Fujii, K. Yokoyama, T. Koyama et al.     Groups of social organisms in nature are resilient systems that can overcome unpredicted threats by helping its members. These social organisms are assumed to behave both …             Structural basis for the membrane association of ankyrinG via palmitoylation ▶     Yuichiro Fujiwara, Hiroko X. Kondo, Matsuyuki Shirota et al.     By clustering various ion channels and transporters, ankyrin-G (AnkG) configures the membrane-excitation platforms in neurons and cardiomyocytes. AnkG itself localizes to …             Tissue-specific Differentiation Potency of Mesenchymal Stromal Cells from Perinatal Tissues ▶     Ahlm Kwon, Yonggoo Kim, Myungshin Kim et al.     Human perinatal tissue is an abundant source of mesenchymal stromal cells(MSCs) and lacks the ethical concerns. Perinatal MSCs can be obtained from various tissues as like …             Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell ▶     Anasuya Chattopadhyay, Cornelius J. O’Connor, Fengzhi Zhang et al.     Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Elevated gankyrin levels are linked to aberrant …             The resveratrol-enriched rice DJ526 boosts motor coordination and physical strength ▶     Hea-Jong Chung, Satya Priya Sharma, Hyeon-Jin Kim et al.     The main objective of current genetic modifications in crops is to boost agricultural production or to develop GM crops with an improved nutrient profile by introducing a new …             Protein Repeats from First Principles ▶     Pablo Turjanski, R. Gonzalo Parra, Rocío Espada et al.     Some natural proteins display recurrent structural patterns. Despite being highly similar at the tertiary structure level, repeating patterns within a single repeat protein can …             Regnase-1 in microglia negatively regulates high mobility group box 1-mediated inflammation and neuronal injury ▶     Xiao-Xi Liu, Chen Wang, Shao-Fei Huang et al.     Extracellular high mobility group box 1 (HMGB1) has been demonstrated to function as a proinflammatory cytokine and induces neuronal injury in response to various pathological …             Molecular Inversion Probes for targeted resequencing in non-model organisms ▶     M. Niedzicka, A. Fijarczyk, K. Dudek et al.     Applications that require resequencing of hundreds or thousands of predefined genomic regions in numerous samples are common in studies of non-model organisms. However few …             Identification of four new gene members of the KAP6 gene family in sheep ▶     Huitong Zhou, Hua Gong, Jiqing Wang et al.     KAP6 is a high glycine-tyrosine keratin-associated protein (HGT-KAP) family. This family is thought to contain multiple genes. In this study, we used a KRTAP6 coding sequence to …             Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice ▶     Zhu-Qin Zhang, Si-Chong Ren, Ying Tan et al.     Sirt6 is a member of the class III histone deacetylase family which is associated with aging and longevity. Sirt6 deficient mice show an aging-like phenotype, while male …             T cell factor-4 functions as a co-activator to promote NF-κB-dependent MMP-15 expression in lung carcinoma cells ▶     Yuliang Liu, Yu Xu, Shuliang Guo et al.     Both TCF-4 and MMP-15 are closely linked to the development of lung cancer, while the regulatory role of TCF-4 in MMP-15 expression is still obscure. Here we found that …             Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors ▶     Akash Pandhare, Petar N. Grozdanov, Michaela Jansen     In spite of extensive efforts over decades an experimentally-derived structure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still lacking. These …             Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway ▶     Yue Hu, Xiaoyan Cong, Lei Chen et al.     PRRS is one of the most important diseases in swine industry. Current PRRS inactivated vaccine provides only a limited protection and cannot induce sufficient cell-mediated …             LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p ▶     Zehua Bian, Liugen Jin, Jiwei Zhang et al.     Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the …             Seasonal heterogeneity of ocean warming: a mortality sink for ectotherm colonizers ▶     Fulvio Maffucci, Raffaele Corrado, Luigi Palatella et al.     Distribution shifts are a common adaptive response of marine ectotherms to climate change but the pace of redistribution depends on species-specific traits that may promote or …             Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA ▶     Iván O. Rivera-Torres, Tony B. Jin, Martine Cadene et al.     Due to their central role in essential physiological processes, potassium channels are common targets for animal toxins. These toxins in turn are of great value as tools for …             A snail-eating snake recognizes prey handedness ▶     Patchara Danaisawadi, Takahiro Asami, Hidetoshi Ota et al.     Specialized predator-prey interactions can be a driving force for their coevolution. Southeast Asian snail-eating snakes (Pareas) have more teeth on the right mandible and …             Bacterial community associated to the pine wilt disease insect vectors Monochamus galloprovincialis and Monochamus alternatus ▶     Marta Alves, Anabela Pereira, Patrícia Matos et al.     Monochamus beetles are the dispersing vectors of the nematode Bursaphelenchus xylophilus, the causative agent of pine wilt disease (PWD). PWD inflicts significant damages in …             Combined approaches of EPR and NMR illustrate only one transmembrane helix in the human IFITM3 ▶     Shenglong Ling, Chengwei Zhang, Wei Wang et al.     Interferon-inducible transmembrane protein IFITM3 was known to restrict the entry of a wide spectrum of viruses to the cytosol of the host. The mechanism used by the protein to …             Diminution of the gut resistome after a gut microbiota-targeted dietary intervention in obese children ▶     Guojun Wu, Chenhong Zhang, Jing Wang et al.     The gut microbiome represents an important reservoir of antibiotic resistance genes (ARGs). Effective methods are urgently needed for managing the gut resistome to fight against …             Optogenetic approaches addressing extracellular modulation of neural excitability ▶     Emily A. Ferenczi, Johannes Vierock, Kyoko Atsuta-Tsunoda et al.     