|  | | | Special Issue: Amos B Smith, III: 50 years of Research and Contributions | Top |  | Featuring Outstanding Contributions to Complex Natural Product Total Synthesis, Bioorganic and Medicinal Chemistry April issue of The Journal of Antibiotics is dedicated to Prof Amos B Smith III in celebration of his successful 50 years of research and outstanding achievement and contribution to the field of Complex Natural Product Total Synthesis, Bioorganic and Medicinal Chemistry. We would like to thank all contributors for this issue, as well as Dr Smith himself for his kind advice in planning of this issue and also for publishing coauthored review article. We are also grateful to the organizers of this special issue guest editors Dr John L Wood, Dr Toshiaki Sunazuka and section editor Dr Keiichi Ajito for their tremendous support in planning and coordination of this issue. | |  | | Editorial | Top |  | Amos B Smith, III: chemist, collaborator and mentorJohn L Wood J Antibiot 2016 69: 189; 10.1038/ja.2016.1 Full Text | PDF |  |  |  | Professor Amos B Smith, IIIToshiaki Sunazuka J Antibiot 2016 69: 190; 10.1038/ja.2016.31 Full Text | PDF |  |  |  | The first total synthesis and the second- or third-generation approachKeiichi Ajito J Antibiot 2016 69: 191; 10.1038/ja.2016.30 Full Text | PDF |  | Review Articles | Top |  | Organic synthesis in the Smith Group: a personal selection of a dozen lessons learned at the University of PennsylvaniaKevin P C Minbiole J Antibiot 2016 69: 192-202; advance online publication, March 2, 2016; 10.1038/ja.2016.21 Abstract | Full Text |  |  |  | Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic—kendomycinShu Xu and Hirokazu Arimoto J Antibiot 2016 69: 203-212; advance online publication, February 10, 2016; 10.1038/ja.2016.5 Abstract | Full Text |  |  |  | The Petasis-Ferrier rearrangement: developments and applicationsEmily C Minbiole and Kevin P C Minbiole J Antibiot 2016 69: 213-219; advance online publication, January 6, 2016; 10.1038/ja.2015.136 Abstract | Full Text |  |  |  | Synthesis of the phorboxazoles—potent, architecturally novel marine natural productsZachary Shultz and James W Leahy J Antibiot 2016 69: 220-252; advance online publication, March 9, 2016; 10.1038/ja.2016.8 Abstract | Full Text |  | Original Articles | Top |  | Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem-catalyzed pyrrole synthesisMinami Yamaguchi, Daichi Itagaki, Hirofumi Ueda and Hidetoshi Tokuyama J Antibiot 2016 69: 253-258; advance online publication, February 17, 2016; 10.1038/ja.2016.13 Abstract | Full Text |  |  |  | Synthesis of the ABCDEF and FGHI ring system of yessotoxin and adriatoxinYuan Zhang and Jon D Rainier J Antibiot 2016 69: 259-272; advance online publication, March 9, 2016; 10.1038/ja.2016.18 Abstract | Full Text |  |  |  | Practical synthesis of the C-ring precursor of paclitaxel from 3-methoxytolueneKeisuke Fukaya, Yu Yamaguchi, Ami Watanabe, Hiroaki Yamamoto, Tomoya Sugai, Takeshi Sugai, Takaaki Sato and Noritaka Chida J Antibiot 2016 69: 273-279; advance online publication, February 10, 2016; 10.1038/ja.2016.6 Abstract | Full Text |  |  |  | Total synthesis of ent-(+)-cinanthrenol ALiangyu Zhu and Rongbiao Tong J Antibiot 2016 69: 280-286; advance online publication, November 11, 2015; 10.1038/ja.2015.114 Abstract | Full Text |  |  |  | Synthesis and structure–activity relationship study of FD-891: importance of the side chain and C8–C9 epoxide for cytotoxic activity against cancer cellsTomohiro Itagaki, Ayano Kawamata, Miho