Laboratory Investigation - Table of Contents alert Volume 96 Issue 5

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TABLE OF CONTENTS Volume 96, Issue 5 (May 2016) In this issue Inside the Uscap Journals Mini Review Research Articles Technical Report Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the Uscap Journals Top Inside the USCAP Journals 2016 96: 494-495; 10.1038/labinvest.2016.47 Full Text Mini Review Top Multifactorial theory applied to the neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson’s disease In this review, multifactorial theory is applied to study the causal relationship between Parkinson's disease and paraquat exposure. Hypotheses and recommendations are provided for better experimental design that integrate laboratory investigation with the environmental context. Xiao-feng Zhang, Mark Thompson and Yi-hua Xu 2016 96: 496-507; advance online publication, February 1, 2016; 10.1038/labinvest.2015.161 Abstract | Full Text Research Articles Top BLOOD, LYMPHATICS, IMMUNE SYSTEM AND STEM CELLS Notch1 signaling contributes to stemness in head and neck squamous cell carcinoma Elevated Notch1 expression is associated with poor prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Notch1 knockdown in HNSCC cancer stem cells inhibits tumor formation and increases survival in an animal model. Notch1 may therefore be a critical regulator of stemness in HNSCC cells and a target for future therapies. Sang H Lee, Sung I Do, Hyun J Lee, Hyun J Kang, Bon S Koo and Young C Lim 2016 96: 508-516; advance online publication, February 29, 2016; 10.1038/labinvest.2015.163 Abstract | Full Text Requirement of CXCL12-CXCR7 signaling for CD20− CD138− double-negative population in lymphoplasmacytic lymphoma This study describes the search for cancer-initiating cells in lymphoplasmacytic lymphoma. The authors discovered a potential candidate cell type, a hypoxia-induced subpopulation of cells that are CD20- CD138-. and overexpress the C-X-C chemokine receptor 7. Such cells may be targets for therapeutic intervention. Naoki Wada, Jun-ichiro Ikeda, Satoshi Nojima, Shin-ichiro Tahara, Kenji Ohshima, Daisuke Okuzaki and Eiichi Morii 2016 96: 517-525; advance online publication, February 15, 2016; 10.1038/labinvest.2016.28 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS ResolvinD1 reduces apoptosis and inflammation in primary human alveolar epithelial type 2 cells In this study the authors examine the mechanism of resolvin D1 (RvD1) in the amelioration of inflammatory lung disease. They show that RvD1 reduces apoptosis by inducing the phosphorylation of the kinase AKT and attenuates pro-inflammatory responses by suppressing the degradation and phosphorylation of the transcription factor inhibitor IκB-α. Wanli Xie, Huiqing Wang, Qing Liu, Yongsheng Li, Jianjun Wang, Shanglong Yao and Qingping Wu 2016 96: 526-536; advance online publication, February 15, 2016; 10.1038/labinvest.2016.31 Abstract | Full Text Human amniotic mesenchymal stem cells alleviate lung injury induced by ischemia and reperfusion after cardiopulmonary bypass in dogs This study assesses the capacity of human amniotic MSC to ameliorate injury in a dog model of cardiopulmonary bypass. The authors found that transplantation of mesenchymal stem cells (MSC) may inhibit the pathological immune processes contributing to ischemia/reperfusion injury. Yong Qiang, Guiyou Liang and Limei Yu 2016 96: 537-546; advance online publication, February 29, 2016; 10.1038/labinvest.2016.37 Abstract | Full Text GENITOURINARY AND REPRODUCTIVE SYSTEMS DA-1229, a dipeptidyl peptidase IV inhibitor, protects against renal injury by preventing podocyte damage in an animal model of progressive renal injury This study shows that DA-1229, a dipeptidyl peptidase IV (DPPIV) inhibitor, improves proteinuria, renal fibrosis and inflammation associated with decreased urinary nephrin loss. DA-1229 restores the high glucose/angiotensin II-induced increase of DPPIV activity and preserves the nephrin levels in podocytes. These findings suggest that DA-1229 exerts its renoprotective effects by preventing podocyte injury. Jee Eun Lee, Jung Eun Kim, Mi Hwa Lee, Hye Kyoung Song, Jung Yeon Ghee, Young Sun Kang, Hye Sook Min, Hyun Wook Kim, Jin Joo Cha, Jee Young Han, Sang Youb Han and Dae Ryong Cha 2016 96: 547-560; advance online publication, February 15, 2016; 10.1038/labinvest.2016.34 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study The nucleus pulposus (NP) is important in intervertebral disc degeneration, which leads to low back pain. This paper shows that carbonic anhydrase 12 (CA12), a novel NP marker, is down-regulated in degenerated NPs by the prolyl hydroxylase/HIF-1 axis, and may lead to decreased extracellular matrix synthesis. Shuai Chen, Xiang-Qian Fang, Qiang Wang, Shao-Wei Wang, Zhi-Jun Hu, Zhi-Jie Zhou, Wen-Bing Xu, Ji-Ying Wang, An Qin and Shun-Wu Fan 2016 96: 561-569; advance online publication, February 22, 2016; 10.1038/labinvest.2016.32 Abstract | Full Text Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain Abnormal Wnt signaling is associated with bone mass disorders. Overexpression of the Wnt modulator frizzled related protein (Frzb) promotes osteogenesis and shifts the balance between canonical and non-canonical Wnt signaling cascades. These effects are regulated by the FrzbNTN domain. These data provide novel perspectives on the Wnt signaling pathway as a therapeutic target for bone and joint diseases. Sarah Thysen, Frederic Cailotto and Rik Lories 2016 96: 570-580; advance online publication, February 29, 2016; 10.1038/labinvest.2016.38 Abstract | Full Text PERIPHERAL AND CENTRAL NERVOUS SYSTEM Distinctive properties of plaque-type dura mater graft-associated Creutzfeldt–Jakob disease in cell-protein misfolding cyclic amplification In this paper, the authors introduce a new method for identifying iatrogenic Creutzfeldt-Jakob disease (CJD) using protein misfolding cyclic amplification. Based on the preference for the genotype at codon 129 of substrates and the protease resistance prion protein type of amplified products, CJD cases derived from sporadic CJD-VV2 could be rapidly and easily differentiated from those linked to sporadic CJD-MM1 within just one week Atsuko Takeuchi, Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Masanori Morita, Shusei Uno and Tetsuyuki Kitamoto 2016 96: 581-587; advance online publication, February 15, 2016; 10.1038/labinvest.2016.27 Abstract | Full Text Technical Report Top MODELS AND TECHNIQUES Adapting coculture in vitro models of the blood–brain barrier for use in cancer research: maintaining an appropriate endothelial monolayer for the assessment of transendothelial migration This technical report describes how to prevent endothelial cells from invading the lower face of large-pore-size inserts in co-culture systems. The authors used this new method to set up an in vitro model of the blood-brain barrier, and successfully adapted the method for use in transendothelial migration assays of cancer cells. Elodie Vandenhaute, Aurore Drolez, Emmanuel Sevin, Fabien Gosselet, Caroline Mysiorek and Marie-Pierre Dehouck 2016 96: 588-598; advance online publication, February 22, 2016; 10.1038/labinvest.2016.35 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. 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