The extracellular ionic environment in neural tissue has the capacity to influence, and be influenced by, natural bouts of neural activity. We employed optogenetic approaches to …             MicroRNA profiling of cisplatin-resistant oral squamous cell carcinoma cell lines enriched with cancer-stem-cell-like and epithelial-mesenchymal transition-type features ▶     Ruma Dey Ghosh, Sangeeta Ghuwalewala, Pijush Das et al.     Oral cancer is of major public health problem in India. Current investigation was aimed to identify the specific deregulated miRNAs which are responsible for development of …             Reverse genetics in high throughput: rapid generation of complete negative strand RNA virus cDNA clones and recombinant viruses thereof ▶     T. Nolden, F. Pfaff, S. Nemitz et al.     Reverse genetics approaches are indispensable tools for proof of concepts in virus replication and pathogenesis. For negative strand RNA viruses (NSVs) the limited number of …             Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release ▶     Lei Wang, Wanhai Qin, Jing Zhang et al.     Members of the Trimeric Autotransporter Adhesin (TAA) family play a crucial role in the adhesion of Gram-negative pathogens to host cells, but the immunopathogenesis of TAAs …             Molecular Interactions between Tarantula Toxins and Low-Voltage-Activated Calcium Channels ▶     Autoosa Salari, Benjamin S. Vega, Lorin S. Milescu et al.     Few gating-modifier toxins have been reported to target low-voltage-activated (LVA) calcium channels, and the structural basis of toxin sensitivity remains incompletely …             N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes ▶     A. Prokesch, H. J. Pelzmann, A. R. Pessentheiner et al.     Histone acetylation depends on the abundance of nucleo-cytoplasmic acetyl-CoA. Here, we present a novel route for cytoplasmic acetyl-CoA production in brown adipocytes. …             BET Bromodomain Suppression Inhibits VEGF-induced Angiogenesis and Vascular Permeability by Blocking VEGFR2-mediated Activation of PAK1 and eNOS ▶     Mingcheng Huang, Qian Qiu, Youjun Xiao et al.     The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a critical modulator of angiogenesis. Increasing evidence indicate the important role of …             Localisation and protein-protein interactions of the Helicobacter pylori taxis sensor TlpD and their connection to metabolic functions ▶     Wiebke Behrens, Tobias Schweinitzer, Jonathan L. McMurry et al.     The Helicobacter pylori energy sensor TlpD determines tactic behaviour under low energy conditions and is important in vivo. We explored protein-protein interactions of TlpD and …             Molecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines ▶     Anne L. Wyllie, Alienke J. Wijmenga-Monsuur, Marlies A. van Houten et al.     Following the introduction of pneumococcal conjugate vaccines (PCVs) for infants, surveillance studies on Streptococcus pneumoniae carriage have proven valuable for monitoring …             Developmental potential of clinically discarded human embryos and associated chromosomal analysis ▶     Guidong Yao, Jiawei Xu, Zhimin Xin et al.     Clinically discarded human embryos, which are generated from both normal and abnormal fertilizations, have the potential of developing into blastocysts. A total of 1,649 …             Arctic foxes as ecosystem engineers: increased soil nutrients lead to increased plant productivity on fox dens ▶     Tazarve Gharajehdaghipour, James D. Roth, Paul M. Fafard et al.     Top predators can provide fundamental ecosystem services such as nutrient cycling, and their impact can be even greater in environments with low nutrients and productivity, such …             A four-dimensional snapshot hyperspectral video-endoscope for bio-imaging applications ▶     Hoong-Ta Lim, Vadakke Matham Murukeshan     Hyperspectral imaging has proven significance in bio-imaging applications and it has the ability to capture up to several hundred images of different wavelengths offering …             Micropapillary: A component more likely to harbour heterogeneous EGFR mutations in lung adenocarcinomas ▶     Yi-Ran Cai, Yu-Jie Dong, Hong-Bo Wu et al.     The micropapillary (MP) subtype has recently been established to be a distinct marker of poor prognosis in lung adenocarcinomas (LACs). According to the 2015 WHO classification …             Evaluating the effectiveness of localized control strategies to curtail chikungunya ▶     Martial L. Ndeffo-Mbah, David P. Durham, Laura A. Skrip et al.     Chikungunya, a re-emerging arbovirus transmitted to humans by Aedes aegypti and Ae. albopictus mosquitoes, causes debilitating disease characterized by an acute febrile phase and …             Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells ▶     Marie Rhee, Seung-Hwan Lee, Ji-Won Kim et al.     The preadipocyte factor 1 (Pref-1) is involved in the proliferation and differentiation of various precursor cells. However, the intracellular signaling pathways that control …             Ultrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues ▶     Zhiyong Wen, Xiaona Li, Daiying Zuo et al.     A series of 3-(3′-hydroxy-4′-methoxyphenyl)selenyl-5,6,7-trimethoxy-1H-indoles and 3-(3′-hydroxy-4′-methoxyphenyl)thio-5,6,7-trimethoxy-1H-indoles were obtained as a new class of …             Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients ▶     Patricia López, Banesa de Paz, Javier Rodríguez-Carrio et al.     Intestinal dysbiosis, characterized by a reduced Firmicutes/Bacteroidetes ratio, has been reported in systemic lupus erythematosus (SLE) patients. In this study, in vitro …             Prevention of gastrointestinal lead poisoning using recombinant Lactococcus lactis expressing human metallothionein-I fusion protein ▶     Xue Xiao, Changbin Zhang, Dajun Liu et al.     Low-level lead poisoning is an insidious disease that affects millions of children worldwide, leading to biochemical and neurological dysfunctions. 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