Takeuchi, Keisuke Hamada, Yoshiharu Iwabuchi, Tadashi Eguchi, Fumitaka Kudo, Takeo Usui and Naoki Kanoh J Antibiot 2016 69: 287-293; advance online publication, January 27, 2016; 10.1038/ja.2015.148 Abstract | Full Text |  |  |  | Stereoselective access to tubuphenylalanine and tubuvaline: improved Mn-mediated radical additions and assembly of a tubulysin tetrapeptide analogGregory K Friestad, Koushik Banerjee, Jean-Charles Marié, Umesh Mali and Lei Yao J Antibiot 2016 69: 294-298; advance online publication, February 17, 2016; 10.1038/ja.2016.7 Abstract | Full Text |  |  |  | Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenolTomohiro Asakawa, Yusuke Kawabe, Atsushi Yoshida, Yoshiyuki Aihara, Tamiko Manabe, Yoshitsugu Hirose, Asuka Sakurada, Makoto Inai, Yoshitaka Hamashima, Takumi Furuta, Toshiyuki Wakimoto and Toshiyuki Kan J Antibiot 2016 69: 299-312; advance online publication, February 24, 2016; 10.1038/ja.2016.14 Abstract | Full Text |  |  |  | Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiolsChung-Min Park, Tyler D Biggs and Ming Xian J Antibiot 2016 69: 313-318; advance online publication, January 13, 2016; 10.1038/ja.2015.144 Abstract | Full Text |  |  |  | Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking modelAkihiro Sugawara, Hideaki Shima, Akito Sueki, Tomoyasu Hirose, Hidehito Matsui, Hayato Nakano, Hideaki Hanaki, Kiyoko S Akagawa, Satoshi Ōmura and Toshiaki Sunazuka J Antibiot 2016 69: 319-326; advance online publication, September 30, 2015; 10.1038/ja.2015.91 Abstract | Full Text |  |  |  | The use of fluorescently-tagged apoptolidins in cellular uptake and response studiesKatherine M Chong, Nalin Leelatian, Sean M Deguire, Asa A Brockman, David Earl, Rebecca A Ihrie, Jonathan M Irish, Brian O Bachmann and Gary A Sulikowski J Antibiot 2016 69: 327-330; advance online publication, March 9, 2016; 10.1038/ja.2016.22 Abstract | Full Text |  |  |  | Synthetic studies toward citrinadin A: construction of the pentacyclic coreMonica E McCallum, Genessa M Smith, Takanori Matsumaru, Ke Kong, John A Enquist Jr and John L Wood J Antibiot 2016 69: 331-336; advance online publication, March 9, 2016; 10.1038/ja.2016.25 Abstract | Full Text |  | Notes | Top |  | The enantioselective synthesis and biological evaluation of chimeric promysalin analogs facilitated by diverted total synthesisKyle W Knouse and William M Wuest J Antibiot 2016 69: 337-339; advance online publication, February 10, 2016; 10.1038/ja.2016.4 Full Text | PDF |  |  |  | Furan-iminium cation cyclization (FIC) in a total synthesis of manzamine alkaloidsKazuyuki Tokumaru, Toshiyuki Ohfusa, Shigeru Arai and Atsushi Nishida J Antibiot 2016 69: 340-343; advance online publication, March 9, 2016; 10.1038/ja.2016.24 Full Text | PDF |  |  |  | Natural product-derived quaternary ammonium compounds with potent antimicrobial activityMaureen D Joyce, Megan C Jennings, Celina N Santiago, Madison H Fletcher, William M Wuest and Kevin PC Minbiole J Antibiot 2016 69: 344-347; advance online publication, November 18, 2015; 10.1038/ja.2015.107 Full Text | PDF |  |  |  | Anti-obesity activities of the yoshinone A and the related marine γ-pyrone compounds OPENTomoyuki Koyama, Yoshinori Kawazoe, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga and Daisuke Uemura J Antibiot 2016 69: 348-351; advance online publication, March 2, 2016; 10.1038/ja.2016.19 Full Text | PDF |  |  |  |  |  |  |  |  |  |  | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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