Nature Reviews Immunology Contents May 2016 Volume 16 Number 5 pp 272-334

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TABLE OF CONTENTS
May 2016 Volume 16 Number 5		Advertisement
Impact Factor 30.458 *	In this issue Research Highlights Reviews Also this month  Featured article: MicroRNAs as regulatory elements in immune system logic Ming O. Li & Alexander Y. Rudensky	NEW WHITE PAPER: The Latest Advances in Cell and Tissue Engrafted Mice This white paper provides an in-depth overview of mice engrafted with human cells and tissues and how they can help to bridge the biological gap between mice and humans.  Learn More About: How cell and tissue engrafted mice are generated The application of immune system engrafted models in basic and applied research And, read an evaluation of the available super immunodeficient models for cell and issue  Download Your Copy Today
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RESEARCH HIGHLIGHTS Top Macrophages: Reservoir reinforcements p273 | doi:10.1038/nri.2016.47 Peritoneal cavity macrophages are rapidly recruited by a non-vascular route to the injured liver to mediate tissue repair. PDF Immunometabolism: An inner limit for ILC2s p274 | doi:10.1038/nri.2016.46 Arginase 1 regulates ILC2 metabolism and the development of type 2 inflammation in the lungs. PDF Macrophages: Dissolving cholesterol to unclog arteries p274 | doi:10.1038/nri.2016.50 Cyclodextrin promotes atherosclerosis regression through oxysterol-mediated, LXR-dependent macrophage reprogramming. PDF JOURNAL CLUB Heterologous immunity meets tissue-specific training p275 | doi:10.1038/nri.2016.41 Tracy Hussell describes a 2003 study by Chen et al. that pioneered the concept of heterologous immunity. PDF T cell responses: Metabolic pathways take sides p276 | doi:10.1038/nri.2016.51 Asymmetric distribution of metabolic pathway components sustains differential CD8+ T cell fates. PDF Tissue repair: Biological scaffolds modulate immune cells p276 | doi:10.1038/nri.2016.52 Biological scaffolds create an immune microenvironment that is favourable for tissue regeneration. PDF Tumour immunology: Metastasis in action p277 | doi:10.1038/nri.2016.45 Circulating tumour cells fragment as they metastasize, providing 'information' to immune cells that promote or inhibit metastasis. PDF Immunology JOBS of the week Faculty Positions in Immunology ~ Dana-Farber / Harvard Medical School Dana-Farber Cancer Institute & Harvard medical School Tier 2 Canada Research Chair in Human Immunology and Inflammation Dalhousie University Post-doctoral Research Fellow – Dormancy / Immunology Fred Hutchinson Cancer Research Center Faculty Position in Tumor Immunology Northwestern University Faculty Positions in Cancer Immunology University of New Mexico More Science jobs from Immunology EVENT International Conference on Human & Translational Immunology 16.09.16 Rhodes, Greece More science events from
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REVIEWS		Top
MicroRNAs as regulatory elements in immune system logic Arnav Mehta & David Baltimore p279 | doi:10.1038/nri.2016.40 This Review details the key roles of microRNAs (miRNAs) in regulating immune cell development and function. The authors describe how miRNAs govern cell fate decisions during haematopoiesis and discuss how aberrant miRNA expression can lead to pathologies such as autoimmunity and cancer. Abstract | Full Text | PDF
Development and maintenance of intestinal regulatory T cells Takeshi Tanoue, Koji Atarashi & Kenya Honda p295 | doi:10.1038/nri.2016.36 Intestinal regulatory T cells (Treg cells) are distinct from those in other organs and function to maintain tolerance to harmless dietary antigens and commensal microorganisms. The unique features of these cells, as well as the signals involved in their development and maintenance, are discussed in this Review. Abstract | Full Text | PDF
Emerging insights into natural killer cells in human peripheral tissues Niklas K. Björkström, Hans-Gustaf Ljunggren & Jakob Michaëlsson p310 | doi:10.1038/nri.2016.34 In this Review, the authors describe the diversity and characteristics of tissue-resident human natural killer cells, with focus on those found in the liver, uterus and lungs. They also discuss important unresolved questions and future challenges in the field. Abstract | Full Text | PDF
The immunology of host defence peptides: beyond antimicrobial activity Robert E.W. Hancock, Evan F. Haney & Erin E. Gill p321 | doi:10.1038/nri.2016.29 In this Review, the authors detail the diverse roles of host defence peptides (HDPs) in innate immunity and their association with inflammatory diseases. They highlight the complexity of the immune signalling pathways that are influenced by natural and synthetic HDPs and show that systems biology approaches are important to understand this complexity. Abstract | Full Text | PDF | Supplementary information
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