Nature Reviews Genetics Contents May 2016 Volume 17 Number 5 pp251-312

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TABLE OF CONTENTS
May 2016 Volume 17 Number 5
Impact Factor 36.978 *	In this issue Research Highlights Reviews Also this month Article Series: Applications of next-generation sequencing Article Series: Disease mechanisms  Featured article: Translating RNA sequencing into clinical diagnostics: opportunities and challenges Sara A. Byron, Kendall R. Van Keuren-Jensen, David M. Engelthaler, John D. Carpten & David W. Craig
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RESEARCH HIGHLIGHTS Top Human genetics: Loss-of-function variants [mdash] not always what they seem p251 | doi:10.1038/nrg.2016.33 PDF Development: A colourful map of cell fate p252 | doi:10.1038/nrg.2016.48 PDF Genetic testing: Clinical sequencing right on target p253 | doi:10.1038/nrg.2016.34 PDF Reprogramming: Your contacts reveal your past p253 | doi:10.1038/nrg.2016.35 PDF Molecular evolution: Friends with benefits [mdash] sex speeds up adaptation p254 | doi:10.1038/nrg.2016.32 PDF Gene regulation: Optical control of epigenetics p254 | doi:10.1038/nrg.2016.40 PDF Technique: Transcript tracking by CRISPR p254 | doi:10.1038/nrg.2016.41 PDF IN BRIEF Complex disease: A global view of regulatory networks | Technique: Unwanted sequences DASH off | Genetic testing: Whole-exome sequencing for clinical diagnostics | Resource: A comprehensive catalogue of human RNA-binding protein reagents | Genetic variation: New tool to map genetic modifiers of transcription factor-gene target connections | Bioinformatics: Taking the epigenome to another dimension PDF
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REVIEWS		Top
Article series: Applications of next-generation sequencing Translating RNA sequencing into clinical diagnostics: opportunities and challenges Sara A. Byron, Kendall R. Van Keuren-Jensen, David M. Engelthaler, John D. Carpten & David W. Craig p257 | doi:10.1038/nrg.2016.10 RNA sequencing (RNA-seq) is a powerful approach for comprehensive analyses of transcriptomes. This Review describes the widespread potential applications of RNA-seq in clinical medicine, such as detecting disease-associated mutations and gene expression disruptions, as well as characteristic non-coding RNAs, circulating extracellular RNAs or pathogen RNAs. The authors also highlight the challenges in adopting RNA-seq routinely into clinical practice. Abstract | Full Text | PDF
Endogenous microRNA sponges: evidence and controversy Daniel W. Thomson & Marcel E. Dinger p272 | doi:10.1038/nrg.2016.20 Empirical evidence supporting the competitive endogenous RNA (ceRNA) hypothesis is accumulating, but studies that model transcriptome-wide binding site abundance suggest that physiological expression changes of most individual transcripts do not compromise microRNA (miRNA) activity. This Review aims to critically evaluate the evidence for and against the ceRNA hypothesis to assess the impact of endogenous miRNA-sponge interactions. Abstract | Full Text | PDF
Article series: Disease mechanisms Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Andrew P. Feinberg, Michael A. Koldobskiy & Anita Gondor p284 | doi:10.1038/nrg.2016.13 Disruption to the epigenome is increasingly appreciated as a major contributor to the development of cancer. The authors discuss how conceptualizing genes affecting the epigenome as epigenetic modulators, epigenetic modifiers or epigenetic mediators provides a valuable framework for understanding diverse aspects of the causes and consequences of epigenome alteration in cancer. Abstract | Full Text | PDF
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases Shengdar Q. Tsai & J. Keith Joung p300 | doi:10.1038/nrg.2016.28 Applying CRISPR-Cas9 genome editing technologies in safe and reliable ways requires a firm appreciation of the specificity of target-site recognition and cleavage. In this Review the authors discuss various approaches for characterizing off-target effects of CRISPR-Cas9 genome editing, how mechanistic knowledge can drive the engineering of more-specific nucleases, and the implications for research and therapeutic applications. Abstract | Full Text | PDF
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