Nature Reviews Molecular Cell Biology contents January 2016 Volume 17 Number 5 pp 263-328

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TABLE OF CONTENTS
May 2016 Volume 17 Number 5		Advertisement
Impact Factor 37.806 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Adult stem cells Article series: DNA damage  Featured article: VRACs and other ion channels and transporters in the regulation of cell volume and beyond Thomas J. Jentsch	nature.com webcasts Nature Publishing Group presents a custom webcast on Advances in neuroscience: New methods for correlating structure and function Thursday May 5, 2016 8AM PDT, 10AM CDT, 11AM EDT, 4PM BST, 5PM CEST Register for the webcast and live Q&A session Sponsored by:  Leica Microsystems
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RESEARCH HIGHLIGHTS Top Cell migration: Nuclear envelope ruptures as cells squeeze through tight spaces p263 | doi:10.1038/nrm.2016.47 Two studies report that the nuclear envelope undergoes rupture and resealing when migrating cells pass through tight spaces. PDF RNA metabolism: Co-transcriptional splicing at nucleotide resolution p264 | doi:10.1038/nrm.2016.44 Two new methods for nascent RNA sequencing show that, in yeast, splicing can occur surprisingly quickly following intron synthesis by RNA polymerase II. PDF Chromatin: SIRT6 keeps pericentromeric transcription in check p264 | doi:10.1038/nrm.2016.46 SIRT6-mediated deacetylation of H3K18ac is important for inhibiting pericentric transcription to prevent cellular defects associated with cancer and ageing. PDF JOURNAL CLUB Beadle and Tatum and the origins of molecular biology p266 | doi:10.1038/nrm.2016.42 Recognition of the innovative nature of the Beadle and Tatum experiment of mutation induction followed by selection has faded in the decades since; Bernard Strauss explains why. PDF Cell signalling: Dual specificity of SH2 domains p266 | doi:10.1038/nrm.2016.49 Binding of SH2 domains to membrane lipids is crucial for spatiotemporal regulation of phosphotyrosine signalling cascades. PDF IN BRIEF Regeneration: Switching it on and off with enhancers | Translation: The features of pathologic RAN translation | Cell migration: Recycling active integrin for adhesion reassembly | Post-translational modifications: ERα activation through methylation | Transcription: Pol II and topoisomerase 1 hand-in-hand | Plant development: Non-cell-autonomous retrotransposon silencing PDF JOBS of the week Cell & Molecular Biology Southwest Hospital, Third Military Medical University Single-Cell Molecular/Microfluidics Biology Post-Docs California Institute of Technology Postdoctoral Scientist Cedars-Sinai Research Technician (f/m) – MTA, BTA German Center for Neurodegenerative Deseases More Science jobs from
REVIEWS		Top
Article series: Adult stem cells Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease Albert E. Almada & Amy J. Wagers p267 | doi:10.1038/nrm.2016.7 Adult muscles contain quiescent stem cells, known as satellite cells, which are activated upon injury, enabling muscle repair and replenishment of the stem cell pool. Recent studies have shed light on the molecular circuitry regulating satellite cell fate decision and the impairment of this circuitry during degenerative muscle diseases and ageing. Abstract | Full Text | PDF
Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases Per Hydbring, Marcos Malumbres & Piotr Sicinski p280 | doi:10.1038/nrm.2016.27 Mammalian cyclins and cyclin-dependent kinases (CDKs) have non-canonical, cell cycle-independent functions in processes such as transcription and DNA damage repair. Through these and other activities, they regulate cell death, differentiation, the immune response and metabolism. Abstract | Full Text | PDF
VRACs and other ion channels and transporters in the regulation of cell volume and beyond Thomas J. Jentsch p293 | doi:10.1038/nrm.2016.29 Vertebrate cell volume is controlled to maintain homeostasis. Volume adjustment is achieved by regulating transmembrane transport of ions and small organic osmolytes through diverse transporters and channels (including volume regulated anion channels (VRACs)), which are also implicated in other physiological processes such as metabolite transport and apoptosis, as well as in pathology. Abstract | Full Text | PDF | Supplementary information
Article series: DNA damage Nuclear DNA damage signalling to mitochondria in ageing Evandro Fei Fang et al. p308 | doi:10.1038/nrm.2016.14 Signalling from the nucleus to mitochondria (NM signalling) is crucial for regulating mitochondrial function and ageing. It is initiated by nuclear DNA damage and controls genomic and mitochondrial integrity. Pharmacological modulation of NM signalling holds promise for improving lifespan and healthspan. Abstract | Full Text | PDF
PERSPECTIVES		Top
VIEWPOINT Microtubules: 50 years on from the discovery of tubulin Gary Borisy et al. p322 | doi:10.1038/nrm.2016.45 To celebrate almost 50 years from the discovery of tubulin, six eminent researchers reflect on how the field of microtubule research has advanced over the past five decades, discuss impacts on clinical translation, and provide their thoughts on what key questions need to be addressed in the near future. Abstract | Full Text | PDF
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