The EMBO Journal Table of Contents for 15 February 2016; Vol. 35, No. 4

15 February 2016 | Volume 35, Number 4 Submit Table of Contents News & Views Review Articles Volume 35, Number 4 News & Views Doughnuts, daisy chains and crescent moons: the quest for the elusive apoptotic pore Two new super‐resolution imaging studies suggest the formation of large Bax‐delineated pores during mitochondrial outer membrane permeabilization upon apoptosis induction. Grant Dewson Published online 18.01.2016 In need of good neighbours: transcription factors require local DNA hypomethylation for target binding Transcription factors (TFs) bind only a subset of possible target sites in the genome, but the basis for this specificity has remained unclear. A new study shows DNA methylation to control target site access for specific transcription factors. Ino D Karemaker and Michiel Vermeulen Published online 12.01.2016 Review Touch, act and go: landing and operating on nucleosomes This review summarizes the emerging structural understanding of nucleosome recognition by multiprotein readers, writers and erasers of chromatin marks, which are key for integrating information from both DNA and histone modifications. Valentina Speranzini, Simona Pilotto, Titia K Sixma, and Andrea Mattevi Published online 19.01.2016 Articles Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores Super‐resolution analyses show that Bax oligomerizes into lines, arcs, and rings to mediate mitochondrial outer membrane permeabilization during apoptosis. Raquel Salvador‐Gallego, Markus Mund, Katia Cosentino, Jale Schneider, Joseph Unsay, Ulrich Schraermeyer, Johann Engelhardt, Jonas Ries, and Ana J García‐Sáez Published online 18.01.2016 Bax assembles into large ring‐like structures remodeling the mitochondrial outer membrane in apoptosis STED nanoscopy shows that upon apoptosis induction Bax molecules form ring‐like structures in the mitochondrial outer membrane (MOM) surrounding areas devoid of membrane proteins. The findings suggest the formation of large Bax‐delineated pores during MOM permeabilization. Lena Große, Christian A Wurm, Christian Brüser, Daniel Neumann, Daniel C Jans, and Stefan Jakobs Published online 18.01.2016 Non‐acidic activation of pain‐related Acid‐Sensing Ion Channel 3 by lipids ASIC3 is a proton‐sensitive ion channel linked to pain perception. The finding that certain lipids activate ASIC3 in the absence of tissue acidification challenges our view of pain‐causing agents and suggests crosstalk between pH fluctuations and lipid signaling. Sébastien Marra, Romain Ferru‐Clément, Véronique Breuil, Anne Delaunay, Marine Christin, Valérie Friend, Stéphane Sebille, Christian Cognard, Thierry Ferreira, Christian Roux, Liana Euller‐Ziegler, Jacques Noel, Eric Lingueglia, and Emmanuel Deval Published online 15.01.2016 HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG‐I Deacetylation of the cytoplasmic RIG‐I viral sensor by HDAC6 is required for viral RNA detection. HDAC6 depletion impairs in vivo responses against RNA but not DNA viruses in mice. Su Jin Choi, Hyun‐Cheol Lee, Jae‐Hoon Kim, Song Yi Park, Tae‐Hwan Kim, Woon‐Kyu Lee, Duk‐Jae Jang, Ji‐Eun Yoon, Young‐Il Choi, Seihwan Kim, JinYeul Ma, Chul‐Joong Kim, Tso‐Pang Yao, Jae U Jung, Joo‐Yong Lee, and Jong‐Soo Lee Published online 08.01.2016 Identification and function of conformational dynamics in the multidomain GTPase dynamin Dynamin‐catalyzed membrane fission requires long‐range nucleotide and/or membrane binding‐induced conformational changes and domain rearrangements that are identified and functionally characterized in this study. Saipraveen Srinivasan, Venkatasubramanian Dharmarajan, Dana Kim Reed, Patrick R Griffin, and Sandra L Schmid Published online 18.01.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.